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  1. Article ; Online: Determining the optimal radiation-surgery interval (RSI) for oncologic proctectomy following radiotherapy for rectal adenocarcinoma.

    Bobel, Matthew C / McGee, Michael F

    Journal of surgical oncology

    2023  Volume 127, Issue 8, Page(s) 1252–1258

    Abstract: Preoperative radiotherapy has improved outcomes in rectal cancer patients, however, the optimal interval between radiation and proctectomy is unknown. A review of contemporary literature suggests an 8-12 week interval between radiation and surgery likely ...

    Abstract Preoperative radiotherapy has improved outcomes in rectal cancer patients, however, the optimal interval between radiation and proctectomy is unknown. A review of contemporary literature suggests an 8-12 week interval between radiation and surgery likely improves tumor response rates for rectal cancer patients undergoing proctectomy, which may convey modest improvements in long-term oncologic outcomes. Prolonged radiation-surgery intervals may expose surgeons to pelvic fibrosis, however, which may impact later-term proctectomies and compromise perioperative and oncologic outcomes.
    MeSH term(s) Humans ; Treatment Outcome ; Neoplasm Staging ; Adenocarcinoma/radiotherapy ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Rectal Neoplasms/radiotherapy ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Proctectomy ; Retrospective Studies ; Neoadjuvant Therapy/adverse effects
    Language English
    Publishing date 2023-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: High-Efficiency Retroviral Transduction for Type 1 Regulatory T Cell Differentiation.

    McGee, Michael C / August, Avery / Huang, Weishan

    Bio-protocol

    2022  Volume 12, Issue 17

    Abstract: Type 1 regulatory T (Tr1) cells are an immunoregulatory ... ...

    Abstract Type 1 regulatory T (Tr1) cells are an immunoregulatory CD4
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination.

    McGee, Michael C / Huang, Weishan

    Journal of medical virology

    2022  Volume 94, Issue 6, Page(s) 2578–2587

    Abstract: Influenza (flu) infection is a leading cause of respiratory diseases and death worldwide. Although seasonal flu vaccines are effective at reducing morbidity and mortality, such effects rely on the odds of successful prediction of the upcoming viral ... ...

    Abstract Influenza (flu) infection is a leading cause of respiratory diseases and death worldwide. Although seasonal flu vaccines are effective at reducing morbidity and mortality, such effects rely on the odds of successful prediction of the upcoming viral strains. Additional threats from emerging flu viruses that we cannot predict and avian flu viruses that can be directly transmitted to humans urge the strategic development of universal vaccination that can protect against flu viruses of different subtypes and across species. Annual flu vaccines elicit mainly humoral responses. Under circumstances when antibodies induced by vaccination fail to recognize and neutralize the emerging virus adequately, virus-specific cytotoxic T lymphocytes (CTLs) are the major contributors to the control of viral replication and elimination of infected cells. Our studies exploited the evolutionary conservation of influenza A nucleoprotein (NP) and the fact that NP-specific CTL responses pose a constant selecting pressure on functional CTL epitopes to screen for NP epitopes that are highly conserved among heterosubtypes but are subjected to positive selection historically. We identified a region on NP that is evolutionarily conserved and historically positively selected (NP
    MeSH term(s) Animals ; Epitopes ; Humans ; Influenza A virus/genetics ; Influenza Vaccines/genetics ; Influenza, Human/prevention & control ; Mice ; Nucleoproteins/genetics ; Orthomyxoviridae Infections ; T-Lymphocytes, Cytotoxic ; Vaccination
    Chemical Substances Epitopes ; Influenza Vaccines ; Nucleoproteins
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1320: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Correction: Magazine et al. Mutations and Evolution of the SARS-CoV-2 Spike Protein.

    Magazine, Nicholas / Zhang, Tianyi / Wu, Yingying / McGee, Michael C / Veggiani, Gianluca / Huang, Weishan

    Viruses

    2023  Volume 15, Issue 9

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations for Universal Vaccine Development.

