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  1. Book ; Thesis: Prävalenz und natürlicher Verlauf ienes Demenzrisikosyndroms

    Toro, Pablo

    die leichte kognitive Beeinträchtigung in der deutschen Allgemeinbevölkerung; erste Ergebnisse aus der dritten Untersuchugnswelle der Interdisziplinären Längsschnittstudie des Erwachsenenalters

    2010  

    Author's details vorgelegt von Pablo Esteban Toro Espinoza
    Language German
    Size 98 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2011
    HBZ-ID HT017134722
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Psiquiatría y criminalidad.

    Toro Martínez, Esteban

    Vertex (Buenos Aires, Argentina)

    2016  Volume XXVII, Issue 127, Page(s) 188–190

    Title translation Psychiatry and criminality.
    Language Spanish
    Publishing date 2016-05
    Publishing country Argentina
    Document type Journal Article
    ISSN 0327-6139
    ISSN 0327-6139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk Factors for Oronasal Fistula in Primary Palatoplasty: A Case-Control Study From a Reference Center in Medellín, Colombia.

    Correa Acebedo, Esteban / Gallego Gónima, Sabrina / Vásquez Sañudo, Vanesa / Vélez Toro, Juan Sebastián / Salinas, Ana María

    The Journal of craniofacial surgery

    2024  

    Abstract: Background: Oronasal fistula is one of the most critical complications in primary palatoplasty, with a reported incidence between 5% and 46% with multiple associated risk factors described previously. In addition, in more than half of the patients, it ... ...

    Abstract Background: Oronasal fistula is one of the most critical complications in primary palatoplasty, with a reported incidence between 5% and 46% with multiple associated risk factors described previously. In addition, in more than half of the patients, it implies additional surgeries, increasing risks for the patient and health care costs. In this case-control study, the authors aim to determine the specific risk factors for oronasal fistula after primary palatoplasty in the study population.
    Methods: A retrospective review was undertaken to identify all patients undergoing primary palatoplasty between 2017 and 2019. Patients who developed oronasal fistula were included (cases) and compared with patients from the same cohort without fistula (controls). Demographic, clinical, and perioperative variables and their association with postoperative fistula presentation were explored through crude and adjusted analysis.
    Results: One hundred thirty-nine patients with a median age of 6 years (5-6) who underwent primary palatoplasty were found. Forty-five presented an oronasal fistula, corresponding to 32% of the population, and 64% required subsequent repair of an oronasal fistula. In the crude analysis, the surgeon's experience (OR: 0.44) was associated significantly with the outcome. Adjusted analysis showed an association between surgical site infection and syndromic presentation.
    Conclusions: The experience of the surgeon is a protective factor for the oronasal fistula presentation; in addition, the presentation of infection of the operative site, the syndromic presentation, and the clinical follow-up at 1 year were also relevant; the latter, possibly due to the social context of our patients.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000010047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Beyond skeletal studies: A computational analysis of nasal airway function in climate adaptation.

    Bastir, Markus / Sanz-Prieto, Daniel / Burgos, Manuel A / Pérez-Ramos, Alejandro / Heuzé, Yann / Maréchal, Laura / Evteev, Andrej / Toro-Ibacache, Viviana / Esteban-Ortega, Francisco

    American journal of biological anthropology

    2024  , Page(s) e24932

    Abstract: Objectives: Ecogeographic variation in human nasal anatomy has historically been analyzed on skeletal morphology and interpreted in the context of climatic adaptations to respiratory air-conditioning. Only a few studies have analyzed nasal soft tissue ... ...

    Abstract Objectives: Ecogeographic variation in human nasal anatomy has historically been analyzed on skeletal morphology and interpreted in the context of climatic adaptations to respiratory air-conditioning. Only a few studies have analyzed nasal soft tissue morphology, actively involved in air-conditioning physiology.
    Materials and methods: We used in vivo computer tomographic scans of (N = 146) adult individuals from Cambodia, Chile, Russia, and Spain. We conducted (N = 438) airflow simulations during inspiration using computational fluid dynamics to analyze the air-conditioning capacities of the nasal soft tissue in the inflow, functional, and outflow tract, under three different environmental conditions: cold-dry; hot-dry; and hot-humid. We performed statistical comparisons between populations and sexes.
    Results: Subjects from hot-humid regions showed significantly lower air-conditioning capacities than subjects from colder regions in all the three conditions, specifically within the isthmus region in the inflow tract, and the anterior part of the internal functional tract. Posterior to the functional tract, no differences were detected. No differences between sexes were found in any of the tracts and under any of the conditions.
    Discussion: Our statistical analyses support models of climatic adaptations of anterior nasal soft tissue morphology that fit with, and complement, previous research on dry skulls. However, our results challenge a morpho-functional model that attributes air-conditioning capacities exclusively to the functional tract located within the nasal cavity. Instead, our findings support studies that have suggested that both, the external nose and the intra-facial soft tissue airways contribute to efficiently warming and humidifying air during inspiration. This supports functional interpretations in modern midfacial variation and evolution.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2692-7691
    ISSN (online) 2692-7691
    DOI 10.1002/ajpa.24932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hemocromatosis no ligada al gen HFE: a propósito de un caso.

