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Article ; Online: A phytobacterial TIR domain effector manipulates NAD

Eastman, Samuel / Smith, Thomas / Zaydman, Mark A / Kim, Panya / Martinez, Samuel / Damaraju, Neha / DiAntonio, Aaron / Milbrandt, Jeffrey / Clemente, Thomas E / Alfano, James R / Guo, Ming

The New phytologist

2021 Volume 233, Issue 2, Page(s) 890–904

Abstract: The Pseudomonas syringae DC3000 type III effector HopAM1 suppresses plant immunity and contains a Toll/interleukin-1 receptor (TIR) domain homologous to immunity-related TIR domains of plant nucleotide-binding leucine-rich repeat receptors that hydrolyze ...

Abstract	The Pseudomonas syringae DC3000 type III effector HopAM1 suppresses plant immunity and contains a Toll/interleukin-1 receptor (TIR) domain homologous to immunity-related TIR domains of plant nucleotide-binding leucine-rich repeat receptors that hydrolyze nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Bacterial Proteins/metabolism ; NAD/metabolism ; Plant Diseases/microbiology ; Pseudomonas syringae/physiology ; Receptors, Interleukin-1/metabolism ; Virulence
Chemical Substances	Arabidopsis Proteins ; Bacterial Proteins ; Receptors, Interleukin-1 ; NAD (0U46U6E8UK)
Language	English
Publishing date	2021-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.17805
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Article ; Online: Seroprevalencia frente a SARS-CoV-2 en los trabajadores de un hospital de Madrid.

Pérez-García, Felipe / Pérez-Zapata, Aurora / Arcos Varela, Naroa / de la Mata Herrera, Manuel / Ortiz García, María / Simón Ramos, Encarnación / Calero Barzano, Carlos / Clemente García, Begoña / García Miranda, Laura / Martín Soto, Lorena / Ropero Martínez, María / Barrabés Bayascas, Rosa María / Cuadros-González, Juan

Revista espanola de salud publica

2021 Volume 95

Abstract: Objective: The impact of the first wave of the pandemic due to SARS-CoV-2 has been enormous in Spanish hospitals, being Madrid one of the most affected communities. The aim of this study was to analyze the impact of the pandemic on the workers of a ... ...

Title translation	SARS-CoV-2 seroprevalence among workers in a hospital in Madrid.
Abstract	Objective: The impact of the first wave of the pandemic due to SARS-CoV-2 has been enormous in Spanish hospitals, being Madrid one of the most affected communities. The aim of this study was to analyze the impact of the pandemic on the workers of a hospital located in one of the most affected areas of Madrid (Alcalá de Henares) using a chemiluminescence immunoassay (CLIA). Methods: We conducted a seroprevalence survey between June 25 Results: A total of 2,219 workers were included and 847 of them (38.2%) presented IgG antibodies against SARS-CoV-2, being seroprevalence significantly higher for HCW (39.3%) than for nHCW (30.7%, p=0.006). We found no differences regarding positivity rates compared with the first diagnostic approach for symptomatic and asymptomatic workers, or infected workers per professional category. In the multivariate logistic regression analysis, the use of PPE (protective, OR=0.65; 95%CI: 0.48-0.89; p<0.001) and previous contact with COVID-19 patients (risk factor, OR=1.93; 95%CI: 1.37-2.72; p<0.001) were independent factors that were associated with SARS-CoV-2 seropositivity. Conclusions: More than 38% of our workers presented IgG antibodies against SARS-CoV-2. We found no differences in the positivity rates between diagnostic approaches. The use of PPE (protective) and previous contact with COVID-19 patients (risk factor) were associated with infection.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Health Personnel ; Hospitals ; Humans ; Personnel, Hospital ; SARS-CoV-2 ; Seroepidemiologic Studies ; Spain/epidemiology
Chemical Substances	Antibodies, Viral
Language	Spanish
Publishing date	2021-10-22
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
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Article ; Online: Enfermedad de Graves con autoanticuerpos contra el receptor de la TSH negativos: a propósito de 5 casos.

