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Article ; Online: Use of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)-(Equine) (BAT

Parrera, Geraldine S / Astacio, Hugo / Tunga, Priya / Anderson, Deborah M / Hall, Christine L / Richardson, Jason S

2021 Volume 14, Issue 1

Abstract: Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. ... ...

Abstract	Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT
MeSH term(s)	Botulinum Antitoxin/adverse effects ; Botulism/chemically induced ; Botulism/therapy ; Humans
Chemical Substances	Botulinum Antitoxin
Language	English
Publishing date	2021-12-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Systematic Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins14010019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Measurement of the decay B(-) ---> D(*0)e(-)nu[overline](e).

Aubert, B / Bona, M / Karyotakis, Y / Lees, J P / Poireau, V / Prudent, X / Tisserand, V / Zghiche, A / Tico, J Garra / Grauges, E / Lopez, L / Palano, A / Pappagallo, M / Eigen, G / Stugu, B / Sun, L / Abrams, G S / Battaglia, M / Brown, D N /

Button-Shafer, J / Cahn, R N / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Osipenkov, I L / Ronan, M T / Tackmann, K / Tanabe, T / Wenzel, W A / Del Amo Sanchez, P / Hawkes, C M / Soni, N / Watson, A T / Koch, H / Schroeder, T / Walker, D / Asgeirsson, D J / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Mattison, T S / McKenna, J A / Barrett, M / Khan, A / Saleem, M / Teodorescu, L / Blinov, V E / Bukin, A D / Buzykaev, A R / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Todyshev, K Yu / Bondioli, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Martin, E C / Stoker, D P / Abachi, S / Buchanan, C / Gary, J W / Liu, F / Long, O / Shen, B C / Vitug, G M / Zhang, L / Paar, H P / Rahatlou, S / Sharma, V / Campagnari, C / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Schalk, T / Schumm, B A / Seiden, A / Wilson, M G / Winstrom, L O / Chen, E / Cheng, C H / Doll, D A / Echenard, B / Fang, F / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Andreassen, R / Mancinelli, G / Meadows, B T / Mishra, K / Sokoloff, M D / Blanc, F / Bloom, P C / Ford, W T / Hirschauer, J F / Kreisel, A / Nagel, M / Nauenberg, U / Olivas, A / Smith, J G / Ulmer, K A / Wagner, S R / Ayad, R / Gabareen, A M / Soffer, A / Toki, W H / Wilson, R J / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Merkel, J / Petzold, A / Spaan, B / Wacker, K / Klose, V / Kobel, M J / Lacker, H M / Mader, W F / Nogowski, R / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Latour, E / Lombardo, V / Thiebaux, Ch / Verderi, M / Clark, P J / Gradl, W / Playfer, S / Robertson, A I / Watson, J E / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cecchi, A / Cibinetto, G / Franchini, P / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Santoro, V / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Chaisanguanthum, K S / Morii, M / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bard, D J / Dauncey, P D / Nash, J A / Vazquez, W Panduro / Tibbetts, M / Behera, P K / Chai, X / Charles, M J / Mallik, U / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gao, Y Y / Gritsan, A V / Guo, Z J / Lae, C K / Denig, A G / Fritsch, M / Schott, G / Arnaud, N / Béquilleux, J / D'Orazio, A / Davier, M / da Costa, J Firmino / Grosdidier, G / Höcker, A / Lepeltier, V / Le Diberder, F / Lutz, A M / Pruvot, S / Roudeau, P / Schune, M H / Serrano, J / Sordini, V / Stocchi, A / Wang, W F / Wormser, G / Lange, D J / Wright, D M / Bingham, I / Burke, J P / Chavez, C A / Fry, J R / Gabathuler, E / Gamet, R / Hutchcroft, D E / Payne, D J / Touramanis, C / Bevan, A J / George, K A / Di Lodovico, F / Sacco, R / Cowan, G / Flaecher, H U / Hopkins, D A / Paramesvaran, S / Salvatore, F / Wren, A C / Davis, C L / Barlow, N R / Barlow, R J / Chia, Y M / Edgar, C L / Lafferty, G D / West, T J / Yi, J I / Anderson, J / Chen, C / Jawahery, A / Roberts, D A / Simi, G / Tuggle, J M / Dallapiccola, C / Hertzbach, S S / Li, X / Moore, T B / Salvati, E / Saremi, S / Cowan, R / Dujmic, D / Fisher, P H / Koeneke, K / Sciolla, G / Spitznagel, M / Taylor, F / Yamamoto, R K / Zhao, M / McLachlin, S E / Patel, P M / Robertson, S H / Lazzaro, A / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Simard, M / Taras, P / Viaud, F B / Nicholson, H / De Nardo, G / Lista, L / Monorchio, D / Sciacca, C / Baak, M A / Raven, G / Snoek, H L / Jessop, C P / Knoepfel, K J / Losecco, J M / Benelli, G / Corwin, L A / Honscheid, K / Kagan, H / Kass, R / Morris, J P / Rahimi, A M / Regensburger, J J / Sekula, S J / Wong, Q K / Blount, N L / Brau, J / Frey, R / Igonkina, O / Kolb, J A / Lu, M / Rahmat, R / Sinev, N B / Strom, D / Strube, J / Torrence, E / Castelli, G / Gagliardi, N / Gaz, A / Margoni, M / Morandin, M / Pompili, A / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Voci, C / Ben-Haim, E / Briand, H / Calderini, G / Chauveau, J / David, P / Del Buono, L / de la Vaissière, Ch / Hamon, O / Leruste, Ph / Malclès, J / Ocariz, J / Perez, A / Prendki, J / Gladney, L / Biasini, M / Covarelli, R / Manoni, E / Angelini, C / Batignani, G / Bettarini, S / Carpinelli, M / Cenci, R / Cervelli, A / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Mazur, M A / Morganti, M / Neri, N / Paoloni, E / Rizzo, G / Walsh, J J / Biesiada, J / Lau, Y P / Pegna, D Lopes / Lu, C / Olsen, J / Smith, A J S / Telnov, A V / Baracchini, E / Cavoto, G / Del Re, D / Di Marco, E / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Jackson, P D / Mazzoni, M A / Morganti, S / Piredda, G / Polci, F / Renga, F / Voena, C / Ebert, M / Hartmann, T / Schröder, H / Waldi, R / Adye, T / Franek, B / Olaiya, E O / Roethel, W / Wilson, F F / Emery, S / Escalier, M / Gaidot, A / Ganzhur, S F / de Monchenault, G Hamel / Kozanecki, W / Vasseur, G / Yèche, Ch / Zito, M / Chen, X R / Liu, H / Park, W / Purohit, M V / White, R M / Wilson, J R / Allen, M T / Aston, D / Bartoldus, R / Bechtle, P / Claus, R / Coleman, J P / Convery, M R / Dingfelder, J C / Dorfan, J / Dubois-Felsmann, G P / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Graham, M T / Grenier, P / Hast, C / Innes, W R / Kaminski, J / Kelsey, M H / Kim, H / Kim, P / Kocian, M L / Leith, D W G S / Li, S / Luitz, S / Luth, V / Lynch, H L / Macfarlane, D B / Marsiske, H / Messner, R / Muller, D R / Nelson, S / O'Grady, C P / Ofte, I / Perazzo, A / Perl, M / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Snyder, A / Su, D / Sullivan, M K / Suzuki, K / Swain, S K / Thompson, J M / Va'vra, J / Wagner, A P / Weaver, M / Wisniewski, W J / Wittgen, M / Wright, D H / Wulsin, H W / Yarritu, A K / Yi, K / Young, C C / Ziegler, V / Burchat, P R / Edwards, A J / Majewski, S A / Miyashita, T S / Petersen, B A / Wilden, L / Ahmed, S / Alam, M S / Bula, R / Ernst, J A / Pan, B / Saeed, M A / Zain, S B / Spanier, S M / Wogsland, B J / Eckmann, R / Ritchie, J L / Ruland, A M / Schilling, C J / Schwitters, R F / Izen, J M / Lou, X C / Ye, S / Bianchi, F / Gamba, D / Pelliccioni, M / Bomben, M / Bosisio, L / Cartaro, C / Cossutti, F / Della Ricca, G / Lanceri, L / Vitale, L / Azzolini, V / Lopez-March, N / Martinez-Vidal, F / Milanes, D A / Oyanguren, A / Albert, J / Banerjee, Sw / Bhuyan, B / Hamano, K / Kowalewski, R / Nugent, I M / Roney, J M / Sobie, R J / Harrison, P F / Ilic, J / Latham, T E / Mohanty, G B / Band, H R / Chen, X / Dasu, S / Flood, K T / Hollar, J J / Kutter, P E / Pan, Y / Pierini, M / Prepost, R / Wu, S L / Neal, H

