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Article ; Online: Emerging roles of RNA-binding proteins in fatty liver disease.

Adesanya, Oluwafolajimi / Das, Diptatanu / Kalsotra, Auinash

2024 Volume 15, Issue 2, Page(s) e1840

Abstract: A rampant and urgent global health issue of the 21st century is the emergence and progression of fatty liver disease (FLD), including alcoholic fatty liver disease and the more heterogenous metabolism-associated (or non-alcoholic) fatty liver disease ( ... ...

Abstract	A rampant and urgent global health issue of the 21st century is the emergence and progression of fatty liver disease (FLD), including alcoholic fatty liver disease and the more heterogenous metabolism-associated (or non-alcoholic) fatty liver disease (MAFLD/NAFLD) phenotypes. These conditions manifest as disease spectra, progressing from benign hepatic steatosis to symptomatic steatohepatitis, cirrhosis, and, ultimately, hepatocellular carcinoma. With numerous intricately regulated molecular pathways implicated in its pathophysiology, recent data have emphasized the critical roles of RNA-binding proteins (RBPs) in the onset and development of FLD. They regulate gene transcription and post-transcriptional processes, including pre-mRNA splicing, capping, and polyadenylation, as well as mature mRNA transport, stability, and translation. RBP dysfunction at every point along the mRNA life cycle has been associated with altered lipid metabolism and cellular stress response, resulting in hepatic inflammation and fibrosis. Here, we discuss the current understanding of the role of RBPs in the post-transcriptional processes associated with FLD and highlight the possible and emerging therapeutic strategies leveraging RBP function for FLD treatment. This article is categorized under: RNA in Disease and Development > RNA in Disease.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/genetics ; RNA-Binding Proteins/genetics ; Phenotype ; RNA ; RNA, Messenger
Chemical Substances	RNA-Binding Proteins ; RNA (63231-63-0) ; RNA, Messenger
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2634714-3
ISSN	1757-7012 ; 1757-7004
ISSN (online)	1757-7012
ISSN	1757-7004
DOI	10.1002/wrna.1840
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Government preparedness and response towards COVID-19 outbreak in Nigeria: A retrospective analysis of the last 6 months.

Adesanya, Oluwafolajimi A

Journal of global health

2020 Volume 10, Issue 2, Page(s) 20382

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Civil Defense/statistics & numerical data ; Disease Outbreaks/statistics & numerical data ; Humans ; Nigeria/epidemiology ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Retrospective Studies
Keywords	covid19
Language	English
Publishing date	2020-08-19
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2978
ISSN (online)	2047-2986
ISSN	2047-2978
DOI	10.7189/jogh.10.020382
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving the Management and Treatment of Diabetic Foot Infection: Challenges and Research Opportunities.

Turzańska, Kaja / Adesanya, Oluwafolajimi / Rajagopal, Ashwene / Pryce, Mary T / Fitzgerald Hughes, Deirdre

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Diabetic foot infection (DFI) management requires complex multidisciplinary care pathways with off-loading, debridement and targeted antibiotic treatment central to positive clinical outcomes. Local administration of topical treatments and advanced wound ...

Abstract	Diabetic foot infection (DFI) management requires complex multidisciplinary care pathways with off-loading, debridement and targeted antibiotic treatment central to positive clinical outcomes. Local administration of topical treatments and advanced wound dressings are often used for more superficial infections, and in combination with systemic antibiotics for more advanced infections. In practice, the choice of such topical approaches, whether alone or as adjuncts, is rarely evidence-based, and there does not appear to be a single market leader. There are several reasons for this, including a lack of clear evidence-based guidelines on their efficacy and a paucity of robust clinical trials. Nonetheless, with a growing number of people living with diabetes, preventing the progression of chronic foot infections to amputation is critical. Topical agents may increasingly play a role, especially as they have potential to limit the use of systemic antibiotics in an environment of increasing antibiotic resistance. While a number of advanced dressings are currently marketed for DFI, here we review the literature describing promising future-focused approaches for topical treatment of DFI that may overcome some of the current hurdles. Specifically, we focus on antibiotic-impregnated biomaterials, novel antimicrobial peptides and photodynamic therapy.
MeSH term(s)	Humans ; Diabetic Foot/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Communicable Diseases/drug therapy ; Bandages ; Diabetes Mellitus/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043913
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Thoracic endometriosis syndrome: Cutting the gordian knot - A case report and review of the literature.

