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  1. Book ; Thesis: Interaktion des peripheren Chemound des Baroreflexes bei Patienten mit elektrischer Carotissinus-Stimulation

    Ehrenbrink, Arvo Joel / Tank, Jens / Heußer, Karsten

    2021  

    Institution Medizinische Hochschule Hannover
    Medizinische Hochschule Hannover / Institut für Klinische Pharmakologie
    Author's details vorgelegt von Arvo Joel Ehrenbrink ; Medizinische Hochschule Hannover, Institut für Klinische Pharmakologie ; Betreuer/in der Arbeit: Prof. Dr. med. Jens Tank, PD Dr. med. Karsten Heusser
    Language German
    Size 5 ungezählte Blätter, 55 Seiten, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    HBZ-ID HT030635153
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 209 order for loan Magazin

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  2. Book ; Thesis: Die autonome Regulation des Herz-Kreislauf-Systems unter physiologischen, pathophysiologischen und therapeutischen Bedingungen

    Heusser, Karsten

    2003  

    Author's details vorgelegt von Karsten Heusser
    Language German
    Size Getr. Zählung
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Habil.-Schr., 2003
    HBZ-ID HT013938575
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 E 600 order for loan Magazin

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  3. Book ; Thesis: Einfluß eines magnetischen 3-Hertz-Wechselfeldes mit einer Induktion von 0.1 Millitesla auf ausgewählte Parameter des menschlichen EEG

    Heußer, Karsten

    1996  

    Author's details eingereicht von Karsten Heußer
    Language German
    Size 82 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 1996
    HBZ-ID HT007492031
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 C 59 order for loan Magazin

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  4. Book ; Online ; Thesis: Vergleich der kardiovaskulären Regulation und der kardiovaskulären Auswirkungen in Ruhe und bei Pressatmung bei akuter Gravitations- und Lageänderung

    Latscha, Rina Verfasser] / [Bloch, Wilhelm [Gutachter] / Heusser, Karsten [Gutachter]

    2023  

    Author's details Rina Latscha ; Gutachter: Wilhelm Bloch, Karsten Heusser
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes.

    Heusser, Karsten / Tank, Jens / Diedrich, André / Fischer, Annelie / Heise, Tim / Jordan, Jens

    Kidney international reports

    2023  Volume 8, Issue 11, Page(s) 2254–2264

    Abstract: Introduction: Reductions in sympathetic nervous system activity may contribute to beneficial effects of sodium glucose cotransporter 2 (SGLT2) inhibition on cardiovascular outcomes. Therefore, we tested the hypothesis that SGLT2 inhibition with ... ...

    Abstract Introduction: Reductions in sympathetic nervous system activity may contribute to beneficial effects of sodium glucose cotransporter 2 (SGLT2) inhibition on cardiovascular outcomes. Therefore, we tested the hypothesis that SGLT2 inhibition with empagliflozin (Empa) lowers muscle sympathetic nerve activity (MSNA) in patients with type 2 diabetes mellitus (T2DM) compared with hydrochlorothiazide (HCT) to discern SGLT2-specific actions from responses to increased natriuresis.
    Methods: We randomized patients with T2DM on metformin monotherapy to either 25 mg/d Empa (
    Results: Both drugs elicited volume depletion, as indicated by increased thoracic impedance. Compared with HCT, Empa caused 1.23 kg more body weight loss (
    Conclusion: Increased renal sodium excretion eliciting body weight loss may promote sympathetic activation. However, sympathetic excitation in the face of increased sodium loss may be attenuated by SGLT2 inhibitor-specific actions.
    Language English
    Publishing date 2023-09-03
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.08.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus.

    Heusser, Karsten / Tank, Jens / Diedrich, André / Fischer, Annelie / Heise, Tim / Jordan, Jens

    Frontiers in neuroscience

    2023  Volume 16, Page(s) 1107752

    Abstract: Introduction: Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, ... ...

    Abstract Introduction: Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce.
    Methods: We studied 61 patients with type 2 diabetes mellitus (22 women, 60.9 ± 1.4 years; 39 men, 60.9 ± 1.4 years). They had to have diabetes for at least 2 years, a hemoglobin A1c of 6.5-10%, a body-mass-index of 20-40 kg/m
    Results: MSNA was 37.5 ± 2.5 bursts/min in women and 39.0 ± 2.0 bursts/min in men (
    Discussion: We conclude that relatively few older patients with type 2 diabetes mellitus exhibit increased MSNA. The large interindividual variability in MSNA cannot be explained by gender, blood pressure, body mass index, or glycemic control.
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1107752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation.

    Heusser, Karsten / Heusser, Ramona / Jordan, Jens / Urechie, Vasile / Diedrich, André / Tank, Jens

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 697582

    Abstract: Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to blood ...

    Abstract Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to blood pressure values. In an X-Y plot the data points scatter around a sigmoidal curve. After fitting the parameters of a sigmoidal function to the data, the graph's characteristics represent a rather comprehensive quantitative reflex description. Variants of the 4-parameter Boltzmann sigmoidal equation are widely used for curve fitting. Unfortunately, their 'slope parameters' do not correspond to the graph's actual slope which complicates the analysis and bears the risk of misreporting. We propose a modified Boltzmann sigmoidal function with preserved goodness of fit whose parameters are one-to-one equivalent to the sigmoidal curve's characteristics.
    Language English
    Publishing date 2021-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.697582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.

