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  1. Article ; Online: Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response.

    Mónica, Flores-Ramos / Gerardo Bernabé, Ramírez-Rodríguez / Rodrigo, Guiza Zayas / Melissa, Solares-Bravo / Lorena, Rodríguez-Bores

    Journal of psychiatric research

    2024  Volume 171, Page(s) 277–285

    Abstract: Response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated ... ...

    Abstract Response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated with refractory depressive states. We propose to analyze the human neural progenitor cells derived from the olfactory epithelium (HNPCs-OE) as an indicator of neurogenesis in humans. Therefore, we compared the number and content of HNPCs-OE in depressed patients taking antidepressants, according to response to treatment. Twenty depressed patients were followed during eight weeks after antidepressant treatment was prescribed. At the end evaluation they were divided in two groups according to Hamilton depression rating scale (HDRS) scores: responders and non-responders. We compared the number and components of HNPCs-OE between groups and observed an elevation of interleukine-8 in those patients who do not achieve response to treatment, BDNF levels were no related to antidepressant response.
    MeSH term(s) Humans ; Brain-Derived Neurotrophic Factor ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Neurogenesis ; Stem Cells
    Chemical Substances Brain-Derived Neurotrophic Factor ; Antidepressive Agents
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.01.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of gamma-aminobutyric acid in female depression

    Flores-Ramos, Mónica / Salinas, Margus / Carvajal-Lohr, Armando / Rodríguez-Bores, Lorena

    Gaceta medica de Mexico

    2017  Volume 153, Issue 4, Page(s) 486–495

    Abstract: Depression is a common psychiatric disorder and a leading cause of disability worldwide. Multiple and diverse factors are involved in its cause although biologic factors are prominent. The present study reviews the evidence about the role that gamma- ... ...

    Title translation El papel del ácido gamma-aminobutírico en la depresión de la mujer
    Abstract Depression is a common psychiatric disorder and a leading cause of disability worldwide. Multiple and diverse factors are involved in its cause although biologic factors are prominent. The present study reviews the evidence about the role that gamma-aminobutyric acid plays in the complex pathogenesis of depression, particularly in women. The implication of gamma-aminobutyric acid (GABA) is based mainly from animal models whereas clinical studies in depressed patients show alterations of GABA levels in plasma and cerebrospinal fluid. Neuroimaging studies using spectroscopy indicate also decreased GABA levels in different brain areas which in turn may normalize after antidepressant therapy, and these findings translate into clinical response. It has been observed that depression has a higher prevalence among women which suggests a link between depression and hormonal changes. Similarly, gonadal hormones have a regulatory effect on the hypothalamic–pituitary–adrenal axis through GABA receptors making women more vulnerable to suffer stress and depression. Therefore, the implication of GABA in the neurobiology of depression should be explored in order to search for new therapeutic strategies.
    Language Spanish
    Publishing date 2017
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.17002544
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  3. Article ; Online: Validez de la Escala de Evaluación Cognitiva de Montreal (MoCA) para determinar deterioro cognitivo en pacientes con esquizofrenia

    Lorena Rodríguez-Bores Ramírez / Ricardo Saracco-Álvarez / Raúl Escamilla-Orozco / Ana Fresán Orellana

    Salud Mental, Vol 37, Iss 6, Pp 517-

    2014  Volume 522

    Abstract: Introducción La esquizofrenia es un trastorno mental que posee múltiples dimensiones sintomáticas y las alteraciones cognitivas son características cardinales en la evolución del trastorno. El uso de clinimetría para evaluar dichas deficiencias puede ... ...

    Abstract Introducción La esquizofrenia es un trastorno mental que posee múltiples dimensiones sintomáticas y las alteraciones cognitivas son características cardinales en la evolución del trastorno. El uso de clinimetría para evaluar dichas deficiencias puede aportar información en la investigación en este campo. Objetivo Determinar la validez y confiabilidad de la Escala de Evaluación Cognitiva Montreal (MoCA) para la evaluación del déficit cognitivo en pacientes con el diagnóstico de esquizofrenia. Material y métodos Se evaluaron cien pacientes con diagnóstico de esquizofrenia reclutados en la Clínica de Esquizofrenia del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz. Se aplicaron las escalas de MoCA, MMSE y PANSS para la valoración de las funciones cognitivas. Se estableció la confiabilidad del MoCA con el Alfa de Cronbach y se estableció su validez concurrente con el MMSE y la subescala cognitiva de la PANSS. Resultados De acuerdo al MMSE (con ajuste de escolaridad) el 8% de los pacientes fueron clasificados con deterioro cognitivo en contraste con el puntaje total del MoCA que reporto 69% de la muestra con deterioro cognitivo. La escala MoCA obtuvo una confiabilidad (Alfa de Cronbach= 0.71) similar a la observada por el MMSE (a=0.70) y adecuada validez concurrente. Conclusiones La MoCA es un instrumento confiable y válido para establecer la presencia de deterioro cognitivo leve en pacientes con esquizofrenia, sencillo y de fácil aplicación en la práctica clínica psiquiátrica cotidiana.
    Keywords Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language Spanish
    Publishing date 2014-01-01T00:00:00Z
    Publisher Instituto Nacional de Psiquiatría
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Basic and clinical aspects of osteoporosis in inflammatory bowel disease.

    Rodríguez-Bores, Lorena / Barahona-Garrido, Josué / Yamamoto-Furusho, Jesús K

    World journal of gastroenterology

    2007  Volume 13, Issue 46, Page(s) 6156–6165

    Abstract: Low bone mineral density and the increased risk of fracture in gastrointestinal diseases have a multifactorial pathogenesis. Inflammatory bowel disease (IBD) has been associated with an increased risk of osteoporosis and osteopenia and epidemiologic ... ...

    Abstract Low bone mineral density and the increased risk of fracture in gastrointestinal diseases have a multifactorial pathogenesis. Inflammatory bowel disease (IBD) has been associated with an increased risk of osteoporosis and osteopenia and epidemiologic studies have reported an increased prevalence of low bone mass in patients with IBD. Certainly, genetics play an important role, along with other factors such as systemic inflammation, malnutrition, hypogonadism, glucocorticoid therapy in IBD and other lifestyle factors. At a molecular level the proinflammatory cytokines that contribute to the intestinal immune response in IBD are known to enhance bone resorption. There are genes influencing osteoblast function and it is likely that LRP5 may be involved in the skeletal development. Also the identification of vitamin D receptors (VDRs) and some of its polymorphisms have led to consider the possible relationships between them and some autoimmune diseases and may be involved in the pathogenesis through the exertion of its immunomodulatory effects during inflammation. Trying to explain the physiopathology we have found that there is increasing evidence for the integration between systemic inflammation and bone loss likely mediated via receptor for activated nuclear factor kappa-B (RANK), RANK-ligand, and osteoprotegerin, proteins that can affect both osteoclastogenesis and T-cell activation. Although glucocorticoids can reduce mucosal and systemic inflammation, they have intrinsic qualities that negatively impact on bone mass. It is still controversial if all IBD patients should be screened, especially in patients with preexisting risk factors for bone disease. Available methods to measure BMD include single energy x-ray absorptiometry, DXA, quantitative computed tomography (QCT), radiographic absorptiometry, and ultrasound. DXA is the establish method to determine BMD, and routinely is measured in the hip and the lumbar spine. There are several treatments options that have proven their effectiveness, while new emergent therapies such as calcitonin and teriparatide among others remain to be assessed.
    MeSH term(s) Bone Resorption/physiopathology ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/physiopathology ; Osteoporosis/drug therapy ; Osteoporosis/etiology ; Osteoporosis/physiopathology ; Risk Factors
    Language English
    Publishing date 2007-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v13.i46.6156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mental health problems among healthcare workers involved with the COVID-19 outbreak.

    Robles, Rebeca / Rodríguez, Evelyn / Vega-Ramírez, Hamid / Álvarez-Icaza, Dení / Madrigal, Eduardo / Durand, Sol / Morales-Chainé, Silvia / Astudillo, Claudia / Real-Ramírez, Janet / Medina-Mora, María-Elena / Becerra, Claudia / Escamilla, Raúl / Alcocer-Castillejos, Natasha / Ascencio, Leticia / Díaz, Dulce / González, Hugo / Barrón-Velázquez, Evalinda / Fresán, Ana / Rodríguez-Bores, Lorena /
    Quijada-Gaytán, Juan-Manuel / Zabicky, Gady / Tejadilla-Orozco, Diana / González-Olvera, Jorge-Julio / Reyes-Terán, Gustavo

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2020  Volume 43, Issue 5, Page(s) 494–503

    Abstract: Objective: The mental health problems and perceived needs of healthcare workers involved with coronavirus disease (COVID-19) may vary due to individual and contextual characteristics. The objective of this study was to evaluate healthcare workers' ... ...

