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Article ; Online: Commentary on the Risk Assessment of Lead by the Food Safety Commission of Japan.

Irie, Fumi

2022 Volume 10, Issue 3, Page(s) 102–111

Abstract: This article describes in detail the process of and the basis for the risk assessment of lead, started as a self-tasking assessment in April 2008 and finalized in June 2021 by the Food Safety Commission of Japan (FSCJ). Discussion points addressed in the ...

Abstract	This article describes in detail the process of and the basis for the risk assessment of lead, started as a self-tasking assessment in April 2008 and finalized in June 2021 by the Food Safety Commission of Japan (FSCJ). Discussion points addressed in the working group set under the FSCJ in April 2019 are also presented in this commentary. To reflect the overall exposure to lead from various sources, blood lead level (BLL) was used as the basic metric for the assessment. For the evaluation of effects on human health, the approach of overall weight of evidence was taken, rather than selecting one critical endpoint, in consideration of the uncertainties inherent to epidemiological studies, particularly those examining the effects associated with low-level lead exposure. The overall evidence compiled for the assessment suggested that BLLs in the range of 1-2 μg/dL might be associated with some effects on human health. The representative value of BLL for the entire population was difficult to obtain due to the lack of a national population-based survey in Japan. Instead, the current average BLL of the Japanese population was estimated based on recent studies conducted in Japan. The estimated average exposure level was below or equal to 1 μg/dL and close to the levels at which some effects on human health might occur, as suggested by epidemiological studies. Hence, the continued enforcement of measures to reduce lead exposure is indispensable. Furthermore, a national human biomonitoring program to continuously assess the exposure status of the Japanese population, which can be ultimately used for assuring the effectiveness of control measures, is needed.
Language	English
Publishing date	2022-09-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768899-9
ISSN	2187-8404 ; 2187-8404
ISSN (online)	2187-8404
ISSN	2187-8404
DOI	10.14252/foodsafetyfscj.D-22-00007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke

Kayo Wakisaka / Ryu Matsuo / Fumi Irie / Yoshinobu Wakisaka / Tetsuro Ago / Masahiro Kamouchi / Takanari Kitazono

PLoS ONE, Vol 19, Iss

2024 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke.

Wakisaka, Kayo / Matsuo, Ryu / Irie, Fumi / Wakisaka, Yoshinobu / Ago, Tetsuro / Kamouchi, Masahiro / Kitazono, Takanari

PloS one

2024 Volume 19, Issue 1, Page(s) e0296833

Abstract: Background: It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke.: ... ...

Abstract	Background: It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. Methods: We enrolled patients with acute ischemic stroke from a multicenter hospital-based stroke registry in Fukuoka, Japan. We measured WC on admission and categorized patients into four groups (Q1-Q4) according to the quartiles in females and males. The clinical outcomes were poor functional outcome (modified Rankin scale score 2-6) and death from any cause. Logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval of the outcomes of interest after adjusting for potential confounding factors, including body mass index (BMI). Results: A total of 11,989 patients (70.3±12.2 years, females: 36.1%) were included in the analysis. The risk of poor functional outcome significantly decreased for Q2-Q4 (vs. Q1) at discharge and Q2-Q3 (vs. Q1) at 3 months, even after adjusting for potential confounders, including BMI. In contrast, adjustment of BMI eliminated the significant association between WC and all-cause death at discharge and 3 months. The association between high WC and favorable functional outcome was not affected by fasting insulin levels or homeostatic model assessment for insulin resistance and was only found in patients without diabetes (P = 0.02 for heterogeneity). Conclusions: These findings suggest that abdominal adiposity has an additional impact on post-stroke functional outcome, independent of body weight and insulin action.
MeSH term(s)	Male ; Female ; Humans ; Ischemic Stroke/complications ; Adiposity ; Stroke ; Obesity, Abdominal/complications ; Insulins ; Risk Factors
Chemical Substances	Insulins
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296833
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Article ; Online: Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke.

Irie, Fumi / Matsuo, Ryu / Mezuki, Satomi / Wakisaka, Yoshinobu / Kamouchi, Masahiro / Kitazono, Takanari / Ago, Tetsuro

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9290

Abstract: Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this ... ...

