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  1. Article ; Online: Revisiting China's response to coronavirus disease 2019.

    Zhou, Guangbiao / Chen, Saijuan / Zhang, Zongjiu / Chen, Zhu

    Frontiers of medicine

    2024  Volume 17, Issue 6, Page(s) 1011–1013

    MeSH term(s) Humans ; COVID-19 ; China/epidemiology
    Language English
    Publishing date 2024-02-01
    Publishing country China
    Document type Editorial
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-024-1059-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer.

    Zhou, Guangbiao

    Cancer biology & medicine

    2019  Volume 16, Issue 4, Page(s) 700–713

    Abstract: Each year there will be an estimated 2.1 million new lung cancer cases and 1.8 million lung cancer deaths worldwide. Tobacco smoke is the No.1 risk factors of lung cancer, accounting for > 85% lung cancer deaths. Air pollution, or haze, comprises ambient ...

    Abstract Each year there will be an estimated 2.1 million new lung cancer cases and 1.8 million lung cancer deaths worldwide. Tobacco smoke is the No.1 risk factors of lung cancer, accounting for > 85% lung cancer deaths. Air pollution, or haze, comprises ambient air pollution and household air pollution, which are reported to cause 252,000 and 304,000 lung cancer deaths each year, respectively. Tobacco smoke and haze (hereafter, smohaze) contain fine particles originated from insufficient combustion of biomass or coal, have quite similar carcinogens, and cause similar diseases. Smohaze exert hazardous effects on exposed populations, including induction of a large amount of mutations in the genome, alternative splicing of mRNAs, abnormalities in epigenomics, initiation of tumor-promoting chronic inflammation, and facilitating immune escape of transformed cells. Tackling smohaze and development of multi-targets-based preventive and therapeutic approaches targeting smohaze-induced carcinogenesis are the key to conquer lung cancer in the future.
    Language English
    Publishing date 2019-12-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2019.0180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Marine Power on Cancer

    Lichuan Wu / Ke Ye / Sheng Jiang / Guangbiao Zhou

    Marine Drugs, Vol 19, Iss 488, p

    Drugs, Lead Compounds, and Mechanisms

    2021  Volume 488

    Abstract: Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to ...

    Abstract Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to identify novel drugs and drug candidates to fight against malignant neoplasms. The marine compounds show potent anticancer activity in vitro and in vivo, and relatively few drugs have been approved by the U.S. Food and Drug Administration for the treatment of metastatic malignant lymphoma, breast cancer, or Hodgkin′s disease. This review provides a summary of the anticancer effects and mechanisms of action of selected marine compounds, including cytarabine, eribulin, marizomib, plitidepsin, trabectedin, zalypsis, adcetris, and OKI-179. The future development of anticancer marine drugs requires innovative biochemical biology approaches and introduction of novel therapeutic targets, as well as efficient isolation and synthesis of marine-derived natural compounds and derivatives.
    Keywords marine environment drug ; natural compounds ; anticancer ; mechanisms of action ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: The mechanisms of wine phenolic compounds for preclinical anticancer therapeutics.

    Duan, Jing / Guo, Hua / Fang, Yulin / Zhou, Guangbiao

    Food & nutrition research

    2021  Volume 65

    Abstract: Background: Wine is one of the oldest and most popular drinks worldwide, which is rich in phenolic compounds. Epidemiological studies show that moderate consumption of wine can reduce the risk of certain diseases, and this effect is attributed to its ... ...

    Abstract Background: Wine is one of the oldest and most popular drinks worldwide, which is rich in phenolic compounds. Epidemiological studies show that moderate consumption of wine can reduce the risk of certain diseases, and this effect is attributed to its phenolic compounds.
    Objective: The objective of this review was to elaborate the effects of wine-derived phenolic compounds for preclinical anticancer therapeutics and their major mechanisms.
    Methods: In this review, we discuss the classification and content of common phenolic compounds in wine and summarize previous studies that have evaluated the anticancer properties of wine-derived phenolic compounds and their mechanisms.
    Results: Wine-derived phenolic compounds have been proven to participate in several mechanisms against cancers, including deoxyribonucleic acid damage, oxidative stress, cell proliferation, cell cycle arrest, cell apoptosis, autophagy, cell invasion and metastasis, immunity and metabolism, regulation of multiple signaling molecules, and gene expression. However, the exact anticancer mechanisms of the phenolic compounds in wine need to be further investigated.
    Conclusion: Wine-derived phenolic compounds are promising chemoprotective and chemotherapeutic agents for cancer.
    Language English
    Publishing date 2021-08-23
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2418338-6
    ISSN 1654-661X ; 1654-661X ; 1654-6628
    ISSN (online) 1654-661X
    ISSN 1654-661X ; 1654-6628
    DOI 10.29219/fnr.v65.6507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Back to the spring of 2020: facts and hope of COVID-19 outbreak.

