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Article ; Online: Adherence to the practice guideline of community acquired pneumonia in the Hospital Universitario San Jorge, Pereira, Colombia

Jorge Enrique Machado-Alba, Berenice Isaza Martinez, Monica Sepulveda Marín, Alejandro Rivera Palacios, Sandra Liceth Ceballos

Revista Médica de Risaralda, Vol 18, Iss 2, Pp 134-

2012 Volume 139

Abstract: ... of Community Acquired Pneumonia CAP in the Hospital Universitario San Jorge of Pereira (HUSJ). Methods ...

Abstract	Objetive: To determine the variables associated with nonadherence to practice guideline of Community Acquired Pneumonia CAP in the Hospital Universitario San Jorge of Pereira (HUSJ). Methods: Cross-sectional study of all patients over 18 years of either sex with a diagnosis of NAC between January 1, 2010 and March 30, 2012. The information was taken from the medical records considering socio-demographic, clinical (diagnosis, symptoms, comorbidities), paraclinical (leukogram, X-ray, blood cultures) and therapeutic variables (time of hospitalization and medication costs). Adherence was determined according to the fulfillment of this guide. 2 tests and logistic regression were applied. Results: We found 297 cases of NAC, with slight male predominance (159 men vs 138 women) and mean age 56.3±22.4 years. Adherence to the practice guideline was 14.1% of cases. The antibiotics used were Ampicillin + Sulbactam in 180 patients (60.6% of cases), Ceftriaxone in 53 (17.8%) and Clarithromycin in 31 (10.4%). Blood cultures were 92 and 8.6% reported gram-positive cocci. The low cost of hospitalization (p=0,03, OR:2,07; 95%CI: 1,02-4,14) and chest X-ray report (p<0,001, OR:16,7; 95%CI:2,26-124,11)was statistically significantly associated with adherence to the guide. Non-adherence was associated with lack of guidance from physicians. Discussion: The HUSJ should update your practice guideline and socialize NAC care among physicians and follow up the implementation to reduce hospital stay, complications and costs.
Keywords	pneumonia ; practice guideline ; Guideline Adherence ; Anti-Infective Agents ; Colombia ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	360
Language	Spanish
Publishing date	2012-12-01T00:00:00Z
Publisher	Universidad Tecnológica de Pereira
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MultiToxPred 1.0: a novel comprehensive tool for predicting 27 classes of protein toxins using an ensemble machine learning approach.

Beltrán, Jorge F / Herrera-Belén, Lisandra / Parraguez-Contreras, Fernanda / Farías, Jorge G / Machuca-Sepúlveda, Jorge / Short, Stefania

BMC bioinformatics

2024 Volume 25, Issue 1, Page(s) 148

Abstract: Protein toxins are defense mechanisms and adaptations found in various organisms and microorganisms, and their use in scientific research as therapeutic candidates is gaining relevance due to their effectiveness and specificity against cellular targets. ... ...

Abstract	Protein toxins are defense mechanisms and adaptations found in various organisms and microorganisms, and their use in scientific research as therapeutic candidates is gaining relevance due to their effectiveness and specificity against cellular targets. However, discovering these toxins is time-consuming and expensive. In silico tools, particularly those based on machine learning and deep learning, have emerged as valuable resources to address this challenge. Existing tools primarily focus on binary classification, determining whether a protein is a toxin or not, and occasionally identifying specific types of toxins. For the first time, we propose a novel approach capable of classifying protein toxins into 27 distinct categories based on their mode of action within cells. To accomplish this, we assessed multiple machine learning techniques and found that an ensemble model incorporating the Light Gradient Boosting Machine and Quadratic Discriminant Analysis algorithms exhibited the best performance. During the tenfold cross-validation on the training dataset, our model exhibited notable metrics: 0.840 accuracy, 0.827 F1 score, 0.836 precision, 0.840 sensitivity, and 0.989 AUC. In the testing stage, using an independent dataset, the model achieved 0.846 accuracy, 0.838 F1 score, 0.847 precision, 0.849 sensitivity, and 0.991 AUC. These results present a powerful next-generation tool called MultiToxPred 1.0, accessible through a web application. We believe that MultiToxPred 1.0 has the potential to become an indispensable resource for researchers, facilitating the efficient identification of protein toxins. By leveraging this tool, scientists can accelerate their search for these toxins and advance their understanding of their therapeutic potential.
MeSH term(s)	Algorithms ; Benchmarking ; Discriminant Analysis ; Machine Learning ; Research Design ; Toxins, Biological
Chemical Substances	Toxins, Biological
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-024-05748-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current Status of Omics in Biological Quality Elements for Freshwater Biomonitoring.

