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  1. Article ; Online: Revolutionizing antimicrobial stewardship, infection prevention, and public health with artificial intelligence: the middle path.

    Marra, Alexandre R / Langford, Bradley J / Nori, Priya / Bearman, Gonzalo

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e219

    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Editorial
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Confronting the Disruption of the Infectious Diseases Workforce by Artificial Intelligence: What This Means for Us and What We Can Do About It.

    Langford, Bradley J / Branch-Elliman, Westyn / Nori, Priya / Marra, Alexandre R / Bearman, Gonzalo

    Open forum infectious diseases

    2024  Volume 11, Issue 3, Page(s) ofae053

    Abstract: With the rapid advancement of artificial intelligence (AI), the field of infectious diseases (ID) faces both innovation and disruption. AI and its subfields including machine learning, deep learning, and large language models can support ID clinicians' ... ...

    Abstract With the rapid advancement of artificial intelligence (AI), the field of infectious diseases (ID) faces both innovation and disruption. AI and its subfields including machine learning, deep learning, and large language models can support ID clinicians' decision making and streamline their workflow. AI models may help ensure earlier detection of disease, more personalized empiric treatment recommendations, and allocation of human resources to support higher-yield antimicrobial stewardship and infection prevention strategies. AI is unlikely to replace the role of ID experts, but could instead augment it. However, its limitations will need to be carefully addressed and mitigated to ensure safe and effective implementation. ID experts can be engaged in AI implementation by participating in training and education, identifying use cases for AI to help improve patient care, designing, validating and evaluating algorithms, and continuing to advocate for their vital role in patient care.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Revolutionizing antimicrobial stewardship, infection prevention, and public health with artificial intelligence

    Alexandre R. Marra / Bradley J. Langford / Priya Nori / Gonzalo Bearman

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol

    the middle path

    2023  Volume 3

    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Brave new world: Leveraging artificial intelligence for advancing healthcare epidemiology, infection prevention, and antimicrobial stewardship.

    Marra, Alexandre R / Nori, Priya / Langford, Bradley J / Kobayashi, Takaaki / Bearman, Gonzalo

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 12, Page(s) 1909–1912

    MeSH term(s) Humans ; Antimicrobial Stewardship ; Artificial Intelligence ; Anti-Bacterial Agents/therapeutic use ; Delivery of Health Care
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global collaborations in antimicrobial stewardship: All hands on deck.

    Ashiru-Oredope, Diane / Langford, Bradley J / Bonaconsa, Candice / Nampoothiri, Vrinda / Charani, Esmita / Goff, Debra A

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e66

    Abstract: Tackling antimicrobial resistance (AMR) through antimicrobial stewardship (AMS) interventions is a key objective within the World Health Organization (WHO)'s Global Action on AMR. We outline the reasons why global collaborations for AMS are needed. We ... ...

    Abstract Tackling antimicrobial resistance (AMR) through antimicrobial stewardship (AMS) interventions is a key objective within the World Health Organization (WHO)'s Global Action on AMR. We outline the reasons why global collaborations for AMS are needed. We provide examples of global collaborations, and we offer considerations when starting on a global health journey focused on AMS.
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Go V.I.R.A.L.: Social Media Engagement Strategies in Infectious Diseases.

    Langford, Bradley J / Laguio-Vila, Maryrose / Gauthier, Timothy P / Shah, Aditya

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 74, Issue Suppl_3, Page(s) e10–e13

    Abstract: Social media has emerged as a tool to facilitate communication and dissemination of information for both patients and healthcare professionals. We describe 3 social media engagement strategies used to reach a broad and diverse audience on the topics of ... ...

    Abstract Social media has emerged as a tool to facilitate communication and dissemination of information for both patients and healthcare professionals. We describe 3 social media engagement strategies used to reach a broad and diverse audience on the topics of infectious diseases and antimicrobial stewardship, including the use of memes, a clue-based knowledge assessment quiz, and a personality quiz. We describe a novel acronym "VIRAL" to guide engaging social media strategies in healthcare, including eye catching Visuals, Interactive content, showing Respect and empathy for the audience, Adapting to new technology, and making Learning fun.
    MeSH term(s) Antimicrobial Stewardship ; Communicable Diseases/drug therapy ; Communication ; Humans ; Social Media
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  7. Article ; Online: Evaluating a pilot, structured, face-to-face, antimicrobial stewardship, prospective audit-and-feedback program in emergency general surgery service in a community hospital.

    Chan, April J / Tsang, Melanie E / Langford, Bradley J / Nisenbaum, Rosane / Wan, Michael / Downing, Mark A

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e96

    Abstract: Background: Prospective audit and feedback (PAF) is an established practice in critical care settings but not in surgical populations. We pilot-tested a structured face-to-face PAF program for our acute-care surgery (ACS) service.: Methods: This was ... ...

    Abstract Background: Prospective audit and feedback (PAF) is an established practice in critical care settings but not in surgical populations. We pilot-tested a structured face-to-face PAF program for our acute-care surgery (ACS) service.
    Methods: This was a mixed-methods study. For the quantitative analysis, the structured PAF period was from August 1, 2017, to April 30, 2019. The ad hoc PAF period was from May 1, 2019, to January 31, 2021. Interrupted time-series segmented negative binomial regression analysis was used to evaluate change in antimicrobial usage measured in days of therapy per 1,000 patient days for all systemic and targeted antimicrobials. Secondary outcomes included
    Results: In total, 776 ACS patients were included in the structured PAF period and 783 patients were included in the in ad hoc PAF period. No significant changes in level or trend for antimicrobial usage were detected for all and targeted antimicrobials. Similarly, no significant differences were detected for secondary outcomes. The survey response rate was 25% (n = 10). Moreover, 50% agreed that PAF provided them with skills to use antimicrobials more judiciously, and 80% agreed that PAF improved the quality of antimicrobial treatment for their patients.
    Conclusion: Structured PAF showed clinical outcomes similar to ad hoc PAF. Structured PAF was well received and was perceived as beneficial by surgical staff.
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Real-life implications of prevalence meta-analyses? Doi plots and prediction intervals are the answer - Authors' reply.

