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  1. Article ; Online: Bacterial membrane dynamics: Compartmentalization and repair.

    Bramkamp, Marc / Scheffers, Dirk-Jan

    Molecular microbiology

    2023  Volume 120, Issue 4, Page(s) 490–501

    Abstract: In every bacterial cell, the plasma membrane plays a key role in viability as it forms a selective barrier between the inside of the cell and its environment. This barrier function depends on the physical state of the lipid bilayer and the proteins ... ...

    Abstract In every bacterial cell, the plasma membrane plays a key role in viability as it forms a selective barrier between the inside of the cell and its environment. This barrier function depends on the physical state of the lipid bilayer and the proteins embedded or associated with the bilayer. Over the past decade or so, it has become apparent that many membrane-organizing proteins and principles, which were described in eukaryote systems, are ubiquitous and play important roles in bacterial cells. In this minireview, we focus on the enigmatic roles of bacterial flotillins in membrane compartmentalization and bacterial dynamins and ESCRT-like systems in membrane repair and remodeling.
    Language English
    Publishing date 2023-05-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.15077
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
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  2. Article ; Online: The Cell Wall of

    Angeles, Danae Morales / Scheffers, Dirk-Jan

    Current issues in molecular biology

    2020  Volume 41, Page(s) 539–596

    Abstract: The cell wall ... ...

    Abstract The cell wall of
    MeSH term(s) Bacillus subtilis/metabolism ; Bacillus subtilis/physiology ; Biosynthetic Pathways/physiology ; Cell Wall/metabolism ; Cell Wall/physiology ; Cytoskeleton/metabolism ; Cytoskeleton/physiology ; Peptidoglycan/metabolism ; Uronic Acids/metabolism
    Chemical Substances Peptidoglycan ; Uronic Acids ; teichuronic acid (37251-79-9)
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.21775/cimb.041.539
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  3. Article ; Online: Evaluation of Kdo-8-N

    Ziylan, Zeynep Su / de Putter, Geert-Jan / Roelofs, Meike / van Dijl, Jan Maarten / Scheffers, Dirk-Jan / Walvoort, Marthe T C

    RSC chemical biology

    2023  Volume 4, Issue 11, Page(s) 884–893

    Abstract: 8-Azido-3,8-dideoxy-α/β-d- ...

    Abstract 8-Azido-3,8-dideoxy-α/β-d-
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d3cb00110e
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  4. Article ; Online: Selectivity and Activity of Benzene-1,2,4-triol and its Dimers as Antimicrobial Compounds Against Xanthomonas citri subsp. citri.

    Cavalca, Lúcia B / Atlason, Úlfur Á / Trofin, Alexandru / Ribeiro, Camila M / Pavan, Fernando R / Deuss, Peter J / Scheffers, Dirk-Jan

    ChemPlusChem

    2024  , Page(s) e202300616

    Abstract: Citrus canker, caused by the bacterium Xanthomonas citri subsp. citri, is one of the main threats to citrus fruit production. Several phenolic compounds active against X. citri have been described in recent years. Benzene-1,2,4-triol is a bio-based ... ...

    Abstract Citrus canker, caused by the bacterium Xanthomonas citri subsp. citri, is one of the main threats to citrus fruit production. Several phenolic compounds active against X. citri have been described in recent years. Benzene-1,2,4-triol is a bio-based phenolic compound that has shown high potential as a scaffold for the synthesis of new anti-X. citri compounds. However, benzene-1,2,4-triol is prone to oxidative dimerization. We evaluated the antibacterial activity of benzene-1,2,4-triol, its oxidized dimers, and analogous compounds. Benzene-1,2,4-triol has a low inhibitory concentration against X. citri (0.05 mM) and is also active against other bacterial species. Spontaneous formation of benzenetriol dimers (e. g. by contact with oxygen in aqueous solution) reduced the antimicrobial activity of benzenetriol solutions. Dimers themselves displayed lower antibacterial activity and where shown to be more stable in solution. Unlike many other phenolic compounds with anti-X. citri activity, benzene-1,2,4-triol does not act by membrane permeabilization, but seems to limit the availability of iron to cells. Benzene-1,2,4-triol is widely recognized as toxic - our results indicate that the toxicity of benzene-1,2,4-triol is largely due to spontaneously formed dimers. Stabilization of benzene-1,2,4-triol will be required to allow the safe use of this compound.
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202300616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights.