Physical review letters

2008 Volume 100, Issue 23, Page(s) 231803

Abstract: ... at the SLAC e(+)e(-) PEP-II storage rings, we reconstruct B(-) ---> D(*0)e(-)nu[overline](e) decays using ... 08, F(1)|V(cb)|=(35.9+/-0.6+/-1.4) x 10(-3), and B(B(-) --> D(*0)e(-)nu[overline](e))=(5.56+/-0.08+ ... on w, the dot product of the four velocities of B(-) and D(*0), and using the form factor description ...

Abstract	Using 226 x 10(6) BB[overline] events recorded on the Upsilon(4S) resonance with the BABAR detector at the SLAC e(+)e(-) PEP-II storage rings, we reconstruct B(-) ---> D(0)e(-)nu[overline](e) decays using the decay chain D(0) --> D(0)pi(0) and D(0)-->K(-)pi(+). From the dependence of their differential rate on w, the dot product of the four velocities of B(-) and D(0), and using the form factor description by Caprini et al. with the parameters F(1) and rhoA(1)(2), we obtain the results rhoA(1)(2) = 1.16+/-0.06+/-0.08, F(1)\|V(cb)\|=(35.9+/-0.6+/-1.4) x 10(-3), and B(B(-) --> D(0)e(-)nu[overline](e))=(5.56+/-0.08+/-0.41)%.
Language	English
Publishing date	2008-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.100.231803
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Article ; Online: Use of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine) (BAT ® ) in Clinical Study Subjects and Patients

Geraldine S. Parrera / Hugo Astacio / Priya Tunga / Deborah M. Anderson / Christine L. Hall / Jason S. Richardson

Toxins, Vol 14, Iss 19, p

A 15-Year Systematic Safety Review

2022 Volume 19

Abstract: ... Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine)) is an equine-derived heptavalent botulinum antitoxin ...

Abstract	Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT ® (Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine)) is an equine-derived heptavalent botulinum antitoxin indicated for the treatment of symptomatic botulism in adult and pediatric patients. This review assesses the cumulative safety profile for BAT product from 2006 to 2020, using data received from clinical studies, an expanded-access program, a post-licensure registry, spontaneous and literature reports. The adverse event (AE) incidence rate for BAT product was calculated conservatively using only BAT product exposures for individuals with a record (512) and was alternatively estimated using all BAT product exposure data, including post-licensure deployment information (1128). The most frequently reported BAT product-related AEs occurring in greater than 1% of the 512–1128 BAT product-exposed individuals were hypersensitivity, pyrexia, tachycardia, bradycardia, anaphylaxis, and blood pressure increase reported in 2.3–5.1%, 1.8–3.9%, 1.0–2.2%, 0.89–2.0%, 0.62–1.4%, and 0.62–1.4%, respectively. For patients properly managed in an intensive care setting, the advantages of BAT product appear to outweigh potential risks in patients due to morbidity and mortality of botulism. AEs of special interest, including bradycardia, hemodynamic instability, hypersensitivity, serum sickness, and febrile reactions in the registry, were specifically solicited.
Keywords	safety review ; equine-derived ; Botulism Antitoxin Heptavalent ; BAT product ; botulism ; Medicine ; R
Subject code	333
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Identity of antibody to hepatitis B e/1 antigen as an atypical rheumatoid factor.