    Soucy, Jean-Paul R / Langford, Bradley J / So, Miranda / Raybardhan, Sumit / MacFadden, Derek / Daneman, Nick / Bertagnolio, Silvia

    The Lancet. Microbe

    2023  Volume 4, Issue 7, Page(s) e491

    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00098-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Documenting the indication for antimicrobial prescribing: A retrospective observational study of long-term care homes.

    Champaneria, Kayuri / Langford, Bradley J / Allen, Jean-Paul / Brown, Kevin / Daneman, Nick / Schwartz, Kevin / Leung, Valerie

    Journal of the American Geriatrics Society

    2024  

    Abstract: Background: Overuse of antimicrobials in residents of long-term care homes is common and can result in harm. Antimicrobial stewardship interventions are needed in the long-term care (LTC) homes setting to improve the appropriate use of antimicrobials. ... ...

    Abstract Background: Overuse of antimicrobials in residents of long-term care homes is common and can result in harm. Antimicrobial stewardship interventions are needed in the long-term care (LTC) homes setting to improve the appropriate use of antimicrobials. Previous literature has highlighted the importance of documenting antimicrobial indication as a strategy that contributes to improve antimicrobial use; however, there is a lack of evidence in LTC homes. This study examines the prevalence, clarity, and facility-level variability of antibiotic indication documentation in this setting.
    Methods: This is an observational retrospective study of oral antibiotic prescriptions dispensed to 218 homes between January 1 2021 and December 31 2022 in Ontario, Canada. Indication was obtained from reviewing antibiotic prescription data. Clarity was determined by comparing documented indication to the National Antimicrobial Prescribing Survey (NAPS). Descriptive analysis was performed to examine the prevalence and clarity of indication documentation. Funnel plots were generated to examine variability in prevalence of indication documentation and clarity at the home level.
    Results: Overall, 22.9% (7998/34,867) of prescriptions had an indication documented. The proportion of indications that were clear was 37% (2984/7998). The most common indications were for urinary (45%), skin and soft tissue (19.9%) and respiratory infections (15.0%). At the home level, the median prevalence of indication was 19.6% (interquartile range [IQR]: 10.8%-31.4%) and median prevalence of clear indications was 35.1% (IQR: 23.8%-42.9%). Funnel plots revealed substantial variability in indication prevalence with 46.3% of homes falling outside of 99% limits but minimal variability in indication clarity between homes with only 8.7% of homes outside of 99% control limits.
    Conclusions: There is an opportunity to increase both the prevalence and clarity of antibiotic prescriptions in LTC homes. Future work should focus on determining how best to support prescription indication documentation in this setting with consideration being given to prescription workflow and most common antibiotic prescription indications.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.168: Show issues Location:
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  10. Article ; Online: Evaluating the impact of mandatory indications on antibiotic utilization in a community hospital.

    Chan, April J / Nisenbaum, Rosane / Downing, Mark / Langford, Bradley J

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e121

    Abstract: Objective: We evaluated the impact of introducing a mandatory indication field into electronic order entry for targeted antibiotics in adult inpatients.: Design: Retrospective, before-and-after trial.: Setting: A 400-bed community hospital.: ... ...

    Abstract Objective: We evaluated the impact of introducing a mandatory indication field into electronic order entry for targeted antibiotics in adult inpatients.
    Design: Retrospective, before-and-after trial.
    Setting: A 400-bed community hospital.
    Interventions: All adult electronic intravenous (IV) and enteral orders for targeted antibiotics (moxifloxacin, ciprofloxacin, clindamycin, vancomycin, and metronidazole) had a mandatory indication field added. Control antibiotics (amoxicillin-clavulanate, ceftriaxone and piperacillin-tazobactam) were chosen to track shifts in antibiotic prescribing due to the introduction of mandatory indication field.
    Methods: Descriptive statistics were used to summarize the primary outcome, measured in Defined Daily Doses (DDD) per 1000 patient days (PD). Interrupted time-series (ITS) analysis was performed to compare levels and trends in antibiotic usage of targeted and control antibiotics during 24 months before and after the intervention. Additionally, a descriptive analysis of mandatory indication fields for targeted antibiotics in the postintervention period was conducted.
    Results: In total, 4,572 study antibiotic orders were evaluated after the intervention. Preset mandatory indications were selected for 30%-55% of orders. There was decreased usage of targeted antibiotics (mean, 92.02 vs 72.07 DDD/1000-PD) with increased usage of control antibiotics (mean, 102.73 vs 119.91 DDD/1000-PD). ITS analysis showed no statistically significant difference in overall antibiotic usage before and after the intervention for all targeted antibiotics.
    Conclusion: This study showed moderate use of preset mandatory indications, suggesting that the preset list of indications can be optimized. There was no impact on overall antibiotic usage with the use of mandatory indications. More prospective research is needed to study the utility of this intervention in different contexts.
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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