    Martínez-Ávila, María Cristina / Toro-Trujillo, Esteban / Alvarez-Londoño, Angelina

    Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

    2022  Volume 41, Issue 4, Page(s) 261–264

    Abstract: Hereditary hemochromatosis (HH) consists of a progressive iron overload that leads to an abnormal accumulation of iron in different target organs; and, if not treated in time, can cause multi-organ dysfunction. Various genetic mutations associated with ... ...

    Title translation Non-HFE hemochromatosis: a case report.
    Abstract Hereditary hemochromatosis (HH) consists of a progressive iron overload that leads to an abnormal accumulation of iron in different target organs; and, if not treated in time, can cause multi-organ dysfunction. Various genetic mutations associated with HH have been described, the most frequent is associated with the HFE-gene, which is found in 90% of cases. At present, therapeutic phlebotomy continues to be the treatment of choice for the management of this pathology. We report the case of a patient under follow-up for severe liver fibrosis, with persistence of a high ferrokinetic profile, who five years later was diagnosed with HH not associated to a mutation in the HFE-gene; He was managed with periodic phlebotomies, rapidly presenting a significant clinical improvement and decrease of ferritin levels.
    MeSH term(s) Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Hemochromatosis Protein/genetics ; Humans ; Iron Overload/diagnosis ; Iron Overload/genetics ; Male ; Mutation ; Phlebotomy
    Chemical Substances Hemochromatosis Protein
    Language Spanish
    Publishing date 2022-06-02
    Publishing country Peru
    Document type Case Reports ; Journal Article
    ZDB-ID 2058591-3
    ISSN 1609-722X ; 1609-722X
    ISSN (online) 1609-722X
    ISSN 1609-722X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Thyroid Ultrasound Appropriateness Identification Through Natural Language Processing of Electronic Health Records.

    Jacome, Cristian Soto / Torres, Danny Segura / Fan, Jungwei W / Loor-Torres, Ricardo / Duran, Mayra / Zahidy, Misk Al / Cabezas, Esteban / Borras-Osorio, Mariana / Toro-Tobon, David / Wu, Yuqi / Wu, Yonghui / Ospina, Naykky Singh / Brito, Juan P

    Mayo Clinic Proceedings. Digital health

    2024  Volume 2, Issue 1, Page(s) 67–74

    Abstract: Objective: To address thyroid cancer overdiagnosis, we aim to develop a natural language processing (NLP) algorithm to determine the appropriateness of thyroid ultrasounds (TUS).: Patients and methods: Between 2017 and 2021, we identified 18,000 TUS ... ...

    Abstract Objective: To address thyroid cancer overdiagnosis, we aim to develop a natural language processing (NLP) algorithm to determine the appropriateness of thyroid ultrasounds (TUS).
    Patients and methods: Between 2017 and 2021, we identified 18,000 TUS patients at Mayo Clinic and selected 628 for chart review to create a ground truth dataset based on consensus. We developed a rule-based NLP pipeline to identify TUS as appropriate TUS (aTUS) or inappropriate TUS (iTUS) using patients' clinical notes and additional meta information. In addition, we designed an abbreviated NLP pipeline (aNLP) solely focusing on labels from TUS order requisitions to facilitate deployment at other health care systems. Our dataset was split into a training set of 468 (75%) and a test set of 160 (25%), using the former for rule development and the latter for performance evaluation.
    Results: There were 449 (95.9%) patients identified as aTUS and 19 (4.06%) as iTUS in the training set; there are 155 (96.88%) patients identified as aTUS and 5 (3.12%) were iTUS in the test set. In the training set, the pipeline achieved a sensitivity of 0.99, specificity of 0.95, and positive predictive value of 1.0 for detecting aTUS. The testing cohort revealed a sensitivity of 0.96, specificity of 0.80, and positive predictive value of 0.99. Similar performance metrics were observed in the aNLP pipeline.
    Conclusion: The NLP models can accurately identify the appropriateness of a thyroid ultrasound from clinical documentation and order requisition information, a critical initial step toward evaluating the drivers and outcomes of TUS use and subsequent thyroid cancer overdiagnosis.
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2949-7612
    ISSN (online) 2949-7612
    DOI 10.1016/j.mcpdig.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

    Rondaan, Christien / Maso, Alessandra / Birlutiu, Rares-Mircea / Fernandez Sampedro, Marta / Soriano, Alex / Diaz de Brito, Vicens / Gómez Junyent, Joan / Del Toro, Maria Dolores / Hofstaetter, Jochen Gerhard / Salles, Mauro José / Esteban, Jaime / Wouthuyzen-Bakker, Marjan

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  

    Abstract: Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a ... ...