Anderson-Visoná, K / Villarejos, V M

The Journal of infectious diseases

1980 Volume 141, Issue 5, Page(s) 603–608

Abstract: ... B e antigen were tested for precipitating specificities of the antibody and for rheumatoid factor ... Chronic carriers of hepatitis B surface antigen (HBsAg) who were positive for antibody to hepatitis ... with human IgG, but all were negative by the hemagglutination-RF test with rabbit IgG. Antibody to e/1 ...

Abstract	Chronic carriers of hepatitis B surface antigen (HBsAg) who were positive for antibody to hepatitis B e antigen were tested for precipitating specificities of the antibody and for rheumatoid factor (RF) over a two-year period. Twenty-one of 69 carriers were RF-positive by the latex-RF test with human IgG, but all were negative by the hemagglutination-RF test with rabbit IgG. Antibody to e/1 antigen was identified as an IgM antibody reactive in the latex-RF test, whereas antibody to e/2 antigen belonged to the IgG class and showed no RF reactivity. Antibody production seems to follow a sequential evolution: antibody to e/1 antigen appears early and that to e/2 antigen follows shortly thereafter. Antibody to e/2 antigen remains as the permanent antibody, whereas that to e/1 antigen sometimes disappears. The fact that antibody to e/1antigen is present only in certain chronic carriers of HBsAg would account for discrepancies in reported results of RF test in viral hepatitis.
MeSH term(s)	Antibodies, Viral ; Antibody Specificity ; Carrier State/immunology ; Epitopes ; Hepatitis B Antibodies ; Hepatitis B Antigens ; Hepatitis B Surface Antigens ; Humans ; Immunoglobulin M ; Rheumatoid Factor/immunology
Chemical Substances	Antibodies, Viral ; Epitopes ; Hepatitis B Antibodies ; Hepatitis B Antigens ; Hepatitis B Surface Antigens ; Immunoglobulin M ; Rheumatoid Factor (9009-79-4)
Language	English
Publishing date	1980-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/141.5.603
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Article ; Online: Effect of amino acids on transcription and translation of key genes in E. coli K and B grown at a steady state in minimal medium.

Baez, Antonino / Kumar, Amit / Sharma, Ashish K / Anderson, Eric D / Shiloach, Joseph

New biotechnology

2018 Volume 49, Page(s) 120–128

Abstract: ... of amino acids, E. coli B and K were grown at a steady state of 0.35 h ... Growing E. coli to high densities is a common strategy for biologicals production. The process is ...

Abstract	Growing E. coli to high densities is a common strategy for biologicals production. The process is implemented by using complex or minimal media with different feeding strategies. To understand the effect of amino acids, E. coli B and K were grown at a steady state of 0.35 h
MeSH term(s)	Amino Acids/pharmacology ; Bioreactors/microbiology ; Citric Acid Cycle/drug effects ; Culture Media/pharmacology ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Gene Expression Regulation, Bacterial/drug effects ; Gene Ontology ; Genes, Bacterial ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/genetics ; Proteomics ; Transcription, Genetic/drug effects ; Transcriptome/genetics
Chemical Substances	Amino Acids ; Culture Media
Language	English
Publishing date	2018-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2400836-9
ISSN	1876-4347 ; 1876-4347
ISSN (online)	1876-4347
ISSN	1876-4347
DOI	10.1016/j.nbt.2018.10.004
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Article ; Online: Managing epilepsy in austerity - Evaluating the utility and value of the epilepsy specialist nurse in an open access model of service delivery. Aneurin Bevan Epilepsy Specialist Team (A.B.E.S.T.).

