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  1. Article ; Online: Sincerely, a black primatologist: An open letter to biological anthropologists highlighting the experiences of a black primatologist.

    Wilson, Thomas C

    American journal of biological anthropology

    2023  Volume 180, Issue 3, Page(s) 423–426

    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2692-7691
    ISSN (online) 2692-7691
    DOI 10.1002/ajpa.24687
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  2. Article ; Online: A Novel Discriminating Tool for Microcytic Anemia in Childhood.

    Ogino, Jayme / Wilson, Melissa L / Hofstra, Thomas C / Chan, Randall Y

    Clinical pediatrics

    2024  , Page(s) 99228231221330

    Abstract: Accurate and timely interpretation of microcytic anemia can be diagnostically challenging in the primary care setting. We sought to develop a novel model for distinguishing iron-deficiency anemia from thalassemia trait in the modern pediatric population. ...

    Abstract Accurate and timely interpretation of microcytic anemia can be diagnostically challenging in the primary care setting. We sought to develop a novel model for distinguishing iron-deficiency anemia from thalassemia trait in the modern pediatric population. Demographic history and red blood cell indices were retrospectively characterized for 76 children referred to our pediatric hematology clinic for evaluation of microcytic anemia. Statistically significant variables were sequentially added into a logistic regression model to develop the final model. The final discriminating model incorporates red cell distribution width, mean corpuscular hemoglobin concentration, and red blood cell values. Favorable predictive performance is seen in the initial (sensitivity 89.2%, specificity 92.3%) and external validation cohort (sensitivity 84.4%, specificity 88.9%). This novel tool may aid in determining the cause of hypochromic, microcytic anemia in the primary care setting. Finally, the study cohort reflects an underrepresented group in the development of screening tools, and thus offers generalizability.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228231221330
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  3. Article ; Online: Environmental regulation of male fertility is mediated through Arabidopsis transcription factors bHLH89, 91, and 10.

    Robson, Jordan K / Tidy, Alison C / Thomas, Stephen G / Wilson, Zoe A

    Journal of experimental botany

    2023  Volume 75, Issue 7, Page(s) 1934–1947

    Abstract: Formation of functional pollen and successful fertilization rely on the spatial and temporal regulation of anther and pollen development. This process responds to environmental cues to maintain optimal fertility despite climatic changes. Arabidopsis ... ...

    Abstract Formation of functional pollen and successful fertilization rely on the spatial and temporal regulation of anther and pollen development. This process responds to environmental cues to maintain optimal fertility despite climatic changes. Arabidopsis transcription factors basic helix-loop-helix (bHLH) 10, 89, and 91 were previously thought to be functionally redundant in their control of male reproductive development, however here we show that they play distinct roles in the integration of light signals to maintain pollen development under different environmental conditions. Combinations of the double and triple bHLH10,89,91 mutants were analysed under normal (200 μmol m-2 s-1) and low (50 μmol m-2 s-1) light conditions to determine the impact on fertility. Transcriptomic analysis of a new conditionally sterile bhlh89,91 double mutant shows differential regulation of genes related to sexual reproduction, hormone signal transduction, and lipid storage and metabolism under low light. Here we have shown that bHLH89 and bHLH91 play a role in regulating fertility in response to light, suggesting that they function in mitigating environmental variation to ensure fertility is maintained under environmental stress.
    MeSH term(s) Transcription Factors/metabolism ; Arabidopsis/genetics ; Arabidopsis Proteins/metabolism ; Fertility/genetics ; Reproduction ; Gene Expression Regulation, Plant ; Flowers
    Chemical Substances Transcription Factors ; Arabidopsis Proteins
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erad480
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  4. Article ; Online: Thrombolysis for ischaemic stroke despite direct oral anticoagulation.

    Purrucker, Jan C / Meinel, Thomas R / Wilson, Duncan / Xian, Ying / Wu, Teddy Y / Seiffge, David J

    Stroke and vascular neurology

    2024  

    Abstract: Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of ... ...