Adesanya, Oluwafolajimi A / Kolawole, Oludayo E

International journal of surgery case reports

2019 Volume 66, Page(s) 68–71

Abstract: Introduction: Thoracic Endometriosis Syndrome (TES) is a rare disorder characterized by the presence of functional endometrial tissue in the thoracic cavity, often associated with the visceral or parietal pleura, lung parenchyma or airways. The aim of ... ...

Abstract	Introduction: Thoracic Endometriosis Syndrome (TES) is a rare disorder characterized by the presence of functional endometrial tissue in the thoracic cavity, often associated with the visceral or parietal pleura, lung parenchyma or airways. The aim of this case report is to illustrate the classic manner of presentation of TES and the modalities of therapy employed in a low-resource setting in the South-Western region of Nigeria. Case presentation: We report the case of a 37-year old woman who presented with right-sided pleuritic chest pain, cough and dyspnea closely associated with her menstrual cycle. On examination, there were reduced breath sounds and decreased air entry on the right hemithorax as well as dull percussion notes on the right middle and lower lung zones. Chest X-ray revealed signs of right-sided pleural effusion. Working diagnosis of right-sided Catamenial Pneumothorax was made for which she had 3 sessions of chemical pleurodesis which failed to close the air leaks. She eventually has a right-sided posterolateral thoracotomy and was co-managed by the O&G team with monthly Goserelin injections. Conclusion: This case illustrates the difficulties physicians in low-resource settings face in the diagnosis and treatment of TES and the importance of a high index of suspicion as well as a multidisciplinary approach in patient care.
Language	English
Publishing date	2019-11-27
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2019.11.032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics.

Adesanya, Oluwafolajimi A / Uche-Orji, Christabel I / Adedeji, Yeshua A / Joshua, John I / Adesola, Adeniyi A / Chukwudike, Chibuike J

Infectious microbes & diseases

2020 Volume 2, Issue 4, Page(s) 144–150

Abstract: Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy ... ...

Abstract	Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against
Language	English
Publishing date	2020-10-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2641-5917
ISSN (online)	2641-5917
DOI	10.1097/IM9.0000000000000040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacillus Calmette-Guerin (BCG): the adroit vaccine.

Adesanya, Oluwafolajimi A / Uche-Orji, Christabel I / Adedeji, Yeshua A / Joshua, John I / Adesola, Adeniyi A / Chukwudike, Chibuike J

AIMS microbiology

2021 Volume 7, Issue 1, Page(s) 96–113

Abstract: Background: The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and is regarded as one of the oldest human vaccines known today. It is recommended primarily due to its effect in preventing the most severe forms of tuberculosis, ... ...

