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  1. AU=Sehn Laurie H
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  1. Book: Progress in aggressive lymphomas

    Sehn, Laurie H.

    (Best practice & research. Clinical haematology ; volume 31, issue 3 (September 2018))

    2018  

    Author's details Laurie H. Sehn, guest editor
    Series title Best practice & research. Clinical haematology ; volume 31, issue 3 (September 2018)
    Best practice & research
    Collection Best practice & research
    Language English
    Size Seite 185-335, Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019836022
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1029 -31,3- verfügbar in Königswinter Königswinter

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  2. Book: Aggressive B-cell lymphoma

    Sehn, Laurie H.

    (Hematology/oncology clinics of North America ; volume 30, number 6 (December 2016))

    2016  

    Author's details editor Laurie H. Sehn
    Series title Hematology/oncology clinics of North America ; volume 30, number 6 (December 2016)
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size xiv Seiten, Seite 1148-1379, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019221879
    ISBN 978-0-323-47741-3 ; 0-323-47741-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1077 -30,6- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Introduction to a How I Treat series on managing complications in patients with lymphoid cancer.

    Sehn, Laurie H

    Blood

    2022  Volume 139, Issue 10, Page(s) 1427

    MeSH term(s) Humans ; Lymphoid Tissue ; Neoplasms
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  4. Article ; Online: Looking to achieve cure the first time around for DLBCL patients who are older and/or with co-morbidities.

    Brem, Elizabeth A / Sehn, Laurie H

    Seminars in hematology

    2024  Volume 60, Issue 5, Page(s) 285–290

    Abstract: Diffuse large B-cell lymphoma (DLBCL) is an aggressive but often curable malignancy. Older patients, especially those 80 years and older, have poor outcomes compared to those < 60, likely due to a number of reasons including disease biology, ... ...

    Abstract Diffuse large B-cell lymphoma (DLBCL) is an aggressive but often curable malignancy. Older patients, especially those 80 years and older, have poor outcomes compared to those < 60, likely due to a number of reasons including disease biology, comorbidities, and treatment intolerance. Prospective data informing the treatment of older patients and those with multiple co-morbidities is limited. Here, we intend to review available data for regimens other than standard R-CHOP (rituximab, cyclophosphamide, adriamycin, prednisone) or R-pola-CHP (rituximab, polatuzumab vedotin [pola], cyclophosphamide, adriamycin, prednisone), tools available that may aid in treatment selection, and future directions, including the incorporation of newer treatment modalities into therapy for more vulnerable patients.
    MeSH term(s) Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Morbidity ; Prospective Studies ; Middle Aged ; Aged, 80 and over ; Aged
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2024.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Balancing risk and benefit during coronavirus.

    Sehn, Laurie H

    Blood

    2020  Volume 135, Issue 21, Page(s) 1817

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/radiotherapy ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Radiation Oncology ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020006279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CAR T cells as a second-line therapy for large B-cell lymphoma: a paradigm shift?

    Westin, Jason / Sehn, Laurie H

    Blood

    2022  Volume 139, Issue 18, Page(s) 2737–2746

    Abstract: The standard of care treatment strategy for patients with relapsed or refractory large B-cell lymphoma (LBCL) has been high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) if chemotherapy sensitive in suitable patients. Because ... ...

    Abstract The standard of care treatment strategy for patients with relapsed or refractory large B-cell lymphoma (LBCL) has been high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) if chemotherapy sensitive in suitable patients. Because of treatment intensity, this approach has only been feasible in half of patients and because of chemotherapy resistance has only been successful in a quarter of transplant-eligible patients. Chimeric antigen receptor (CAR) T-cell therapy, using genetically modified autologous T cells targeting CD19, has been approved for third-line therapy of LBCL and has been associated with durable remissions in a proportion of patients. In this review, we interpret the design and results of 3 randomized phase 3 trials comparing CAR T-cell therapy and ASCT and their implications for CAR T-cell therapy as a potential new standard of care for second-line treatment in appropriate patients with refractory or early relapsing LBCL.
    MeSH term(s) Antigens, CD19 ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunotherapy, Adoptive/methods ; Lymphoma, Large B-Cell, Diffuse/pathology ; Receptors, Chimeric Antigen/therapeutic use ; T-Lymphocytes ; Transplantation, Autologous
    Chemical Substances Antigens, CD19 ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  7. Article ; Online: Developing a classification of hematologic neoplasms in the era of precision medicine.

    Cazzola, Mario / Sehn, Laurie H

    Blood

    2022  Volume 140, Issue 11, Page(s) 1193–1199

    Abstract: The recently developed International Consensus (IC) classification of hematologic neoplasms is primarily based on input from clinical advisory committees composed of pathologists, hematologists, oncologists, and genomic scientists. Morphology continues ... ...

    Abstract The recently developed International Consensus (IC) classification of hematologic neoplasms is primarily based on input from clinical advisory committees composed of pathologists, hematologists, oncologists, and genomic scientists. Morphology continues to represent a fundamental element in the definition of hematologic neoplasms. Acknowledging that the abnormal morphology is a result of dysregulated hematopoiesis driven by somatic gene mutations or altered expression, the IC classification considers genomic features more extensively. Defining nosologic entities based on underlying molecular mechanism(s) of disease is fundamental for enabling the development of precision treatments. Because translational and clinical research continuously advance the field, the classification of hematologic neoplasms will need to be regularly refined and updated; the basic question is what mechanism should be used for this purpose. Scientific hematopathology societies, in collaboration with hematology societies, should be primarily responsible for establishing a standing International Working Group, which would in turn collaborate with the World Health Organization (WHO)/International Agency for Research on Cancer (IARC) to realize and disseminate the classification. The current classification, with its strong morphology component, represents a basis for refinement. Through data sharing, the creation of large comprehensive patient data sets will allow the use of methods of inference, including statistical analyses and machine learning models, aimed at further identifying distinct disease subgroups. A collaborative clinico-pathologic review process will provide a mechanism for updating pathologic and genomic criteria within a clinical context. An interactive Web-based portal would make the classification more immediately available to the scientific community, while providing accessory features that enable the practical application of diagnostic, prognostic, and predictive information.
    MeSH term(s) Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/therapy ; Humans ; Precision Medicine ; World Health Organization
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  9. Article ; Online: Diffuse Large B-Cell Lymphoma. Reply.

    Sehn, Laurie H / Salles, Gilles

    The New England journal of medicine

    2021  Volume 384, Issue 23, Page(s) 2262

    MeSH term(s) Humans ; Lymphoma, Follicular ; Lymphoma, Large B-Cell, Diffuse/drug therapy
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2105452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Introduction to a review series on Hodgkin lymphoma: change is here.

    Sehn, Laurie H

    Blood

    2018  Volume 131, Issue 15, Page(s) 1629–1630

    MeSH term(s) Hodgkin Disease/diagnosis ; Hodgkin Disease/genetics ; Hodgkin Disease/metabolism ; Hodgkin Disease/therapy ; Humans
    Language English
    Publishing date 2018-03-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-02-824045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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