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Article: External knowledge sourcing for R&D activities

Riccobono, Francesca / Bruccoleri, Manfredi / Perrone, Giovanni

Technology analysis & strategic management Vol. 27, No. 2 , p. 142-160

antecedents and implications of governance mode choice

2015 Volume 27, Issue 2, Page(s) 142–160

Author's details	Francesca Riccobono, Manfredi Bruccoleri and Giovanni Perrone
Keywords	external knowledge sourcing ; alliances and joint ventures ; mergers and acquisitions ; innovative performance ; contingency approach
Language	English
Publisher	Routledge, Taylor & Francis
Publishing place	Abingdon, Oxfordshire
Document type	Article
ZDB-ID	32138-2
ISSN	0953-7325
Database	ECONomics Information System

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Article ; Online: Reply to Anwar R. Padhani, Ivo G. Schoots, Jelle O. Barentsz. Fast Magnetic Resonance Imaging as a Viable Method for Directing the Prostate Cancer Diagnostic Pathway. Eur Urol Oncol 2021;4:863-5: Fast-MRI Feasibility in Biopsy-naïve Patients: Clarifications on the Study Methods and Results.

Russo, Filippo / Mazzetti, Simone / Regge, Daniele / Ambrosini, Ilaria / Giannini, Valentina / Manfredi, Matteo / De Luca, Stefano / Bollito, Enrico / Porpiglia, Francesco

European urology oncology

2021 Volume 4, Issue 6, Page(s) 866–867

MeSH term(s)	Biopsy ; Feasibility Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms/diagnostic imaging ; Research Design
Language	English
Publishing date	2021-07-24
Publishing country	Netherlands
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2021.06.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A French validation study of the Coma Recovery Scale-Revised (CRS-R).

Schnakers, Caroline / Majerus, Steve / Giacino, Joseph / Vanhaudenhuyse, Audrey / Bruno, Marie-Aurelie / Boly, Melanie / Moonen, Gustave / Damas, Pierre / Lambermont, Bernard / Lamy, Maurice / Damas, Francois / Ventura, Manfredi / Laureys, Steven

Brain injury

2008 Volume 22, Issue 10, Page(s) 786–792

Abstract: ... CRS-R) as compared to other coma scales such as the Glasgow Coma Scale (GCS), the Full Outline ... Twenty-four clinicians with different professional backgrounds, levels of expertise and CRS-R experience ... was obtained between the CRS-R and the three other standardized behavioural scales. Inter-rater ...

Abstract	Primary objective: The aim of the present study was to explore the concurrent validity, inter-rater agreement and diagnostic sensitivity of a French adaptation of the Coma Recovery Scale-Revised (CRS-R) as compared to other coma scales such as the Glasgow Coma Scale (GCS), the Full Outline of UnResponsiveness scale (FOUR) and the Wessex Head Injury Matrix (WHIM). Research design: Multi-centric prospective study. Method and procedures: To test concurrent validity and diagnostic sensitivity, the four behavioural scales were administered in a randomized order in 77 vegetative and minimally conscious patients. Twenty-four clinicians with different professional backgrounds, levels of expertise and CRS-R experience were recruited to assess inter-rater agreement. Main outcomes and results: Good concurrent validity was obtained between the CRS-R and the three other standardized behavioural scales. Inter-rater reliability for the CRS-R total score and sub-scores was good, indicating that the scale yields reproducible findings across examiners and does not appear to be systematically biased by profession, level of expertise or CRS-R experience. Finally, the CRS-R demonstrated a significantly higher sensitivity to detect MCS patients, as compared to the GCS, the FOUR and the WHIM. Conclusion: The results show that the French version of the CRS-R is a valid and sensitive scale which can be used in severely brain damaged patients by all members of the medical staff.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain Damage, Chronic/diagnosis ; Brain Injuries/diagnosis ; Coma/diagnosis ; Consciousness/physiology ; Diagnosis, Differential ; Female ; Humans ; Language ; Male ; Middle Aged ; Monitoring, Physiologic ; Observer Variation ; Persistent Vegetative State/diagnosis ; Prognosis ; Prospective Studies ; Recovery of Function/physiology ; Sensitivity and Specificity ; Trauma Severity Indices
Language	English
Publishing date	2008-09
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699050802403557
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Magnetic resonance cholangiopancreatograpy (MRCP)

Manfredi, Riccardo / Mucelli, Roberto Pozzi

biliary and pancreatic ducts

2013

Author's details	Riccardo Manfredi ; Roberto Pozzi Mucelli
Language	English
Size	XIV, 207 S. : zahlr. Ill.
Publisher	Springer
Publishing place	Milan u.a.
Publishing country	Italy
Document type	Book
HBZ-ID	HT017532749
ISBN	978-88-470-2843-2 ; 88-470-2843-4 ; 9788847028449 ; 8847028442
Database	Catalogue ZB MED Medicine, Health

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2012 A 5107	order for loan	Magazin

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Article: The aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF-1024) displays cardioprotection in postischemic ventricular dysfunction of the rat heart.

