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Article ; Online: Acute occupational inhalation injuries-United States, 2011-2022.

Myers, Nirmala T / Dodd, Katelynn E / Hale, Janet M / Blackley, David J / Scott Laney, A / Hall, Noemi B

2024 Volume 67, Issue 4, Page(s) 376–383

Abstract: Background: Inhalation injuries due to acute occupational exposures to chemicals are preventable. National surveillance of acute inhalation exposures is limited. This study identified the most common acute inhalation exposure-related incidents by ... ...

Abstract	Background: Inhalation injuries due to acute occupational exposures to chemicals are preventable. National surveillance of acute inhalation exposures is limited. This study identified the most common acute inhalation exposure-related incidents by industry sector among US workers. Methods: To characterize inhalation-related injuries and their exposures during April 2011-March 2022, state and federal records from the Occupational Safety and Health Administration (OSHA) Occupational Safety and Health Information System (OIS) accident database were analyzed. Industry-specific injury, hospitalization, and fatality rates were calculated. Results: The most frequent acute inhalation incidents investigated by OSHA were caused by inorganic gases (52.9%) such as carbon monoxide (CO) or acids, bases, and oxidizing chemical agents (12.9%) such as anhydrous ammonia. The largest number of fatal and nonfatal injuries were reported in the manufacturing (28.6%) and construction (17.2%) sectors. Conclusions: Workers were affected by acute inhalation exposures in most industries. Using this surveillance, employers can recognize frequently-occurring preventable acute inhalation exposures by industry, such as inorganic gases in the manufacturing sector, and implement prevention measures. Training of workers on exposure characteristics and limits, adverse health effects, and use of protective equipment by exposure agent can prevent inhalation injuries.
MeSH term(s)	Humans ; United States/epidemiology ; Occupational Injuries/epidemiology ; Accidents, Occupational ; Industry ; Occupational Exposure/adverse effects ; Gases
Chemical Substances	Gases
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.23573
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Zs.A 1605: Show issues

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Article ; Online: Cytokine-skewed Tfh cells: functional consequences for B cell help.

Olatunde, Adesola C / Hale, J Scott / Lamb, Tracey J

Trends in immunology

2021 Volume 42, Issue 6, Page(s) 536–550

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Animals ; B-Lymphocytes ; Cell Differentiation ; Cytokines ; Germinal Center ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer
Chemical Substances	Cytokines
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2021.04.006
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Endometriosis of the Appendix: When Appendicitis Is Less Than Straightforward.

Hale, Justin / Scott, Benjamin / Suydam, Camille / Brockmeyer, Joel

Military medicine

2023 Volume 188, Issue 11-12, Page(s) e3730–e3733

Abstract: We present a case report of a 49-year-old female with a history of ulcerative colitis who originally presented to the general surgery clinic after an incidental finding on computed tomography was concerning for a dilated, fluid-filled appendix. She ... ...

Abstract	We present a case report of a 49-year-old female with a history of ulcerative colitis who originally presented to the general surgery clinic after an incidental finding on computed tomography was concerning for a dilated, fluid-filled appendix. She ultimately underwent a laparoscopic appendectomy. The pathology returned consistent with early acute appendicitis, with endometrial tissue along the outer wall of the appendix. We then performed a literature review regarding appendiceal masses and the occurrence of endometriomas and/or endometriosis of the appendix. A PubMed search was performed using the key words of appendix and appendicitis and endometrioma. Specific articles were examined mentioning the occurrence of endometriomas of the appendix and isolated endometriosis of the appendix. Between 2% and 6% of cases of appendicitis present due to an appendiceal mass, usually an inflammatory phlegmon. A variety of other causes, including primary malignancy, secondary malignancy, and combinations of pathologies, may lead to the eventual removal of the appendix. Specifically, endometriosis of the appendix is reported in less than 1% of females on post-appendectomy pathologic analysis. Although specific symptoms may guide a provider, there are few distinguishing symptoms that would point a provider toward a different etiology, to include malignancy, for appendicitis. Further information is needed to determine when a patient has an increased risk for an underlying pathology when presenting with appendicitis. This information will help drive continued treatment and lead to improved screening for appendiceal masses.
MeSH term(s)	Female ; Humans ; Middle Aged ; Appendicitis/complications ; Appendicitis/diagnosis ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Appendix/surgery ; Appendectomy/methods ; Appendiceal Neoplasms/complications
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad233
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Article ; Online: Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity.

Baessler, Andrew / Hale, J Scott

Trends in immunology

2019 Volume 40, Issue 5, Page(s) 377–379

Abstract: Group A Streptococcus (GAS) infection causes recurrent tonsillitis (RT) in some individuals. A recent study (Dan et al. Sci. Transl. Med. 2019;11:eaau3776) demonstrates that RT is associated with an impaired antibody response against a key streptococcal ... ...