    Abstract Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.
    Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.
    Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).
    Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Subspecies Distribution and Antimicrobial Susceptibility Testing of Mycobacterium abscessus Clinical Isolates in Madrid, Spain: a Retrospective Multicenter Study.

    Ruedas-López, Alba / Tato, Marta / Broncano-Lavado, Antonio / Esteban, Jaime / Ruiz-Serrano, María Jesús / Sánchez-Cueto, María / Toro, Carlos / Domingo, Diego / Cacho, Juana / Barrado, Laura / López-Roa, Paula

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0504122

    Abstract: Mycobacterium abscessus (MABS) is the most pathogenic and drug-resistant rapidly growing mycobacteria. However, studies on MABS epidemiology, especially those focusing on subspecies level, are scarce. We aimed to determine MABS subspecies distribution ... ...

    Abstract Mycobacterium abscessus (MABS) is the most pathogenic and drug-resistant rapidly growing mycobacteria. However, studies on MABS epidemiology, especially those focusing on subspecies level, are scarce. We aimed to determine MABS subspecies distribution and its correlation with phenotypic and genotypic antibiotic profiles. A retrospective multicenter study of 96 clinical MABS isolates in Madrid between 2016 to 2021 was conducted. Identification at the subspecies level and resistance to macrolides and aminoglycosides were performed by the GenoType NTM-DR assay. The MICs of 11 antimicrobials tested against MABS isolates were determined using the broth microdilution method (RAPMYCOI Sensititer titration plates). Clinical isolates included 50 (52.1%) MABS subsp.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Clarithromycin ; Mycobacterium abscessus ; Amikacin/pharmacology ; Linezolid ; Cefoxitin ; Spain/epidemiology ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium Infections, Nontuberculous/microbiology ; Macrolides ; Drug Resistance, Bacterial/genetics ; Imipenem ; Aminoglycosides ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A) ; Amikacin (84319SGC3C) ; Linezolid (ISQ9I6J12J) ; Cefoxitin (6OEV9DX57Y) ; Macrolides ; Imipenem (71OTZ9ZE0A) ; Aminoglycosides
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05041-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Una entrevista con el profesor Isabelino Siede

    Isabelino A. Siede / María-Eugenia Villa / Juan Esteban-Clavijo / Natalia Godoy-Toro / Marta Restrepo

    Forum Revista Departamento de Ciencia Política, Iss

    2021  Volume 20

    Keywords educación política ; ética ; ciudadanía ; escuela ; propuestas de enseñanza ; Political science ; J ; International relations ; JZ2-6530
    Language Spanish
    Publishing date 2021-07-01T00:00:00Z
    Publisher Universidad Nacional de Colombia, sede Medellín
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Tic-Tac: A Translational Approach in Mechanisms Associated with Irregular Heartbeat and Sinus Rhythm Restoration in Atrial Fibrillation Patients.

    Parra-Lucares, Alfredo / Villa, Eduardo / Romero-Hernández, Esteban / Méndez-Valdés, Gabriel / Retamal, Catalina / Vizcarra, Geovana / Henríquez, Ignacio / Maldonado-Morales, Esteban A J / Grant-Palza, Juan H / Ruíz-Tagle, Sofía / Estrada-Bobadilla, Victoria / Toro, Luis

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Atrial fibrillation (AF) is a prevalent cardiac condition predominantly affecting older adults, characterized by irregular heartbeat rhythm. The condition often leads to significant disability and increased mortality rates. Traditionally, two therapeutic ...

    Abstract Atrial fibrillation (AF) is a prevalent cardiac condition predominantly affecting older adults, characterized by irregular heartbeat rhythm. The condition often leads to significant disability and increased mortality rates. Traditionally, two therapeutic strategies have been employed for its treatment: heart rate control and rhythm control. Recent clinical studies have emphasized the critical role of early restoration of sinus rhythm in improving patient outcomes. The persistence of the irregular rhythm allows for the progression and structural remodeling of the atria, eventually leading to irreversible stages, as observed clinically when AF becomes permanent. Cardioversion to sinus rhythm alters this progression pattern through mechanisms that are still being studied. In this review, we provide an in-depth analysis of the pathophysiological mechanisms responsible for maintaining AF and how they are modified during sinus rhythm restoration using existing therapeutic strategies at different stages of clinical investigation. Moreover, we explore potential future therapeutic approaches, including the promising prospect of gene therapy.
    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/therapy ; Heart Rate ; Tics ; Heart Diseases ; Heart Atria
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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