    Magazine, Nicholas / Zhang, Tianyi / Bungwon, Anang D / McGee, Michael C / Wu, Yingying / Veggiani, Gianluca / Huang, Weishan

    ImmunoHorizons

    2024  Volume 8, Issue 3, Page(s) 214–226

    Abstract: Despite the success of global vaccination programs in slowing the spread of COVID-19, these efforts have been hindered by the emergence of new SARS-CoV-2 strains capable of evading prior immunity. The mutation and evolution of SARS-CoV-2 have created a ... ...

    Abstract Despite the success of global vaccination programs in slowing the spread of COVID-19, these efforts have been hindered by the emergence of new SARS-CoV-2 strains capable of evading prior immunity. The mutation and evolution of SARS-CoV-2 have created a demand for persistent efforts in vaccine development. SARS-CoV-2 Spike protein has been the primary target for COVID-19 vaccine development, but it is also the hotspot of mutations directly involved in host susceptibility and virus immune evasion. Our ability to predict emerging mutants and select conserved epitopes is critical for the development of a broadly neutralizing therapy or a universal vaccine. In this article, we review the general paradigm of immune responses to COVID-19 vaccines, highlighting the immunological epitopes of Spike protein that are likely associated with eliciting protective immunity resulting from vaccination in humans. Specifically, we analyze the structural and evolutionary characteristics of the SARS-CoV-2 Spike protein related to immune activation and function via the TLRs, B cells, and T cells. We aim to provide a comprehensive analysis of immune epitopes of Spike protein, thereby contributing to the development of new strategies for broad neutralization or universal vaccination.
    MeSH term(s) Humans ; Spike Glycoprotein, Coronavirus/genetics ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2 ; Epitopes ; Vaccine Development
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines ; Epitopes
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2400003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: TCR/ITK Signaling in Type 1 Regulatory T cells.

    McGee, Michael C / August, Avery / Huang, Weishan

    Advances in experimental medicine and biology

    2021  Volume 1278, Page(s) 115–124

    Abstract: Type 1 regulatory T (Tr1) cells can modulate inflammation through multiple direct and indirect molecular and cellular mechanisms and have demonstrated potential for anti-inflammatory therapies. Tr1 cells do not express the master transcription factor of ... ...

    Abstract Type 1 regulatory T (Tr1) cells can modulate inflammation through multiple direct and indirect molecular and cellular mechanisms and have demonstrated potential for anti-inflammatory therapies. Tr1 cells do not express the master transcription factor of conventional regulatory T cells, Foxp3, but express high levels of the immunomodulatory cytokine, IL-10. IL-2-inducible T-cell kinase (ITK) is conserved between mouse and human and is highly expressed in T cells. ITK signaling downstream of the T-cell receptor (TCR) is critical for T-cell subset differentiation and function. Upon activation by TCR, ITK is critical for Ras activation, leading to downstream activation of MAPKs and upregulation of IRF4, which further enable Tr1 cell differentiation and suppressive function. We summarize here the structure, signaling pathway, and function of ITK in T-cell lineage designation, with an emphasis on Tr1 cell development and function.
    MeSH term(s) Animals ; Mice ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, T-Cell/genetics ; Signal Transduction ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Receptors, Antigen, T-Cell ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; emt protein-tyrosine kinase (EC 2.7.10.2)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-15-6407-9_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Layer 4 Gates Plasticity in Visual Cortex Independent of a Canonical Microcircuit.

    Frantz, Michael G / Crouse, Emily C / Sokhadze, Guela / Ikrar, Taruna / Stephany, Céleste-Élise / Nguyen, Collins / Xu, Xiangmin / McGee, Aaron W

    Current biology : CB

    2023  Volume 33, Issue 12, Page(s) 2586

    Language English
    Publishing date 2023-06-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.05.038
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    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Management of Acute Upper Gastrointestinal Bleeding in Critical Care Transport.

