LIVIVO - Search results -

Search results

Result 1 - 10 of total 87

Search options

Article ; Online: Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota.

Chen, Qian / Ren, Dongwen / Wu, Jiaqi / Yu, Haiyang / Chen, Xiaopeng / Wang, Jia / Zhang, Yi / Liu, Mengyang / Wang, Tao

Journal of natural medicines

2020 Volume 75, Issue 1, Page(s) 84–98

Abstract: ... The Shenyan Kangfu tablet (SYKFT) is a prescription of traditional Chinese medicine for treating ...

Abstract	Inflammation plays a predominant role in the pathogenesis of diabetic kidney disease (DKD). The Shenyan Kangfu tablet (SYKFT) is a prescription of traditional Chinese medicine for treating chronic kidney disease. However, the concrete mechanism is still unclear. According to previous clinical trial, we explored the effects and potential mechanism on DKD in db/db model supplemented with SYKFT. As a result, SYKFT reduced stimulated blood glucose and HbA1c levels, alleviated renal dysfunction, glomerular and tubular damage, and renal inflammation (TNF-α and IL-1β) in db/db mice. The primary mechanistic study illustrated that SYKFT improved renal injury mainly associated with inhibition of NF-κB in vivo and in vitro. This study further observed that SYKFT increased relative abundance of Firmicutes and decreased Bacteroidetes, showing direct correlation between representative microbiota relative abundance and renal function parameters. SYKFT effectively decreased the relative abundance of Bacteroides, and positive correlation between the relative abundance and protein expression of NF-κB, TNF-α and IL-1β predicted that anti-inflammatory activity of SYKFT was associated with modulating the gut microbiota. Therefore, we first demonstrated SYKFT alleviated DKD through regulating renal inflammatory signaling cascades and intestinal microbiota and also pointed out the role of specific gut microbiota in the development of DKD.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Diabetic Nephropathies/drug therapy ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Gastrointestinal Microbiome/drug effects ; Inflammation/drug therapy ; Male ; Mice ; Tablets/pharmacology ; Tablets/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Drugs, Chinese Herbal ; Tablets ; shenyan kangfu
Language	English
Publishing date	2020-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-020-01452-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2692: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota

Chen, Qian / Ren, Dongwen / Wu, Jiaqi / Yu, Haiyang / Chen, Xiaopeng / Wang, Jia / Zhang, Yi / Liu, Mengyang / Wang, Tao

Natural medicines. 2021 Jan., v. 75, no. 1

2021

Abstract: ... The Shenyan Kangfu tablet (SYKFT) is a prescription of traditional Chinese medicine for treating ...

Abstract	Inflammation plays a predominant role in the pathogenesis of diabetic kidney disease (DKD). The Shenyan Kangfu tablet (SYKFT) is a prescription of traditional Chinese medicine for treating chronic kidney disease. However, the concrete mechanism is still unclear. According to previous clinical trial, we explored the effects and potential mechanism on DKD in db/db model supplemented with SYKFT. As a result, SYKFT reduced stimulated blood glucose and HbA1c levels, alleviated renal dysfunction, glomerular and tubular damage, and renal inflammation (TNF-α and IL-1β) in db/db mice. The primary mechanistic study illustrated that SYKFT improved renal injury mainly associated with inhibition of NF-κB in vivo and in vitro. This study further observed that SYKFT increased relative abundance of Firmicutes and decreased Bacteroidetes, showing direct correlation between representative microbiota relative abundance and renal function parameters. SYKFT effectively decreased the relative abundance of Bacteroides, and positive correlation between the relative abundance and protein expression of NF-κB, TNF-α and IL-1β predicted that anti-inflammatory activity of SYKFT was associated with modulating the gut microbiota. Therefore, we first demonstrated SYKFT alleviated DKD through regulating renal inflammatory signaling cascades and intestinal microbiota and also pointed out the role of specific gut microbiota in the development of DKD.
Keywords	Bacteroides ; Firmicutes ; Oriental traditional medicine ; anti-inflammatory activity ; blood glucose ; clinical trials ; inflammation ; intestinal microorganisms ; kidney diseases ; models ; pathogenesis ; protein synthesis ; renal function
Language	English
Dates of publication	2021-01
Size	p. 84-98.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-020-01452-3
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 2692: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Discussion on pharmacological mechanism of laosun kangfu tablets].

Cheng, Jia-yi / Yan, Xing-yu / Yang, Jing-ling

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2007 Volume 32, Issue 14, Page(s) 1457–1461

Abstract: Objective: to study pharmacological mechanism of Laosun Kangfu tablet.: Method: Blood ... the kidney-notifying actions.: Conclusion: Effects of Huoxue Xiaozhong and Xingqi Zhitong of Laosun Kangfu ...