Rossoni, Giuseppe / Manfredi, Barbara / Cavalca, Viviana / Razzetti, Roberta / Bongrani, Stefano / Polvani, Gian Luca / Berti, Ferruccio

The Journal of pharmacology and experimental therapeutics

2003 Volume 307, Issue 2, Page(s) 633–639

Abstract: To analyze the protective effects of the aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2 ...

Abstract	To analyze the protective effects of the aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF-1024), a compound endowed with DA2-dopaminergic/alpha2-adrenergic receptor agonistic activity, in myocardial ischemia/reperfusion damage. A model of isolated and perfused (15 ml/min) electrically driven (300 beats/min) rat heart subjected to global ischemia (1 ml/min for 20 min) and reperfusion (15 ml/min for 30 min) was followed. Cardiac mechanics changes were evaluated together with biochemical markers of cardiac ischemia in perfusate and tissue tumor necrosis factor-alpha (TNF-alpha). CHF-1024, perfused through the heart for 15 min before ischemia at different molar concentrations (1-100 nM), significantly improved left ventricle developed pressure during reperfusion, and normalized left ventricular end-diastolic pressure and coronary perfusion pressure. This anti-ischemic effect of CHF-1024 was associated to a decrease in creatine kinase and lactate dehydrogenase, both released during heart reperfusion. These events were concomitant with maintenance of a higher production of 6-keto-prostaglandin F1alpha The ability of CHF-1024 to improve postischemic ventricular dysfunction was correlated with a dose-dependent inhibition of the release of both norepinephrine (NE), from sympathetic nerve endings, and TNF-alpha from cardiac tissue. The effect of CHF-1024 on NE release was almost completely antagonized by specific antagonists of presynaptic inhibitory receptors domperidone and rauwolscine. The finding that this new aminotetraline derivative possesses anti-ischemic properties and limits NE release from cardiac nerve endings may bear some therapeutic potential in cardiovascular diseases.
MeSH term(s)	Animals ; Cardiotonic Agents/therapeutic use ; Creatine Kinase/metabolism ; Epoprostenol/metabolism ; Heart/drug effects ; L-Lactate Dehydrogenase/metabolism ; Male ; Myocardial Ischemia/complications ; Myocardial Reperfusion ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/prevention & control ; Myocardium/metabolism ; Norepinephrine/metabolism ; Rats ; Rats, Wistar ; Tetrahydronaphthalenes/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism ; Ventricular Dysfunction/etiology ; Ventricular Dysfunction/prevention & control
Chemical Substances	Cardiotonic Agents ; Tetrahydronaphthalenes ; Tumor Necrosis Factor-alpha ; Epoprostenol (DCR9Z582X0) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Creatine Kinase (EC 2.7.3.2) ; CHF 1024 (HPH2L3QA2F) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2003-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.103.054700
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Article ; Online: Logical entropy – special issue

Manfredi Giovanni

4 open, Vol 5, p E

2022 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Logical entropy and negative probabilities in quantum mechanics

Manfredi Giovanni

4 open, Vol 5, p

2022 Volume 8

Abstract: The concept of Logical Entropy, SL = 1-Σni=1 pi2 SL=1-∑i=1npi2$ {S}_{\mathrm{L}}=1-{\sum }_{i=1}^n {p}_i^2$, where the pi are normalized probabilities, was introduced by David Ellerman in a series of recent papers. Although the mathematical formula ... ...

Abstract	The concept of Logical Entropy, SL = 1-Σni=1 pi2 SL=1-∑i=1npi2$ {S}_{\mathrm{L}}=1-{\sum }_{i=1}^n {p}_i^2$, where the pi are normalized probabilities, was introduced by David Ellerman in a series of recent papers. Although the mathematical formula itself is not new, Ellerman provided a sound probabilistic interpretation of SL as a measure of the distinctions of a partition on a given set. The same formula comes across as a useful definition of entropy in quantum mechanics, where it is linked to the notion of purity of a quantum state. The quadratic form of the logical entropy lends itself to a generalization of the probabilities that include negative values, an idea that goes back to Feynman and Wigner. Here, we analyze and reinterpret negative probabilities in the light of the concept of logical entropy. Several intriguing quantum-like properties of the logical entropy are derived and discussed in finite dimensional spaces. For infinite-dimensional spaces (continuum), we show that, under the sole hypothesis that the logical entropy and the total probability are preserved in time, one obtains an evolution equation for the probability density that is basically identical to the quantum evolution of the Wigner function in phase space, at least when one considers only the momentum variable. This result suggest that the logical entropy plays a profound role in establishing the peculiar rules of quantum physics.
Keywords	entropy ; negative probabilities ; quantum physics ; wigner functions ; Medicine ; R ; Science ; Q
Subject code	160
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Benefits, Risks and Gender Differences in Sport, and Exercise Dependence

Paola Manfredi

International Journal of Environmental Research and Public Health, Vol 19, Iss 5288, p

Key Role of Alexithymia

2022 Volume 5288

Abstract: The literature has long highlighted the benefits of sport, but too much sport could indicate a dependence without a substance, namely exercise dependence. The literature has only recently investigated this issue and therefore several questions are open, ... ...