    Chakraborty, Parichita / Oosterhuis, Dorenda / Bonsignore, Riccardo / Casini, Angela / Olinga, Peter / Scheffers, Dirk-Jan

    ChemMedChem

    2021  Volume 16, Issue 19, Page(s) 3060–3070

    Abstract: The rise of antimicrobial resistance has necessitated novel strategies to efficiently combat pathogenic bacteria. Metal-based compounds have been proven as a possible alternative to classical organic drugs. Here, we have assessed the antibacterial ... ...

    Abstract The rise of antimicrobial resistance has necessitated novel strategies to efficiently combat pathogenic bacteria. Metal-based compounds have been proven as a possible alternative to classical organic drugs. Here, we have assessed the antibacterial activity of seven gold complexes of different families. One compound, a cyclometalated Au(III) C^N complex, showed activity against Gram-positive bacteria, including multi-drug resistant clinical strains. The mechanism of action of this compound was studied in Bacillus subtilis. Overall, the studies point towards a complex mode of antibacterial action, which does not include induction of oxidative stress or cell membrane damage. A number of genes related to metal transport and homeostasis were upregulated upon short treatment of the cells with gold compound. Toxicity tests conducted on precision-cut mouse tissue slices ex vivo revealed that the organogold compound is poorly toxic to mouse liver and kidney tissues, and may thus, be treated as an antibacterial drug candidate.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Gram-Positive Bacteria/drug effects ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Organogold Compounds/chemical synthesis ; Organogold Compounds/chemistry ; Organogold Compounds/pharmacology ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Organogold Compounds
    Language English
    Publishing date 2021-07-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202100342
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    Zs.A 6280: Show issues Location:
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  6. Article ; Online: LipidII: Just Another Brick in the Wall?

    Scheffers, Dirk-Jan / Tol, Menno B

    PLoS pathogens

    2015  Volume 11, Issue 12, Page(s) e1005213

    Abstract: Nearly all bacteria contain a peptidoglycan cell wall. The peptidoglycan precursor molecule is LipidII, containing the basic peptidoglycan building block attached to a lipid. Although the suitability of LipidII as an antibacterial target has long been ... ...

    Abstract Nearly all bacteria contain a peptidoglycan cell wall. The peptidoglycan precursor molecule is LipidII, containing the basic peptidoglycan building block attached to a lipid. Although the suitability of LipidII as an antibacterial target has long been recognized, progress on elucidating the role(s) of LipidII in bacterial cell biology has been slow. The focus of this review is on exciting new developments, both with respect to antibacterials targeting LipidII as well as the emerging role of LipidII in organizing the membrane and cell wall synthesis. It appears that on both sides of the membrane, LipidII plays crucial roles in organizing cytoskeletal proteins and peptidoglycan synthesis machineries. Finally, the recent discovery of no less than three different categories of LipidII flippases will be discussed.
    MeSH term(s) Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Peptidoglycan/metabolism
    Chemical Substances Bacterial Proteins ; Peptidoglycan
    Language English
    Publishing date 2015-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005213
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  7. Article ; Online: A 1 MDa protein complex containing critical components of the Escherichia coli divisome.

    Trip, Erik N / Scheffers, Dirk-Jan

    Scientific reports

    2015  Volume 5, Page(s) 18190

    Abstract: Cell division in bacteria is an essential process that is carried out at mid-cell by a group of cell division proteins referred to as the divisome. In Escherichia coli, over two dozen cell division proteins have been identified of which ten are essential. ...

