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  1. Book ; Online: Fast Facts : Complex Perianal Fistulas in Crohn's Disease

    Warusavitarne, Janindra / Kotze, Paulo Gustavo

    A multidisciplinary approach to a clinical challenge

    2021  

    Abstract: Over the course of their Crohn's disease, up to half of affected individuals will develop a perianal penetrating complication (either perianal fistula or abscess). Symptoms can be debilitating, and the impact on quality of life significant. This first ... ...

    Author's details Janindra Warusavitarne, Paulo Gustavo Kotze
    Abstract Over the course of their Crohn's disease, up to half of affected individuals will develop a perianal penetrating complication (either perianal fistula or abscess). Symptoms can be debilitating, and the impact on quality of life significant. This first edition of 'Fast Facts: Complex Perianal Fistulas in Crohn's Disease' explains how fistulas form, who is at risk and the principles of diagnosis and classification. Later chapters explore the medical and surgical options, including innovative therapies. The intention throughout is to emphasize the importance of ‘joined-up thinking’ when caring for patients. Perianal fistulas are often challenging to treat in patients with Crohn’s disease, and a multidisciplinary approach is needed to get the best outcomes. Table of Contents: • Epidemiology, etiology and pathology • Anatomy and classification • Diagnosis • Management principles • Medical treatment Local perianal surgical (sphincter-preserving) interventions • Innovative therapies • Managing complications
    MeSH term(s) Rectal Fistulas. ; Crohn Disease/complications.
    Keywords Crohn's disease
    Language English
    Size 1 online resource (86 pages) :, 29 figures, 28 in color, 7 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 3-318-06816-0 ; 3-318-06815-2 ; 978-3-318-06816-0 ; 978-3-318-06815-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases.

    Kotze, Paulo Gustavo

    Clinics in colon and rectal surgery

    2022  Volume 35, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2022-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2048635-2
    ISSN 1531-0043
    ISSN 1531-0043
    DOI 10.1055/s-0041-1740034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Upgrading therapeutic ambitions and treatment outcomes.

    Kotze, Paulo Gustavo / Vermeire, Severine

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 2, Page(s) 84–85

    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00885-x
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  4. Article ; Online: Author's reply: "Early surgery for Crohn's disease-An appeal for a reassessment of biologics".

    Avellaneda, Nicolás / Kotze, Paulo Gustavo

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 12, Page(s) 1777–1778

    MeSH term(s) Humans ; Crohn Disease/drug therapy ; Crohn Disease/surgery ; Biological Products/therapeutic use
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-10-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.09.005
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  5. Article: The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases

    Kotze, Paulo Gustavo

    Clinics in Colon and Rectal Surgery

    (The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases)

    2022  Volume 35, Issue 01, Page(s) 3–4

    Series title The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases
    Language English
    Publishing date 2022-01-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2048635-2
    ISSN 1530-9681 ; 1531-0043
    ISSN (online) 1530-9681
    ISSN 1531-0043
    DOI 10.1055/s-0041-1740034
    Database Thieme publisher's database

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  6. Article ; Online: WARNING TO DELAY IN DIAGNOSING MICROSCOPIC COLITIS IN OLDER ADULTS. A SERIES OF CASES.

    Kotze, Lorete Maria da Silva / Kotze, Luiz Roberto / Souza, Raquel Canzi Almada de / Kotze, Paulo Gustavo / Nisihara, Renato

    Arquivos de gastroenterologia

    2024  Volume 61, Page(s) e23114

    Abstract: Background: Microscopic colitis (MC) is a chronic inflammatory bowel disease causing non-bloody diarrhea, and several cases are undiagnosed as a hidden cause of chronic diarrhea.: Objective: We aimed to report the symptoms, delay diagnosis and the ... ...

