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Article ; Online: TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans.

Hernandez-Mixteco, Margarita / Bernal-Morales, Blandina / Valenzuela, Olga Lidia / Rodríguez-Landa, Juan Francisco / Cerna-Cortes, Jorge Francisco / García-Montalvo, Eliud Alfredo

Brain research

2023 Volume 1817, Page(s) 148479

Abstract: ... on the rs4570625 (-703G/T) single nucleotide polymorphism of TPH2 gene. By using conventional polymerase chain ... respectively. We found that individuals with the homozygous recessive T/T genotype had lower stress and ... with the T/T genotype. These results suggest that T/T genotype could decrease the susceptibility ...

Abstract	Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of serotonin synthesis. TPH2 is the brain-specific isoform of this enzyme, and genetic variations in the TPH2 gene have been shown to impact its transcription and enzymatic activity and are associated with mood disorders. In this study we focused on the rs4570625 (-703G/T) single nucleotide polymorphism of TPH2 gene. By using conventional polymerase chain reaction (PCR), we examined the effect of this polymorphism on stress, anxiety, and depression symptoms as well as quality of life, evaluated based on the Holmes-Rahe Inventory, the Beck Anxiety Inventory, the Beck Depression Inventory, and the World Health Organization Quality of Life - Short Version, respectively. We found that individuals with the homozygous recessive T/T genotype had lower stress and depression scores. In addition, the quality of life in the psychological health domain was better in males with the T/T genotype. These results suggest that T/T genotype could decrease the susceptibility to developing stress and depression in the Mexican population without a diagnosis for an emotional disorder.
MeSH term(s)	Humans ; Male ; Depression/genetics ; Depression/psychology ; Genotype ; Polymorphism, Single Nucleotide/genetics ; Quality of Life ; Tryptophan Hydroxylase/genetics ; Stress, Psychological/genetics ; Stress, Psychological/psychology ; Psychosocial Functioning ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics
Chemical Substances	TPH2 protein, human (EC 1.14.16.4) ; Tryptophan Hydroxylase (EC 1.14.16.4)
Language	English
Publishing date	2023-07-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2023.148479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 161: Show issues

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Article ; Online: Association of -319 C/T and +49 A/G polymorphisms of CTLA-4 gene in patients with hepatitis C virus infection.

Enciso-Vargas, Moisés / Ruíz-Madrigal, Bertha / Muñoz-Valle, José Francisco / Morales-Balderas, Omar Yair / Hernández-Nazara, Zamira Helena / Martínez-López, Erika / Dávalos-Cobian, Carlos / Padilla-Gutiérrez, Jorge Ramón / Torres-Baranda, José Rodrigo / Domínguez-Rosales, José Alfredo / Maldonado-González, Montserrat

Medicina clinica

2017 Volume 150, Issue 7, Page(s) 251–256

Abstract: ... We aimed to investigate the frequency and association of -319 C/T and +49 A/G polymorphism in the CTLA-4 ... in the promoter region, and +49 A/G in exon 1) were analysed by T-ARMS-PCR in 420 individuals, including 205 chronic HCV ... an important role of the -319 C/T and +49 A/G polymorphisms in HCV infection. ...

