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Article ; Online: Implementing Adolescent Wellbeing and Health Programs in Schools: Insights from a Mixed Methods and Multiple Informant Study.

Dariotis, Jacinda K / Mabisi, Keren / Jackson-Gordon, Rachel / Yang, Nan / Rose, Emma Jane / Mendelson, Tamar / Fishbein, Diana H

Prevention science : the official journal of the Society for Prevention Research

2023 Volume 24, Issue 4, Page(s) 663–675

Abstract: ... were implemented with ninth graders (N = 70) in three schools situated in low-resourced urban ... neighborhoods. Study outcomes were derived from four data sources: (1) focus group participants (N = 45); (2 ...

Abstract	Determining the factors that influence implementation of school-based wellbeing and health programs is essential for achieving desired program effects. Using a convergent mixed-methods, multiple informant design, this study considered factors that influence implementation of health programs for ninth grade students and in what ways implementation is differentially perceived by multiple informants (i.e., participants, instructors, and independent observers). Two types of programs-mindfulness and health education-were implemented with ninth graders (N = 70) in three schools situated in low-resourced urban neighborhoods. Study outcomes were derived from four data sources: (1) focus group participants (N = 45); (2) program instructor fidelity ratings; (3) independent observer fidelity ratings and notes; and (4) instructor open-ended session responses. Using thematic and mixed methods integration analyses, we identified themes related to implementation promoting or challenging factors. Theme names differed when data sources were separately analyzed by informant. Mixed methods integration analysis indicated that four themes were common across all informant groups: (1) competent, attentive, and engaging instructors are essential; (2) programs should involve interactive components (e.g., physical activities, applied learning opportunities); (3) adequate time for program delivery is key for student exposure and engagement; and (4) students' availability and preferences should guide program scheduling. A fifth theme, unique to instructor and observer perspectives, was that program implementation was negatively impacted by distractions from multiple sources, including instructors, students, and settings. Recommendations from students, instructors, and observers for implementation optimization are discussed.
MeSH term(s)	Adolescent ; Humans ; Adolescent Health ; Schools ; Students ; Learning
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-022-01481-2
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Article ; Online: Safety and efficacy of secukinumab in patients with giant cell arteritis (TitAIN): a randomised, double-blind, placebo-controlled, phase 2 trial.

Venhoff, Nils / Schmidt, Wolfgang A / Bergner, Raoul / Rech, Jürgen / Unger, Leonore / Tony, Hans-Peter / Finzel, Stephanie / Andreica, Ioana / Kofler, David M / Weiner, Stefan M / Lamprecht, Peter / Schulze-Koops, Hendrik / App, Christine / Pournara, Effie / Mendelson, Meryl H / Sieder, Christian / Maricos, Meron / Thiel, Jens

The Lancet. Rheumatology

2024 Volume 5, Issue 6, Page(s) e341–e350

Abstract: ... to receive secukinumab (n=27) or placebo (n=25). Four of 27 patients in the secukinumab group and eight of 25 ...