Scatti Regàs, Aina / Pujol Borrell, Ricard / Ferrer Costa, Roser / Puerto Carranza, Elsa / Clemente León, María

Anales de pediatria

2020 Volume 93, Issue 6, Page(s) 417–419

Title translation	Graves disease with negative TSH receptor antibodies: A presentation of 5 cases.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Graves Disease ; Humans ; Infant, Newborn ; Male ; Receptors, Thyrotropin
Chemical Substances	Receptors, Thyrotropin
Language	Spanish
Publishing date	2020-02-21
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpedi.2020.01.008
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Article ; Online: Pourquoi l’art a-t-il cessé d’être subversif ?

Clemente Padin

M@GM@, Vol 18, Iss

2020 Volume 2

Abstract: On a pensé pour diverses raisons que l’art nous permet de lutter pour défendre nos droits en raison ... un. Cela a tenu au fait que le système socio-économique a réussi à transformer l’artiste, le producteur d’art ... de celui qui le nourrit. La pandémie de la Covid-19 n’a fait qu’aggraver la situation, avec ses pertes d’emplois et d ...

Abstract	On a pensé pour diverses raisons que l’art nous permet de lutter pour défendre nos droits en raison de son caractère soi-disant subversif contre la nature arbitraire du pouvoir. Cependant, l’art est aussi innocent qu’une brique, qui permet aussi bien de construire une maison, que de casser la tête de quelqu’un. Cela a tenu au fait que le système socio-économique a réussi à transformer l’artiste, le producteur d’art, en « chien de compagnie » des puissants de ce monde. Personne ne penserait à mordre la main de celui qui le nourrit. La pandémie de la Covid-19 n’a fait qu’aggraver la situation, avec ses pertes d’emplois et d’investissements, et pire encore, l’attitude de nombreux potentats qui tournent le dos aux demandes du peuple, insensibles à la douleur et à l’oppression de leurs frères.
Keywords	mythanalyse ; art ; société ; Social Sciences ; H
Language	Spanish
Publishing date	2020-09-01T00:00:00Z
Publisher	Osservatorio Processi Comunicativi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aspectos claves de la Neumología y la Cirugía Torácica sometidos a debate en la era COVID-19.

Jiménez-Ruiz, Carlos A / Valido Morales, Agustin / Perez Chica, Gerardo / Urrutia Landa, Isabel / Rodriguez Portal, Jose Antonio / Arnedillo Muñoz, Aurelio / Cózar Bernal, Fernando / Peces-Barba, Germán / Diego Roza, Carmen / Solano Reina, Segismundo / Rodriguez Suarez, Pedro / Garcia Rio, Francisco / Salas Llinas, Ernest / Garcia Clemente, Marta María / Valencia Gallardo, Jose Manuel / Rodriguez Nieto, María Jesús / Martin de Carpi, Teresa / Sánchez de Cos Escuin, Julio / Estrada Trigueros, Graciliano /

Godoy Mayoral, Raúl / Barbeta Sánchez, Enric / Fernández Villar, Alberto / Ros Lucas, Jose Antonio / Martinez Moragón, Eva / Tomás López, Laura

Open respiratory archives

2021 Volume 3, Issue 4, Page(s) 100123

Title translation	Key Pulmonology and Thoracic Surgery Issues under Discussion in the COVID-19 Era.
Language	Spanish
Publishing date	2021-08-18
Publishing country	Spain
Document type	Journal Article
ISSN	2659-6636
ISSN (online)	2659-6636
DOI	10.1016/j.opresp.2021.100123
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Article: Condrolisis idiopática de cadera. Evolución a largo plazo.

García-Mata, S / Jiménez Sarmiento, O / Duart Clemente, J / Hidalgo Ovejero, A

Anales del sistema sanitario de Navarra

2016 Volume 39, Issue 2, Page(s) 309–314

Abstract: Idiopathic chondrolysis of the hip is a very rare disease occurring during adolescence. Pain and limp are the most common symptoms and are a consequence of an accelerated loss of the articular cartilage with a lower range of move-ment producing rigidity ... ...