    Manuel, Jorge / Halbe, Eva / Ewald, Ann Charlotte / Hoff, Alex / Jordan, Jens / Tank, Jens / Heusser, Karsten / Gerlach, Darius A

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1297197

    Abstract: Introduction: Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic ... ...

    Abstract Introduction: Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic functional connectivity changes during glucose loading using functional magnetic resonance imaging (fMRI).
    Methods: To do so, we conducted oral glucose tolerance tests while acquiring functional images before, and 10 and 45 min after glucose ingestion in a healthy male and cross-sectionally in 20 healthy participants on two different diets.
    Results: At group level, 39 fMRI sessions were not sufficient to detect glucose-mediated connectivity changes. However, 10 repeated sessions in a single subject revealed significant intrinsic functional connectivity increases 45 min after glucose intake in the arcuate, paraventricular, and dorsomedial nuclei, as well as in the posterior hypothalamic area, median eminence, and mammillary bodies.
    Discussion: Our methodology allowed to outline glucose-sensitive hypothalamic pathways in a single human being and holds promise in delineating individual pathophysiology mechanisms in patients with dysglycemia.
    Language English
    Publishing date 2023-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1297197
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  9. Article ; Online: Cerebral blood flow autoregulation assessment by correlation analysis between mean arterial blood pressure and transcranial doppler sonography or near infrared spectroscopy is different: A pilot study.

    Thudium, Marcus / Moestl, Stefan / Hoffmann, Fabian / Hoff, Alex / Kornilov, Evgeniya / Heusser, Karsten / Tank, Jens / Soehle, Martin

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287578

    Abstract: Purpose: Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been ... ...

    Abstract Purpose: Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been introduced to clinical practice. In a pilot study, we aimed to evaluate the validity of these indices using incremental lower body negative pressure (LBNP) until presyncope representing beginning cerebral hypoperfusion as well as lower body positive pressure (LBPP) with added mild hypoxia to induce cerebral hyperperfusion in healthy subjects.
    Methods: Five male subjects received continuous hemodynamic, TCD and NIRS monitoring. Decreasing levels of LBNP were applied in 5-minute steps until subjects reached presyncope. Increasing levels of LBPP were applied stepwise up to 20 or 25 mmHg. Normobaric hypoxia was added until an oxygen saturation of 84% was reached. This was continued for 10 minutes. ORx and Mx indices were calculated using previously described methods.
    Results: Both Indices showed an increase > 0.3 indicating impaired cerebral autoregulation during presyncope. However, there was no significant difference in Mx at presyncope compared to baseline (p = 0.168). Mean arterial pressure and cardiac output decreased only in presyncope, while stroke volume was decreased at the last pressure level. Neither Mx nor ORx showed significant changes during LBPP or hypoxia. Agreement between Mx and ORx was poor during the LBNP and LBPP experiments (R2 = 0.001, p = 0.3339).
    Conclusion: Mx and ORx represent impaired cerebral autoregulation, but in Mx this may not be distinguished sufficiently from baseline. LBPP and hypoxia are insufficient to reach the upper limit of cerebral autoregulation as indicated by Mx and ORx.
    MeSH term(s) Humans ; Male ; Arterial Pressure/physiology ; Pilot Projects ; Spectroscopy, Near-Infrared/methods ; Ultrasonography, Doppler, Transcranial/methods ; Cerebrovascular Circulation/physiology ; Blood Flow Velocity/physiology ; Oximetry ; Homeostasis/physiology ; Blood Pressure/physiology
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287578
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  10. Article ; Online: Cerebral blood flow autoregulation assessment by correlation analysis between mean arterial blood pressure and transcranial doppler sonography or near infrared spectroscopy is different

    Marcus Thudium / Stefan Moestl / Fabian Hoffmann / Alex Hoff / Evgeniya Kornilov / Karsten Heusser / Jens Tank / Martin Soehle

    PLoS ONE, Vol 18, Iss 6, p e

    A pilot study.

    2023  Volume 0287578

    Abstract: Purpose Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been ... ...

    Abstract Purpose Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been introduced to clinical practice. In a pilot study, we aimed to evaluate the validity of these indices using incremental lower body negative pressure (LBNP) until presyncope representing beginning cerebral hypoperfusion as well as lower body positive pressure (LBPP) with added mild hypoxia to induce cerebral hyperperfusion in healthy subjects. Methods Five male subjects received continuous hemodynamic, TCD and NIRS monitoring. Decreasing levels of LBNP were applied in 5-minute steps until subjects reached presyncope. Increasing levels of LBPP were applied stepwise up to 20 or 25 mmHg. Normobaric hypoxia was added until an oxygen saturation of 84% was reached. This was continued for 10 minutes. ORx and Mx indices were calculated using previously described methods. Results Both Indices showed an increase > 0.3 indicating impaired cerebral autoregulation during presyncope. However, there was no significant difference in Mx at presyncope compared to baseline (p = 0.168). Mean arterial pressure and cardiac output decreased only in presyncope, while stroke volume was decreased at the last pressure level. Neither Mx nor ORx showed significant changes during LBPP or hypoxia. Agreement between Mx and ORx was poor during the LBNP and LBPP experiments (R2 = 0.001, p = 0.3339). Conclusion Mx and ORx represent impaired cerebral autoregulation, but in Mx this may not be distinguished sufficiently from baseline. LBPP and hypoxia are insufficient to reach the upper limit of cerebral autoregulation as indicated by Mx and ORx.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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