Abstract	Background: The treatment of giant cell arteritis with glucocorticoid-sparing agents is an unmet medical need. We evaluated the efficacy and safety of secukinumab, an anti-interleukin-17A monoclonal antibody, in patients with giant cell arteritis. Methods: We conducted a Bayesian randomised, parallel-group, double-blind, placebo-controlled, multicentre, phase 2 study at 11 clinics or hospitals in Germany. Patients aged 50 years or older with new-onset or relapsing giant cell arteritis who were naive to biological therapy and already receiving glucocorticoids with a prednisolone equivalent dose of 25-60 mg/day were eligible for inclusion. Participants were assigned (1:1) to receive 300 mg secukinumab or placebo subcutaneously once a week up to week 4 and every 4 weeks thereafter. In both treatment groups, prednisolone dose was tapered down to 0 mg over a 26-week period. Patients, investigator staff, and clinical trial team were masked to the treatment assignment. The primary endpoint was the median proportion (Bayesian analysis) of patients with sustained remission until week 28 in the full analysis set (ie, all patients who received at least one dose of assigned treatment, analysed according to treatment assigned at randomisation). Sustained remission rate of the placebo group from a previous trial of tocilizumab in patients with giant cell arteritis was used to derive the prior distribution of placebo sustained remission rate for the primary endpoint. The safety of secukinumab was assessed in the safety set (ie, all patients who received at least one dose of study treatment, analysed according to study treatment received). This trial is completed and is registered with ClinicalTrials.gov, NCT03765788. Findings: Of the 65 patients who were assessed for eligibility, 52 patients (median age 75 years [IQR 69-79]; 35 [67%] female and 17 [33%] male, 52 [100%] White) were enrolled between Jan 30, 2019 and March 30, 2020 and were randomly assigned to receive secukinumab (n=27) or placebo (n=25). Four of 27 patients in the secukinumab group and eight of 25 patients in the placebo group discontinued treatment by week 28 of the study. On the basis of the Bayesian analysis, the median proportion of patients in sustained remission until week 28 was 70% (95% credibility interval 52-85) in the secukinumab group versus 20% (12-30) in the placebo group. The incidence of adverse events was similar in the secukinumab (27 [100%] of 27 patients had any adverse event) and placebo groups (24 [96%] of 25 patients had any adverse event); the most common adverse events were hypertension (six [22%] of 27 patients in the secukinumab group and eight [32%] of 25 patients in the placebo group) and nasopharyngitis (five [19%] of 27 patients in the secukinumab group and five [20%] of 25 patients in the placebo group). Two patients (one in each group) died during the study, neither of which was considered to be related to study treatment. Interpretation: Patients with active giant cell arteritis had a higher sustained remission rate in the secukinumab group than in the placebo group at week 28, in combination with glucocorticoid taper regimen. Secukinumab was tolerated well with no new safety concerns. This proof-of-concept phase 2 study further supports the development of secukinumab as a treatment option for people with giant cell arteritis. Funding: Novartis Pharma.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Antibodies, Monoclonal, Humanized ; Bayes Theorem ; Giant Cell Arteritis/drug therapy ; Glucocorticoids ; Prednisolone ; Double-Blind Method
Chemical Substances	Antibodies, Monoclonal, Humanized ; Glucocorticoids ; Prednisolone (9PHQ9Y1OLM) ; secukinumab (DLG4EML025)
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase II ; Journal Article
ISSN	2665-9913
ISSN (online)	2665-9913
DOI	10.1016/S2665-9913(23)00101-7
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Article: Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism.

Chen, Kevin S / Noureldein, Mohamed H / McGinley, Lisa M / Hayes, John M / Rigan, Diana M / Kwentus, Jacquelin F / Mason, Shayna N / Mendelson, Faye E / Savelieff, Masha G / Feldman, Eva L

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1306004

Abstract: Introduction: Stem cells are a promising therapeutic in Alzheimer's disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidate ... ...

Abstract	Introduction: Stem cells are a promising therapeutic in Alzheimer's disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidate therapeutic mechanisms of human neural stem cells (hNSCs) in an animal model of AD. Methods: hNSCs were transplanted into the fimbria fornix of the hippocampus using the 5XFAD mouse model. Spatial memory was assessed by Morris water maze. Amyloid plaque burden was quantified. Spatial transcriptomics was performed and differentially expressed genes (DEGs) identified both globally and within the hippocampus. Subsequent pathway enrichment and ligand-receptor network analysis was performed. Results: hNSC transplantation restored learning curves of 5XFAD mice. However, there were no changes in amyloid plaque burden. Spatial transcriptomics showed 1,061 DEGs normalized in hippocampal subregions. Plaque induced genes in microglia, along with populations of stage 1 and stage 2 disease associated microglia (DAM), were normalized upon hNSC transplantation. Pathologic signaling between hippocampus and DAM was also restored. Discussion: hNSCs normalized many dysregulated genes, although this was not mediated by a change in amyloid plaque levels. Rather, hNSCs appear to exert beneficial effects in part by modulating microglia-mediated neuroinflammation and signaling in AD.
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1306004
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Article: Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism.