    Abstract Background: Microscopic colitis (MC) is a chronic inflammatory bowel disease causing non-bloody diarrhea, and several cases are undiagnosed as a hidden cause of chronic diarrhea.
    Objective: We aimed to report the symptoms, delay diagnosis and the treatment of MC in a case series.
    Methods: All patients were treated at a Gastroenterology reference office from May 2022 to June 2023. Personal history including preexisting disorders, use of medications and smoking habits were collected. The delay between the onset of symptoms and the correct diagnosis was informed. All patients consented to use budesonide MMX (Corament®) off label.
    Results: During the study period, six Caucasoid patients were diagnosed with MC, five females and one male, between the ages of 65 and 74. All patients had comorbities and were taking multiple prescription drugs. Laboratory findings showed negative serology for celiac disease for all patients, normal levels of albumin and vitamin B12. The delay between the symptoms and the MC diagnosis varied from 2 months to 6 years. All patients had a previous diagnosis of irritable bowel syndrome. All patients were in complete clinical remission during the treatment and referred no side effects of the drug.
    Conclusion: Older females using high-risk medications are suggestive of MC. Preventing delay in the diagnosis of MC is crucial to improvement in patients´ quality of life. Budesonide MMX appears to be effective, safe and well-tolerated.
    Background: • Microscopic Colitis is a chronic inflammatory bowel disease causing non-bloody diarrhea.
    Background: • Several cases are undiagnosed and can be a hidden cause of chronic diarrhea.
    Background: • Treatment with budesonide MMX (Corament®, off label) was effective and safe.
    MeSH term(s) Female ; Humans ; Male ; Aged ; Quality of Life ; Colitis, Microscopic/diagnosis ; Colitis, Microscopic/drug therapy ; Inflammatory Bowel Diseases ; Budesonide/therapeutic use ; Pathologic Complete Response ; Diarrhea/drug therapy ; Diarrhea/etiology
    Chemical Substances Budesonide (51333-22-3)
    Language English
    Publishing date 2024-03-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.24612023-114
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  7. Article ; Online: MICROSCOPIC COLITIS: CONSIDERATIONS FOR GASTROENTEROLOGISTS, ENDOSCOPISTS, AND PATHOLOGISTS.

    Kotze, Lorete Maria da Silva / Kotze, Paulo Gustavo / Kotze, Luiz Roberto / Nisihara, Renato

    Arquivos de gastroenterologia

    2023  Volume 60, Issue 2, Page(s) 188–193

    Abstract: Diagnosis of microscopic colitis necessitates effective communication among gastroenterologists, endoscopists, and pathologists. •The gastroenterologist should refer every patient with chronic watery diarrhea to perform a colonoscopy in spite of the ... ...

    Abstract •Diagnosis of microscopic colitis necessitates effective communication among gastroenterologists, endoscopists, and pathologists. •The gastroenterologist should refer every patient with chronic watery diarrhea to perform a colonoscopy in spite of the benign course of the disease and the absence of alarm symptoms. •The endoscopist should take 2 or 3 biopsy samples of the colonic mucosa from the right and left colon, put in separate recipients, despite that the mucosa looked macroscopically normal. •The pathologist should be encouraged to use objective histological criteria to make the diagnosis. Microscopic colitis is a chronic inflammatory bowel disease characterized by non-bloody diarrhea that can range from mild to severe. It is difficult to attribute up to 10-20% of chronic diarrhea to microscopic colitis. The three determinants factors of the diagnosis are characteristic clinical symptoms, normal endoscopic picture of the colon, and pathognomonic histological picture. This manuscript aimed to update considerations and recommendations for professionals involved (gastroenterologist, endoscopists and pathologist) in the diagnosis of MC. In addition, a short recommendation about treatment.
    MeSH term(s) Humans ; Gastroenterologists ; Pathologists ; Biopsy ; Colitis, Microscopic/diagnosis ; Colitis, Microscopic/drug therapy ; Colitis, Microscopic/pathology ; Colon ; Colonoscopy ; Diarrhea ; Colitis
    Language English
    Publishing date 2023-09-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.20230222-143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Obesity and Crohn's disease: what comes first, the egg or the chicken?

    Kotze, Paulo Gustavo

    Arquivos de gastroenterologia

    2017  Volume 54, Issue 3, Page(s) 268

    Language English
    Publishing date 2017-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.201700000-37
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  9. Article ; Online: HOSPITALIZATION, USE OF BIOLOGICS AND SURGERY RATES IN INFLAMMATORY BOWEL DISEASES: A SINGLE-CENTRE COMPARATIVE ANALYSIS BETWEEN PUBLIC AND PRIVATE HEALTHCARE SYSTEMS IN A TERTIARY UNIT FROM LATIN AMERICA.

    Zacharias, Patrícia / Magro, Daniéla Oliveira / Perussolo, Milena / Baraúna, Fernanda da Silva Barbosa / Kotze, Paulo Gustavo

    Arquivos de gastroenterologia

    2024  Volume 61, Page(s) e23140

    Abstract: Background: Inflammatory bowel diseases (IBD) have rising incidence and prevalence rates globally. In IBD, there are scarce stu-dies comparing differences between patients according to socioeconomic status. Our aim was to comparatively evaluate ... ...

