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Article: Co-firing plants with retrofitted carbon capture and storage for power-sector emissions mitigation. Jing-Li Fan et al.

Fan, Jing-Li

2023 Volume 13, Issue 8, Page(s) 807

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678X
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses.

Shao, Hao-Tian / Gao, Liang / Li, Hao-Tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze-En / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry science

2023 Volume 102, Issue 8, Page(s) 102761

Abstract: ... enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ...

Abstract	Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
MeSH term(s)	Animals ; Female ; Meloxicam/analysis ; Egg Yolk/chemistry ; Chickens ; Drug Residues/analysis ; Ovum/chemistry ; Administration, Oral ; Eggs/analysis
Chemical Substances	Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
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Article ; Online: Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway.

Zhang, Hui / Wang, Huihua / Zhang, Qing / Wang, Hui / Zhu, Yuhang / Wang, Fangfang / Lin, Jun / Zhou, Jue / Qu, Fan

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1387–1400

Abstract: Context: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing ...

Abstract	Context: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1. Objective: To investigate the effects of BSTJFs on ovarian granulosa cells exposed to DEHP and determine the potential molecular mechanisms. Methods and materials: Human granulosa-like tumor cell line (KGN) cells were divided into control, DEHP, BSTJF1 and BSTJF2 groups. The DEHP group were given 1 μM DEHP for 24 h. They were then given BSTJF1 at 200 μg/mL or BSTJF2 at 100 μg/mL for 24 h. The control group was treated with the same concentration of DMSO (0.1%). Oxidative stress and mitochondrial function were measured. The mRNA and protein expression levels of HDAC3 and HSP90AA were determined. Integrative network pharmacology analysis of BSTJF2 was also performed. Results: DEHP (1 μM) significantly suppressed the proliferation of KGN cells by 17%, significantly increased ROS levels by 28% and MDA levels by 47%, significantly decreased MMP levels by 22% and mtDNA copy by 30%. DEHP significantly increased protein expression of HDAC3 by 21%and HSP90AA by 64%. All these changes were significantly reversed by BSTJFs. Integrative network pharmacology analysis revealed HSP90AA was a key target (degree = 8). Both RGFP966 and BSTJF2 significantly reversed the increased expression of HDAC3 and HSP90AA, attenuated oxidative stress, and mitochondrial damage which were induced by DEHP. Conclusion: BSTJFs might have therapeutic potential on oxidative stress and mitochondrial damage through the HDAC3/HSP90AA pathway which encourages further clinical trials.
MeSH term(s)	Humans ; Female ; Diethylhexyl Phthalate ; Oxidative Stress ; Granulosa Cells ; Busulfan ; Cell Line, Tumor
Chemical Substances	Diethylhexyl Phthalate (C42K0PH13C) ; Busulfan (G1LN9045DK)
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2249193
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characteristics and chemical reactivity of biogenic volatile organic compounds from dominant forest species in the Jing-Jin-Ji area, China

Ying Lin / Xiaoxiu Lun / Wei Tang / Zhongzhi Zhang / Xiaoxi Jing / Chong Fan / Qiang Wang

Forest Ecosystems, Vol 8, Iss 1, Pp 1-

2021 Volume 14

Abstract: ... forest species in the Jing-Jin-Ji area of China. Based on the field survey, forest resources data and ... Salix babylonica and Larix gmelinii) in the Jing-Jin-Ji area in 2017. Then the spatiotemporal emission ... emission from the Jing-Jin-Ji area accounted for 61.9 % and 1.8 % in summer and winter, respectively. Up ...