    Zhou, Guangbiao / Chen, Saijuan / Chen, Zhu

    Frontiers of medicine

    2020  Volume 14, Issue 2, Page(s) 113–116

    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Clinical Trials as Topic ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Disease Outbreaks/prevention & control ; Hope ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-14
    Publishing country China
    Document type Editorial
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-020-0758-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Marine Power on Cancer: Drugs, Lead Compounds, and Mechanisms.

    Wu, Lichuan / Ye, Ke / Jiang, Sheng / Zhou, Guangbiao

    Marine drugs

    2021  Volume 19, Issue 9

    Abstract: Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to ...

    Abstract Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to identify novel drugs and drug candidates to fight against malignant neoplasms. The marine compounds show potent anticancer activity in vitro and in vivo, and relatively few drugs have been approved by the U.S. Food and Drug Administration for the treatment of metastatic malignant lymphoma, breast cancer, or Hodgkin's disease. This review provides a summary of the anticancer effects and mechanisms of action of selected marine compounds, including cytarabine, eribulin, marizomib, plitidepsin, trabectedin, zalypsis, adcetris, and OKI-179. The future development of anticancer marine drugs requires innovative biochemical biology approaches and introduction of novel therapeutic targets, as well as efficient isolation and synthesis of marine-derived natural compounds and derivatives.
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biological Products/chemistry ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Humans ; Neoplasms/drug therapy ; Seawater
    Chemical Substances Antineoplastic Agents ; Biological Products
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19090488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.

    Xie, Dawei / Wang, Zheng / Sun, Beibei / Qu, Liwei / Zeng, Musheng / Feng, Lin / Guo, Mingzhou / Wang, Guizhen / Hao, Jihui / Zhou, Guangbiao

    Frontiers of medicine

    2023  Volume 17, Issue 5, Page(s) 907–923

    Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) ... ...

    Abstract The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing FAK variants (FAK
    MeSH term(s) Female ; Humans ; Alternative Splicing ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Focal Adhesion Protein-Tyrosine Kinases/genetics ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Focal Adhesion Protein-Tyrosine Kinases/therapeutic use ; Nerve Tissue Proteins/genetics ; Neuroendocrine Tumors/genetics ; Oncogenes ; Pancreatic Neoplasms/metabolism
    Chemical Substances Focal Adhesion Protein-Tyrosine Kinases (EC 2.7.10.2) ; Nerve Tissue Proteins ; SRRM4 protein, human ; PTK2 protein, human (EC 2.7.10.2)
    Language English
    Publishing date 2023-09-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-023-1009-7
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  9. Article: Marine Power on Cancer: Drugs, Lead Compounds, and Mechanisms

    Wu, Lichuan / Ye, Ke / Jiang, Sheng / Zhou, Guangbiao

    Marine drugs. 2021 Aug. 27, v. 19, no. 9

    2021  

    Abstract: Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to ...

    Abstract Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to identify novel drugs and drug candidates to fight against malignant neoplasms. The marine compounds show potent anticancer activity in vitro and in vivo, and relatively few drugs have been approved by the U.S. Food and Drug Administration for the treatment of metastatic malignant lymphoma, breast cancer, or Hodgkin′s disease. This review provides a summary of the anticancer effects and mechanisms of action of selected marine compounds, including cytarabine, eribulin, marizomib, plitidepsin, trabectedin, zalypsis, adcetris, and OKI-179. The future development of anticancer marine drugs requires innovative biochemical biology approaches and introduction of novel therapeutic targets, as well as efficient isolation and synthesis of marine-derived natural compounds and derivatives.
    Keywords Food and Drug Administration ; antineoplastic activity ; biosphere ; breast neoplasms ; drugs ; lymphoma ; metastasis ; therapeutics
    Language English
    Dates of publication 2021-0827
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19090488
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Advances in COVID-19

    Zhou, Guangbiao / Chen, Saijuan / Chen, Zhu

    Frontiers of Medicine

    the virus, the pathogenesis, and evidence-based control and therapeutic strategies

    2020  Volume 14, Issue 2, Page(s) 117–125

    Keywords General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-020-0773-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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