Title translation	Asociación de los polimorfismos −319 C/T y +49 A/G del gen CTLA-4 en pacientes con infección por el virus de la hepatitis C.
Abstract	Introduction and objective: Molecular changes in the CTLA-4 gene can modify the ability to control T lymphocyte proliferation, and promote the persistence or elimination of the hepatitis C virus (HCV). We aimed to investigate the frequency and association of -319 C/T and +49 A/G polymorphism in the CTLA-4 gene in patients infected with HCV. Methods: The CTLA-4 gene polymorphisms (-319 C/T in the promoter region, and +49 A/G in exon 1) were analysed by T-ARMS-PCR in 420 individuals, including 205 chronic HCV infected patients and 215 healthy subjects. Results: We found a positive association of +49G allele with HCV infection (OR 1.48; 95% CI 1.09-2.02; p=.02), and with males (OR 1.80; 95% CI 1.16-2.79; p=.02), both in chronic disease (without cirrhosis). Also, significant differences in +49 A/G genotypes distribution between HCV infected patients and healthy subjects were shown in a dominant genetic model (GG+GA versus AA; OR 1.57; 95% CI 1.05-2.33; p=.04). No significant differences were observed in the -319 C/T polymorphism between HCV infected patients and healthy subjects. Moreover, -319C/+49G haplotype confers susceptibility to HCV genotype 3 infection (OR 10.68; 95% CI 1.17-96.97; p=.04). Conclusions: The +49G allele confers susceptibility to HCV infection and with male gender, both in chronic disease. In addition, the -319C/+49G haplotype confers susceptibility to HCV genotype 3 infection. Our results support an important role of the -319 C/T and +49 A/G polymorphisms in HCV infection.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; CTLA-4 Antigen/genetics ; Cross-Sectional Studies ; Female ; Hepatitis C, Chronic/genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
Chemical Substances	CTLA-4 Antigen ; CTLA4 protein, human
Language	Spanish
Publishing date	2017-10-14
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.06.074
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Article ; Online: Correction: Magnetic aerogels from FePt and CoPt

Schoske, L / Lübkemann-Warwas, F / Morales, I / Wesemann, C / Eckert, J G / Graf, R T / Bigall, N C

Nanoscale

2024

Abstract: Correction for 'Magnetic aerogels from FePt and ... ...

Abstract	Correction for 'Magnetic aerogels from FePt and CoPt
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Published Erratum
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d4nr90086c
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Article ; Online: Flavonoid Metabolites in Serum and Urine after the Ingestion of Selected Tropical Fruits.

Chomphen, Lalita / Yamanont, Paveena / Morales, Noppawan Phumala

Nutrients

2024 Volume 16, Issue 1

Abstract: ... of healthy volunteers was given 200 g of fresh fruit after overnight fasting and a 24-h flavonoid-free diet ... with the time to maximum concentration (T ...

Abstract	The serum concentration and urinary excretion of flavonoids after the ingestion of guava, pineapple, and pomelo were determined using liquid chromatography-mass spectroscopy (LC-MS/MS). Each group of healthy volunteers was given 200 g of fresh fruit after overnight fasting and a 24-h flavonoid-free diet. The results demonstrate that only the glucuronic-conjugated metabolites of luteolin, quercetin, kaempferol, and myricetin were detected after fruit ingestion. The metabolites were first detected after 2 h, with the time to maximum concentration (T
MeSH term(s)	Humans ; Fruit ; Kaempferols ; Quercetin ; Chromatography, Liquid ; Luteolin ; Tandem Mass Spectrometry ; Flavonoids ; Psidium ; Eating
Chemical Substances	Kaempferols ; Quercetin (9IKM0I5T1E) ; Luteolin (KUX1ZNC9J2) ; Flavonoids
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16010161
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Article: Current and New Insights on Delivery Systems for Plant Sterols in Food.

Blanco-Morales, V / Mercatante, D / Rodriguez-Estrada, M T / Garcia-Llatas, G

Advances in experimental medicine and biology

2023 Volume 1440, Page(s) 403–435

Abstract: Plant sterols are minor bioactive components of food lipids, which are often used for the formulation of functional foods due to their cholesterol-lowering properties. However, they have low solubility and tend to crystallize, which may affect their ... ...