Abstract	Abstract Background Biogenic volatile organic compounds (BVOCs) play an essential role in tropospheric atmospheric chemical reactions. There are few studies conducted on BVOCs emission of dominant forest species in the Jing-Jin-Ji area of China. Based on the field survey, forest resources data and the measured standard emission factors, the Guenther model developed in 1993 (G93) was applied in this paper to estimate the emission of BVOCs from several dominant forest species (Platycladus orientalis, Quercus variabilis, Betula platyphylla, Populus tomentosa, Pinus tabuliformis, Robinia pseudoacacia, Ulmus pumila, Salix babylonica and Larix gmelinii) in the Jing-Jin-Ji area in 2017. Then the spatiotemporal emission characteristics and atmospheric chemical reactivity of these species were extensively evaluated. Results The results showed that the total annual BVOCs emission was estimated to be 70.8 Gg C·year− 1, consisting 40.5 % (28.7 Gg C·year− 1) of isoprene, 36.0 % (25.5 Gg C·year− 1) of monoterpenes and 23.4 % (16.6 Gg C·year− 1) of other VOCs. The emissions from Platycladus orientalis, Quercus variabilis, Populus tomentosa and Pinus tabulaeformis contributed 56.1 %, 41.2 %, 36.0 % and 31.1 %, respectively. The total BVOCs emission from the Jing-Jin-Ji area accounted for 61.9 % and 1.8 % in summer and winter, respectively. Up to 28.8 % of emission was detected from Chengde followed by Beijing with 24.9 %, that mainly distributed in the Taihang Mountains and the Yanshan Mountains. Additionally, the Robinia pseudoacacia, Populus tomentosa, Quercus variabilis, and Pinus tabulaeformis contributed mainly to BVOCs reaction activity. Conclusions The BVOCs emission peaked in summer (June, July, and August) and bottomed out in winter (December, January, and February). Chengde contributed the most, followed by Beijing. Platycladus orientalis, Quercus variabilis, Populus tomentosa, Pinus tabulaeformis and Robinia pseudoacacia represent the primary contributors to BVOCs emission and atmospheric reactivity, hence the ...
Keywords	Biogenic volatile organic compounds (BVOCs) ; Isoprene ; Monoterpenes ; Jing-Jin-Ji area ; Spatiotemporal characteristics ; Chemical reactivity ; Ecology ; QH540-549.5
Subject code	571
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses

Shao, Hao-Tian / Gao, Liang / Li, Hao-tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze'en / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry Science. 2023 Apr. 27, p.102761-

2023 , Page(s) 102761–

Abstract: ... results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs ...

Abstract	Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under two different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under two dosing schedules: 10 doses at 24-hour intervals and 15 doses at 12-hour intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at two time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 days for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
Keywords	animal-based foods ; egg albumen ; eggs ; food safety ; half life ; high performance liquid chromatography ; meloxicam ; nonsteroidal anti-inflammatory agents ; oral administration ; ova ; poultry science ; withdrawal interval ; Jing Hong laying hens ; HPLC ; the weight ratio of white to yolk
Language	English
Dates of publication	2023-0427
Size	p. 102761
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cluster analysis of Qian Jing-hua's experience in treatment of lung cancer

Zhi-Li Guo / Jing-Hua Qian / Yi-Ping Fan / Kai-Tao Luo / Hong-Sheng Ding

TMR Theory and Hypothesis, Vol 1, Iss 3, Pp 54-

2018 Volume 62

Abstract: Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the ... ...

Abstract	Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the prescription for the treatment of lung cancer by using frequency analysis, association rule analysis and cluster analysis. Results: 746 prescriptions were included in this study, commonly used drugs 170 flavors. Traditional Chinese medicine with a high frequency of use were Baihuasheshecao (Hedyotis diffusa), Maorenshen (Actinidia valvata Dunn), Shishangbai (Selaginella doederleinii Hieron), Shijianchuan (Salvia chinensis Benth), Huangqi (Astragali Radix), Sanyeqing (Tetrastlgma hemsleyanum), Baimaoteng (HerbaSolani), Zhuling (Polyporus), Nvzhenzi (Ligustrum lucidum Ait) etc. Through the analysis of association rule, we find out the core prescription according to the support degree (10 %, 20 %, 30 %) and the confidence degree, and set the correlation degree to 8 and punishment degree to 2. Finally: The core prescription efficacy of the drug group was analyzed and the theoretical connotation of preventive treatment of disease was obtained. Conclusion: The core prescription of preventive treatment of disease is to clear up heat and detoxification on the basis of strengthening the spleen, replenishing qi and tonifying kidney. The use of blood supplements and yin tonics throughout the course is reduced during treatments. The treatments also pay attention to the function of spleen and stomach of lung cancer patients, and adjust heat and detoxification force according to different conditions of patients and pay attention to the relief of patients’ emotions.
Keywords	Data mining technology ; Lung cancer ; Help the right and remove evil spirits ; Association rules ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	TMR publishing group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Hui Zhang / Huihua Wang / Qing Zhang / Hui Wang / Yuhang Zhu / Fangfang Wang / Jun Lin / Jue Zhou / Fan Qu

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1387-

2023 Volume 1400

Abstract: ... Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has ...

