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  1. Book ; Online ; Thesis: Nidogen-1 and Nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage

    Krügel, Jenny [Verfasser]

    2009  

    Author's details vorgelegt von Jenny Krügel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Basement membrane components are key players in specialized extracellular matrices.

    Kruegel, Jenny / Miosge, Nicolai

    Cellular and molecular life sciences : CMLS

    2010  Volume 67, Issue 17, Page(s) 2879–2895

    Abstract: More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular ... ...

    Abstract More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular matrices (sECMs) with unique components that support important functions including differentiation, proliferation, migration, and chemotaxis of cells during development. The composition of these sECM is as unique as the tissues to which they are localized, opening the possibility that such matrices can fulfill distinct functions. Changes in BM composition play significant roles in facilitating the development of various diseases. Furthermore, tissues have to provide sECM for their stem cells during development and for their adult life. Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches.
    MeSH term(s) Animals ; Basement Membrane/chemistry ; Basement Membrane/physiology ; Cell Culture Techniques ; Collagen Type IV/analysis ; Collagen Type IV/metabolism ; Extracellular Matrix/chemistry ; Heparan Sulfate Proteoglycans/analysis ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Laminin/analysis ; Laminin/metabolism ; Membrane Glycoproteins/analysis ; Membrane Glycoproteins/metabolism ; Mice ; Stem Cells/chemistry ; Tissue Engineering/methods
    Chemical Substances Collagen Type IV ; Heparan Sulfate Proteoglycans ; Laminin ; Membrane Glycoproteins ; nidogen ; perlecan (143972-95-6)
    Language English
    Publishing date 2010-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-010-0367-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Renal Cells Express Different Forms of Vimentin: The Independent Expression Alteration of these Forms is Important in Cell Resistance to Osmotic Stress and Apoptosis.

    Buchmaier, Bettina S / Bibi, Asima / Müller, Gerhard A / Dihazi, Gry H / Eltoweissy, Marwa / Kruegel, Jenny / Dihazi, Hassan

    PloS one

    2018  Volume 13, Issue 5, Page(s) e0196935

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0068301.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0068301.].
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0196935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Basement membrane components are key players in specialized extracellular matrices

    Kruegel, Jenny / Miosge, Nicolai

    Cellular and molecular life sciences CMLS. 2010 Sept., v. 67, no. 17

    2010  

    Abstract: More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular ... ...

    Abstract More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular matrices (sECMs) with unique components that support important functions including differentiation, proliferation, migration, and chemotaxis of cells during development. The composition of these sECM is as unique as the tissues to which they are localized, opening the possibility that such matrices can fulfill distinct functions. Changes in BM composition play significant roles in facilitating the development of various diseases. Furthermore, tissues have to provide sECM for their stem cells during development and for their adult life. Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches.
    Keywords neoplasms ; basement membrane
    Language English
    Dates of publication 2010-09
    Size p. 2879-2895.
    Publisher SP Birkhäuser Verlag Basel
    Publishing place Basel
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-010-0367-x
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 47/14: Show issues

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  5. Article ; Online: Alport syndrome--insights from basic and clinical research.

    Kruegel, Jenny / Rubel, Diana / Gross, Oliver

    Nature reviews. Nephrology

    2012  Volume 9, Issue 3, Page(s) 170–178

    Abstract: In 1927, Arthur C. Alport first published his description of a triad of symptoms in a family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A few years after his death, this group of symptoms was renamed Alport syndrome. ... ...

    Abstract In 1927, Arthur C. Alport first published his description of a triad of symptoms in a family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A few years after his death, this group of symptoms was renamed Alport syndrome. To this day, Alport syndrome still inevitably leads to end-stage renal disease and the need for renal replacement therapy, starting in young adulthood. During the past two decades, research into this rare disease has focused on the effects of mutations in collagen type IV and the role of changes in podocytes and the glomerular basement membrane that lead to early kidney fibrosis. Animal models of Alport syndrome also demonstrate the pathogenetic importance of interactions between podocytes and the extracellular matrix. Such models might also help researchers to answer basic questions about podocyte function and the development of fibrosis, and to develop new therapeutic approaches that might be of use in other kidney diseases. In this Review, we discuss the latest basic and clinical research on Alport syndrome, focusing on the roles of podocyte pathology and the extracellular matrix. We also highlight early diagnosis and treatment options for young patients with this disorder.
    MeSH term(s) Animals ; Diagnosis, Differential ; Disease Progression ; Hearing Loss/etiology ; Humans ; Kidney/pathology ; Kidney/physiopathology ; Nephritis, Hereditary/complications ; Nephritis, Hereditary/diagnosis ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/pathology ; Nephritis, Hereditary/physiopathology ; Nephritis, Hereditary/therapy
    Language English
    Publishing date 2012-11-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2012.259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  6. Article ; Online: New insights into cartilage repair - the role of migratory progenitor cells in osteoarthritis.

