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  1. Article ; Online: Freestanding carbon nanofoam papers with tunable porosity as lithium-sulfur battery cathodes.

    Neale, Zachary G / Lefler, Matthew J / Long, Jeffrey W / Rolison, Debra R / Sassin, Megan B / Carter, Rachel

    Nanoscale

    2023  Volume 15, Issue 42, Page(s) 16924–16932

    Abstract: To reach energy density demands greater than 3 mA h ... ...

    Abstract To reach energy density demands greater than 3 mA h cm
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr02699j
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  2. Article: Social dominance and cooperation in female vampire bats.

    Crisp, Rachel J / Brent, Lauren J N / Carter, Gerald G

    Royal Society open science

    2021  Volume 8, Issue 7, Page(s) 210266

    Abstract: When group-living animals develop individualized social relationships, they often regulate cooperation and conflict through a dominance hierarchy. Female common vampire bats have been an experimental system for studying cooperative relationships, yet ... ...

    Abstract When group-living animals develop individualized social relationships, they often regulate cooperation and conflict through a dominance hierarchy. Female common vampire bats have been an experimental system for studying cooperative relationships, yet surprisingly little is known about female conflict. Here, we recorded the outcomes of 1023 competitive interactions over food provided ad libitum in a captive colony of 33 vampire bats (24 adult females and their young). We found a weakly linear dominance hierarchy using three common metrics (Landau's
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.210266
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  3. Article ; Online: Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers.

    Saulters, Emma L / Kennedy, Paul T / Carter, Rachel J / Alsufyani, Abdullah / Jones, Terence M / Woolley, John F / Dahal, Lekh N

    Cancer research communications

    2024  Volume 4, Issue 1, Page(s) 118–133

    Abstract: Squamous cell carcinomas, which arise from the cells that line the mucosal surfaces of the head and neck, represent the most common type of head and neck cancers (HNSCC). Human papillomavirus (HPV) infection has been strongly associated with the ... ...

    Abstract Squamous cell carcinomas, which arise from the cells that line the mucosal surfaces of the head and neck, represent the most common type of head and neck cancers (HNSCC). Human papillomavirus (HPV) infection has been strongly associated with the development of oropharyngeal cancers, which are cancers that occur in the back of the throat, including the tonsils and base of the tongue. HNSCCs with and without HPV infection have distinct pathology, with HPV-positive patients having higher levels of immune infiltration, activation in the tumor microenvironment and better response to radiation and chemotherapy. It is, however, unclear whether HPV infection in HNSCCs has the potential to activate innate-immune sensing pathways and if these cancers possess intrinsic immunogenicity associated with HPV infection. Here we investigate the innate immune stimulator of interferon genes (STING) pathway and immune responses to STING activation in HNSCCs and uncover fundamental differences in the regulation of this pathway in cell lines versus primary human clinical specimens. We show that while STING is differentially expressed in HPV-positive and -negative HNSCC cell lines, they exhibit a gross functional defect in signaling through this pathway. However, STING activation in immune cell populations generated immune signatures predicted to elicit useful tumoricidal mechanisms. In contrast, IHC analysis of human tissue microarrays revealed enhanced STING expression in HPV-related tumors and high intratumoral expression of STING correlated with increased survival.
    Significance: STING is an important innate immune sensor of cytosolic DNA, inducing essential antiviral and antitumoral responses. This research shows that STING expression is enhanced in HPV-positive HNSCC patient tissue, with high intratumoral STING expression correlating with increased survival. In addition, STING activation in immune cell populations augmented antitumoral effects against HNSCCs, suggesting patients may benefit from the use of STING agonists in combination with traditional therapies.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/complications ; Papillomavirus Infections/complications ; Head and Neck Neoplasms/complications ; Carcinoma, Squamous Cell/complications ; Human Papillomavirus Viruses ; Tumor Microenvironment
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-23-0299
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  4. Article ; Online: A multisite transition to nursing program: an innovative approach to facilitate incoming nursing students' academic success.

    Schultz, Celeste M / Woods, Rachel A / Krassa, Teresa J / Carter, Alisha C / Leipold, Catherine

    International journal of nursing education scholarship

    2023  Volume 20, Issue 1

    Abstract: Objectives: Evaluate effectiveness of a multisite program promoting the successful transition of baccalaureate and graduate entry (with a prior degree) students into pre-licensure curricula. Faculty concern around nursing students' successful completion ...