Abstract	AbstractContext di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1.Objective To investigate the effects of BSTJFs on ovarian granulosa cells exposed to DEHP and determine the potential molecular mechanisms.Methods and materials Human granulosa-like tumor cell line (KGN) cells were divided into control, DEHP, BSTJF1 and BSTJF2 groups. The DEHP group were given 1 μM DEHP for 24 h. They were then given BSTJF1 at 200 μg/mL or BSTJF2 at 100 μg/mL for 24 h. The control group was treated with the same concentration of DMSO (0.1%). Oxidative stress and mitochondrial function were measured. The mRNA and protein expression levels of HDAC3 and HSP90AA were determined. Integrative network pharmacology analysis of BSTJF2 was also performed.Results DEHP (1 μM) significantly suppressed the proliferation of KGN cells by 17%, significantly increased ROS levels by 28% and MDA levels by 47%, significantly decreased MMP levels by 22% and mtDNA copy by 30%. DEHP significantly increased protein expression of HDAC3 by 21%and HSP90AA by 64%. All these changes were significantly reversed by BSTJFs. Integrative network pharmacology analysis revealed HSP90AA was a key target (degree = 8). Both RGFP966 and BSTJF2 significantly reversed the increased expression of HDAC3 and HSP90AA, attenuated oxidative stress, and mitochondrial damage which were induced by DEHP.Conclusion BSTJFs might have therapeutic potential on oxidative stress and mitochondrial damage through the HDAC3/HSP90AA pathway which encourages further clinical trials.
Keywords	Endocrine-disrupting chemical ; reactive oxygen species ; integrative network pharmacology analysis ; Chinese herbal medicine ; Therapeutics. Pharmacology ; RM1-950
Subject code	571
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome

Xiaoming Pan / Yinger Gu / Xian Zhang / Biwei Shi / Long Cui / Fangfang Wang / Fan Qu

Integrative Medicine Research, Vol 11, Iss 1, Pp 100775- (2022)

A retrospective cohort study

2022

Abstract: ... cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF ...

Abstract	Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias.
Keywords	Anti-Müllerian hormone ; Chinese herbal medicine ; growth differentiation factor-8 ; in vitro fertilization ; polycystic ovary syndrome ; Miscellaneous systems and treatments ; RZ409.7-999
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time series-based PM2.5 concentration prediction in Jing-Jin-Ji area using machine learning algorithm models

Ma, Xin / Chen, Tengfei / Ge, Rubing / Cui, Caocao / Xu, Fan / Lv, Qi

Heliyon. 2022 Sept., v. 8, no. 9 p.e10691-

2022

Abstract: Globally all countries encounter air pollution problems along their development path. As a significant indicator of air quality, PM₂.₅ concentration has long been proven to be affecting the population's death rate. Machine learning algorithms proven to ... ...

Abstract	Globally all countries encounter air pollution problems along their development path. As a significant indicator of air quality, PM₂.₅ concentration has long been proven to be affecting the population's death rate. Machine learning algorithms proven to outperform traditional statistical approaches are widely used in air pollution prediction. However research on the model selection discussion and environmental interpretation of model prediction results is still scarce and urgently needed to lead the policy making on air pollution control. Our research compared four types of machine learning algorisms LinearSVR, K-Nearest Neighbor, Lasso regression, Gradient boosting by looking into their performance in predicting PM₂.₅ concentrations among different cities and seasons. The results show that the machine learning model is able to forecast the next day PM₂.₅ concentration based on the previous five days' data with better accuracy. The comparative experiments show that based on city level the Gradient Boosting prediction model has better prediction performance with mean absolute error (MAE) of 9 ug/m³ and root mean square error (RMSE) of 10.25-16.76 ug/m³, lower compared with the other three models, and based on season level four models have the best prediction performances in winter time and the worst in summer time. And more importantly the demonstration of models' different performances in each city and each season is of great significance in environmental policy implications.
Keywords	air pollution ; air pollution control ; air quality ; algorithms ; environmental policy ; models ; mortality ; prediction ; summer ; winter ; Jing-Jin-Ji city group ; PM2.5 prediction ; Lasso regression ; Gradient boosting ; Linear SVR ; K-Nearest Neighbor
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10691
Database	NAL-Catalogue (AGRICOLA)

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Article: Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: a retrospective cohort study.

Pan, Xiaoming / Gu, Yinger / Zhang, Xian / Shi, Biwei / Cui, Long / Wang, Fangfang / Qu, Fan

Integrative medicine research

2021 Volume 11, Issue 1, Page(s) 100775

Abstract: ... cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF ...

Abstract	Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias.
Language	English
Publishing date	2021-09-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2696588-4
ISSN	2213-4220
ISSN	2213-4220
DOI	10.1016/j.imr.2021.100775
Database	MEDical Literature Analysis and Retrieval System OnLINE

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