Chen, Kevin S / Noureldein, Mohamed H / McGinley, Lisa M / Hayes, John M / Rigan, Diana M / Kwentus, Jacquelin F / Mason, Shayna N / Mendelson, Faye E / Savelieffd, Masha G / Feldman, Eva L

bioRxiv : the preprint server for biology

2023

Abstract	Introduction: Stem cells are a promising therapeutic in Alzheimer's disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidate therapeutic mechanisms of human neural stem cells (hNSCs) in an animal model of AD. Methods: hNSCs were transplanted into the fimbria fornix of the hippocampus using the 5XFAD mouse model. Spatial memory was assessed by Morris water maze. Amyloid plaque burden was quantified. Spatial transcriptomics was performed and differentially expressed genes (DEGs) identified both globally and within the hippocampus. Subsequent pathway enrichment and ligand-receptor network analysis was performed. Results: hNSC transplantation restored learning curves of 5XFAD mice. However, there were no changes in amyloid plaque burden. Spatial transcriptomics showed 1061 DEGs normalized in hippocampal subregions. Plaque induced genes in microglia, along with populations of stage 1 and stage 2 disease associated microglia (DAM), were normalized upon hNSC transplantation. Pathologic signaling between hippocampus and DAM was also restored. Discussion: hNSCs normalized many dysregulated genes, although this was not mediated by a change in amyloid plaque levels. Rather, hNSCs appear to exert beneficial effects in part by modulating microglia-mediated neuroinflammation and signaling in AD.
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.01.565161
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Article ; Online: Pharmacokinetics of small hyperbranched polyglycerols as an osmotic agent for peritoneal dialysis: Plasma exposure, organ distribution and excretion in rats.

Du, Caigan / Jayo, Roxana / Mendelson, Asher A / Chafeeva, Irina / Roza, Gerald da / Liggins, Richard / Kizhakkedathu, Jayachandran N

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2023 Volume 43, Issue 4, Page(s) 324–333

Abstract: ... nephrectomy (BNx)) received a single dose of : Results: During 8-h dwell with IP injected therapeutic dose ... of HPG-based hypertonic solutions, the plasma levels of 1 kDa HPG reached the peak at 2 h, followed ... by a decrease to the end, whereas 3 kDa HPG increased for the duration of the 8 h. At the experimental endpoint ...

Abstract	Background: Small hyperbranched polyglycerol (HPG) has been recently of interest for peritoneal dialysis, but its pharmacokinetics is barely understood. This study investigated the absorption, distribution and excretion of 1 and 3 kDa HPG. Methods: Rats (naive, 5/6 nephrectomy (5/6 Nx) or bilateral nephrectomy (BNx)) received a single dose of Results: During 8-h dwell with IP injected therapeutic dose of HPG-based hypertonic solutions, the plasma levels of 1 kDa HPG reached the peak at 2 h, followed by a decrease to the end, whereas 3 kDa HPG increased for the duration of the 8 h. At the experimental endpoint, the distribution of both sizes of HPG in major organs was minimal, whereas most of 1 kDa HPG was excreted via urine, and of 3 kDa remained in peritoneal cavity. The elimination of both 1 and 3 kDa HPG after either IP or IV administration was significantly delayed by 5/6 Nx or BNx as compared to naive controls. Further, 24-h faecal excretion of HPG (3 kDa) was <5% of injected dose that was not different between healthy and BNx rats. Conclusion: Data suggest size-dependent peritoneal absorption of osmotic HPG that are not specifically absorbed by any of the organs tested. The clearance of small HPG mainly depends on kidney excretion, implying the risk of HPG accumulation in patients with end-stage kidney disease who receive maintenance dialysis with HPG.
MeSH term(s)	Rats ; Animals ; Peritoneal Dialysis ; Polymers ; Peritoneal Cavity ; Glycerol/pharmacokinetics
Chemical Substances	polyglycerol (25618-55-7) ; Polymers ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.1177/08968608221144856
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Article ; Online: Rational Control on Quantum Emitter Formation in Carbon-Doped Monolayer Hexagonal Boron Nitride.