    Abstract Background: Inflammatory bowel diseases (IBD) have rising incidence and prevalence rates globally. In IBD, there are scarce stu-dies comparing differences between patients according to socioeconomic status. Our aim was to comparatively evaluate hospitalizations, use of biologics and rates of surgery in patients with IBD between public and private healthcare systems.
    Methods: Single-center retrospective cohort study in patients with IBD from a tertiary referral unit from Latin America, between 2015 and 2021. CD and UC patients were classified into two subgroups: public and private systems. Demographic characteristics, hospitalizations, need for surgery and biologics were compared.
    Results: A total of 500 patients were included, 322 with CD and 178 with UC. CD-related hospitalizations were frequently observed in both healthcare systems (76.28% in private and 67.46% in public). More than half of the patients had been submitted to one or more CD-related abdominal surgery, with no significant difference between the subgroups. Although there was no difference in the rates of use of biological therapy in CD subgroups, infliximab was more used in the public setting (57.69% vs 43.97%). There was no difference in UC-related hospitalizations between the subgroups (public 30.69% and private 37.66%) as well as the rates of colectomy (public: 16.83%, private: 19.48%). Biologics were prescribed almost twice as often in private as compared to public (45.45 vs 22.77%).
    Conclusion: There were no differences in the rates of hospitalization and abdominal surgery between the systems. In patients with UC, there was greater use of biological therapy in the private healthcare setting.
    Background: • In a tertiary IBD center in Latin America.
    Background: • More than half of the patients had been submitted to one or more CD-related abdominal surgical procedure.
    Background: • Between the two healthcare systems, there was no difference in the rates of use of biological therapy in patients with CD, and in UC-related hospitalizations.
    Background: • Biologics were prescribed almost twice as often in the private system as compared to the public in patients with UC.
    MeSH term(s) Humans ; Biological Products/therapeutic use ; Latin America ; Retrospective Studies ; Hospitalization ; Inflammatory Bowel Diseases/surgery
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-03-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.24612023-140
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  10. Article ; Online: BODY FAT COMPOSITION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES: A COMPARATIVE STUDY BETWEEN SKINFOLDS AND ULTRASONOGRAPHY.

    Tuma, Isadora Sayuri Macedo / Cambi, Maria Paula Carlin / Moraes, Thyago Proença de / Magro, Daniéla Oliveira / Kotze, Paulo Gustavo

    Arquivos de gastroenterologia

    2024  Volume 61, Page(s) e23088

    Abstract: Background: Inflammatory bowel diseases (IBD) are associated with important changes in nutritional status.: Objective: The aim of the study was to compare body fat composition between two anthropometric methods: skinfolds and ultrasonography, in ... ...

    Abstract Background: Inflammatory bowel diseases (IBD) are associated with important changes in nutritional status.
    Objective: The aim of the study was to compare body fat composition between two anthropometric methods: skinfolds and ultrasonography, in patients with IBD.
    Methods: Single-center cross-sectional study with IBD patients in remission or active disease. For the agreement analysis between the body fat assessment methods, the Bland Altman method was used.
    Results: A total of 101 patients with IBD were included, 75 with Crohn's disease and 26 with ulcerative colitis. Approximately 56% of the patients with Crohn's disease and 65.4% of those with ulcerative colitis had a body fat composition above normal levels, with no significant difference between the diseases (P=0.63). The Bland-Altman concordance analysis showed that the methods for assessing the percentage of fat by the adipometer and ultrasound were not in full agreement (P=0.001), despite both presented good correlation (CC 0.961; P=0.000).
    Conclusion: The analysis of body fat percentage in patients with IBD was different between the skinfolds and ultrasound. Both methods can be used to assess the of body fat percentage of patients with IBD. However, monitoring of body fat sequentially and longitudinally should always be performed using the same method throughout the disease course. Prospective longitudinal studies are warranted to precisely define the role of these two methods of measuring body composition in patients with IBD.
    Background: • Inflammatory bowel diseases are associated with changes in nutritional status.
    Background: • Skinfolds measurements and ultrasound are valid methods for assessing body composition and body fat.
    Background: • These methods despite comparable are not identical and are useful in clinical nutritional practices in IBD.
    MeSH term(s) Humans ; Crohn Disease/diagnostic imaging ; Colitis, Ulcerative/diagnostic imaging ; Cross-Sectional Studies ; Prospective Studies ; Body Composition ; Adipose Tissue/diagnostic imaging ; Inflammatory Bowel Diseases/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2024-03-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.246102023-88
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