    Tafoya, Louis A / McGee, John C / Kaisler, Sean / Gottula, Adam L / Lauria, Michael J / Braude, Darren A

    Air medical journal

    2023  Volume 42, Issue 2, Page(s) 110–118

    Abstract: Upper gastrointestinal bleeding is a relatively common and life-threatening condition encountered by critical care transport crews. It is of paramount importance that transport crews understand the underlying pathophysiology of variceal and nonvariceal ... ...

    Abstract Upper gastrointestinal bleeding is a relatively common and life-threatening condition encountered by critical care transport crews. It is of paramount importance that transport crews understand the underlying pathophysiology of variceal and nonvariceal gastrointestinal bleeding as well as the nuanced management of this patient population. This article reviews the current clinical evidence on initial resuscitation, medical management, and advanced invasive therapies (such as balloon tamponade devices) that transport crews should be familiar with to manage these patients. In addition, we present a novel method of continuous balloon pressure monitoring of balloon tamponade devices that is applicable to the transport environment.
    MeSH term(s) Humans ; Gastrointestinal Hemorrhage/therapy ; Gastrointestinal Hemorrhage/epidemiology ; Acute Disease ; Critical Care ; Resuscitation
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2072853-0
    ISSN 1532-6497 ; 1067-991X
    ISSN (online) 1532-6497
    ISSN 1067-991X
    DOI 10.1016/j.amj.2022.12.006
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    Zs.A 5623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy.

    McGee, Michael C / August, Avery / Huang, Weishan

    Journal of leukocyte biology

    2020  Volume 109, Issue 1, Page(s) 49–53

    Abstract: Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been ...

    Abstract Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy.
    MeSH term(s) Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Agammaglobulinaemia Tyrosine Kinase/immunology ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; COVID-19/enzymology ; COVID-19/immunology ; Cytokines/immunology ; Humans ; Immunity, Innate/drug effects ; Lymphopenia/drug therapy ; Lymphopenia/enzymology ; Lymphopenia/immunology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/immunology ; Protein-Tyrosine Kinases/metabolism ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; COVID-19 Drug Treatment
    Chemical Substances Cytokines ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; BTK protein, human (EC 2.7.10.2) ; emt protein-tyrosine kinase (EC 2.7.10.2)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.5COVR0620-306R
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    Zs.A 603: Show issues Location:
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  10. Article: Th2 and Th17-Associated Immunopathology Following SARS-CoV-2 Breakthrough Infection in Spike-Vaccinated ACE2-humanized Mice.

    Zhang, Tianyi / Magazine, Nicholas / McGee, Michael C / Carossino, Mariano / Veggiani, Gianluca / Kousoulas, Konstantin G / August, Avery / Huang, Weishan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Vaccines have demonstrated remarkable effectiveness in protecting against COVID-19; however, concerns regarding vaccine-associated enhanced respiratory diseases (VAERD) following breakthrough infections have emerged. Spike protein subunit vaccines for ... ...

    Abstract Vaccines have demonstrated remarkable effectiveness in protecting against COVID-19; however, concerns regarding vaccine-associated enhanced respiratory diseases (VAERD) following breakthrough infections have emerged. Spike protein subunit vaccines for SARS-CoV-2 induce VAERD in hamsters, where aluminum adjuvants promote a Th2-biased immune response, leading to increased type 2 pulmonary inflammation in animals with breakthrough infections. To gain a deeper understanding of the potential risks and the underlying mechanisms of VAERD, we immunized ACE2-humanized mice with SARS-CoV-2 Spike protein adjuvanted with aluminum and CpG-ODN. Subsequently, we exposed them to increasing doses of SARS-CoV-2 to establish a breakthrough infection. The vaccine elicited robust neutralizing antibody responses, reduced viral titers, and enhanced host survival. However, following a breakthrough infection, vaccinated animals exhibited severe pulmonary immunopathology, characterized by a significant perivascular infiltration of eosinophils and CD4
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.18.563016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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