Abstract	Objective: to study pharmacological mechanism of Laosun Kangfu tablet. Method: Blood-activating and stasis-removing was tested by establishing cute cold pathogens induced blood stasis rat model and microcirculation disturbance state rat model by means of dripping adrenine on the mensentery. The resisting oxidation was tested by establishing the freely falling body damages models. The kidney-notifying was tested by Acetic acid hydrocortisone-caused kidney asthenia of mice. Result: All of the experimental results showed that there were Significant differences between the treatment groups and the control groups, such as promoting blood circulation and removing blood stasis, resisting the oxidation, the kidney-notifying actions. Conclusion: Effects of Huoxue Xiaozhong and Xingqi Zhitong of Laosun Kangfu tablet is because the action of improving microcirculation, antioxidation and regulating endocrine.
MeSH term(s)	Animals ; Blood Viscosity/drug effects ; Drug Combinations ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Erythrocyte Count ; Female ; Hydrocortisone/blood ; Male ; Malondialdehyde/blood ; Medicine, Chinese Traditional ; Mice ; Microcirculation/drug effects ; Plants, Medicinal/chemistry ; Rats ; Rats, Wistar ; Splanchnic Circulation/drug effects ; Superoxide Dismutase/blood ; Tablets
Chemical Substances	Drug Combinations ; Drugs, Chinese Herbal ; Tablets ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1) ; Hydrocortisone (WI4X0X7BPJ)
Language	Chinese
Publishing date	2007-07
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3056: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multi-task multi-level feature adversarial network for joint Alzheimer's disease diagnosis and atrophy localization using sMRI.

Han, Kangfu / He, Man / Yang, Feng / Zhang, Yu

Physics in medicine and biology

2022 Volume 67, Issue 8

Abstract: Capitalizing on structural magnetic resonance imaging (sMRI), existing deep learning methods (especially convolutional neural networks, CNNs) have been widely and successfully applied to computer-aided diagnosis of Alzheimer's disease (AD) and its ... ...

Abstract	Capitalizing on structural magnetic resonance imaging (sMRI), existing deep learning methods (especially convolutional neural networks, CNNs) have been widely and successfully applied to computer-aided diagnosis of Alzheimer's disease (AD) and its prodromal stage (i.e. mild cognitive impairment, MCI). But considering the generalization capability of the obtained model trained on limited number of samples, we construct a multi-task multi-level feature adversarial network (M
MeSH term(s)	Alzheimer Disease/diagnostic imaging ; Atrophy/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Neural Networks, Computer ; Neuroimaging/methods
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac5ed5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hierarchical-order multimodal interaction fusion network for grading gliomas.

He, Man / Han, Kangfu / Zhang, Yu / Chen, Wufan

Physics in medicine and biology

2021 Volume 66, Issue 21

Abstract: ... ...

Abstract	Significance
MeSH term(s)	Brain Neoplasms/diagnostic imaging ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasm Grading ; Neural Networks, Computer ; ROC Curve
Language	English
Publishing date	2021-11-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac30a1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bacterial Artificial Chromosome Libraries of Pulse Crops

Kangfu Yu

Journal of Biomedicine and Biotechnology, Vol

Characteristics and Applications

2012 Volume 2012

Abstract: Pulse crops are considered minor on a global scale despite their nutritional value for human consumption. Therefore, they are relatively less extensively studied in comparison with the major crops. The need to improve pulse crop production and quality ... ...

Abstract	Pulse crops are considered minor on a global scale despite their nutritional value for human consumption. Therefore, they are relatively less extensively studied in comparison with the major crops. The need to improve pulse crop production and quality will increase with the increasing global demand for food security and people's awareness of nutritious food. The improvement of pulse crops will require fully utilizing all their genetic resources. Bacterial artificial chromosome (BAC) libraries of pulse crops are essential genomic resources that have the potential to accelerate gene discovery and enhance molecular breeding in these crops. Here, we review the availability, characteristics, applications, and potential applications of the BAC libraries of pulse crops.
Keywords	Biotechnology ; TP248.13-248.65 ; Medicine ; R
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Light-weight cross-view hierarchical fusion network for joint localization and identification in Alzheimer's disease with adaptive instance-declined pruning.

Han, Kangfu / Luo, Jiaxiu / Xiao, Qing / Ning, Zhenyuan / Zhang, Yu

Physics in medicine and biology

2021 Volume 66, Issue 8

Abstract: Magnetic resonance imaging (MRI) has been widely used in assessing development of Alzheimer's disease (AD) by providing structural information of disease-associated regions (e.g. atrophic regions). In this paper, we propose a light-weight cross-view ... ...

