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  1. Article ; Online: Editorial overview: Biotechnological insights of marine and terrestrial microbiome.

    Vezzulli, Luigi / Ventura, Marco

    Current opinion in biotechnology

    2022  Volume 73, Page(s) vii–ix

    MeSH term(s) Biotechnology ; Microbiota
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Editorial
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2021.12.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3071: Show issues Location:
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  2. Article ; Online: Viral Load Reduction and High-Dose Ivermectin in Early Treatment: A Reappraisal.

    Tedeschi, Simone / Ventura, Luigi

    International journal of antimicrobial agents

    2022  Volume 59, Issue 5, Page(s) 106575

    MeSH term(s) COVID-19 ; Humans ; Ivermectin/therapeutic use ; SARS-CoV-2 ; Viral Load
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2022-03-20
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2022.106575
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    Zs.MO 500: Show issues

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  3. Article ; Online: "Immunohistochemical analysis of Sigma-1 receptor (σ-1R) expression in human pineal gland in relation to different causes of death".

    Mondello, Cristina / Micali, Antonio / Baldino, Gennaro / Cardia, Luigi / Alibrandi, Angela / Asmundo, Alessio / Sapienza, Daniela / Puzzolo, Domenico / Ventura Spagnolo, Elvira

    Legal medicine (Tokyo, Japan)

    2024  Volume 69, Page(s) 102434

    Abstract: Sigma-1 receptor (σ-1R) modulates cellular signaling pathways, probably acting as a ligand operated chaperone. When activated, the receptor translocates from the interface mitochondrion associated membrane of the endoplasmic reticulum to the cell ... ...

    Abstract Sigma-1 receptor (σ-1R) modulates cellular signaling pathways, probably acting as a ligand operated chaperone. When activated, the receptor translocates from the interface mitochondrion associated membrane of the endoplasmic reticulum to the cell membrane. σ-1R was demonstrated in some brain regions, including the pineal gland, and was proposed to be involved in several cerebral processes, including neuroprotective responses against homeostasis alterations. On this basis, the immunohistochemical expression of σ-1R in human pineal glands was evaluated, with particular regard to the different causes of death. Thirty-eight pineal glands obtained from forensic autopsies were divided into five groups according to the cause of death: sudden death, drowning, fire fatality, hanging, and hemorrhagic shock, and examined with hematoxylin-eosin stain and immunohistochemistry for σ-1R. Both pinealocytes and perivascular spaces were evaluated. The pineal glands from sudden death were only mildly positive for σ-1R, while a more evident immunopositivity was observed in hanging, fire fatality, hemorrhagic shock, and drowning. These results were confirmed in a two-by-two comparison between the sudden death group and other groups. Our data demonstrate for the first time with immunohistochemical techniques the presence of σ-1R expression in the human pineal gland and propose a direct correlation between σ-1R expression and duration of the death process, in particular when hypoxic conditions and/or excessive psychological stress are present.
    Language English
    Publishing date 2024-03-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2019555-2
    ISSN 1873-4162 ; 1344-6223
    ISSN (online) 1873-4162
    ISSN 1344-6223
    DOI 10.1016/j.legalmed.2024.102434
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    Zs.A 5250: Show issues Location:
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  4. Article ; Online: Perioperative discordance in mesothelioma cell type after pleurectomy/decortication-a possible detrimental effect of neoadjuvant chemotherapy due to epithelial to mesenchymal transition?

    Ventura, Luigi / Lee, Michelle / Baranowski, Ralitsa / Hargrave, Joanne / Sheaff, Michael / Waller, David

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 37, Issue 5

    Abstract: Objectives: The goal was to evaluate the accuracy of preoperative histological assessment and the factors affecting the accuracy and the subsequent effect on postoperative survival after surgical treatment for malignant pleural mesothelioma (MPM).: ... ...

    Abstract Objectives: The goal was to evaluate the accuracy of preoperative histological assessment and the factors affecting the accuracy and the subsequent effect on postoperative survival after surgical treatment for malignant pleural mesothelioma (MPM).
    Methods: We analysed the perioperative course of patients who underwent surgery for MPM in a single institution over a 5-year period. The primary end point was to evaluate the proportion of histological discordance between preoperative assessment and postoperative histological diagnosis. The secondary end point was to evaluate its prognostic effect on postoperative survival after surgical treatment.
    Results: One-hundred and twenty-nine patients were included in this study. Histological discordance between preoperative assessment and postoperative histological diagnosis was found in 27 of 129 patients (20.9%): epithelial to biphasic/sarcomatoid (negative discordance) in 24 and biphasic to epithelial (positive discordance) in 3 (P-value < 0.001). All 24 patients who exhibited epithelial-to-mesenchymal transition (EMT) had received neoadjuvant chemotherapy (P-value: 0.006). In the 34 patients who underwent upfront surgery, only 1 case (2.9%) of EMT was identified (P-value: 0.127). EMT was not associated with a less invasive method of biopsy (P-value: 0.058) or with the volume or maximum diameter of the biopsy (P-value: 0.358 and 0.518, respectively), but it was significantly associated with the receipt of neoadjuvant chemotherapy (P-value: 0.006). At a median follow-up of 17 months (IQR: 11.0-28.0), 50 (39%) patients are still alive. Overall survival was significantly reduced in those patients who received neoadjuvant chemotherapy and who exhibited discordance (EMT) compared to those who did not: 11 (95% CI: 6.2-15.8) months versus 19 (95% CI: 14.2-23.8) months (P-value < 0.001). In addition, there was no difference in overall survival between those who received neoadjuvant chemotherapy and those who had upfront surgery: 16 (95% CI: 2.5-19.5) months versus 30 (95% CI: 11.6-48.4) months (P-value: 0.203).
    Conclusions: The association of neoadjuvant chemotherapy with perioperative histological discordance can be explained by EMT, which leads to worse survival. Therefore, there is an argument for the preferential use of upfront surgery in the treatment of otherwise resectable MPM.
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad145
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  5. Article: The Effects of Preserving the Diaphragm on Early and Late Outcome of Lung-Sparing Radical Surgery for Malignant Pleural Mesothelioma.