John, Keri / Tailor, Sunil / Anderson, Joseph / Lawthom, Charlotte

Seizure

2019 Volume 65, Page(s) 98–100

Abstract: Purpose: Healthcare organisations in the UK primarily measure clinical activity from data collected on numbers of attendances at outpatient clinics, inpatient admissions and procedures performed etc. Telephone contacts with patients are not typically ... ...

Abstract	Purpose: Healthcare organisations in the UK primarily measure clinical activity from data collected on numbers of attendances at outpatient clinics, inpatient admissions and procedures performed etc. Telephone contacts with patients are not typically measured as clinical activity. This service evaluation examines the utility and value of the Epilepsy Specialist Nurse (ESN) within an innovative 'Open Access Model', giving a breakdown of clinical workload and outcomes. Methods: A retrospective service evaluation analysing all patient encounters made by the ESN and their outcomes, over a 3-month period from the 01/02/2017 to 30/04/2017. Results: During the 3-month data collection period there were 620 patient encounters with 251 different patients. Nurse-led clinic appointments and telephone calls were the two most common types of encounter. Eighteen percent of ESN time was spent on the phone directly addressing patient concerns (368 encounters). Of these calls, 72% led to prevention of a clinic appointment (268 appointments avoided) while only 22% needed a subsequent clinic appointment. The most common outcome of telephone encounters was 'medication management' (25%). Conclusions: The evaluation demonstrates that timely intervention by telephone reduces the need for outpatient appointments and leads to treatment changes being implemented quickly to address individual need.
MeSH term(s)	Access to Information ; Delivery of Health Care ; Electronic Health Records/statistics & numerical data ; Epilepsy/nursing ; Female ; Humans ; Male ; Nurse Clinicians/psychology ; Referral and Consultation ; Retrospective Studies ; Telephone
Language	English
Publishing date	2019-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2019.01.007
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Article ; Online: Inhibitory effects of ascorbic acid, vitamin E, and vitamin B-complex on the biological activities induced by Bothrops venom.

Oliveira, Carlos Henrique de Moura / Assaid Simão, Anderson / Marcussi, Silvana

Pharmaceutical biology

2016 Volume 54, Issue 5, Page(s) 845–852

Abstract: ... a vitamin complex, composed of ascorbic acid, vitamin E, and all the B-complex vitamins ... B. jararacussu, and B. alternatus snake venoms, and the hemagglutinating activity induced by B ... from B. alternatus (1:2.5 and 1:5, to vitamin complex and ascorbic acid) and B. moojeni (1:2.5 and 1:5 ...