Liu, Hongwei / Mendelson, Noah / Abidi, Irfan H / Li, Shaobo / Liu, Zhenjing / Cai, Yuting / Zhang, Kenan / You, Jiawen / Tamtaji, Mohsen / Wong, Hoilun / Ding, Yao / Chen, Guojie / Aharonovich, Igor / Luo, Zhengtang

ACS applied materials & interfaces

2022 Volume 14, Issue 2, Page(s) 3189–3198

Abstract: ... for N-C bonds. For the same samples, we observe an increase in the SPE density from 0.13 to 0.30 ...

Abstract	Single-photon emitters (SPEs) in hexagonal boron nitride (hBN) are promising candidates for quantum light generation. Despite this, techniques to control the formation of hBN SPEs down to the monolayer limit are yet to be demonstrated. Recent experimental and theoretical investigations have suggested that the visible wavelength single-photon emitters in hBN originate from carbon-related defects. Here, we demonstrate a simple strategy for controlling SPE creation during the chemical vapor deposition growth of monolayer hBN via regulating surface carbon concentration. By increasing the surface carbon concentration during hBN growth, we observe increases in carbon doping levels by 2.4-fold for B-C bonds and 1.6-fold for N-C bonds. For the same samples, we observe an increase in the SPE density from 0.13 to 0.30 emitters/μm
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c21781
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Article ; Online: Cocirculation of A(H3N2) and B/Victoria increased morbidity in hospitalized patients in the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel.

Jurkowicz, Menucha / Nemet, Ital / Atari, Nofar / Fratty, Ilana S / Kliker, Limor / Sherbany, Hilda / Keller, Nathan / Leibovitz, Eugene / Mendelson, Ella / Mandelboim, Michal / Stein, Michal

Journal of medical virology

2023 Volume 95, Issue 2, Page(s) e28498

Abstract: ... influenza from this season (n = 636). Quantitative polymerase chain reaction was performed on clinical ...

Abstract	Community surveillance found the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel to be a high-intensity season with an early and steep morbidity peak. To further characterize disease severity in the 2019-2020 season, we analyzed a cohort of hospitalized patients with laboratory-confirmed influenza from this season (n = 636). Quantitative polymerase chain reaction was performed on clinical samples to detect the presence of influenza. Demographic, clinical, and laboratory data were retrieved via electronic health records and MDClone. Electronic health records were accessed to obtain data on intensive care unit patients, missing data and for data verification purposes. Univariate analysis was performed to compare demographic, comorbidity, and clinical characteristics across the three influenza strains. The A(H1N1)pdm09 predominant 2019-2020 influenza season in Israel was characterized by an early and steep morbidity peak, vaccine delays and shortages, and with the A(H3N2) and B/Victoria strains disproportionately targeting children and young adults, most probably due to reduced immunity to these strains. A greater proportion of children <5 years infected with A(H3N2) and B/Victoria developed severe influenza compared with those infected with A(H1N1)pdm09. Our study emphasizes the vulnerability of infants and young children in the face of rapidly evolving influenza strains and underscores the importance of influenza prevention measures in this population.
MeSH term(s)	Child ; Infant ; Young Adult ; Humans ; Child, Preschool ; Influenza, Human/epidemiology ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Seasons ; Israel ; Influenza Vaccines ; Morbidity ; Influenza B virus
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28498
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Article ; Online: A survey of patient and public perceptions and awareness of SARS-CoV-2-related risks among participants in India and South Africa.

