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Article ; Online: Thalidomide for necrobiotic xanthogranuloma.

Ali, F R / Lear, J T

2021 Volume 47, Issue 4, Page(s) 769–770

MeSH term(s)	Dexamethasone ; Humans ; Necrobiotic Xanthogranuloma/diagnosis ; Necrobiotic Xanthogranuloma/drug therapy ; Thalidomide/therapeutic use
Chemical Substances	Thalidomide (4Z8R6ORS6L) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2021-12-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.15047
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Book ; Online: The Game of Tumbleweed is PSPACE-complete

Bahack, Lear

2022

Abstract: ... reduction from a Boolean formula game of T.J. Schaefer, known to be PSPACE-complete. We embed the non-planar ...

Abstract	Tumbleweed is a popular two-player perfect-information new territorial game played at the prestigious Mind Sport Olympiad. We define a generalized version of the game, where the board size is arbitrary and so is the possible number of neutral stones. Our result: the complexity of deciding for a given configuration which of the players has a winning strategy is PSPACE-complete. The proof is by a log-space reduction from a Boolean formula game of T.J. Schaefer, known to be PSPACE-complete. We embed the non-planar Schaefer game within the planar Tumbleweed board without using proper "bridges", that are impossible due to the board's topology. Instead, our new technique uses a one-move tight race that forces the players to move only according to the protocol of playing the embedded 4-CNF game.
Keywords	Computer Science - Computational Complexity ; Mathematics - Combinatorics
Publishing date	2022-06-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Sigmoid Sinus Diverticulum-A Unique Case of Pulsatile Tinnitus.

Spangler, Daniel J / McElveen, John T / McLear, Patrick W

Ear, nose, & throat journal

2022 , Page(s) 1455613221097197

Abstract: Sigmoid sinus diverticula are relatively rare but typically cause pulsatile tinnitus (PT) in the involved ear. Occasionally, symptoms produced by blood flowing through the diverticulum are severe enough to necessitate recontouring the sigmoid sinus. ... ...

Abstract	Sigmoid sinus diverticula are relatively rare but typically cause pulsatile tinnitus (PT) in the involved ear. Occasionally, symptoms produced by blood flowing through the diverticulum are severe enough to necessitate recontouring the sigmoid sinus. Recently, a 59-year-old female was evaluated after years of worsening unilateral PT. CT angiography identified a 5 mm sigmoid sinus diverticulum near the sinodural angle. Given the severity of symptoms, the patient's diverticulum was surgically decompressed and recontoured using hydroxyapatite bone cement.
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221097197
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Article ; Online: Suppressed or increased fetal heart rate variability: Which is more associated with intrapartum fetal compromise?

Lear, Christopher A / Nakao, Masahiro / Magawa, Shoichi / Ikeda, Tomoaki / Gunn, Alistair J

Acta obstetricia et gynecologica Scandinavica

2023 Volume 103, Issue 3, Page(s) 621–622

MeSH term(s)	Female ; Pregnancy ; Humans ; Heart Rate, Fetal ; Fetus ; Prenatal Care ; Parturition ; Fetal Monitoring ; Fetal Distress/diagnosis
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Letter
ZDB-ID	80019-3
ISSN	1600-0412 ; 0001-6349
ISSN (online)	1600-0412
ISSN	0001-6349
DOI	10.1111/aogs.14762
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Article ; Online: Bony Facial Trauma Score Predicts Clinical Outcomes in Facial Trauma.

Curran, Kent / De La Chapa, Julian / Weidman, Allan / Reddy, Adithya / Lear, Taylor / Oyer, Samuel

Facial plastic surgery & aesthetic medicine

2023 Volume 26, Issue 2, Page(s) 180–184

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Male ; Adult ; Female ; Facial Injuries/diagnosis ; Facial Injuries/surgery ; Multiple Trauma/diagnosis ; Retrospective Studies ; Length of Stay ; Malocclusion
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3006458-2
ISSN	2689-3622 ; 2689-3614
ISSN (online)	2689-3622
ISSN	2689-3614
DOI	10.1089/fpsam.2023.0049
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Zs.A 5869: Show issues

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Article: Agave distribution and floral display influence foraging rates of an endangered pollinating bat and implications for conservation.

Lear, Kristen M / Moore, Clinton T / King, Elizabeth G / Gómez-Ruiz, Emma / Flores Maldonado, Jose Juan / Ibarra Sanchez, Cuauhtemoc / Castañeda Aguilera, Ana / Prebyl, Thomas J / Hepinstall-Cymerman, Jeffrey

Ecology and evolution

2024 Volume 14, Issue 3, Page(s) e11125

Abstract: Wildlife conservation involves making management decisions with incomplete knowledge of ecological relationships. Efforts to augment foraging resources for the endangered Mexican long-nosed bat ( ...

Abstract	Wildlife conservation involves making management decisions with incomplete knowledge of ecological relationships. Efforts to augment foraging resources for the endangered Mexican long-nosed bat (
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.11125
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Article ; Online: Circadian patterns of heart rate variability in fetal sheep after hypoxia-ischaemia: A biomarker of evolving brain injury.