Abstract	Background: The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and is regarded as one of the oldest human vaccines known today. It is recommended primarily due to its effect in preventing the most severe forms of tuberculosis, including disseminated tuberculosis and meningeal tuberculosis in children; however, its efficacy in preventing pulmonary tuberculosis and TB reactivation in adults has been questioned. Several studies however have found that asides from its role in tuberculosis prevention, the BCG vaccine also has protective effects against a host of other viral infections in humans, an effect which has been termed: heterologous, non-specific or off-target. Objectives: As we approach 100 years since the discovery of the BCG vaccine, we review the evidence of the non-specific protection offered by the vaccine against viral infections, discuss the possible mechanisms of action of these effects, highlight the implications these effects could have on vaccinology and summarize the recent epidemiological correlation between the vaccine and the on-going COVID-19 pandemic. Results: Several epidemiological studies have established that BCG does reduce all-cause mortality in infants, and also the time of vaccination influences this effect significantly. This effect has been attributed to the protective effect of the vaccine in preventing unrelated viral infections during the neonatal period. Some of such viral infections that have been investigated include: herpes simplex virus (HSV), human Papilloma virus (HPV), yellow fever virus (YFV), respiratory syncytial virus (RSV) and influenza virus type A (H1N1). These effects are thought to be mediated via induction of innate immune memory as well as heterologous lymphocytic activation. While epidemiological studies have suggested a correlation, the potential protection of the BCG vaccine against COVID-19 transmission and mortality rates is currently unclear. Ongoing clinical trials and further research may shed more light on the subject in the future. Conclusion: BCG is a multifaceted vaccine, with many numerous potential applications to vaccination strategies being employed for current and future viral infections. There however is a need for further studies into the immunologic mechanisms behind these non-specific effects, for these potentials to become reality, as we usher in the beginning of the second century since the vaccine's discovery.
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2471-1888
ISSN (online)	2471-1888
DOI	10.3934/microbiol.2021007
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Article ; Online: Infectious disease outbreak preparedness and response in Nigeria: history, limitations and recommendations for global health policy and practice.

Olumade, Testimony J / Adesanya, Oluwafolajimi A / Fred-Akintunwa, Iyanuoluwa J / Babalola, David O / Oguzie, Judith U / Ogunsanya, Olusola A / George, Uwem E / Akin-Ajani, Oluwawapelumi D / Osasona, Damilola G

AIMS public health

2020 Volume 7, Issue 4, Page(s) 736–757

Abstract: Effective disease outbreak response has historically been a challenging accomplishment for the Nigerian health system due to an array of hurdles not unique to Nigeria but also found in other African nations which share its large size and complexity. ... ...

Abstract	Effective disease outbreak response has historically been a challenging accomplishment for the Nigerian health system due to an array of hurdles not unique to Nigeria but also found in other African nations which share its large size and complexity. However, the efficiency of the response mounted against the Ebola Virus Disease (EVD) outbreak of 2014 proved that indeed, though challenging, proactive and effective outbreak response is not impossible. With over 20 public health emergencies and infectious disease outbreaks between 2016 and 2018 alone, Nigeria is one of only five members of the World Health Organization (WHO) African Region to report five or more public health events per annum. There are many lessons that can be drawn from Nigeria's experience in handling outbreaks of infectious diseases. In this review, we discuss the history of emerging and re-emerging infectious disease outbreaks in Nigeria and explore the response strategies mounted towards each. We also highlight the significant successes and note-worthy limitations, which we have then utilized to proffer policy recommendations to strengthen the Nigerian public health emergency response systems.
Language	English
Publishing date	2020-09-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2777115-5
ISSN	2327-8994 ; 2327-8994
ISSN (online)	2327-8994
ISSN	2327-8994
DOI	10.3934/publichealth.2020057
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Article ; Online: Infectious disease outbreak preparedness and response in Nigeria

Testimony J Olumade / Oluwafolajimi A Adesanya / Iyanuoluwa J Fred-Akintunwa / David O Babalola / Judith U Oguzie / Olusola A Ogunsanya / Uwem E George / Oluwawapelumi D Akin-Ajani / Damilola G Osasona

AIMS Public Health, Vol 7, Iss 4, Pp 736-

history, limitations and recommendations for global health policy and practice

2020 Volume 757

Abstract	Effective disease outbreak response has historically been a challenging accomplishment for the Nigerian health system due to an array of hurdles not unique to Nigeria but also found in other African nations which share its large size and complexity. However, the efficiency of the response mounted against the Ebola Virus Disease (EVD) outbreak of 2014 proved that indeed, though challenging, proactive and effective outbreak response is not impossible. With over 20 public health emergencies and infectious disease outbreaks between 2016 and 2018 alone, Nigeria is one of only five members of the World Health Organization (WHO) African Region to report five or more public health events per annum. There are many lessons that can be drawn from Nigeria's experience in handling outbreaks of infectious diseases. In this review, we discuss the history of emerging and re-emerging infectious disease outbreaks in Nigeria and explore the response strategies mounted towards each. We also highlight the significant successes and note-worthy limitations, which we have then utilized to proffer policy recommendations to strengthen the Nigerian public health emergency response systems.
Keywords	infectious diseases ; outbreak preparedness ; outbreak response ; global health policy ; nigeria ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	AIMS Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 Outbreak in Africa