Title translation	Idiopatic chondrolysis of the hip. Long-term follow-up of a case.
Abstract	Idiopathic chondrolysis of the hip is a very rare disease occurring during adolescence. Pain and limp are the most common symptoms and are a consequence of an accelerated loss of the articular cartilage with a lower range of move-ment producing rigidity in the last instance. The natural history is unpredictable and varies between complete and spon-taneous recovery and the ankylosis. The current recommended treatment is conservative, restricting the surgical option for residual stiffness. A clinical case of an eleven year old patient is presented. He consulted for a 2 year, torpid course of left groin pain with limp and rigidity. He received treatment with rest, discharge, analgesics and rehabilitation without any improvement initially. He was treated conservatively with NSAIDS, extremity discharge periods, soft traction in the hospital and at home and rehabilitation, recovering mobility and normal gait 6 years after the beginning of the symptoms. Twelve years after the onset of the symptoms the patient leads a normal life without symptoms and has a symmetric range of motion of both hips.
Language	Spanish
Publishing date	2016-05
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	2141772-6
ISSN	1137-6627
ISSN	1137-6627
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Article ; Online: Características sociodemográficas asociadas a la adherencia del tratamiento en adultos con Diabetes Tipo 2

Clemente Cordero-Sánchez / Corina Alba-Alba / Madai Muñoz-Covarrubias / Elizabeth Guzmán-Ortiz / Natalia Ramirez-Giron

Horizonte Sanitario, Vol 21, Iss 2, Pp 276-

2022 Volume 281

Abstract: ... de Morisky, Green y Levine. Resultados. Predominó el sexo femenino (62%), los participantes entre 50 a 59 ... reportaron tener 3 años con DT2, solo el 38% de los encuestados realizan ejercicio físico de 10 a 15 minutos ...

Abstract	Objetivo. Establecer la asociación de las características sociodemográficas y la adherencia al tratamiento en personas adultas mexicanas con Diabetes Tipo 2. Materiales y Método. Diseño descriptivo transversal, la población estuvo constituida por adultos mayores de 18 de edad con diagnóstico de DT2, que acudieron una clínica de diabetes de un hospital público. La muestra estuvo constituida por 100 participantes, se incluyeron adultos conscientes, con diagnóstico de DT2, con evolución mínima de tres años con la enfermedad. Para medir la adherencia al tratamiento se utilizó el Test de Adherencia al Tratamiento de Morisky, Green y Levine. Resultados. Predominó el sexo femenino (62%), los participantes entre 50 a 59 años fueron los que más participaron (59%); cerca de la mitad de los participantes había concluido la primaria (46 %), y la mayoría de ellos reportaron tener pareja (69%). El 23% de los participantes reportaron tener 3 años con DT2, solo el 38% de los encuestados realizan ejercicio físico de 10 a 15 minutos al día y el 28% no realizaba ejercicio físico; la mayoría se encontraba con un tratamiento farmacológico basado en hipoglucemiantes orales (82%). La edad se asoció con la adherencia al tratamiento (p
Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Universidad Juárez Autónoma de Tabasco
Document type	Article ; Online
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Article ; Online: Reflexiones en torno a Tierras Magallánicas (1933) de Alberto De Agostini

Claudia Andrea Cattaneo Clemente

Revista Reflexiones, Vol 101, Iss

2021 Volume 1

Abstract: Introducción Los estudios que se han llevado a cabo en torno al film de Alberto De Agostini ...