Lear, Christopher A / Maeda, Yoshiki / King, Victoria J / Dhillon, Simerdeep K / Beacom, Michael J / Gunning, Mark I / Lear, Benjamin A / Davidson, Joanne O / Stone, Peter R / Ikeda, Tomoaki / Gunn, Alistair J / Bennet, Laura

The Journal of physiology

2023

Abstract: Hypoxia-ischaemia (HI) before birth is a key risk factor for stillbirth and severe neurodevelopmental disability in survivors, including cerebral palsy, although there are no reliable biomarkers to detect at risk fetuses that may have suffered a ... ...

Abstract	Hypoxia-ischaemia (HI) before birth is a key risk factor for stillbirth and severe neurodevelopmental disability in survivors, including cerebral palsy, although there are no reliable biomarkers to detect at risk fetuses that may have suffered a transient period of severe HI. We investigated time and frequency domain measures of fetal heart rate variability (FHRV) for 3 weeks after HI in preterm fetal sheep at 0.7 gestation (equivalent to preterm humans) until 0.8 gestation (equivalent to term humans). We have previously shown that this is associated with delayed development of severe white and grey matter injury, including cystic white matter injury (WMI) resembling that observed in human preterm infants. HI was associated with suppression of time and frequency domain measures of FHRV and reduced their circadian rhythmicity during the first 3 days of recovery. By contrast, circadian rhythms of multiple measures of FHRV were exaggerated over the final 2 weeks of recovery, mediated by a greater reduction in FHRV during the morning nadir, but no change in the evening peak. These data suggest that the time of day at which FHRV measurements are taken affects their diagnostic utility. We further propose that circadian changes in FHRV may be a low-cost, easily applied biomarker of antenatal HI and evolving brain injury. KEY POINTS: Hypoxia-ischaemia (HI) before birth is a key risk factor for stillbirth and probably for disability in survivors, although there are no reliable biomarkers for antenatal brain injury. In preterm fetal sheep, acute HI that is known to lead to delayed development of severe white and grey matter injury over 3 weeks, was associated with early suppression of multiple time and frequency domain measures of fetal heart rate variability (FHRV) and loss of their circadian rhythms during the first 3 days after HI. Over the final 2 weeks of recovery after HI, exaggerated circadian rhythms of frequency domain FHRV measures were observed. The morning nadirs were lower with no change in the evening peak of FHRV. Circadian changes in FHRV may be a low-cost, easily applied biomarker of antenatal HI and evolving brain injury.
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP284560
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Article ; Online: Efficacy and safety of tirbanibulin 1% ointment in actinic keratoses: Data from two phase-III trials and the real-life clinical practice presented at the European Academy of Dermatology and Venereology Congress 2022.

Pellacani, G / Schlesinger, T / Bhatia, N / Berman, B / Lebwohl, M / Cohen, J L / Patel, G K / Kunstfeld, R / Hadshiew, I / Lear, J T

Journal of the European Academy of Dermatology and Venereology : JEADV

2023 Volume 38 Suppl 1, Page(s) 3–15

Abstract: ... the congress in which Dr. Hadshiew and Dr. Lear brought together their clinical experience in Germany and ...

Abstract	Background: The 31 Objectives: We report presented clinical data on the efficacy/effectiveness, safety and tolerability of tirbanibulin 1% ointment that has recently been licensed for actinic keratosis (AK) of the face or scalp in adults. Methods: Summary of presentations given at the EADV Congress. Results: Prof. Pellacani presented two post hoc analyses from two phase-III trials with AK patients (NCT03285477 [N = 351] and NCT03285490 [N = 351]): A descriptive analysis of medical history, concomitant medications, and safety results confirming a favourable profile for tirbanibulin showing that number of baseline AK lesions was not correlated to severity of local skin reactions. The latter analysis showed that cases of tirbanibulin application site pain or pruritus were few, and most were found to be mild. Prof. Kunstfeld reported six real-life clinical cases in Austria showing good tirbanibulin effectiveness, safety and tolerability for the treatment of new or recurring AK lesions. Results demonstrated that after 2- to 4-month follow-up, tirbanibulin was well tolerated and effective in AK patients. Presentations by Dr. Patel confirmed good outcomes and tolerability of tirbanibulin in Olsen grade 1-2 AK (N = 12) and porokeratosis patients (N = 4) treated once daily for 5 consecutive days in the United Kingdom. Furthermore, real-world experience in solid organ transplant recipients (N = 2) demonstrated effectiveness of tirbanibulin in skin field cancerization treatment. A symposium sponsored by Almirall was conducted during the congress in which Dr. Hadshiew and Dr. Lear brought together their clinical experience in Germany and the United Kingdom respectively. Interesting clinical cases of 5 consecutive days of tirbanibulin treatment compared to other treatments were discussed with attendees, as well as current treatment needs of AK patients. Conclusions: This article provides an overview of presentations and symposium discussions, summarizing key phase-III results and real-life clinical experience with tirbanibulin shared by dermatologists across Europe.
MeSH term(s)	Adult ; Humans ; Keratosis, Actinic/drug therapy ; Keratosis, Actinic/pathology ; Dermatology ; Ointments/therapeutic use ; Venereology ; Neoplasm Recurrence, Local ; Treatment Outcome
Chemical Substances	tirbanibulin ; Ointments
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Clinical Trial, Phase III ; Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19636
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The National Association of Medical Examiners Position Paper on the Investigation and Certification of Pediatric Deaths From Environmental Neglect.