    Abstract Objectives: Evaluate effectiveness of a multisite program promoting the successful transition of baccalaureate and graduate entry (with a prior degree) students into pre-licensure curricula. Faculty concern around nursing students' successful completion of nursing programs and passage of the nursing licensure exam stems from challenges students encounter in core courses, study habits, and civility.
    Methods: One hundred eighty-five students participated in a quasi-experimental pre-post-test mixed-methods study. Students completed content modules and open-ended surveys.
    Results: Most students found the program helpful. Statistically significant improvements were shown in medication calculation, reading comprehension, and medical terminology. No statistically significant improvement was shown in anatomy and physiology.
    Conclusions: Our Transition to Nursing program shows promise and adds to proactive strategies in preparing students for a successful transition into nursing programs. Our innovative approach may serve as a model to nursing schools and colleges around the world to promote student success.
    MeSH term(s) Humans ; Education, Nursing, Baccalaureate/methods ; Academic Success ; Students, Nursing ; Curriculum ; Licensure
    Language English
    Publishing date 2023-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2162109-3
    ISSN 1548-923X ; 2194-5772
    ISSN (online) 1548-923X
    ISSN 2194-5772
    DOI 10.1515/ijnes-2022-0016
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  5. Article ; Online: Accelerating Rate Calorimetry and Complementary Techniques to Characterize Battery Safety Hazards.

    Klein, Emily J / Carter, Rachel / Love, Corey T

    Journal of visualized experiments : JoVE

    2021  , Issue 175

    Abstract: The hazards associated with lithium-based battery chemistries are well-documented due to their catastrophic nature. Risk is typically qualitatively assessed through an engineering risk matrix. Within the matrix, potentially hazardous events are ... ...

    Abstract The hazards associated with lithium-based battery chemistries are well-documented due to their catastrophic nature. Risk is typically qualitatively assessed through an engineering risk matrix. Within the matrix, potentially hazardous events are categorized and ranked in terms of severity and probability to provide situational awareness to decision makers and stakeholders. The stochastic nature of battery failures, particularly the lithium-ion chemistry, makes the probability axis of a matrix difficult to properly assess. Fortunately, characterization tools exist, such as accelerated rate calorimetry (ARC), that characterize degrees of battery failure severity. ARC has been used extensively to characterize reactive chemicals but can provide a new application to induce battery failures under safe, controlled experimental conditions and quantify critical safety parameters. Due to the robust nature of the extended volume calorimeter, cells may be safely taken to failure due to a variety of abuses: thermal (simple heating of cell), electrochemical (overcharge), electrical (external short circuit), or physical (crush or nail penetration). This article describes the procedures to prepare and instrument a commercial lithium-ion battery cell for failure in an ARC to collect valuable safety data: onset of thermal runaway, endotherm associated with polymer separator melting, pressure release during thermal runaway, gaseous collection for analytical characterization, maximum temperature of complete reaction, and visual observation of decomposition processes using a high temperature borescope (venting and cell can breach). A thermal "heat-wait-seek" method is used to induce cell failure, in which the battery is heated incrementally to a set point, then the instrument identifies heat generation from the battery. As heat generates a temperature rise in the battery, the calorimeter temperature follows this temperature rise, maintaining an adiabatic condition. Therefore, the cell does not exchange heat with the external environment, so all heat generation from the battery under failure is captured.
    MeSH term(s) Calorimetry ; Electric Power Supplies ; Hot Temperature ; Lithium ; Temperature
    Chemical Substances Lithium (9FN79X2M3F)
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/60342
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  6. Article ; Online: Long-term memory in frog-eating bats.

    Dixon, M May / Jones, Patricia L / Ryan, Michael J / Carter, Gerald G / Page, Rachel A

    Current biology : CB

    2022  Volume 32, Issue 12, Page(s) R557–R558

    Abstract: Long-term memory has clear advantages for animals but also has neurological and behavioral ... ...

    Abstract Long-term memory has clear advantages for animals but also has neurological and behavioral costs
    MeSH term(s) Animals ; Anura/physiology ; Chiroptera/physiology ; Echolocation/physiology ; Memory, Long-Term ; Predatory Behavior/physiology ; Sound
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.05.031
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Mutation Effects on Structure and Dynamics: Adaptive Evolution of the SARS-CoV-2 Main Protease.

    Diessner, Elizabeth M / Takahashi, Gemma R / Cross, Thomas J / Martin, Rachel W / Butts, Carter T

    Biochemistry

    2023  Volume 62, Issue 3, Page(s) 747–758

    Abstract: The main protease of SARS-CoV-2 ( ... ...

    Abstract The main protease of SARS-CoV-2 (M
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; COVID-19/genetics ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation ; Phylogeny ; Protease Inhibitors/chemistry ; SARS-CoV-2/enzymology ; SARS-CoV-2/genetics ; Coronavirus 3C Proteases/genetics ; Evolution, Molecular
    Chemical Substances 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Antiviral Agents ; Protease Inhibitors ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.2c00479
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Structural and Morphological Analysis of the First Alloy/Dealloy of a Bulk Si-Li System at Elevated Temperature.

    Lefler, Matthew J / Yeom, Junghoon / Rudolf, Christopher / Carter, Rachel E / Love, Corey T

    ACS omega

    2022  Volume 7, Issue 26, Page(s) 22317–22325

    Abstract: There have been tremendous improvements in the field of Si electrode materials, either by nanoscale or composite routes, and though silicon-containing carbon electrode materials have begun to penetrate the marketplace, the commercial capacities achieved ... ...

    Abstract There have been tremendous improvements in the field of Si electrode materials, either by nanoscale or composite routes, and though silicon-containing carbon electrode materials have begun to penetrate the marketplace, the commercial capacities achieved by these cells still fall short of the promise of high capacity Si electrodes. Enabling a cheaper feedstock of Si in the bulk form would make this technology more accessible, though there are many challenges that must be overcome. Whereas other methods utilize nanomaterials and composites to overcome volume expansion and pulverization of a Si electrode, this study explores a thermal route to enable the use of carbon-free bulk Si. To accomplish this, a modified Swagelok cell has been constructed to accommodate high temperatures, corrosive molten salt electrolytes, and a molten lithium electrode to study lithiation of a bulk Si wafer at 250 °C. Scanning electron microscopy, X-ray diffraction, and microcomputed tomography were used to examine morphological and structural changes within the Si upon lithiation and delithiation. It was discovered that semiordered Li
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c01145
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  9. Article ; Online: Moving beyond inclusion: Methodological considerations for the menstrual cycle and menopause in research evaluating effects of dietary nitrate on vascular function.

    Baranauskas, Marissa N / Freemas, Jessica A / Tan, Rachel / Carter, Stephen J

    Nitric oxide : biology and chemistry

    2021  Volume 118, Page(s) 39–48

    Abstract: Recent reports have acknowledged the underrepresentation of women in the field of dietary nitrate ( ... ...

    Abstract Recent reports have acknowledged the underrepresentation of women in the field of dietary nitrate (NO
    MeSH term(s) Biomedical Research/methods ; Dietary Supplements ; Estradiol/metabolism ; Female ; Humans ; Menopause/drug effects ; Menopause/metabolism ; Menstrual Cycle/drug effects ; Menstrual Cycle/metabolism ; Nitrates/pharmacology ; Nitric Oxide/biosynthesis ; Nitric Oxide/metabolism ; Sex Factors
    Chemical Substances Nitrates ; Nitric Oxide (31C4KY9ESH) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2021.11.001
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    Zs.A 4677: Show issues Location:
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  10. Article ; Online: The Impact of Neighborhood Deprivation on Glycemic Control for Patients with Type 2 Diabetes During Pregnancy.

    Zahedi-Spung, Leilah / Polnaszek, Brock / Duckham, Hillary / Zhang, Fan / Stout, Molly J / Herrick, Cynthia J / Paul, Rachel / Carter, Ebony B

    Journal of women's health (2002)

    2022  Volume 31, Issue 8, Page(s) 1156–1164

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Diabetes Mellitus, Type 2 ; Female ; Glycated Hemoglobin ; Glycemic Control ; Humans ; Infant, Newborn ; Pregnancy ; Residence Characteristics ; Retrospective Studies
    Chemical Substances Glycated Hemoglobin A
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2021.0273
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    Zs.A 3584: Show issues Location:
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