Oluwafolajimi Adesanya

International Journal of Travel Medicine and Global Health, Vol 8, Iss 3, Pp 96-

Lessons and Insights from the West African Ebola Virus Disease Epidemics

2020 Volume 99

Abstract: Over the years, the African continent has had to battle several outbreaks of infectious diseases in different countries. Some of the most deadly were the Ebola virus disease (EVD) outbreaks that occurred in West Africa between 2014 and 2016 affecting ... ...

Abstract	Over the years, the African continent has had to battle several outbreaks of infectious diseases in different countries. Some of the most deadly were the Ebola virus disease (EVD) outbreaks that occurred in West Africa between 2014 and 2016 affecting Guinea, Liberia, and Sierra Leone and, more recently, from 2018 to 2020 in the Democratic Republic of Congo (DRC). In the era of the COVID-19 pandemic, it is important that as a continent, we draw lessons and insights from our past experiences to guide outbreak response strategies being deployed to curb the latest onslaught. The Ebola outbreaks have shown that disease outbreaks should not be seen only as medical emergencies, but as full blown humanitarian crises, because oftentimes, their socio-economic impacts are more devastating than the more obvious cost to life. In this mini-review, we explore the possible humanitarian costs of the COVID-19 pandemic on the African continent by looking through the lens of our past experiences with the EVD outbreaks, highlighting how the current pandemic could significantly affect the African economy, food security, and vulnerable demographics, like children and the sexual and reproductive health and rights of women and girls. We then proffer recommendations that could be instrumental in preventing a double tragedy involving the devastating health consequences of the virus itself and the deadly fallout from its multi-sectoral knock-on effects in African countries.
Keywords	covid-19 ; sars-cov-2 ; ebola virus disease ; coronavirus ; Medicine ; R
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	International Travel Medicine Center of Iran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 Outbreak in Africa

Adesanya, Oluwafolajimi Adetoye

International Journal of Travel Medicine and Global Health

Lessons and Insights from the West African Ebola Virus Disease Epidemics

2020 Volume 8, Issue 3, Page(s) 96–99

Abstract	Over the years, the African continent has had to battle several outbreaks of infectious diseases in different countries. Some of the most deadly were the Ebola virus disease (EVD) outbreaks that occurred in West Africa between 2014 and 2016 affecting Guinea, Liberia, and Sierra Leone and, more recently, from 2018 to 2020 in the Democratic Republic of Congo (DRC). In the era of the COVID-19 pandemic, it is important that as a continent, we draw lessons and insights from our past experiences to guide outbreak response strategies being deployed to curb the latest onslaught. The Ebola outbreaks have shown that disease outbreaks should not be seen only as medical emergencies, but as full blown humanitarian crises, because oftentimes, their socio-economic impacts are more devastating than the more obvious cost to life. In this mini-review, we explore the possible humanitarian costs of the COVID-19 pandemic on the African continent by looking through the lens of our past experiences with the EVD outbreaks, highlighting how the current pandemic could significantly affect the African economy, food security, and vulnerable demographics, like children and the sexual and reproductive health and rights of women and girls. We then proffer recommendations that could be instrumental in preventing a double tragedy involving the devastating health consequences of the virus itself and the deadly fallout from its multi-sectoral knock-on effects in African countries. Keywords: COVID-19, SARS-CoV-2, Ebola Virus Disease, Coronavirus.
Keywords	covid19
Language	English
Publisher	Maad Rayan Publishing Company
Publishing country	de
Document type	Article ; Online
ISSN	2476-5759
DOI	10.34172/ijtmgh.2020.17
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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