Gill, James R / Christensen, Erik / Dennison, Emily H / Ely, Susan F / Gilson, Thomas / Keyes, Kelly / Lear, Kelly / Lucas, Jonathan / Mahar, Tara J / Quinton, Reade

The American journal of forensic medicine and pathology

2024 Volume 45, Issue 1, Page(s) e1–e4

Abstract: Abstract: Pediatric deaths that occur because of environmental neglect often involve 4 common scenarios: (1) hyperthermia due to environmental exposure, (2) ingestion of an accessible drug or poison, (3) unwitnessed/unsupervised drownings, and (4) ... ...

Abstract	Abstract: Pediatric deaths that occur because of environmental neglect often involve 4 common scenarios: (1) hyperthermia due to environmental exposure, (2) ingestion of an accessible drug or poison, (3) unwitnessed/unsupervised drownings, and (4) unsafe sleep practices. Given the same fact pattern, the manner of death will vary from accident to homicide to undetermined based on local custom and/or the certifier's training and experience. Medical examiner/coroner death certifications are administrative public health determinations made for vital statistical purposes. Because the manner of death is an opinion, it is understandable that manner determinations may vary among practitioners. No prosecutor, judge, or jury is bound by the opinions expressed on the death certificate. This position paper does not dictate how these deaths should be certified. Rather, it describes the challenges of the investigations and manner determinations in these deaths. It provides specific criteria that may improve consistency of certification. Because pediatric deaths often are of public interest, this paper provides the medical examiner/coroner with a professional overview of such manner determination issues to assist various stakeholders in understanding these challenges and variations.
MeSH term(s)	Child ; Humans ; Coroners and Medical Examiners ; Cause of Death ; Accidents ; Homicide ; Certification ; Death Certificates
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	604537-6
ISSN	1533-404X ; 0195-7910
ISSN (online)	1533-404X
ISSN	0195-7910
DOI	10.1097/PAF.0000000000000911
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Article ; Online: Deceleration area and capacity during labour-like umbilical cord occlusions identify evolving hypotension: a controlled study in fetal sheep.

Georgieva, A / Lear, C A / Westgate, J A / Kasai, M / Miyagi, E / Ikeda, T / Gunn, A J / Bennet, L

BJOG : an international journal of obstetrics and gynaecology

2021 Volume 128, Issue 9, Page(s) 1433–1442

Abstract: Objective: Cardiotocography is widely used to assess fetal well-being during labour. The positive predictive value of current clinical algorithms to identify hypoxia-ischaemia is poor. In experimental studies, fetal hypotension is the strongest ... ...

Abstract	Objective: Cardiotocography is widely used to assess fetal well-being during labour. The positive predictive value of current clinical algorithms to identify hypoxia-ischaemia is poor. In experimental studies, fetal hypotension is the strongest predictor of hypoxic-ischaemic injury. Cohort studies suggest that deceleration area and deceleration capacity of the fetal heart rate trace correlate with fetal acidaemia, but it is not known whether they are indices of fetal arterial hypotension. Design: Prospective, controlled study. Setting: Laboratory. Sample: Near-term fetal sheep. Methods: One minute of complete umbilical cord occlusions (UCOs) every 5 minutes (1:5 min, n = 6) or every 2.5 minutes (1:2.5 min, n = 12) for 4 hours or until fetal mean arterial blood pressure fell <20 mmHg. Main outcome measures: Deceleration area and capacity during the UCO series were related to evolving hypotension. Results: The 1:5 min group developed only mild metabolic acidaemia, without hypotension. By contrast, 10/12 fetuses in the 1:2.5-min group progressively developed severe metabolic acidaemia and hypotension, reaching 16.8 ± 0.9 mmHg after 71.2 ± 6.7 UCOs. Deceleration area and capacity remained unchanged throughout the UCO series in the 1:5-min group, but progressively increased in the 1:2.5-min group. The severity of hypotension was closely correlated with both deceleration area (P < 0.001, R Conclusions: Both deceleration area and capacity were strongly associated with developing fetal hypotension, supporting their potential to improve identification of fetuses at risk of hypotension leading to hypoxic-ischaemic injury during labour. Tweetable abstract: Deceleration area and capacity of fetal heart rate identify developing hypotension during labour-like hypoxia.
MeSH term(s)	Animals ; Cardiotocography/methods ; Female ; Heart Rate, Fetal/physiology ; Humans ; Hypoxia-Ischemia, Brain/prevention & control ; Labor, Obstetric ; Pregnancy ; Prospective Studies ; Sheep ; Umbilical Cord/blood supply
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.16638
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