Abstract	Magnetic resonance imaging (MRI) has been widely used in assessing development of Alzheimer's disease (AD) by providing structural information of disease-associated regions (e.g. atrophic regions). In this paper, we propose a light-weight cross-view hierarchical fusion network (CvHF-net), consisting of local patch and global subject subnets, for joint localization and identification of the discriminative local patches and regions in the whole brain MRI, upon which feature representations are then jointly learned and fused to construct hierarchical classification models for AD diagnosis. Firstly, based on the extracted class-discriminative 3D patches, we employ the local patch subnets to utilize multiple 2D views to represent 3D patches by using an attention-aware hierarchical fusion structure in a divide-and-conquer manner. Since different local patches are with various abilities in AD identification, the global subject subnet is developed to bias the allocation of available resources towards the most informative parts among these local patches to obtain global information for AD identification. Besides, an instance declined pruning algorithm is embedded in the CvHF-net for adaptively selecting most discriminant patches in a task-driven manner. The proposed method was evaluated on the AD Neuroimaging Initiative dataset and the experimental results show that our proposed method can achieve good performance on AD diagnosis.
MeSH term(s)	Algorithms ; Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neuroimaging
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/abf200
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bacterial artificial chromosome libraries of pulse crops: characteristics and applications.

Yu, Kangfu

Journal of biomedicine & biotechnology

2011 Volume 2012, Page(s) 493186

Abstract	Pulse crops are considered minor on a global scale despite their nutritional value for human consumption. Therefore, they are relatively less extensively studied in comparison with the major crops. The need to improve pulse crop production and quality will increase with the increasing global demand for food security and people's awareness of nutritious food. The improvement of pulse crops will require fully utilizing all their genetic resources. Bacterial artificial chromosome (BAC) libraries of pulse crops are essential genomic resources that have the potential to accelerate gene discovery and enhance molecular breeding in these crops. Here, we review the availability, characteristics, applications, and potential applications of the BAC libraries of pulse crops.
MeSH term(s)	Agriculture ; Biotechnology ; Chromosomes, Artificial, Bacterial ; Crops, Agricultural/genetics ; Fabaceae ; Gene Library ; Genome, Plant
Language	English
Publishing date	2011-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2052552-7
ISSN	1110-7251 ; 1110-7243
ISSN (online)	1110-7251
ISSN	1110-7243
DOI	10.1155/2012/493186
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5540: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Novel QTL for Low Seed Cadmium Accumulation in Soybean.

Nissan, Nour / Hooker, Julia / Pattang, Arezo / Charette, Martin / Morrison, Malcolm / Yu, Kangfu / Hou, Anfu / Golshani, Ashkan / Molnar, Stephen J / Cober, Elroy R / Samanfar, Bahram

Plants (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Soybean is a valuable crop, used in animal feed and for human consumption. Selecting soybean cultivars with low seed cadmium (Cd) concentration is important for the purpose of minimizing the transfer of Cd into the human body. To ensure international ... ...

Abstract	Soybean is a valuable crop, used in animal feed and for human consumption. Selecting soybean cultivars with low seed cadmium (Cd) concentration is important for the purpose of minimizing the transfer of Cd into the human body. To ensure international trade, farmers need to produce soybean that meets the European Union (EU) Cd limit of 0.2 mg kg
Language	English
Publishing date	2022-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11091146
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Analysis of serum metabolome of laborers exposure to welding fume.

Peng, Fangda / Yu, Lijia / Zhang, Chunmin / Liu, Qicai / Yan, Kai / Zhang, Kangfu / Zheng, Yuqiao / Liu, Wubin / Li, Yan / Fan, Jingguang / Ding, Chunguang

International archives of occupational and environmental health

2023 Volume 96, Issue 7, Page(s) 1029–1037

Abstract: Objective: Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of great importance. The aim of ... ...

Abstract	Objective: Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of great importance. The aim of this study was to screen serum differential metabolites of welding fume exposure based on UPLC-QTOF-MS/MS. Methods: In 2019, 49 participants were recruited at a machinery manufacturing factory. The non-target metabolomics technique was used to clarify serum metabolic signatures in people exposed to welding fume. Differential metabolites were screened by OPLS-DA analysis and Student's t-test. The receiver operating characteristic curve evaluated the discriminatory power of differential metabolites. And the correlations between differential metabolites and metal concentrations in urine and whole blood were analyzed utilizing Pearson correlation analysis. Results: Thirty metabolites were increased significantly, and 5 metabolites were decreased. The differential metabolites are mainly enriched in the metabolism of arachidonic acid, glycero phospholipid, linoleic acid, and thiamine. These results observed that lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol(PGF1α/16:0) had a tremendous anticipating power with relatively increased AUC values (AUC > 0.9), and they also presented a significant correlation of Mo concentrations in whole blood and Cu concentrations in urine, respectively. Conclusion: The serum metabolism was changed significantly after exposure to welding fume. Lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol (PGF1α/16:0) may be a potential biological mediator and biomarker for laborers exposure to welding fume.
MeSH term(s)	Humans ; Air Pollutants, Occupational/analysis ; Welding ; Lysophosphatidylcholines/analysis ; Tandem Mass Spectrometry ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Metabolome ; Inhalation Exposure/analysis
Chemical Substances	Air Pollutants, Occupational ; Lysophosphatidylcholines
Language	English
Publishing date	2023-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	129038-1
ISSN	1432-1246 ; 0340-0131 ; 0367-9977
ISSN (online)	1432-1246
ISSN	0340-0131 ; 0367-9977
DOI	10.1007/s00420-023-01987-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Un I Zs.366: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito