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  1. Book ; Online: Plasma Modified Textiles for Biomedical Applications

    Cools, Pieter / De Geyter, Nathalie / Morent, Rino

    2015  

    Abstract: In the textile market industry, technical textiles are one of the fastest growing businesses. Part of that industry consists of textiles for medical and healthcare applications and are responsible for a continuous increase in its market potential [1]. ... ...

    Abstract In the textile market industry, technical textiles are one of the fastest growing businesses. Part of that industry consists of textiles for medical and healthcare applications and are responsible for a continuous increase in its market potential [1]. Next to their need in hospital environments, there is a growing demand in other sectors such as the food and hotel industry, due to stricter hygiene regulations. In most cases biomedical textile meets a well-defined set of requirements such as minimizing non-specific protein adsorption, drug delivery coatings or the presence of active functional coatings and most importantly excellent biocompatibility (blood-, tissue-or cyto-compatibility) [2]. In general there are very few materials meeting all these characteristics, while at the same time offering the needed structural and mechanical properties. Furthermore, depending on the application, the production process has to be cost-effective and approved by local legislation
    Keywords Science (General)
    Size 1 electronic resource ( p.)
    Publisher Intech
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101752
    ISBN 9789535121411 ; 9535121413
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Multi-scale participatory land resource assessment in Northwest Syria

    Cools, Nathalie

    (Doctoraatsproefschrift ... aan de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K. U. Leuven ; 559)

    2003  

    Author's details door Nathalie Cools
    Series title Doctoraatsproefschrift ... aan de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K. U. Leuven ; 559
    Doctoraatsproefschrift ... aan de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K.U. Leuven / Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K. U. Leuven
    Collection Doctoraatsproefschrift ... aan de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K.U. Leuven / Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen van de K. U. Leuven
    Language English
    Size XIX, 345 S. : Ill., graph. Darst., Kt.
    Publishing place Leuven
    Publishing country Belgium
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leuven, Kath. Univ., Diss
    Note Zsfassung in niederländ. Sprache
    Accompanying material 1 CD-ROM ; 12 cm
    HBZ-ID HT014109282
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    048/989 available for loan (reading room) Freihandmagazin (U1)

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  3. Book ; Online: Non-thermal Plasma Technology for the Improvement of Scaffolds for Tissue Engineering and Regenerative Medicine - A Review

    van Vrekhem, Stijn / van Geyterand, Nathalie / Cools, Pieter / Ghobeira, Rouba / Morent, Rino

    2016  

    Abstract: Non-thermal plasma technology is one of those techniques that suffer relatively little from diffusion limits, slow kinetics, and complex geometries compared to more traditional liquid-based chemical surface modification techniques. Combined with a lack ... ...

    Abstract Non-thermal plasma technology is one of those techniques that suffer relatively little from diffusion limits, slow kinetics, and complex geometries compared to more traditional liquid-based chemical surface modification techniques. Combined with a lack of solvents, preservation of the bulk properties, and fast treatment times; it is a well-liked technique for the treatment of materials for biomedical applications. In this book chapter, a review will be given on what the scientific community determined to be essential to obtain appropriate scaffolds for tissue engineering and how plasma scientists have used non-thermal plasma technology to accomplish this. A distinction will be made depending on the scaffold fabrication technique, as each technique has its own set of specific problems that need to be tackled. Fabrication techniques will include traditional fabrication methods, rapid prototyping, and electrospinning. As for the different plasma techniques, both plasma activation and grafting/polymerization will be included in the review and linked to the in-vitro/in-vivo response to these treatments. The literature review itself is preceded by a more general overview on cell communication, giving useful insights on how surface modification strategies should be developed
    Keywords Science (General)
    Size 1 electronic resource ( p.)
    Publisher Intech
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101753
    ISBN 9789535122807 ; 9535122800
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Advanced imaging shows extra-articular abscesses in two out of three adult patients with septic arthritis of the native hip joint.

    Cools, Jordi / Ghijselings, Stijn / Ruythooren, Fred / Jentjens, Sander / Noppe, Nathalie / Metsemakers, Willem-Jan / Vles, Georges

    Journal of bone and joint infection

    2024  Volume 9, Issue 1, Page(s) 27–35

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ISSN 2206-3552
    ISSN 2206-3552
    DOI 10.5194/jbji-9-27-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?

    Janssens, Ibo / Cools, Nathalie

    Cellular immunology

    2020  Volume 358, Page(s) 104236

    Abstract: In autoimmunity, the important and fragile balance between immunity and tolerance is disturbed, resulting in abnormal immune responses to the body's own tissues and cells. ... ...

    Abstract In autoimmunity, the important and fragile balance between immunity and tolerance is disturbed, resulting in abnormal immune responses to the body's own tissues and cells. CD4
    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; Autoimmune Diseases/immunology ; Autoimmunity/immunology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immune Tolerance/immunology ; Immunosuppression/methods ; Immunotherapy, Adoptive/methods ; Receptors, Antigen, T-Cell/immunology ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2020-10-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2020.104236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: On the road to new treatments for multiple sclerosis: targeting dendritic cell migration into the central nervous system.

    Meena, Megha / Cools, Nathalie

    Neural regeneration research

    2019  Volume 14, Issue 12, Page(s) 2088–2090

    Language English
    Publishing date 2019-08-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.262583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives.

    El Ouaamari, Yousra / Van den Bos, Jasper / Willekens, Barbara / Cools, Nathalie / Wens, Inez

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic lateral sclerosis (ALS), are characterized by acute or chronic ... ...

    Abstract Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic lateral sclerosis (ALS), are characterized by acute or chronic progressive loss of one or several neuronal subtypes. However, despite their increasing prevalence, little progress has been made in successfully treating these diseases. Research has recently focused on neurotrophic factors (NTFs) as potential regenerative therapy for neurodegenerative diseases. Here, we discuss the current state of knowledge, challenges, and future perspectives of NTFs with a direct regenerative effect in chronic inflammatory and degenerative disorders. Various systems for delivery of NTFs, such as stem and immune cells, viral vectors, and biomaterials, have been applied to deliver exogenous NTFs to the central nervous system, with promising results. The challenges that currently need to be overcome include the amount of NTFs delivered, the invasiveness of the delivery route, the blood-brain barrier permeability, and the occurrence of side effects. Nevertheless, it is important to continue research and develop standards for clinical applications. In addition to the use of single NTFs, the complexity of chronic inflammatory and degenerative diseases may require combination therapies targeting multiple pathways or other possibilities using smaller molecules, such as NTF mimetics, for effective treatment.
    MeSH term(s) Humans ; Neurodegenerative Diseases/metabolism ; Nerve Growth Factors/metabolism ; Parkinson Disease/metabolism ; Central Nervous System/metabolism ; Alzheimer Disease
    Chemical Substances Nerve Growth Factors
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cells to the Rescue: Emerging Cell-Based Treatment Approaches for NMOSD and MOGAD.

    Derdelinckx, Judith / Reynders, Tatjana / Wens, Inez / Cools, Nathalie / Willekens, Barbara

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: Cell-based therapies are gaining momentum as promising treatments for rare neurological autoimmune diseases, including neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease. The development of ... ...

    Abstract Cell-based therapies are gaining momentum as promising treatments for rare neurological autoimmune diseases, including neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease. The development of targeted cell therapies is hampered by the lack of adequate animal models that mirror the human disease. Most cell-based treatments, including HSCT, CAR-T cell, tolerogenic dendritic cell and mesenchymal stem cell treatment have entered early stage clinical trials or have been used as rescue treatment in treatment-refractory cases. The development of antigen-specific cell-based immunotherapies for autoimmune diseases is slowed down by the rarity of the diseases, the lack of surrogate outcomes and biomarkers that are able to predict long-term outcomes and/or therapy effectiveness as well as challenges in the manufacturing of cellular products. These challenges are likely to be overcome by future research.
    MeSH term(s) Autoantibodies ; Autoimmune Diseases of the Nervous System/therapy ; Cell- and Tissue-Based Therapy ; Dendritic Cells ; Humans ; Immunotherapy ; Immunotherapy, Adoptive ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Neuromyelitis Optica/therapy
    Chemical Substances Autoantibodies ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2021-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22157925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Beyond the Magic Bullet: Current Progress of Therapeutic Vaccination in Multiple Sclerosis.

    Willekens, Barbara / Cools, Nathalie

    CNS drugs

    2018  Volume 32, Issue 5, Page(s) 401–410

    Abstract: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by neuroinflammation, neurodegeneration and impaired repair mechanisms that lead to neurological disability. The crux of MS is the patient's ... ...

    Abstract Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by neuroinflammation, neurodegeneration and impaired repair mechanisms that lead to neurological disability. The crux of MS is the patient's own immune cells attacking self-antigens in the CNS, namely the myelin sheath that protects nerve cells of the brain and spinal cord. Restoring antigen-specific tolerance via therapeutic vaccination is an innovative and exciting approach in MS therapy. Indeed, leveraging the body's attempt to prevent autoimmunity, i.e., tolerization, focuses on the underlying cause of the disease and could be the key to solving neuroinflammation. In this perspective, antigen-specific vaccination targets only the detrimental and aberrant immune response against the specific disease-associated antigen(s) involved while retaining the capacity of the immune system to respond to unrelated antigens. We review the experimental approaches of tolerance-inducing vaccination in relapsing and progressive forms of MS that have reached the clinical development phase, including vaccination with autologous T cells, autologous tolerogenic dendritic cells, T cell receptor peptide vaccination, altered peptide ligand, ATX-MS-1467, cluster of differentiation (CD)-206-targeted liposomal myelin basic protein peptides and DNA vaccination. Failures, successes and future directions are discussed.
    MeSH term(s) Animals ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/prevention & control ; Humans ; Multiple Sclerosis/immunology ; Multiple Sclerosis/prevention & control ; Vaccination
    Language English
    Publishing date 2018-05-14
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-018-0518-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: FACS-Based Proteomics Enables Profiling of Proteins in Rare Cell Populations.

    Maes, Evelyne / Cools, Nathalie / Willems, Hanny / Baggerman, Geert

    International journal of molecular sciences

    2020  Volume 21, Issue 18

    Abstract: Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre- ... ...

    Abstract Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) is commonly used for its ability to isolate the required cell populations with high purity, even of scarce cell types. The proteomic analysis of a limited number of FACS-sorted cells, however, is very challenging as both sample preparation inefficiencies and limits in terms of instrument sensitivity are present. In this study, we used CD14+CD15+ immune cells sorted out of peripheral blood mononuclear cells isolated from whole blood to improve and evaluate FACS-based proteomics. To optimize both the protein extraction protocol and the mass spectrometry (MS) data acquisition method, PBMCs as well as commercialized HeLa digest were used. To reflect the limited number of sorted cells in some clinical samples, different numbers of sorted cells (1000, 5000, 10,000, or 50,000) were used. This allowed comparing protein profiles across samples with limited protein material and provided further insights in the benefits and limitations of using a very limited numbers of cells.
    MeSH term(s) Cell Separation/methods ; Flow Cytometry/methods ; HeLa Cells ; Humans ; Leukocytes/metabolism ; Leukocytes, Mononuclear/metabolism ; Mass Spectrometry/methods ; Proteome/metabolism ; Proteomics/methods
    Chemical Substances Proteome
    Language English
    Publishing date 2020-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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