    Gerter, Regina / Kruegel, Jenny / Miosge, Nicolai

    Matrix biology : journal of the International Society for Matrix Biology

    2012  Volume 31, Issue 3, Page(s) 206–213

    Abstract: Osteoarthritis is one of the most common musculo-skeletal diseases with a complex patholoy and a strong impact on cell biology, differentiation and migration behavior of mesenchymal stem cell-derived progenitor cells. In this review, we elucidate the ... ...

    Abstract Osteoarthritis is one of the most common musculo-skeletal diseases with a complex patholoy and a strong impact on cell biology, differentiation and migration behavior of mesenchymal stem cell-derived progenitor cells. In this review, we elucidate the influence of the pathologically altered extracellular matrix on progenitor cell behavior. Moreover, we discuss the modulation of progenitor cells especially of previously characterized chondrogenic progenitor cells (Koelling et al., 2009) in situ to enhance their regeneration potential. These options comprise the application of growth factors like fibroblast growth factor-2, a Runx-2 knock down and a contemporary anti-inflammatory therapy. This supports endogenous regeneration on behalf of the diseased osteoarthritic cartilage, which otherwise results mainly in an insufficient fibro-cartilaginous repair tissue. Furthermore, new results indicate a role of pericytes in osteoarthritis for these repair attempts. We discuss the biological mechanisms potentially leading to new therapeutic options in osteoarthritis to enhance regeneration in situ.
    MeSH term(s) Cartilage Diseases/metabolism ; Cartilage Diseases/physiopathology ; Cartilage, Articular/metabolism ; Cartilage, Articular/physiology ; Cell Differentiation ; Cell Movement ; Chondrocytes/physiology ; Chondrocytes/transplantation ; Chondrogenesis ; Extracellular Matrix/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins ; Mesenchymal Stromal Cells/metabolism ; Mesenchymal Stromal Cells/physiology ; Osteoarthritis/physiopathology ; Pericytes/metabolism ; Pericytes/physiology ; Regeneration
    Chemical Substances Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2012-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2012.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1694: Show issues Location:
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  7. Article ; Online: Correction

    Bettina S Buchmaier / Asima Bibi / Gerhard A Müller / Gry H Dihazi / Marwa Eltoweissy / Jenny Kruegel / Hassan Dihazi

    PLoS ONE, Vol 13, Iss 5, p e

    Renal Cells Express Different Forms of Vimentin: The Independent Expression Alteration of these Forms is Important in Cell Resistance to Osmotic Stress and Apoptosis.

    2018  Volume 0196935

    Abstract: This corrects the article DOI:10.1371/journal.pone.0068301.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0068301.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Tissue distribution of perlecan domains III and V during embryonic and fetal human development.

    Roediger, Matthias / Kruegel, Jenny / Miosge, Nicolai / Gersdorff, Nikolaus

    Histology and histopathology

    2009  Volume 24, Issue 7, Page(s) 859–868

    Abstract: A major component of basement membranes (BMs) is perlecan, a five-domain heparan sulphate proteoglycan. During murine embryogenesis, nearly all BMs of mesenchymal origin express perlecan, and it is believed to participate in the supramolecular assembly ... ...