Abstract	Context: Natural compounds have been widely studied with the aim of complementing antiophidic serum therapy. Objective: The present study evaluated the inhibitory potential of ascorbic acid and a vitamin complex, composed of ascorbic acid, vitamin E, and all the B-complex vitamins, on the biological activities induced by snake venoms. Material and methods: The effect of vitamins was evaluated on the phospholipase, proteolytic, coagulant, and fibrinogenolytic activities induced by Bothrops moojeni (Viperidae), B. jararacussu, and B. alternatus snake venoms, and the hemagglutinating activity induced by B. jararacussu venom. Results: The vitamin complex (1:5 and 1:10 ratios) totally inhibited the fibrinogenolytic activity and partially the phospholipase activity and proteolytic activity on azocasein induced by the evaluated venoms. Significant inhibition was observed in the coagulation of human plasma induced by venoms from B. alternatus (1:2.5 and 1:5, to vitamin complex and ascorbic acid) and B. moojeni (1:2.5 and 1:5, to vitamin complex and ascorbic acid). Ascorbic acid inhibited 100% of the proteolytic activities of B. moojeni and B. alternatus on azocasein, at 1:10 ratio, the effects of all the venoms on fibrinogen, the hemagglutinating activity of B. jararacussu venom, and also extended the plasma coagulation time induced by all venoms analyzed. Discussion and conclusion: The vitamins analyzed showed relevant in vitro inhibitory potential over the activities induced by Bothrops venoms, suggesting their interaction with toxins belonging to the phospholipase A2, protease, and lectin classes. The results can aid further research in clarifying the possible mechanisms of interaction between vitamins and snake enzymes.
MeSH term(s)	Adult ; Animals ; Ascorbic Acid/administration & dosage ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Bothrops ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Proteolysis/drug effects ; Viper Venoms/antagonists & inhibitors ; Viper Venoms/toxicity ; Vitamin B Complex/administration & dosage ; Vitamin E/administration & dosage ; Young Adult
Chemical Substances	Viper Venoms ; Vitamin B Complex (12001-76-2) ; Vitamin E (1406-18-4) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.3109/13880209.2015.1087038
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Article ; Online: Evaluation of Immunogenicity and Efficacy of Fasciola hepatica Tetraspanin 2 (TSP2) Fused to E. coli Heat-Labile Enterotoxin B Subunit LTB Adjuvant Following Intranasal Vaccination of Cattle

Gemma Zerna / Vignesh A. Rathinasamy / Hayley Toet / Glenn Anderson / Robert Dempster / Terry W. Spithill / Travis Beddoe

Vaccines, Vol 9, Iss 1213, p

2021 Volume 1213

Abstract: ... other trematode species. The Escherichia coli heat-labile enterotoxin’s B subunit (LTB) is a potent mucosal ...

Abstract	Fasciolosis, caused by the liver flukes Fasciola hepatica and F. gigantica, is an economically important and globally distributed zoonotic disease. Liver fluke infections in livestock cause significant losses in production and are of particular concern to regions where drug resistance is emerging. Antigens of the F. hepatica surface tegument represent promising vaccine candidates for controlling this disease. Tetraspanins are integral tegumental antigens that have shown partial protection as vaccine candidates against other trematode species. The Escherichia coli heat-labile enterotoxin’s B subunit (LTB) is a potent mucosal adjuvant capable of inducing an immune response to fused antigens. This study investigates the potential of F. hepatica tetraspanin 2 extracellular loop 2 (rFhTSP2) as a protective vaccine antigen and determines if fusion of FhTSP2 to LTB can enhance protection in cattle. Cattle were immunised subcutaneously with rFhTSP2 mixed in the Freund’s adjuvant and intranasally with rLTB-FhTSP2 in saline, accounting for equal molar ratios of tetraspanin in both groups. Vaccination with rFhTSP2 stimulated a strong specific serum IgG response, whereas there was no significant serum IgG response following rLTB-FhTSP2 intranasal vaccination. There was no substantial antigen specific serum IgA generated in all groups across the trial. Contrastingly, after the fluke challenge, a rise in antigen specific saliva IgA was observed in both vaccination groups on Day 42, with the rLTB-FhTSP2 vaccination group showing significant mucosal IgA production at Day 84. However, neither vaccine group showed a significant reduction of fluke burden nor faecal egg output. These results suggest that intranasal vaccination with rLTB-FhTSP2 does elicit a humoral mucosal response but further work is needed to evaluate if mucosal delivery of liver fluke antigens fused to LTB is a viable vaccine strategy.
Keywords	vaccine ; Fasciola hepatica ; LTB ; AB 5 toxin ; tetraspanin ; tegument membrane ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of amino acids on transcription and translation of key genes in E. coli K and B grown at a steady state in minimal medium

Baez, Antonino / Amit Kumar / Ashish K. Sharma / Eric D. Anderson / Joseph Shiloach

New biotechnology. 2019 Mar. 25, v. 49

2019

Abstract: ... of amino acids, E. coli B and K were grown at a steady state of 0.35 h−1 in glucose minimal medium with and ... proteins involved in amino acid biosynthesis than E. coli B. These findings are correlated with higher ... biosynthesis in E. coli B or Yx/s and qx, which were higher than those of E. coli K, suggesting ...