Machuca-Sepúlveda, Jorge / Miranda, Javiera / Lefin, Nicolás / Pedroso, Alejandro / Beltrán, Jorge F / Farias, Jorge G

Biology

2023 Volume 12, Issue 7

Abstract: Freshwater ecosystems have been experiencing various forms of threats, mainly since the last century. The severity of this adverse scenario presents unprecedented challenges to human health, water supply, agriculture, forestry, ecological systems, and ... ...

Abstract	Freshwater ecosystems have been experiencing various forms of threats, mainly since the last century. The severity of this adverse scenario presents unprecedented challenges to human health, water supply, agriculture, forestry, ecological systems, and biodiversity, among other areas. Despite the progress made in various biomonitoring techniques tailored to specific countries and biotic communities, significant constraints exist, particularly in assessing and quantifying biodiversity and its interplay with detrimental factors. Incorporating modern techniques into biomonitoring methodologies presents a challenging topic with multiple perspectives and assertions. This review aims to present a comprehensive overview of the contemporary advancements in freshwater biomonitoring, specifically by utilizing omics methodologies such as genomics, metagenomics, transcriptomics, proteomics, metabolomics, and multi-omics. The present study aims to elucidate the rationale behind the imperative need for modernization in this field. This will be achieved by presenting case studies, examining the diverse range of organisms that have been studied, and evaluating the potential benefits and drawbacks associated with the utilization of these methodologies. The utilization of advanced high-throughput bioinformatics techniques represents a sophisticated approach that necessitates a significant departure from the conventional practices of contemporary freshwater biomonitoring. The significant contributions of omics techniques in the context of biological quality elements (BQEs) and their interpretations in ecological problems are crucial for biomonitoring programs. Such contributions are primarily attributed to the previously overlooked identification of interactions between different levels of biological organization and their responses, isolated and combined, to specific critical conditions.
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070923
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Variability of benthic macroinvertebrate biomass in two contrasting streams in southern Chile

Machuca-Sepúlveda, Jorge / Fierro, Pablo / Nimptsch, Jorge

Hydrobiologia. 2022 Feb., v. 849, no. 3

2022

Abstract: Organism biomass, a continuous quantity, may be useful for general community and diversity assessment. Body length and biomass of benthic macroinvertebrates from two aquatic environments with different impact levels are determined in this study, ... ...

Abstract	Organism biomass, a continuous quantity, may be useful for general community and diversity assessment. Body length and biomass of benthic macroinvertebrates from two aquatic environments with different impact levels are determined in this study, classifying organisms using functional and taxonomic characteristics. Lyophilized benthic macroinvertebrate biomass was quantified to test for significant differences between an impacted and reference (less environmental impact) site. Results show that macroinvertebrate assemblages from the less impacted stream had higher average biomass than the assemblage from the perturbed site, and significant differences in biomass of Plecoptera, Trichoptera, predators, filterers and gills breathers were found between sites. The biomass signature was calculated for each analyzed scenario, weighting the presence of all specimens sampled considering the total biomass in a single regression curve equation. The cubic polynomial model had the best fit to the data. More background from theory to practice should be considered in biomonitoring research; hence we propose the application of macroinvertebrate biomass as an additional metric that will help evaluate the ecological status of streams, thus contributing to the knowledge of community-based biomonitoring of benthic macroinvertebrates.
Keywords	Plecoptera ; Trichoptera ; biomass ; body length ; environmental impact ; environmental monitoring ; equations ; freeze drying ; macroinvertebrates ; mathematical models ; streams ; Chile
Language	English
Dates of publication	2022-02
Size	p. 641-660.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	214428-1
ISSN	1573-5117 ; 0018-8158
ISSN (online)	1573-5117
ISSN	0018-8158
DOI	10.1007/s10750-021-04731-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Current Status of Omics in Biological Quality Elements for Freshwater Biomonitoring

Machuca-Sepúlveda, Jorge / Miranda, Javiera / Lefin, Nicolás / Pedroso, Alejandro / Beltrán, Jorge F. / Farias, Jorge G.