Mbamalu, Oluchi / Surendran, Surya / Nampoothiri, Vrinda / Bonaconsa, Candice / Edathadathil, Fabia / Zhu, Nina / Carter, Vanessa / Lambert, Helen / Tarrant, Carolyn / Ahmad, Raheelah / Brink, Adrian / Steenkamp, Ebrahim / Holmes, Alison / Singh, Sanjeev / Charani, Esmita / Mendelson, Marc

PLOS global public health

2023 Volume 3, Issue 7, Page(s) e0001078

Abstract: ... There were 844 respondents (India: n = 660, South Africa: n = 184; response rate 87.6%), with a 61.1% vs ...

Abstract	A cross-sectional survey among participants in India and South Africa to explore perceptions and awareness of SARS-CoV-2-related risks. Main outcome measures-proportion of participants aware of SARS-CoV-2, and their perception of infection risks as it related to their views and perceptions on vaccination, i.e., using COVID-19 vaccine uptake as proxy for awareness level. Self-administered questionnaires were used to collect data via web- and paper-based surveys over three months. Pearson's Chi-squared test assessed relationships between variables; a p-value less than 0.05 was considered significant. There were 844 respondents (India: n = 660, South Africa: n = 184; response rate 87.6%), with a 61.1% vs 38.3% female to male ratio. Post-high-school or university education was the lowest qualification reported by most respondents in India (77.3%) and South Africa (79.3%). Sources of pandemic information were usually media and journal publications (73.2%), social media (64.6%), family and friends (47.7%) and government websites (46.2%). Most respondents correctly identified infection prevention measures (such as physical distancing, mask use), with 90.0% reporting improved hand hygiene practices since the pandemic. Hesitancy or refusal to accept the SARS-CoV-2 vaccine was reported among 17.9% and 50.9% of respondents in India and South Africa, respectively; reasons cited included rushed vaccine development and the futility of vaccines for what respondents considered a self-limiting flu-like illness. In South Africa, vaccine acceptance was associated with improved hand hygiene practices since the pandemic and flu vaccination in the preceding year. No relationship was noted between awareness and practice of infection prevention measures (such as hand hygiene) and socio-demographic factors such as employment status or availability of amenities. Pandemic response and infection prevention and control measures through vaccination campaigns should consider robust public engagement and contextually-fit communication strategies with multimodal, participatory online and offline initiatives to address public concerns, specifically towards vaccines developed for this pandemic and general vaccine hesitancy.
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0001078
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Article ; Online: Deep cross-modal feature learning applied to predict acutely decompensated heart failure using in-home collected electrocardiography and transthoracic bioimpedance.

Pan, Xiang / Wang, Chuangqi / Yu, Yudong / Reljin, Natasa / McManus, David D / Darling, Chad E / Chon, Ki H / Mendelson, Yitzhak / Lee, Kwonmoo

Artificial intelligence in medicine

2023 Volume 140, Page(s) 102548

Abstract: Background: Deep learning has been successfully applied to ECG data to aid in the accurate and more rapid diagnosis of acutely decompensated heart failure (ADHF). Previous applications focused primarily on classifying known ECG patterns in well- ... ...