Abstract	Plant sterols are minor bioactive components of food lipids, which are often used for the formulation of functional foods due to their cholesterol-lowering properties. However, they have low solubility and tend to crystallize, which may affect their biological effects, the sensory profile of the sterol-enriched food, and its consumer acceptability. Moreover, due to the unsaturated structure of sterols, they are susceptible to oxidation, so different encapsulation systems have been developed to improve their dispersibility/solubility, stability, delivery, and bioaccessibility. This chapter provides an overview of the main encapsulation systems currently used for plant sterols and their application in model and food systems, with a particular focus on their efficiency and impact on sterol bioaccessibility.
MeSH term(s)	Cholesterol ; Food, Fortified ; Oxidation-Reduction ; Phytosterols/chemistry ; Phytosterols/metabolism ; Sterols
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Phytosterols ; Sterols
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-3-031-43883-7_20
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Magnetic aerogels from FePt and CoPt

Schoske, L / Lübkemann-Warwas, F / Morales, I / Wesemann, C / Eckert, J G / Graf, R T / Bigall, N C

Nanoscale

2024 Volume 16, Issue 8, Page(s) 4229–4238

Abstract: Here the synthesis of magnetic aerogels from iron platinum and cobalt platinum nanoparticles is presented. The use of hydrazine monohydrate as destabilizing agent triggers the gelation directly from organic solution, and therefore a phase transfer to ... ...

Abstract	Here the synthesis of magnetic aerogels from iron platinum and cobalt platinum nanoparticles is presented. The use of hydrazine monohydrate as destabilizing agent triggers the gelation directly from organic solution, and therefore a phase transfer to aqueous media prior to the gelation is not necessary. The aerogels were characterized through Transmission Electron Microscopy, Scanning Electron Microscopy, Powder X-Ray Diffraction Analysis and Argon Physisorption measurements to prove the formation of a porous network and define their compositions. Additionally, magnetization measurements in terms of hysteresis cycles at 5 K and 300 K (M-H-curves) as well as zero field cooled-field cooled measurements (ZFC-FC measurements) of the dried colloids and the respective xero- and aerogels were performed, in order to analyze the influence of the gelation process and the network structure on the magnetic properties.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr05892a
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Article: Successful treatment of squamous cell carcinoma with intralesional methotrexate.

Vega-González, L G / Morales-Pérez, M I / Molina-Pérez, T / Sereno-Gómez, B

JAAD case reports

2022 Volume 24, Page(s) 68–70

Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2022.04.016
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Article: A Compilation of Drug Etiologies of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Abulatan, Isaac T / Ben-David, Sage G / Morales-Colon, Lery A / Beason, Elisabeth / Fakoya, Adegbenro O

Cureus

2023 Volume 15, Issue 11, Page(s) e48728

Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are adverse reactions that affect the mucocutaneous surfaces by causing necrosis and detachment of the epidermis. The difference between SJS and TEN is in the percentage of the body ... ...

Abstract	Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are adverse reactions that affect the mucocutaneous surfaces by causing necrosis and detachment of the epidermis. The difference between SJS and TEN is in the percentage of the body surface area (BSA) affected. TEN is known to affect greater BSA than SJS. The pathogenesis of SJS/TEN is attributed to drug-specific cell-mediated cytotoxic reactions that directly and indirectly lead to keratinocyte apoptosis through mediators. Clinical presentation begins with influenza-like symptoms, with the disease affecting the skin, oral, ocular, and urogenital regions most frequently. Although SJS/TEN is mainly due to various drugs, infection and vaccination can also induce SJS/TEN. This review outlines a compilation of all drugs implicated in SJS/TEN cases based on studies, mainly in case reports and other study types. Drug classes implicated in SJS/TEN cases include antibiotics, anticonvulsants, antineoplastics, analgesics, and diuretics, among others. There is no fully established diagnostic modality for SJS/TEN; treatment is done mainly by withdrawing the offending agent. In addition to withdrawing the offending agent, a multidisciplinary care team is essential in managing these patients. Several pharmacologic modalities have also been proposed in treatment, but there is still insufficient evidence for the efficacy of one against the other.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.48728
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Article ; Online: Co-occurrence of native and invasive macroalgae might be facilitated under global warming.

Bommarito, C / Noè, S / Díaz-Morales, D M / Lukić, I / Hiebenthal, C / Rilov, G / Guy-Haim, T / Wahl, M

The Science of the total environment

2023 Volume 912, Page(s) 169087

Abstract: ... photosynthesis, respiration, and nutrients' uptake rates of mono- and co-cultured G. vermiculophylla while growth ... a growth reduction might result from increasing stress and energy demand of G. vermiculophylla under ... warming (RCP2.6 and RCP8.5 scenarios) treatments, both F. vesiculosus and G. vermiculophylla appear ...