Abstract	Group A Streptococcus (GAS) infection causes recurrent tonsillitis (RT) in some individuals. A recent study (Dan et al. Sci. Transl. Med. 2019;11:eaau3776) demonstrates that RT is associated with an impaired antibody response against a key streptococcal virulence factor. This factor, SpeA, can induce abnormal T follicular helper (Tfh) cells that are able to kill B cells.
MeSH term(s)	B-Lymphocytes ; Humans ; Streptococcus ; T-Lymphocytes, Helper-Inducer ; Tonsillitis
Language	English
Publishing date	2019-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2019.03.007
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection.

Sircy, Linda M / Ramstead, Andrew G / Joshi, Hemant / Baessler, Andrew / Mena, Ignacio / García-Sastre, Adolfo / Williams, Matthew A / Scott Hale, J

bioRxiv : the preprint server for biology

2023

Abstract: Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in ... ...

Abstract	Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in generating long-lived high affinity antibodies, the germinal center has increasingly become a target for the development of novel or improvement of less-efficacious vaccines. However, there remains a major gap in current influenza research to effectively target T follicular helper cells during vaccination to alter the germinal center reaction. In this study, we used a heterologous infection or immunization priming strategy to seed an antigen-specific memory CD4+ T cell pool prior to influenza infection in mice to evaluate the effect of recalled memory T follicular helper cells in increased help to influenza-specific primary B cells and enhanced generation of neutralizing antibodies. We found that heterologous priming with intranasal infection with acute lymphocytic choriomeningitis virus (LCMV) or intramuscular immunization with adjuvanted recombinant LCMV glycoprotein induced increased antigen-specific effector CD4+ T and B cellular responses following infection with a recombinant influenza strain that expresses LCMV glycoprotein. Heterologously primed mice had increased expansion of secondary Th1 and Tfh cell subsets, including increased CD4+ T
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.29.555253
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa.

Jensen, Owen / Trivedi, Shubhanshi / Meier, Jeremy D / Fairfax, Keke C / Hale, J Scott / Leung, Daniel T

Science immunology

2022 Volume 7, Issue 67, Page(s) eabe8931

Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests that MAIT ... ...

Abstract	Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests that MAIT cells can also provide B cell help. In this study, we describe a population of CXCR5
MeSH term(s)	Adolescent ; Adult ; Animals ; Antibodies/immunology ; Antibody Formation/immunology ; B-Lymphocytes/immunology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mucosal-Associated Invariant T Cells/immunology ; Mucous Membrane/immunology ; Mucous Membrane/microbiology ; Vibrio cholerae/immunology
Chemical Substances	Antibodies
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abe8931
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Article ; Online: OCA-B/Pou2af1 is sufficient to promote CD4

Sun, Wenxiang / Hughes, Erik P / Kim, Heejoo / Perovanovic, Jelena / Charley, Krystal R / Perkins, Bryant / Du, Junhong / Ibarra, Andrea / Syage, Amber R / Hale, J Scott / Williams, Matthew A / Tantin, Dean

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 9, Page(s) e2309153121

Abstract: The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA-B expression is sufficient to ...

Abstract	The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA-B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short-lived effector T cell populations are expanded but show increased
MeSH term(s)	Animals ; Mice ; Memory T Cells ; CD4-Positive T-Lymphocytes ; Immunologic Memory ; Memory ; Receptors, Interleukin-7 ; Trans-Activators ; GADD45 Proteins ; Antigens, Differentiation
Chemical Substances	Receptors, Interleukin-7 ; Pou2af1 protein, mouse ; Trans-Activators ; Gadd45b protein, mouse ; GADD45 Proteins ; Antigens, Differentiation
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2309153121
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Zs.A 1148: Show issues

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Article ; Online: Co-formulation of the rF1V plague vaccine with depot-formulated cytokines enhances immunogenicity and efficacy to elicit protective responses against aerosol challenge in mice.

Galloway, Darrell R / Li, Jiahui / Nguyen, Nguyen X / Falkenberg, Frank W / Henning, Lisa / Krile, Robert / Chou, Ying-Liang / Herron, James N / Hale, J Scott / Williamson, E Diane

Frontiers in immunology

2024 Volume 15, Page(s) 1277526

Abstract: This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the protective response following aerosol challenge in a murine model. The results of this study showed that ...