    Abstract Cell division in bacteria is an essential process that is carried out at mid-cell by a group of cell division proteins referred to as the divisome. In Escherichia coli, over two dozen cell division proteins have been identified of which ten are essential. These division proteins localize sequentially and interdependently to the division site, after which constriction eventually produces two daughter cells. Various genetic and biochemical techniques have identified many interactions amongst cell division proteins, however the existence of the divisome as a large multi-protein complex has never been shown. Here, we identify a 1 MDa protein complex by native page that contains seven essential cell division proteins (FtsZ, ZipA, FtsK, FtsQ, FtsB, FtsL, and FtsN). The 1 MDa complex is present in rapidly dividing cells, but absent when cultures enter the stationary growth phase. Slight overexpression of the ftsQ D237N mutation that blocks cell division prevents formation of this 1 MDa complex. In cells depleted of FtsN, the 1 MDa complex is not assembled. Combined, our findings indicate that a large protein complex containing many different cell division proteins indeed exists. We note that this complex is very fragile and sensitive to the expression of tagged versions of FtsQ.
    MeSH term(s) Cell Division ; Escherichia coli/physiology ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Gene Expression ; Multiprotein Complexes/metabolism ; Mutation
    Chemical Substances Escherichia coli Proteins ; Multiprotein Complexes
    Language English
    Publishing date 2015-12-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep18190
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  8. Article ; Online: The PASTA domains of

    Morales Angeles, Danae / Macia-Valero, Alicia / Bohorquez, Laura C / Scheffers, Dirk-Jan

    Microbiology (Reading, England)

    2020  Volume 166, Issue 9, Page(s) 826–836

    Abstract: Bacterial cell division is mediated by a protein complex known as the divisome. Many protein-protein interactions in the divisome have been characterized. In this report, we analyse the role of the PASTA (Penicillin-binding protein And Serine Threonine ... ...

    Abstract Bacterial cell division is mediated by a protein complex known as the divisome. Many protein-protein interactions in the divisome have been characterized. In this report, we analyse the role of the PASTA (Penicillin-binding protein And Serine Threonine kinase Associated) domains of
    MeSH term(s) Bacillus subtilis/genetics ; Bacillus subtilis/growth & development ; Bacillus subtilis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Membrane Proteins/metabolism ; Penicillin-Binding Proteins/chemistry ; Penicillin-Binding Proteins/metabolism ; Peptidyl Transferases/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Stability ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Temperature
    Chemical Substances Bacterial Proteins ; DivIB protein, Bacillus subtilis ; Membrane Proteins ; Penicillin-Binding Proteins ; Recombinant Fusion Proteins ; Peptidyl Transferases (EC 2.3.2.12)
    Language English
    Publishing date 2020-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.000957
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  9. Article ; Online: Bacterial dynamin as a membrane puncture repair kit.

    de Sousa Borges, Anabela / Scheffers, Dirk-Jan

    Environmental microbiology

    2016  Volume 18, Issue 8, Page(s) 2298–2301

    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.13218
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  10. Article ; Online: Benzenetriol-Derived Compounds against Citrus Canker.

    Cavalca, Lúcia Bonci / Lahive, Ciaran W / Gijsbers, Fleur / Pavan, Fernando Rogério / Scheffers, Dirk-Jan / Deuss, Peter J

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 5

    Abstract: In order to replace the huge amounts of copper salts used in citrus orchards, alternatives have been sought in the form of organic compounds of natural origin with activity against the causative agent of citrus canker, the ... ...

    Abstract In order to replace the huge amounts of copper salts used in citrus orchards, alternatives have been sought in the form of organic compounds of natural origin with activity against the causative agent of citrus canker, the phytopathogen
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Benzene Derivatives/chemistry ; Benzene Derivatives/pharmacology ; Cell Proliferation ; Citrus/drug effects ; Citrus/microbiology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Humans ; Plant Diseases/microbiology ; Plant Leaves/drug effects ; Plant Leaves/microbiology ; Xanthomonas/pathogenicity
    Chemical Substances Anti-Bacterial Agents ; Benzene Derivatives
    Language English
    Publishing date 2021-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26051436
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