    Abstract Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Editorial
    ISSN 2059-8696
    ISSN (online) 2059-8696
    DOI 10.1136/svn-2023-002727
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  5. Article ; Online: Building a Roadmap to Health Equity: Strengthening Public Health Infrastructure in Indian Country.

    Reece, Julianna / Skelton-Wilson, Syreeta / Mitchell-Box, Kristen / Groom, Amy / Thomas, Craig

    Public health reports (Washington, D.C. : 1974)

    2023  Volume 138, Issue 2_suppl, Page(s) 7S–13S

    MeSH term(s) Humans ; Health Equity ; Public Health ; Indians, North American ; Community-Based Participatory Research
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/00333549231186579
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  6. Article ; Online: Auger: The future of precision medicine.

    Pirovano, Giacomo / Wilson, Thomas C / Reiner, Thomas

    Nuclear medicine and biology

    2021  Volume 96-97, Page(s) 50–53

    Abstract: First reported by Lise Meitner in 1922 and independently by Pierre Auger in 1923, the Auger effect has been explored as a potential source for targeted radiotherapy. The Auger effect is based on the emission of a low energy electron (typically <25 keV) ... ...

    Abstract First reported by Lise Meitner in 1922 and independently by Pierre Auger in 1923, the Auger effect has been explored as a potential source for targeted radiotherapy. The Auger effect is based on the emission of a low energy electron (typically <25 keV) from an atom post electron capture (EC), internal conversion (IC), or incident X-rays excitation. This phenomenon can cause the emission of a primary electron and multiple electron tracks typically in the nearest proximity of the emission site (2-500 nm). The short range of the emitted Auger cascade results in medium/high levels of linear energy transfer (4-26 keV/μm) exerted on the surrounding tissue. This property makes Auger emitters the ideal candidates for delivering high levels of targeted radiation to a specific target with dimensions comparable to, for example, the DNA. By using a targeting vector such as a small molecule, peptide or antibody, one has the potential of delivering high levels of radiation to tumor specific biomarkers while circumventing off-site toxicity in healthy cells; a challenge which is harder to overcome when using other, longer range sources of radiation such as beta and alpha emitting radionuclides. Several reviews on Auger emitters have been published over the years with two recent examples. For these reviews and others, we support their analysis and therefore to avoid simple repetition, this commentary will seek to address additional aspects and viewpoints. Specifically, we will focus on those most promising preclinical and clinical studies using small molecules, peptides, antibodies and how these studies may serve as a template for future studies.
    MeSH term(s) Computer Simulation ; Linear Energy Transfer ; Precision Medicine
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2021.03.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1090: Show issues Location:
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  7. Article ; Online: "Letting die" by design: Asylum seekers' lived experience of postcolonial necropolitics.

    Wilson, Brenda K / Burnstan, Alexis / Calderon, Cristina / And / Csordas, Thomas J

    Social science & medicine (1982)

    2023  Volume 320, Page(s) 115714

    Abstract: Although the United States has been a nation of immigrants since its founding, the massive number of asylum seekers arriving at the US-Mexico Border is a relatively new phenomenon that requires attention and study. This paper describes the lived ... ...

    Abstract Although the United States has been a nation of immigrants since its founding, the massive number of asylum seekers arriving at the US-Mexico Border is a relatively new phenomenon that requires attention and study. This paper describes the lived experience of three asylum seekers, demonstrating how physical and mental health are structured by US policies and politics. The in-depth accounts are informed by participant observation and policy analysis of humanitarian, non-governmental organizations advocating for asylum seekers. We focus on health and geographical trajectories using the triple trauma paradigm that includes trauma in the country of origin, trauma incurred during transit/flight, and the trauma of arrival and relocation/resettlement in the host country. We suggest that a form of necropower, understood as processes exacerbating the potentiality for death, is embedded in the structure of the US asylum apparatus.
    MeSH term(s) Humans ; Refugees/psychology ; Mental Health ; Emigrants and Immigrants ; Policy ; Mexico
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.115714
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    Zs.A 625: Show issues Location:
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  8. Article: Dietary Oxidized Linoleic Acids Modulate Fatty Acids in Mice.