Abstract	Growing E. coli to high densities is a common strategy for biologicals production. The process is implemented by using complex or minimal media with different feeding strategies. To understand the effect of amino acids, E. coli B and K were grown at a steady state of 0.35 h−1 in glucose minimal medium with and without amino acids, while their metabolism, protein abundance and gene expression were compared. The results showed that amino acids promoted higher acetate excretion, higher fatty acid biosynthesis (K strain), repressed glucose uptake rate, and decreased expression of proteins associated with the TCA cycle, glyoxylate shunt and amino acid biosynthesis. In presence of amino acids, E. coli K upregulated fatty acid biosynthesis and repressed more genes and proteins involved in amino acid biosynthesis than E. coli B. These findings are correlated with higher yield on glucose (Yx/s) and high specific biomass production rate (qx) in K strain in the presence of amino acids. In contrast, pre-formed precursor molecules such as amino acids did not affect fatty acid biosynthesis in E. coli B or Yx/s and qx, which were higher than those of E. coli K, suggesting that constitutive synthesis of energetically demanding precursors and higher fatty acid β-oxidation activity is key for high biomass-performer E. coli B. Both strains turned off unnecessary pathways and directed their metabolism to proteome efficient overflow metabolism likely to generate energy and provide protein to functions supporting higher growth rate.
Keywords	acetates ; amino acids ; beta oxidation ; biomass production ; biosynthesis ; energy ; Escherichia coli ; excretion ; fatty acids ; feeding methods ; gene expression ; gene expression regulation ; genes ; glucose ; glyoxylate cycle ; proteins ; proteome ; transcription (genetics) ; translation (genetics) ; tricarboxylic acid cycle
Language	English
Dates of publication	2019-0325
Size	p. 120-128.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2400836-9
ISSN	1876-4347 ; 1871-6784
ISSN (online)	1876-4347
ISSN	1871-6784
DOI	10.1016/j.nbt.2018.10.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inhibition of proteases and phospholipases A2 from Bothrops atrox and Crotalus durissus terrificus snake venoms by ascorbic acid, vitamin E, and B-complex vitamins.

Oliveira, Carlos H M / Simão, Anderson A / Trento, Marcus V C / César, Pedro H S / Marcussi, Silvana

Anais da Academia Brasileira de Ciencias

2016 Volume 88, Issue 3 Suppl, Page(s) 2005–2016

Abstract: ... thrombolysis induced by B. atrox and fibrinogenolysis induced by both venoms. It is suggested the presence ... regions present in the enzymes and vitamin E, as well as the inhibitions exercised by antioxidant ...

Abstract	The enzyme inhibition by natural and/ or low-cost compounds may represent a valuable adjunct to traditional serotherapy performed in cases of snakebite, mainly with a view to mitigate the local effects of envenoming. The objective of this study was to evaluate possible interactions between vitamins and enzymes that comprise Bothrops atrox and Crotalus durissus terrificus venoms, in vitro. Proteolysis inhibition assays (substrates: azocasein, collagen, gelatin and fibrinogen), hemolysis, coagulation, hemagglutination were carried out using different proportions of vitamins in face of to inhibit minimum effective dose of each venom. The vitamins were responsible for reducing 100% of breaking azocasein by C.d.t. venom, thrombolysis induced by B. atrox and fibrinogenolysis induced by both venoms. It is suggested the presence of interactions between vitamin and the active site of enzymes, for example the interactions between hydrophobic regions present in the enzymes and vitamin E, as well as the inhibitions exercised by antioxidant mechanism.
Language	English
Publishing date	2016
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765201620160030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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