Biology (Basel). 2023 June 28, v. 12, no. 7

2023

Abstract	Freshwater ecosystems have been experiencing various forms of threats, mainly since the last century. The severity of this adverse scenario presents unprecedented challenges to human health, water supply, agriculture, forestry, ecological systems, and biodiversity, among other areas. Despite the progress made in various biomonitoring techniques tailored to specific countries and biotic communities, significant constraints exist, particularly in assessing and quantifying biodiversity and its interplay with detrimental factors. Incorporating modern techniques into biomonitoring methodologies presents a challenging topic with multiple perspectives and assertions. This review aims to present a comprehensive overview of the contemporary advancements in freshwater biomonitoring, specifically by utilizing omics methodologies such as genomics, metagenomics, transcriptomics, proteomics, metabolomics, and multi-omics. The present study aims to elucidate the rationale behind the imperative need for modernization in this field. This will be achieved by presenting case studies, examining the diverse range of organisms that have been studied, and evaluating the potential benefits and drawbacks associated with the utilization of these methodologies. The utilization of advanced high-throughput bioinformatics techniques represents a sophisticated approach that necessitates a significant departure from the conventional practices of contemporary freshwater biomonitoring. The significant contributions of omics techniques in the context of biological quality elements (BQEs) and their interpretations in ecological problems are crucial for biomonitoring programs. Such contributions are primarily attributed to the previously overlooked identification of interactions between different levels of biological organization and their responses, isolated and combined, to specific critical conditions.
Keywords	biodiversity ; environmental monitoring ; forestry ; freshwater ; human health ; metabolomics ; metagenomics ; modernization ; multiomics ; proteomics ; transcriptomics ; water supply
Language	English
Dates of publication	2023-0628
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070923
Database	NAL-Catalogue (AGRICOLA)

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Article: Physicochemical characterization of the pod husk of

Meza-Sepulveda, Diana C / Hernandez-Urrea, Catherine / Quintero-Saavedra, Jorge I

Heliyon

2024 Volume 10, Issue 7, Page(s) e28761

Abstract: In cocoa production, the harvest and postharvest processes tend to generate residues that, if not properly treated or disposed of, become a source of pests or diseases for the crop and the farmer. The residues are environmental contaminants, which are ... ...

Abstract	In cocoa production, the harvest and postharvest processes tend to generate residues that, if not properly treated or disposed of, become a source of pests or diseases for the crop and the farmer. The residues are environmental contaminants, which are equivalent to 70%-80% of the total fruit (husk, placenta, leachates). In the case of cacao pod husk (CPH), it is hollow form contributes to the accumulation of water or leachates. These residues with no apparent profitable use may have components of agroindustrial interest, such as pectins, cellulose, and starches, in products with high added value. Thus, the physicochemical characterization CPH of clones Castro Naranjal Collection 51 (CCN51), FEDECACAO Arauquita 5 (FEAR5), and FEDECACAO San Vicente 41 (FSV41) is presented to identify different applications such as biopolymers, bioremediation, and renewable energies and their potential biotechnological use in contributing to the circular economy according to the characteristics of each clone. In conclusion, it is important to continue with the research on CPHs of the different clones and to promote the sustainable development of cocoa in the Department of Risaralda, Colombia.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28761
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: William Hunter (1718-1783): su legado a trescientos años de su nacimiento.

Dagnino-Sepúlveda, Jorge

Revista medica de Chile

2019 Volume 147, Issue 1, Page(s) 96–102

Abstract: The aim of this paper is to evaluate some aspects of the life of William Hunter (1718-1783), and to argue that he deserves a better place in history as he was one of the most outstanding figures in British medicine of the 18th century. A Scotsman, ... ...

Title translation	William Hunter (1718-1783): his legacy three hundred years from his birthday.
Abstract	The aim of this paper is to evaluate some aspects of the life of William Hunter (1718-1783), and to argue that he deserves a better place in history as he was one of the most outstanding figures in British medicine of the 18th century. A Scotsman, Presbyterian, from a family without means or connections, he underwent a classic education at the University of Glasgow, completed with apprenticeships with William Cullen and Alexander Monro first in Scotland, and then in London, with William Smellie, James Douglas and James Wilkie, in anatomy, obstetrics and surgery, respectively. Despite initial disadvantages, he was highly successful as an anatomist, educator, surgeon, man-midwife, artist, gentleman and collector. He moved and had influences in the highest medical, cultural and social circles of his time, was named Physician Extraordinary to Queen Charlotte, and was a member of many scientific, medical and cultural societies in Great Britain and in France, such as the Royal Society, the Royal College of Physicians and the Societé Royale de Médicine of Paris. His museum was notable in its magnitude and its diversity, including anatomical preparations, coins, shells, plants, birds, insects, fossils, and minerals. He donated his great museum to the University of Glasgow. His figure has been relegated mainly due to the absence of heirs, individuals or institutional, that could have cared for, maintained, and increased his legacy as happened with his brother John.
MeSH term(s)	Anatomy/history ; Education, Medical/history ; History, 18th Century ; Medicine in the Arts/history ; Obstetrics/history ; United Kingdom
Language	Spanish
Publishing date	2019-03-19
Publishing country	Chile
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/S0034-98872019000100096
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Article ; Online: Caracterización de pacientes con accidente cerebrovascular ingresados en un hospital de baja complejidad en Chile

Jorge Sepúlveda-Contreras

Universidad y Salud , Vol 23, Iss 1, Pp 8-

2020 Volume 12

Abstract: Introducción: El Accidente cerebrovascular se constituye como un problema crítico de salud pública, siendo sus mayores factores de riesgo la hipertensión, el consumo de tabaco, la diabetes, entre otros. Objetivo: Caracterizar a los usuarios que ingresan ... ...