Abstract	Introducción Los estudios que se han llevado a cabo en torno al film de Alberto De Agostini siempre han sido abordados desde su visualidad y aporte histórico. Sin embargo, se vuelve urgente realizar una reflexión sobre los modos de evangelización y exterminio de los pueblos indígenas en el momento de la colonización del territorio austral y cómo éstos son completamente omitidos en las imágenes que registra el film. Tierras Magallánicas se centra en una construcción de imaginarios que ha dejado marcas en nuestra memoria reciente y en el mismo ser humano. Objetivo Este artículo pretende reflexionar el tema de la deshumanización en el proceso de colonización-evangelización de la Patagonia chilena por medio del análisis discursivo de las imágenes del film Tierras Magallánicas de Alberto De Agostini para determinar sus alcances en la sociedad actual al perpetuar una memoria colonizada. Método La metodología es cualitativa del tipo interpretativo, con un enfoque interdisciplinar, pues se estudian las imágenes del film Tierras Magallánicas de Alberto De Agostini desde las cualidades discursivas del mismo para determinar sus alcances en la sociedad actual, utilizando herramientas y fuentes provenientes de la teoría decolonial, la filosofía, la antropología y los estudios de la imagen, lo que permite abordar el objeto de estudio desde una óptica holística. [Continúa leyendo en el artículo]
Keywords	Cine de explorador ; Colonización ; Memoria ; Indígenas fueguinos ; Eurocentrismo ; Social sciences (General) ; H1-99
Language	Spanish
Publishing date	2021-05-01T00:00:00Z
Publisher	Universidad de Costa Rica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lupus eritematoso sistémico de debut atípico: a propósito de 3 casos.

Barrio Nogal, Laura / Clemente Garulo, Daniel / de Lucas Collantes, Carmen / Aparicio López, Cristina / López Robledillo, Juan Carlos

Anales de pediatria

2020 Volume 93, Issue 4, Page(s) 257–259

Title translation	Systemic lupus erythematosus of atypical onset: A presentation of 3 cases.
MeSH term(s)	Child ; Female ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/pathology ; Male
Language	Spanish
Publishing date	2020-02-21
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpedi.2019.12.006
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Article ; Online: A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.

Siibak, Triinu / Clemente, Paula / Bratic, Ana / Bruhn, Helene / Kauppila, Timo E S / Macao, Bertil / Schober, Florian A / Lesko, Nicole / Wibom, Rolf / Naess, Karin / Nennesmo, Inger / Wedell, Anna / Peter, Bradley / Freyer, Christoph / Falkenberg, Maria / Wredenberg, Anna

Human molecular genetics

2017 Volume 26, Issue 13, Page(s) 2515–2525

Abstract: Mutations in the mitochondrial DNA polymerase, POLG, are associated with a variety of clinical presentations, ranging from early onset fatal brain disease in Alpers syndrome to chronic progressive external ophthalmoplegia. The majority of mutations are ... ...

Abstract	Mutations in the mitochondrial DNA polymerase, POLG, are associated with a variety of clinical presentations, ranging from early onset fatal brain disease in Alpers syndrome to chronic progressive external ophthalmoplegia. The majority of mutations are linked with disturbances of mitochondrial DNA (mtDNA) integrity and maintenance. On a molecular level, depending on their location within the enzyme, mutations either lead to mtDNA depletion or the accumulation of multiple mtDNA deletions, and in some cases these molecular changes can be correlated to the clinical presentation. We identified a patient with a dominant p.Y955H mutation in POLG, presenting with a severe, early-onset multi-systemic mitochondrial disease with bilateral sensorineural hearing loss, cataract, myopathy, and liver failure. Using a combination of disease models of Drosophila melanogaster and in vitro biochemistry analysis, we compare the molecular consequences of the p.Y955H mutation to the well-documented p.Y955C mutation. We demonstrate that both mutations affect mtDNA replication and display a dominant negative effect, with the p.Y955H allele resulting in a more severe polymerase dysfunction.
MeSH term(s)	Adult ; Amino Acid Sequence ; Animals ; DNA Polymerase gamma ; DNA Replication/genetics ; DNA, Mitochondrial/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Disease Models, Animal ; Drosophila melanogaster/genetics ; Female ; Humans ; Infant ; Mitochondria/genetics ; Mutation/genetics ; Ophthalmoplegia, Chronic Progressive External/enzymology ; Pedigree ; Phenotype
Chemical Substances	DNA, Mitochondrial ; DNA Polymerase gamma (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2017-07-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddx146
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