    Ochin, Chinedu C / Wilson, Thomas / Garelnabi, Mahdi

    Journal of lipid and atherosclerosis

    2022  Volume 11, Issue 2, Page(s) 197–210

    Abstract: ... control (P group, n =10), Chow supplemented with linoleic acid 9 mg/mouse/day, linoleic control (C group ... 10%, 16% and 58%) for the P, C, A and B groups respectively.: Conclusion: The sustained ...

    Abstract Objective: An elevated concentration of oxidized lipids along with the abnormal accumulation of lipids has been linked to the formation of atheromatous plaque and the development of cardiovascular diseases. This study aims to investigate if consumption of different concentrations of dietary oxidized linoleic acid alters the distribution of long chain fatty acids (LCFAs) within the liver relative to plasma in mice.
    Methods: C57BL/6 male mice (n = 40) were divided into 4 groups: Standard chow as plain control (P group, n =10), Chow supplemented with linoleic acid 9 mg/mouse/day, linoleic control (C group, n=0), oxidized linoleic acid; 9 mg/mouse/day (A group, n=10) and oxidized linoleic acid 18 mg/mouse/day diet (B group, n=10). Liver and plasma samples were extracted, trans-esterified and subsequently analyzed using gas chromatography mass spectrometry (GC-MS) for LCFAs; palmitic acid, stearic acid, oleic acid, linoleic acid and arachidonic acid.
    Results: LCFA methyl esters were eluted and identified based on their respective physiochemical characteristics of GCMS assay with inter assay coefficient of variation percentage (CV%, 1.81-5.28%), limits of quantification and limit of detection values (2.021-11.402 mg/mL and 1.016-4.430 mg/mL) respectively. Correlation analysis of liver and plasma lipids of the mice groups yielded coefficients (r=0.96, 0.6, 0.8 and 0.33) with fatty acid percentage total of (16%, 10%, 16% and 58%) for the P, C, A and B groups respectively.
    Conclusion: The sustained consumption of a diet rich in oxidized linoleic acid disrupted fatty acid metabolism. The intake also resulted in elevated concentration of LCFAs that are precursors of bioactive metabolite molecule.
    Language English
    Publishing date 2022-04-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3016001-7
    ISSN 2288-2561 ; 2287-2892
    ISSN (online) 2288-2561
    ISSN 2287-2892
    DOI 10.12997/jla.2022.11.2.197
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  9. Article ; Online: A one-pot radiosynthesis of [

    Wilson, Thomas C / Pillarsetty, Nagavarakishore / Reiner, Thomas

    Journal of labelled compounds & radiopharmaceuticals

    2020  Volume 63, Issue 9, Page(s) 419–425

    Abstract: In this paper, we disclose a new strategy for the radiosynthesis of [ ...

    Abstract In this paper, we disclose a new strategy for the radiosynthesis of [
    MeSH term(s) Chemistry Techniques, Synthetic ; Fluorine Radioisotopes/chemistry ; Poly(ADP-ribose) Polymerase Inhibitors/chemical synthesis ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Poly(ADP-ribose) Polymerases/metabolism ; Radiochemistry
    Chemical Substances Fluorine Radioisotopes ; Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Fluorine-18 (GZ5I74KB8G)
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3847
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  10. Article ; Online: Response to Letter to the Editor Regarding "Cognitive-and-motor Therapy After Stroke Is Not Superior to Motor and Cognitive Therapy Alone to Improve Cognitive and Motor Outcomes: New Insights From a Meta-analysis".

    Embrechts, Elissa / McGuckian, Thomas B / Dijkerman, Chris H / Steenbergen, Bert / Wilson, Peter H / Nijboer, Tanja C W

    Archives of physical medicine and rehabilitation

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2024.01.011
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