Abstract	Introducción: El Accidente cerebrovascular se constituye como un problema crítico de salud pública, siendo sus mayores factores de riesgo la hipertensión, el consumo de tabaco, la diabetes, entre otros. Objetivo: Caracterizar a los usuarios que ingresan con diagnóstico de Accidente cerebrovascular al Hospital San Luis de Buin-Paine, hospital de baja complejidad perteneciente al Servicio de Salud Metropolitano Sur de Chile. Materiales y métodos: Se realizó una investigación observacional, descriptiva, transversal con aquellos pacientes que ingresaron a servicios de hospitalizados y a la unidad de rehabilitación con diagnóstico de Accidente cerebrovascular isquémico o hemorrágico. Con la muestra (n=135) se realizó una revisión de cada ficha electrónica. El procesamiento estadístico de los datos fue mediante frecuencias absolutas y porcentajes. Resultados: Predominó el ictus isquémico en el 85,92%, con un fuerte incremente en la población sobre 51 años. Los factores de riesgos más frecuentes fueron hipertensión arterial y diabetes mellitus. La profesión u oficio que más se repitió correspondió a Jubilado (27,4%). Conclusiones: Se evidenciaron resultados similares en comparación a otras investigaciones afines al tema. La prevención de las enfermedades cerebrovasculares está asociada al mantenimiento de hábitos y estilos de vida saludables para prevenir la aparición de los factores modificables de riesgo.
Keywords	accidente cerebrovascular ; factores de riesgo ; epidemiología ; Medicine (General) ; R5-920 ; Social history and conditions. Social problems. Social reform ; HN1-995
Language	Spanish
Publishing date	2020-12-01T00:00:00Z
Publisher	Universidad de Nariño
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biopolitics and speculative objects in Chilean health projects.

Castillo-Sepúlveda, Jorge / Tirado, Francisco / Gálvez, Ana

Social studies of science

2022 Volume 53, Issue 2, Page(s) 194–212

Abstract: Biopolitics' is a much-used concept in recent academic literature. One of its main fields of application is in the analysis of public health projects. This article analyses the national Explicit Health Guarantees project in Chile from that perspective. ... ...

Abstract	'Biopolitics' is a much-used concept in recent academic literature. One of its main fields of application is in the analysis of public health projects. This article analyses the national Explicit Health Guarantees project in Chile from that perspective. However, we criticize the standard invocation of 'biopolitics' by observing that such public health projects require technoscientific operations that establish truths and regimes of obligation for the groups involved -understanding regime both as a set of imposed orders and a set of regulated processes. Specifically, the Explicit Health Guarantees project defines what we call 'speculative objects'. These have two characteristics: (a) They relate highly diverse entities into integrated wholes that are and involve objects of knowledge and uncertainty, and (b) this integration creates regimes of obligation considered as scientific truths on many different groups. We conclude by proposing new questions about the notion of biopolitics and its relationship with uncertainty and speculation.
MeSH term(s)	Chile ; Public Health
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1482712-8
ISSN	1460-3659 ; 0306-3127
ISSN (online)	1460-3659
ISSN	0306-3127
DOI	10.1177/03063127221136804
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Left Atrial Appendage Aneurysm: A Case Report and Literature Review.

Ayala Torres, Juan D / Sepulveda Gallego, Jorge Alejandro / Gonzalez Gonzalez, Mateo

Cureus

2024 Volume 16, Issue 3, Page(s) e56280

Abstract: The left atrial appendage aneurysm is an uncommon condition that has garnered attention from the medical community due to its low incidence and varied clinical manifestations. The difficulty in identification is reflected in its incidental detection in ... ...

Abstract	The left atrial appendage aneurysm is an uncommon condition that has garnered attention from the medical community due to its low incidence and varied clinical manifestations. The difficulty in identification is reflected in its incidental detection in imaging studies such as echocardiograms and tomographies, while symptoms range from mild to severe, including heart failure and thromboembolic events. The complex etiology includes congenital and acquired factors, and its management focuses on preventing complications through surgical resection, accompanied by medical strategies such as controlling heart rhythm and anticoagulation. The case of a 67-year-old woman with significant medical history illustrates these challenges. Despite an inconclusive initial diagnosis, a tomography revealed an aneurysm with an intracavitary thrombus, leading to successful surgical resection. However, subsequent infectious complications resulted in her death. The average age of diagnosis is around 30 years, and while it is more common in women, there are no significant gender differences. Surgical management remains the preferred option, especially in severe cases, although in some patients, a watchful waiting approach is chosen. In conclusion, the left atrial appendage aneurysm is a complex entity that requires a multidisciplinary approach to improve clinical outcomes. Early diagnosis and appropriate treatment are crucial to prevent serious complications and improve the quality of life of affected patients.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56280
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