Abstract	Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, including neurological improvement (≥ 4-point decrease in the National Institutes of Health Stroke Scale during hospitalization or 0 points at discharge) and good functional outcomes (modified Rankin Scale score of 0-2) at 3 months, was evaluated using logistic regression analysis and propensity score-matched analysis. Among the participants, 231 (20.1%) were current smokers. The odds ratios (ORs) of favorable outcomes after adjusting for potential confounders were not significantly increased in current smokers (OR 0.85, 95% confidence interval [CI] 0.60-1.22 for neurological improvement; OR 0.95, 95% CI 0.65-1.38 for good functional outcome). No significant association was found in the propensity score-matched cohorts. Smoking cessation is strongly recommended since current smoking was not associated with better outcomes after reperfusion therapy.
MeSH term(s)	Humans ; Male ; Female ; Ischemic Stroke/therapy ; Aged ; Smoking/adverse effects ; Treatment Outcome ; Reperfusion ; Middle Aged ; Aged, 80 and over ; Japan/epidemiology ; Registries ; Thrombolytic Therapy ; Propensity Score
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59508-3
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Article ; Online: Body temperature in the acute phase and clinical outcomes after acute ischemic stroke

Satomi Mezuki / Ryu Matsuo / Fumi Irie / Yuji Shono / Takahiro Kuwashiro / Hiroshi Sugimori / Yoshinobu Wakisaka / Tetsuro Ago / Masahiro Kamouchi / Takanari Kitazono

PLoS ONE, Vol 19, Iss

2024 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Body temperature in the acute phase and clinical outcomes after acute ischemic stroke.

Mezuki, Satomi / Matsuo, Ryu / Irie, Fumi / Shono, Yuji / Kuwashiro, Takahiro / Sugimori, Hiroshi / Wakisaka, Yoshinobu / Ago, Tetsuro / Kamouchi, Masahiro / Kitazono, Takanari

PloS one

2024 Volume 19, Issue 1, Page(s) e0296639

Abstract: Background: This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months.: Methods: We included 7,177 patients with acute ischemic stroke ... ...

Abstract	Background: This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. Methods: We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. Results: The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C. Conclusions: Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Ischemic Stroke/complications ; Body Temperature ; Brain Ischemia/complications ; Stroke/complications ; Fever/complications ; Treatment Outcome
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296639
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Article ; Online: Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke.

Kayo Wakisaka / Ryu Matsuo / Fumi Irie / Yoshinobu Wakisaka / Tetsuro Ago / Masahiro Kamouchi / Takanari Kitazono / Fukuoka Stroke Registry Investigators

PLoS ONE, Vol 19, Iss 1, p e

2024 Volume 0296833

Abstract: Background It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. Methods ... ...

Abstract	Background It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. Methods We enrolled patients with acute ischemic stroke from a multicenter hospital-based stroke registry in Fukuoka, Japan. We measured WC on admission and categorized patients into four groups (Q1-Q4) according to the quartiles in females and males. The clinical outcomes were poor functional outcome (modified Rankin scale score 2-6) and death from any cause. Logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval of the outcomes of interest after adjusting for potential confounding factors, including body mass index (BMI). Results A total of 11,989 patients (70.3±12.2 years, females: 36.1%) were included in the analysis. The risk of poor functional outcome significantly decreased for Q2-Q4 (vs. Q1) at discharge and Q2-Q3 (vs. Q1) at 3 months, even after adjusting for potential confounders, including BMI. In contrast, adjustment of BMI eliminated the significant association between WC and all-cause death at discharge and 3 months. The association between high WC and favorable functional outcome was not affected by fasting insulin levels or homeostatic model assessment for insulin resistance and was only found in patients without diabetes (P = 0.02 for heterogeneity). Conclusions These findings suggest that abdominal adiposity has an additional impact on post-stroke functional outcome, independent of body weight and insulin action.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sex Differences in Long-Term Functional Decline after Ischemic Stroke: A Longitudinal Observational Study from the Fukuoka Stroke Registry.

Irie, Fumi / Matsuo, Ryu / Nakamura, Kuniyuki / Wakisaka, Yoshinobu / Ago, Tetsuro / Kitazono, Takanari / Kamouchi, Masahiro

Cerebrovascular diseases (Basel, Switzerland)

2023 Volume 52, Issue 4, Page(s) 409–416

Abstract: Introduction: Data on sex differences in poststroke functional status for a period longer than 1 year based on large cohorts are sparse. This study aimed to determine whether there are sex differences in long-term functional decline after ischemic ... ...