    Lee, Michelle / Ventura, Luigi / Baranowski, Ralitsa / Hargrave, Joanne / Waller, David

    Journal of clinical medicine

    2022  Volume 11, Issue 22

    Abstract: Background: The accepted aim of radical surgery for malignant pleural mesothelioma (MPM) is the achievement of macroscopic complete resection (MCR) whilst reducing perioperative morbidity by preserving normal tissue. Whilst preservation of the lung by ... ...

    Abstract Background: The accepted aim of radical surgery for malignant pleural mesothelioma (MPM) is the achievement of macroscopic complete resection (MCR) whilst reducing perioperative morbidity by preserving normal tissue. Whilst preservation of the lung by pleurectomy/decortication (PD) has become widely utilised, there remains debate regarding the management of the diaphragm. Muscle-sparing complete excision of the diaphragmatic pleura is technically challenging; thus, surgeons may proceed to extended PD with phrenectomy and possible increased morbidity or to preserve the diaphragmatic pleura at the expense of MCR with potential survival deficit. We aimed to evaluate the effects of an intentional change in protocol to diaphragm-sparing PD whilst maintaining MCR as the treatment of choice for MPM.
    Methods: In a series of 136 patients (111M:25F, median age 68(63-73) years) undergoing radical surgery for MPM, we identified 28 patients (22M:6F, median age 67(60-71) years) in whom MCR was achieved without phrenectomy (PD group). We compared their perioperative outcomes and survival with a historical control group of 18 patients (18M:0F, median age 69(57-78) years) in whom MCR had been achieved with phrenectomy (EPD group) but in whom there was no histological evidence of diaphragm muscle invasion and who, in retrospect, could have undergone muscle-sparing MCR if this procedure had been attempted.
    Results: There was no significant intergroup difference in demographics or tumour cell type; the majority of both groups were found to be epithelial (PD 85.7%, EPD 77.8%). The EPD group was found to be more locally advanced (T3 55.56%) than the PD group (T1 46.43%) (
    Conclusions: A surgical strategy of attempting to spare the diaphragm whilst still achieving MCR wherever possible is justified by improved perioperative outcomes without compromising OS.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11226839
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  6. Article ; Online: Bacillus Calmette-Guérin vaccination and socioeconomic variables vs COVID-19 global features: Clearing up a controversial issue.

    Ventura, Luigi / Vitali, Matteo / Romano Spica, Vincenzo

    Allergy

    2020  Volume 76, Issue 3, Page(s) 884–887

    MeSH term(s) BCG Vaccine/immunology ; COVID-19/epidemiology ; COVID-19/mortality ; Humans ; Incidence ; SARS-CoV-2 ; Socioeconomic Factors ; Vaccination
    Chemical Substances BCG Vaccine
    Language English
    Publishing date 2020-08-14
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14524
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    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  7. Article ; Online: Biophysical signalling from and to the (stem) cells: a novel path to regenerative medicine.

    Ventura, Carlo / Tavazzi, Luigi

    European journal of heart failure

    2016  Volume 18, Issue 12, Page(s) 1405–1407

    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.607
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    Zs.A 5299: Show issues Location:
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  8. Article ; Online: 'Observational medicine': registries and Electronic Health Recording for science and health systems governance.

    Tavazzi, Luigi / Ventura, Carlo

    European journal of heart failure

    2016  Volume 18, Issue 9, Page(s) 1093–1095

    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.615
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    Zs.A 5299: Show issues Location:
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  9. Article ; Online: State of the Art on the Role of

    Stassi, Chiara / Mondello, Cristina / Baldino, Gennaro / Cardia, Luigi / Gualniera, Patrizia / Calapai, Fabrizio / Sapienza, Daniela / Asmundo, Alessio / Ventura Spagnolo, Elvira

    Tomography (Ann Arbor, Mich.)

    2022  Volume 8, Issue 2, Page(s) 961–973

    Abstract: The need of a minimally invasive approach, especially in cases of cultural or religious oppositions to the internal examination of the body, has led over the years to the introduction ... ...

    Abstract The need of a minimally invasive approach, especially in cases of cultural or religious oppositions to the internal examination of the body, has led over the years to the introduction of
    MeSH term(s) Cause of Death ; Computed Tomography Angiography ; Coronary Angiography ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography8020077
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  10. Article ; Online: Response to letter to the editor: "Methodological concerns of Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain".

    De Vivo, Aldo Eros / D'Agostino, Giovanni / D'Anna, Gennaro / Al Qatami, Hosam / Gil, Ines / Ventura, Fausto / Manfrè, Luigi

    Neuroradiology

    2022  Volume 64, Issue 3, Page(s) 431–432

    MeSH term(s) Catheter Ablation ; Humans ; Low Back Pain/surgery ; Radiofrequency Ablation
    Language English
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-021-02871-z
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