Abstract	The literature has long highlighted the benefits of sport, but too much sport could indicate a dependence without a substance, namely exercise dependence. The literature has only recently investigated this issue and therefore several questions are open, particularly with regard to psychopathological significance and gender differences. The aim of this paper is to investigate whether young subjects (M = 20 years) with a risk of exercise dependency and non-dependent symptomatic display other behavioural and psychological suffering and discomforts, or whether such an investment in physical activity is compatible with a framework of relative well-being; and if there are differences related to gender. A total of 396 subjects were involved in this study. Exercise Dependence Scale, Toronto Alexithymia Scale, Subjective Happiness Scale, Satisfaction with Life Scale and an ad hoc questionnaire with information relating to the consumption of alcohol, soft and hard drugs, quality of sleep and nutrition, affective and friendship relationships, hobbies, presence of psychological or physical disorders, motivations for sporting activity, and any traumatic experiences were used. With regard to the Exercise Dependence Scale (EDS), the prevalence of subjects at risk of exercise dependence was 1.5% and that of non-dependents symptomatic was 31.3%. Considering only men, the percentage of subjects at risk of exercise dependence rose to 3% and that of non-dependents symptomatic to 47.9%. Our data support the hypothesis that the risk of exercise dependence and the symptomatic condition without dependence can occur in situations of relative well-being (happiness, satisfaction, relationships) without significant associations with other problematic behaviours. Modest consumption of soft drugs is reported in non-dependent symptomatic subjects. The hypothesis of increased levels of alexithymia is confirmed but limited to the male gender. Gender differences are confirmed in the frequency and motivation to practice sport and in the risk of ...
Keywords	sport ; exercise dependence ; alexithymia ; gender differences ; young adults ; well-being ; Medicine ; R
Subject code	796
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Editorial Comment.

Manfredi, Celeste / Autorino, Riccardo

Urology practice

2023 Volume 10, Issue 6, Page(s) 619–620

Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2352-0787
ISSN (online)	2352-0787
DOI	10.1097/UPJ.0000000000000435.01
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel antioxidant agents deriving from molecular combinations of vitamins C and E analogues: 3,4-dihydroxy-5(R).

Manfredini, S / Vertuani, S / Manfredi, B / Rossoni, G / Calviello, G / Palozza, P

Bioorganic & medicinal chemistry

2000 Volume 8, Issue 12, Page(s) 2791–2801

Abstract: ... malondialdehyde (MDA) production in rat liver microsomal membranes, the 3,4-dihydroxy-5R-2(R,S)-(6-hydroxy-2,5,7,8 ... tetramethylchroman-2(R,S)yl-methyl)-1,3]dioxolan-4S-yl]-5H-furan-2-one (11a-d), exhibited an interesting activity ...

Abstract	Molecular combinations of two antioxidants (i.e., ascorbic acid and the pharmacophore of alpha-tocopherol), namely the 2,3-dihydroxy-2,3-enono-1,4-lactone and the chromane residues, have been designed and tested for their radical scavenging activities. When evaluated for their capability to inhibit malondialdehyde (MDA) production in rat liver microsomal membranes, the 3,4-dihydroxy-5R-2(R,S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2(R,S)yl-methyl)-1,3]dioxolan-4S-yl]-5H-furan-2-one (11a-d), exhibited an interesting activity. In particular the 5R,2R,2R,4S and 5R,2R,2S,4S isomers (11c,d) displayed a potent antioxidant effect compared to the respective synthetic alpha-tocopherol analogue (5) and natural alpha-tocopherol or ascorbic acid, used alone or in combination. Moreover, the mixture of stereoisomers 11a-d also proved to be effective in preventing damage induced by reperfusion on isolated rabbit heart, in particular at the higher concentration of 300 microM. In view of these results our study represents a new approach to potential therapeutic agents for applications in pathological events in which a free radical damage is involved. Design, synthesis and preliminary biological activity are discussed.
MeSH term(s)	Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Ascorbic Acid/analogs & derivatives ; Ascorbic Acid/chemistry ; Ascorbic Acid/pharmacology ; Creatine Kinase/metabolism ; Drug Stability ; In Vitro Techniques ; Lipid Peroxidation/drug effects ; Malondialdehyde/metabolism ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Myocardial Reperfusion Injury/enzymology ; Myocardial Reperfusion Injury/prevention & control ; Rabbits ; Rats ; Rats, Wistar ; Stereoisomerism ; Structure-Activity Relationship ; Vitamin E/analogs & derivatives ; Vitamin E/chemistry ; Vitamin E/pharmacology
Chemical Substances	Antioxidants ; Vitamin E (1406-18-4) ; Malondialdehyde (4Y8F71G49Q) ; Creatine Kinase (EC 2.7.3.2) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2000-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/s0968-0896(00)00205-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3815: Show issues

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