Abstract	Introduction: Data on sex differences in poststroke functional status for a period longer than 1 year based on large cohorts are sparse. This study aimed to determine whether there are sex differences in long-term functional decline after ischemic stroke. Methods: We tracked functional status for 5 years among 3-month survivors of acute ischemic stroke and compared outcomes between women and men using a large-scale hospital-based stroke registry in Fukuoka, Japan. Functional status was assessed using the modified Rankin Scale (mRS). Functional dependency was defined as an mRS score of 3, 4, or 5. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals of outcomes after adjusting for possible confounders. Results: A total of 8,446 patients (71.9 ± 12.5 years, 3,377 (40.0%) female patients) were enrolled in this study. Female sex was associated with a higher risk of functional dependency at 5 years poststroke even when adjusting for age, 3-month mRS score, and other confounding factors (multivariable-adjusted OR vs. men, 1.56 [95% confidence interval, 1.26-1.93]). This significant association of female sex with higher dependency at 5 years was also found among patients who were independent at 3 months poststroke. Subgroup analysis showed that increased risk of functional dependency in female patients was more marked in patients aged ≥75 years than in those aged <75 years (p for heterogeneity = 0.02). Conversely, female sex was associated with a lower risk of death. No sex difference was observed in stroke recurrence during 5 years poststroke. Discussion/conclusion: This longitudinal observational study suggests that female sex was independently associated with an increased risk of functional decline in the chronic phase of stroke, especially in older patients. There was no sex difference in 5-year stroke recurrence, and thus, other factors might be involved in more significant deterioration of functional status in female survivors of ischemic stroke. Further studies are needed to elucidate underlying causes of sex differences in long-term functional decline after stroke.
MeSH term(s)	Humans ; Female ; Male ; Aged ; Child, Preschool ; Ischemic Stroke/complications ; Brain Ischemia/diagnosis ; Brain Ischemia/therapy ; Brain Ischemia/complications ; Treatment Outcome ; Stroke/diagnosis ; Stroke/therapy ; Stroke/complications ; Registries ; Risk Factors
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000526940
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Article ; Online: Non-linear association between body weight and functional outcome after acute ischemic stroke.

Wakisaka, Kayo / Matsuo, Ryu / Matsumoto, Koutarou / Nohara, Yasunobu / Irie, Fumi / Wakisaka, Yoshinobu / Ago, Tetsuro / Nakashima, Naoki / Kamouchi, Masahiro / Kitazono, Takanari

Scientific reports

2023 Volume 13, Issue 1, Page(s) 8697

Abstract: This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into ...

Abstract	This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m
MeSH term(s)	Humans ; Female ; Aged ; Male ; Overweight ; Ischemic Stroke/complications ; Thinness/complications ; Risk Factors ; Body Weight ; Stroke ; Obesity/complications ; Body Mass Index ; Treatment Outcome
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35894-y
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Article ; Online: Modification of the effects of age on clinical outcomes through management of lifestyle-related factors in patients with acute ischemic stroke.

Ohya, Yuichiro / Matsuo, Ryu / Sato, Noriko / Irie, Fumi / Wakisaka, Yoshinobu / Ago, Tetsuro / Kamouchi, Masahiro / Kitazono, Takanari

Journal of the neurological sciences

2023 Volume 446, Page(s) 120589

Abstract: Background and purpose: This study examined the association between age and clinical outcomes after ischemic stroke, and whether the effect of age on post-stroke outcomes can be modified by various factors.: Methods: We included 12,171 patients with ... ...

Abstract	Background and purpose: This study examined the association between age and clinical outcomes after ischemic stroke, and whether the effect of age on post-stroke outcomes can be modified by various factors. Methods: We included 12,171 patients with acute ischemic stroke, who were functionally independent before stroke onset, in a multicenter hospital-based study conducted in Fukuoka, Japan. Patients were categorized into six groups according to age: ≤ 45, 46-55, 56-65, 66-75, 76-85, and > 85 years. Logistic regression analysis was performed to estimate an odds ratio for poor functional outcome (modified Rankin scale score of 3-6 at 3 months) for each age group. Interaction effects of age and various factors were analyzed using a multivariable model. Results: The mean age of the patients was 70.3 ± 12.2 years, and 63.9% were men. Neurological deficits at onset were more severe in the older age groups. The odds ratio of poor functional outcome linearly increased (P for trend <0.001), even after adjusting for potential confounders. Sex, body mass index, hypertension, and diabetes mellitus significantly modified the effect of age on the outcome (P < 0.05). The unfavorable effect of older age was greater in female patients and those with low body weight, whereas the protective effect of younger age was smaller in patients with hypertension or diabetes mellitus. Conclusions: Functional outcome worsened with age in patients with acute ischemic stroke, especially in females and those with low body weight, hypertension, or hyperglycemia.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Middle Aged ; Aged, 80 and over ; Ischemic Stroke ; Brain Ischemia ; Treatment Outcome ; Stroke ; Diabetes Mellitus ; Hypertension ; Life Style ; Body Weight
Language	English
Publishing date	2023-02-15
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120589
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