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  1. Article ; Online: Pleiotropic role of NOTUM in colorectal cancer.

    van Driel, Milou S / Linssen, Jasmijn D G / van Neerven, Sanne M / Vermeulen, Louis

    Gut

    2023  Volume 72, Issue 12, Page(s) 2222–2223

    MeSH term(s) Humans ; Colorectal Neoplasms ; Adenocarcinoma
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target.

    Bootsma, Sanne / van Neerven, Sanne M / Vermeulen, Louis

    Nature genetics

    2021  Volume 53, Issue 1, Page(s) 9–10

    MeSH term(s) Colonic Neoplasms ; Colorectal Neoplasms ; Humans ; Large Neutral Amino Acid-Transporter 1 ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances KRAS protein, human ; Large Neutral Amino Acid-Transporter 1 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-020-00758-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3613: Show issues Location:
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    Zs.MG 46: Show issues

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  3. Article ; Online: Cell competition in development, homeostasis and cancer.

    van Neerven, Sanne M / Vermeulen, Louis

    Nature reviews. Molecular cell biology

    2022  Volume 24, Issue 3, Page(s) 221–236

    Abstract: Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue architecture and function. To ensure the highest tissue fidelity, equally fit cell populations are continuously renewed by ... ...

    Abstract Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue architecture and function. To ensure the highest tissue fidelity, equally fit cell populations are continuously renewed by stochastic replacement events, while cells perceived as less fit are actively removed by their fitter counterparts. This renewal is mediated by surveillance mechanisms that are collectively known as cell competition. Recent studies have revealed that cell competition has roles in most, if not all, developing and adult tissues. They have also established that cell competition functions both as a tumour-suppressive mechanism and as a tumour-promoting mechanism, thereby critically influencing cancer initiation and development. This Review discusses the latest insights into the mechanisms of cell competition and its different roles during embryonic development, homeostasis and cancer.
    MeSH term(s) Humans ; Cell Competition ; Neoplasms ; Cell Physiological Phenomena ; Embryonic Development ; Homeostasis
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00538-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5446: Show issues Location:
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    Zs.MG 26: Show issues

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  4. Article ; Online: High-Fat Diet Impacts on Tumor Development in the Gut.

    van Driel, Milou S / van Neerven, Sanne M / Vermeulen, Louis

    Trends in cancer

    2021  Volume 7, Issue 8, Page(s) 664–665

    Abstract: A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor ... ...

    Abstract A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.
    MeSH term(s) Colorectal Neoplasms/etiology ; Diet, High-Fat/adverse effects ; Gastrointestinal Microbiome ; Humans ; Lipid Metabolism
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.06.005
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  5. Article ; Online: Intestinal stem cell dynamics in homeostasis and cancer.

    Ramadan, Rana / van Driel, Milou S / Vermeulen, Louis / van Neerven, Sanne M

    Trends in cancer

    2022  Volume 8, Issue 5, Page(s) 416–425

    Abstract: The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into ... ...

    Abstract The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.
    MeSH term(s) Homeostasis/physiology ; Humans ; Intestines/physiology ; Neoplasms/genetics ; Stem Cell Niche ; Stem Cells ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition.

    van Driel, Milou S / Linssen, Jasmijn D G / Flanagan, Dustin J / Vlahov, Nikola / Nijman, Lisanne E / de Groot, Nina E / Elbers, Clara C / Koster, Jan / Sansom, Owen J / Vermeulen, Louis / van Neerven, Sanne M

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 4, Page(s) 652–655

    MeSH term(s) Caffeine/pharmacology ; Clone Cells ; Intestines
    Chemical Substances Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Balancing signals in the intestinal niche.

    van Neerven, Sanne M / Vermeulen, Louis

    The EMBO journal

    2017  Volume 36, Issue 4, Page(s) 389–391

    Language English
    Publishing date 2017-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201796431
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
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    Zs.MG 100: Show issues

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  8. Article ; Online: Intestinal organoid co-culture protocol to study cell competition

    van Neerven, Sanne M / Ramadan, Rana / van Driel, Milou S / Huels, David J / Vermeulen, Louis

    STAR protocols

    2021  Volume 3, Issue 1, Page(s) 101050

    Abstract: Intestinal organoid cultures are a powerful tool to study epithelial ... ...