Abstract	This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the protective response following aerosol challenge in a murine model. The results of this study showed that co-formulation of the Alhydrogel-adsorbed rF1V plague fusion vaccine with the depot-formulated cytokines recombinant human interleukin 2 (rhuIL-2) and/or recombinant murine granulocyte macrophage colony-stimulating factor (rmGM-CSF) significantly enhances immunogenicity and significant protection at lower antigen doses against a lethal aerosol challenge. These results provide additional support for the co-application of the depot-formulated IL-2 and/or GM-CSF cytokines to enhance vaccine efficacy.
MeSH term(s)	Humans ; Animals ; Mice ; Plague Vaccine ; Cytokines ; Yersinia pestis ; Antigens, Bacterial ; Vaccines, Synthetic ; Aerosols
Chemical Substances	Plague Vaccine ; Cytokines ; Antigens, Bacterial ; Vaccines, Synthetic ; Aerosols
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1277526
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Article ; Online: Incisional Hernia Development after Live Donor Nephrectomy: Impact of Surgical Technique.

DuBray, Bernard J / Tompson, Joshua J / Shaffer, David / Hale, Doug A / Rega, Scott A / Feurer, Irene D / Forbes, Rachel C

Kidney360

2023 Volume 4, Issue 1, Page(s) 78–82

Abstract: Background: Characteristics of incisional hernia (IH) formation after live donor nephrectomy (LDN) are not well-defined. The goal of this study was to describe the incidence of IH within 3 years after LDN and identify risk factors contributing to their ... ...

Abstract	Background: Characteristics of incisional hernia (IH) formation after live donor nephrectomy (LDN) are not well-defined. The goal of this study was to describe the incidence of IH within 3 years after LDN and identify risk factors contributing to their formation. Methods: We performed a single-center, retrospective review of all LDN between February 2013 and October 2018. Patients with and without IH were compared based on donor and operative variables. Data were analyzed using chi-square tests with column proportions. Multivariable logistic regression with backward elimination was used to evaluate the likelihood of IH on the basis of potential risk factors. Results: Three hundred one individuals underwent live donor nephrectomy. Twenty-eight patients (9.3%) developed an IH, with a median time to development of 7 months (range: 2-24 months). Obesity (body mass index ≥30), periumbilical hand port, and vertical infraumbilical hand port were associated with increased risk of IH development on univariate analysis. On multivariate analysis, obesity and periumbilical hand port location were persistent risk factors for IH. Conclusions: The incidence of IH after LDN is prevalent and associated with obesity and operative technique. Placing the hand port infraumbilical with a transverse fascial incision may reduce the risk of IH after LDN.
MeSH term(s)	Humans ; Incisional Hernia/epidemiology ; Incisional Hernia/etiology ; Living Donors ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Obesity/epidemiology ; Obesity/etiology ; Nephrectomy/adverse effects ; Nephrectomy/methods
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0005262022
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Article ; Online: Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?

Hale, Andrew T / Chari, Aswin / Scott, Rod C / Helen Cross, J / Rozzelle, Curtis J / Blount, Jeffrey P / Tisdall, Martin M

Brain : a journal of neurology

2022 Volume 145, Issue 11, Page(s) 3755–3762

Abstract: Epilepsy surgery is an established safe and effective treatment for selected candidates with drug-resistant epilepsy. In this opinion piece, we outline the clinical and experimental evidence for selectively considering epilepsy surgery prior to drug ... ...

Abstract	Epilepsy surgery is an established safe and effective treatment for selected candidates with drug-resistant epilepsy. In this opinion piece, we outline the clinical and experimental evidence for selectively considering epilepsy surgery prior to drug resistance. Our rationale for expedited surgery is based on the observations that (i) a high proportion of patients with lesional epilepsies (e.g. focal cortical dysplasia, epilepsy-associated tumours) will progress to drug resistance; (ii) surgical treatment of these lesions, especially in non-eloquent areas of brain, is safe; and (iii) earlier surgery may be associated with better seizure outcomes. Potential benefits beyond seizure reduction or elimination include less exposure to antiseizure medications, which may lead to improved developmental trajectories in children and optimize long-term neurocognitive outcomes and quality of life. Further, there exists emerging experimental evidence that brain network dysfunction exists at the onset of epilepsy, where continuing dysfunctional activity could exacerbate network perturbations. This in turn could lead to expanded seizure foci and contribution to the comorbidities associated with epilepsy. Taken together, we rationalize that epilepsy surgery, in carefully selected cases, may be considered prior to drug resistance. Last, we outline the path forward, including the challenges associated with developing the evidence base and implementing this paradigm into clinical care.
MeSH term(s)	Child ; Humans ; Quality of Life ; Epilepsy/drug therapy ; Epilepsy/surgery ; Epilepsy/complications ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/surgery ; Drug Resistant Epilepsy/complications ; Seizures/complications ; Treatment Outcome ; Brain Diseases/complications ; Drug Resistance ; Retrospective Studies
Language	English
Publishing date	2022-07-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awac275
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