Abstract	Background: Deep learning has been successfully applied to ECG data to aid in the accurate and more rapid diagnosis of acutely decompensated heart failure (ADHF). Previous applications focused primarily on classifying known ECG patterns in well-controlled clinical settings. However, this approach does not fully capitalize on the potential of deep learning, which directly learns important features without relying on a priori knowledge. In addition, deep learning applications to ECG data obtained from wearable devices have not been well studied, especially in the field of ADHF prediction. Methods: We used ECG and transthoracic bioimpedance data from the SENTINEL-HF study, which enrolled patients (≥21 years) who were hospitalized with a primary diagnosis of heart failure or with ADHF symptoms. To build an ECG-based prediction model of ADHF, we developed a deep cross-modal feature learning pipeline, termed ECGX-Net, that utilizes raw ECG time series and transthoracic bioimpedance data from wearable devices. To extract rich features from ECG time series data, we first adopted a transfer learning approach in which ECG time series were transformed into 2D images, followed by feature extraction using ImageNet-pretrained DenseNet121/VGG19 models. After data filtering, we applied cross-modal feature learning in which a regressor was trained with ECG and transthoracic bioimpedance. Then, we concatenated the DenseNet121/VGG19 features with the regression features and used them to train a support vector machine (SVM) without bioimpedance information. Results: The high-precision classifier using ECGX-Net predicted ADHF with a precision of 94 %, a recall of 79 %, and an F1-score of 0.85. The high-recall classifier with only DenseNet121 had a precision of 80 %, a recall of 98 %, and an F1-score of 0.88. We found that ECGX-Net was effective for high-precision classification, while DenseNet121 was effective for high-recall classification. Conclusion: We show the potential for predicting ADHF from single-channel ECG recordings obtained from outpatients, enabling timely warning signs of heart failure. Our cross-modal feature learning pipeline is expected to improve ECG-based heart failure prediction by handling the unique requirements of medical scenarios and resource limitations.
MeSH term(s)	Humans ; Heart Failure/diagnosis ; Electrocardiography ; Wearable Electronic Devices ; Support Vector Machine
Language	English
Publishing date	2023-04-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	645179-2
ISSN	1873-2860 ; 0933-3657
ISSN (online)	1873-2860
ISSN	0933-3657
DOI	10.1016/j.artmed.2023.102548
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Article ; Online: Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis.

Hum, Christine / Tahir, Usama / Mei, Shirley H J / Champagne, Josee / Fergusson, Dean A / Lalu, Manoj / Stewart, Duncan J / Walley, Keith / Marshall, John / Dos Santos, Claudia C / Winston, Brent W / Mendelson, Asher A / Dave, Chintan / McIntyre, Lauralyn

Stem cells translational medicine

2024 Volume 13, Issue 4, Page(s) 346–361

Abstract: ... Twenty-six studies (34 experiments, n = 1258 animals) were included in this review. Overall mortality was ...

Abstract	Background: In preclinical studies, mesenchymal stromal cells (MSCs), including umbilical cord-derived MSCs (UC-MSCs), demonstrate the ability to modulate numerous pathophysiological processes related to sepsis; however, a systematic synthesis of the literature is needed to assess the efficacy of UC-MSCs for treating sepsis. Objective: To examine the effects of UC-MSCs on overall mortality (primary outcome) as well as on organ dysfunction, coagulopathy, endothelial permeability, pathogen clearance, and systemic inflammation (secondary outcomes) at prespecified time intervals in preclinical models of sepsis. Methods: A systematic search was conducted on Embase, Ovid MEDLINE, and Web of Science up to June 20, 2023. Preclinical controlled studies using in vivo sepsis models with systemic UC-MSC administration were included. Meta-analyses were conducted and expressed as odds ratios (OR) and ratios of the weighted means with 95% CI for categorical and continuous data, respectively. Risk of bias was assessed with the SYRCLE tool. Results: Twenty-six studies (34 experiments, n = 1258 animals) were included in this review. Overall mortality was significantly reduced with UC-MSC treatment as compared to controls (OR: 0.26, 95% CI: 0.18-0.36). At various prespecified time intervals, UC-MSCs reduced surrogate measures of organ dysfunction related to the kidney, liver, and lung; reduced coagulopathy and endothelial permeability; and enhanced pathogen clearance from multiple sites. UC-MSCs also modulated systemic inflammatory mediators. No studies were rated as low risk across all SYCLE domains. Conclusions: These results demonstrate the efficacy of UC-MSC treatment in preclinical sepsis models and highlight their potential as a therapeutic intervention for septic shock.
MeSH term(s)	Animals ; Multiple Organ Failure ; Umbilical Cord ; Mesenchymal Stem Cells/physiology ; Sepsis/therapy ; Shock, Septic ; Mesenchymal Stem Cell Transplantation/adverse effects ; Mesenchymal Stem Cell Transplantation/methods
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2642270-0
ISSN	2157-6580 ; 2157-6580
ISSN (online)	2157-6580
ISSN	2157-6580
DOI	10.1093/stcltm/szae003
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