Abstract	Climate change is driving compositional shifts in ecological communities directly by affecting species and indirectly through changes in species interactions. For example, competitive hierarchies can be inversed when competitive dominants are more susceptible to climate change. The brown seaweed Fucus vesiculosus is a foundation species in the Baltic Sea, experiencing novel interactions with the invasive red seaweed Gracilaria vermiculophylla, which is known for its high tolerance to environmental stress. We investigated the direct and interactive effects of warming and co-occurrence of the two algal species on their performance, by applying four climate change-relevant temperature scenarios: 1) cooling ) 2 °C below ambient - representing past conditions), 2) ambient summer temperature (18 °C), 3) IPCC RCP2.6 warming scenario (1 °C above ambient), and 4) RCP8.5 warming (3 °C above ambient) for 30 days and two compositional levels (mono and co-cultured algae) in a fully-crossed design. The RCP8.5 warming scenario increased photosynthesis, respiration, and nutrients' uptake rates of mono- and co-cultured G. vermiculophylla while growth was reduced. An increase in photosynthesis and essential nutrients' uptake and, at the same time, a growth reduction might result from increasing stress and energy demand of G. vermiculophylla under warming. In contrast, the growth of mono-cultured F. vesiculosus significantly increased in the highest warming treatment (+3 °C). The cooling treatment (-2 °C) exerted a slight negative effect only on co-cultured F. vesiculosus photosynthesis, compared to the ambient treatment. Interestingly, at ambient and warming (RCP2.6 and RCP8.5 scenarios) treatments, both F. vesiculosus and G. vermiculophylla appear to benefit from the presence of each other. Our results suggest that short exposure of F. vesiculosus to moderate or severe global warming scenarios may not directly affect or even slightly enhance its performance, while G. vermiculophylla net performance (growth) could be directly hampered by warming.
MeSH term(s)	Global Warming ; Seaweed ; Gracilaria ; Climate Change ; Temperature ; Fucus
Language	English
Publishing date	2023-12-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169087
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Zs.A 949: Show issues

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Article ; Online: Composite Biosynthetic Graft for Repair of Long-Segment Tracheal Stenosis: A Pilot In Vivo and In Vitro Feasibility Study.

Karkhanis, Teja / Byju, Achu G / Morales, David L / Zafar, Farhan / Haridas, Balakrishna

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2024

Abstract: Pediatric patients who undergo surgery for long-segment congenital tracheal stenosis (LSCTS) have suboptimal outcomes and postsurgical complications. To address this, we propose a biosynthetic graft comprising (1) a porcine small intestinal submucosa ... ...

Abstract	Pediatric patients who undergo surgery for long-segment congenital tracheal stenosis (LSCTS) have suboptimal outcomes and postsurgical complications. To address this, we propose a biosynthetic graft comprising (1) a porcine small intestinal submucosa extracellular matrix (SIS-ECM) patch for tracheal repair, and (2) a resorbable polymeric exostent for biomechanical support. The SIS-ECM patch was evaluated in vivo in an ovine trachea model over an 8 month period. Concurrently, the biosynthetic graft was evaluated in a benchtop lamb trachea model for biomechanical stability. In vivo results show that SIS-ECM performs better than bovine pericardium (control) by preventing granulation tissue/restenosis, restoring tracheal architecture, blood vessels, matrix components, pseudostratified columnar and stratified epithelium, ciliary structures, mucin production, and goblet cells. In vitro tests show that the biosynthetic graft can provide the desired axial and flexural stability, and biomechanical function approaching that of native trachea. These results encourage future studies to evaluate safety and efficacy, including biomechanics and collapse risk, biodegradation, and in vivo response enabling a stable long-term tracheal repair option for pediatric patients with LSCTS and other tracheal defects.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000002130
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Uk I Zs.199: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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