    Abstract Intestinal organoid cultures are a powerful tool to study epithelial cells
    MeSH term(s) Animals ; Cell Competition ; Coculture Techniques ; Epithelial Cells ; Intestines ; Mice ; Organoids
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.101050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation.

    van Neerven, Sanne M / Vermeulen, Louis

    Differentiation; research in biological diversity

    2019  Volume 108, Page(s) 17–23

    Abstract: The intestinal epithelial layer is the fastest renewing tissue in the human body. Due to its incredible turnover rate, the intestine is especially prone to develop cancer, in particular in the colon. Colorectal cancer (CRC) development is characterized ... ...

    Abstract The intestinal epithelial layer is the fastest renewing tissue in the human body. Due to its incredible turnover rate, the intestine is especially prone to develop cancer, in particular in the colon. Colorectal cancer (CRC) development is characterized by the stepwise accumulation of mutations over time, of which mutations in the tumor suppressor APC are often very early to occur. Generally, mutations in this gene lead to truncated APC proteins that cannot bind to β-catenin to promote its degradation, resulting in a constant overstimulation of the Wnt pathway. The level of intrinsic Wnt activation is dependent on the number of functional β-catenin binding sites remaining within the APC proteins, and the right amount of Wnt signaling is rate-limiting in the formation of polyps. In addition, the intestinal niche provides an extensive spectrum of Wnt ligands, amplifiers and antagonists that locally regulate basal Wnt levels and consequently influence polyp formation propensity. Here we will discuss the crosstalk between transforming epithelial cells and their regional niche in the development of intestinal cancer.
    MeSH term(s) Animals ; Cell Self Renewal ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Stem Cells/metabolism ; Stem Cells/pathology ; Wnt Signaling Pathway
    Language English
    Publishing date 2019-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 184540-8
    ISSN 1432-0436 ; 0301-4681
    ISSN (online) 1432-0436
    ISSN 0301-4681
    DOI 10.1016/j.diff.2019.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1170: Show issues Location:
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  10. Article: Stem Cells in the Exocrine Pancreas during Homeostasis, Injury, and Cancer.

    Lodestijn, Sophie C / van Neerven, Sanne M / Vermeulen, Louis / Bijlsma, Maarten F

    Cancers

    2021  Volume 13, Issue 13

    Abstract: Cell generation and renewal are essential processes to develop, maintain, and regenerate tissues. New cells can be generated from immature cell types, such as stem-like cells, or originate from more differentiated pre-existing cells that self-renew or ... ...

    Abstract Cell generation and renewal are essential processes to develop, maintain, and regenerate tissues. New cells can be generated from immature cell types, such as stem-like cells, or originate from more differentiated pre-existing cells that self-renew or transdifferentiate. The adult pancreas is a dormant organ with limited regeneration capacity, which complicates studying these processes. As a result, there is still discussion about the existence of stem cells in the adult pancreas. Interestingly, in contrast to the classical stem cell concept, stem cell properties seem to be plastic, and, in circumstances of injury, differentiated cells can revert back to a more immature cellular state. Importantly, deregulation of the balance between cellular proliferation and differentiation can lead to disease initiation, in particular to cancer formation. Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a 5-year survival rate of only ~9%. Unfortunately, metastasis formation often occurs prior to diagnosis, and most tumors are resistant to current treatment strategies. It has been proposed that a specific subpopulation of cells, i.e., cancer stem cells (CSCs), are responsible for tumor expansion, metastasis formation, and therapy resistance. Understanding the underlying mechanisms of pancreatic stem cells during homeostasis and injury might lead to new insights to understand the role of CSCs in PDAC. Therefore, in this review, we present an overview of the current literature regarding the stem cell dynamics in the pancreas during health and disease. Furthermore, we highlight the influence of the tumor microenvironment on the growth behavior of PDAC.
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13133295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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