    Abstract A major component of basement membranes (BMs) is perlecan, a five-domain heparan sulphate proteoglycan. During murine embryogenesis, nearly all BMs of mesenchymal origin express perlecan, and it is believed to participate in the supramolecular assembly of BMs. However, the distribution of perlecan in human embryonic and fetal tissues is widely unknown, except for cartilage anlagen of developing extremities and the fetal spine. Clinical syndromes, caused by perlecan-associated mutations or gene-defects, suggest its multifunctional involvement during human development. Here we reveal the immunohistochemistry of perlecan domains III and V during human development from gestational weeks (gw) 6 to 12 in basement membrane zones (BMZs) of the developing brain, nervous system, blood vessels, skin, lung, heart, kidney, liver, intestine and skeletal system. Interestingly, a difference in the distribution of the two perlecan domains was found in the endoneurium of ganglia. Domain III is strongly present from gw 6 onwards, while domain V shows attenuated expression at this stage and has been detected abundantly only from gw 8 onwards, possibly indicating vascularization of the endoneurium during this early stage. We found perlecan to be present particularly at those stages of human development where epithelial-mesenchymal interactions occur.
    MeSH term(s) Basement Membrane/embryology ; Basement Membrane/metabolism ; Fetal Development ; Heparan Sulfate Proteoglycans/chemistry ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Immunohistochemistry ; Protein Structure, Tertiary ; Tissue Distribution
    Chemical Substances Heparan Sulfate Proteoglycans ; perlecan (143972-95-6)
    Language English
    Publishing date 2009
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-24.859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3013: Show issues Location:
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  9. Article: Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage.

    Kruegel, Jenny / Sadowski, Boguslawa / Miosge, Nicolai

    Arthritis and rheumatism

    2008  Volume 58, Issue 5, Page(s) 1422–1432

    Abstract: Objective: To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage.: Methods: The location and quantity of nidogen-1 and nidogen-2 protein and messenger RNA were ... ...

    Abstract Objective: To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage.
    Methods: The location and quantity of nidogen-1 and nidogen-2 protein and messenger RNA were determined in cartilage tissue obtained from healthy donors and from patients with late-stage knee OA. Samples were analyzed by immunohistochemistry, in situ hybridization, and real-time reverse transcription-polymerase chain reaction. Adhesion and inhibition assays, a pre-embedding method, fluorescence-activated cell sorting, and ultrastructural investigations with integrins were also carried out.
    Results: Developing tissue from human embryos showed strong staining for both nidogens in condensed mesenchyme and in rib anlagen. Homogeneous staining for nidogen-1 was observed in the extracellular matrix of healthy articular cartilage, whereas nidogen-2 was localized pericellularly. In late-stage OA cartilage, expression of nidogen-1 was decreased pericellularly around diseased chondrocytes, whereas nidogen-2 was increased. However, both nidogens had strongly increased levels around elongated chondrocytes, especially in areas of deep surface fissures. In vitro, both nidogens functioned as adhesion proteins for cells from the OA defect. In vivo, colocalizations with integrins alphav and beta1 as well as internalization of nidogens by chondrocytes in vitro were observed.
    Conclusion: Nidogens are involved in human limb development. They occur in healthy articular cartilage and show increased expression, primarily around elongated chondrocytes, in OA cartilage. Therefore, the activities of nidogens might be a sign of cartilage regeneration in late-stage OA. Furthermore, the adhesive character of nidogens, specifically as adhesion proteins for chondrocytes from late-stage OA, as well as the enhanced chondrocyte-nidogen interaction in OA indicate that both proteins play a key role in the pathogenesis of OA and either could be applied as a diagnostic marker.
    MeSH term(s) Cartilage, Articular/metabolism ; Cell Adhesion Molecules/biosynthesis ; Disease Progression ; Extracellular Matrix ; Humans ; Membrane Glycoproteins/biosynthesis ; Osteoarthritis/metabolism
    Chemical Substances Cell Adhesion Molecules ; Membrane Glycoproteins ; NID2 protein, human ; nidogen
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.23480
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    Zs.A 24: Show issues Location:
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    Zs.MO 523: Show issues

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  10. Conference proceedings: Dynamische Faktoren bei der Therapie des Gustatorischen Schwitzens mit Botulinumtoxin A

    Köhler, Sabrina / Junghans, Katharina / Krügel, Jenny / Laskawi, Rainer

    2010  , Page(s) 10hnod685

    Event/congress 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Wiesbaden; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2010
    Keywords Medizin, Gesundheit
    Publishing date 2010-04-22
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/10hnod685
    Database German Medical Science

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