    Abstract Objective: The mental health problems and perceived needs of healthcare workers involved with coronavirus disease (COVID-19) may vary due to individual and contextual characteristics. The objective of this study was to evaluate healthcare workers' mental health problems during the common COVID-19 exposure scenario in Mexico, comparing those on the frontline with other healthcare workers according to gender and profession, determining the main risk factors for the most frequent mental health problems.
    Methods: A cross-sectional online study was conducted with a non-probabilistic sample of 5,938 Mexican healthcare workers who completed brief screening measures of mental health problems and ad hoc questions about sociodemographic professional characteristics, conditions related to increased risk of COVID-19 infection, life stressors during the COVID-19 emergency, and perceived need to cope with COVID-19.
    Results: The identified mental health problems were insomnia, depression, and posttraumatic stress disorder (PTSD), all of which were more frequent in frontline healthcare workers (52.1, 37.7, and 37.5%, respectively) and women (47.1, 33.0 %, and 16.3%, respectively). A lack of rest time was the main risk factor for insomnia (OR = 3.1, 95%CI 2.6-3.7, p ≤ 0.0001). Mourning the death of friends or loved ones due to COVID-19 was the main risk factor for depression (OR = 2.2, 95%CI 1.8-2.7, p ≤ 0.0001), and personal COVID-19 status was the main risk factor for PTSD (OR = 2.2, 95%CI 1.7-2.9, p ≤ 0.0001).
    Conclusion: The most frequent mental health problems during the common exposure scenario for COVID-19 in Mexico included the short-term psychological consequences of intense adversity. A comprehensive strategy for preventing mental health problems should focus on individuals with cumulative vulnerability and specific risk factors.
    MeSH term(s) Anxiety ; COVID-19 ; Cross-Sectional Studies ; Depression/epidemiology ; Disease Outbreaks ; Female ; Health Personnel ; Humans ; Mental Health ; SARS-CoV-2
    Language English
    Publishing date 2020-11-28
    Publishing country Brazil
    Document type Journal Article
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2020-1346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Novel genetic markers in inflammatory bowel disease.

    Rodriguez-Bores, Lorena / Fonseca, Gabriela-C / Villeda, Marco-A / Yamamoto-Furusho, Jesus-K

    World journal of gastroenterology

    2007  Volume 13, Issue 42, Page(s) 5560–5570

    Abstract: Genetic factors play a significant role in determining inflammatory bowel disease (IBD) susceptibility. Epidemiologic data support genetic contribution to the pathogenesis of IBD, which include familial aggregation, twin studies, racial and ethnic ... ...

    Abstract Genetic factors play a significant role in determining inflammatory bowel disease (IBD) susceptibility. Epidemiologic data support genetic contribution to the pathogenesis of IBD, which include familial aggregation, twin studies, racial and ethnic differences in disease prevalence. Linkage studies have identified several susceptibility genes contained in different genomic regions named IBD1 to IBD9. Nucleotide oligomerization domain (NOD2) and human leukocyte antigen (HLA) genes are the most extensively studied genetic regions (IBD1 and IBD3 respectively) in IBD. Mutations of the NOD2 gene are associated with Crohn's disease (CD) and several HLA genes are associated with ulcerative colitis (UC) and CD. Toll like receptors (TLRs) have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial patterns. Studying single-nucleotide polymorphisms (SNPs) in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of IBD. Recently, numerous new genes have been identified to be involved in the genetic susceptibility to IBD: NOD1/Caspase-activation recruitment domains 4 (CARD4), Chemokine ligand 20 (CCL20), IL-11, and IL-18 among others. The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD.
    MeSH term(s) Chromosome Mapping ; Genetic Markers ; Humans ; Immunity, Innate ; Inflammatory Bowel Diseases/genetics ; Interferon-gamma/genetics ; Interleukin-17/genetics ; Interleukin-23/genetics ; Major Histocompatibility Complex ; Nod2 Signaling Adaptor Protein/genetics ; Receptors, Calcitriol/genetics
    Chemical Substances Genetic Markers ; IL25 protein, human ; Interleukin-17 ; Interleukin-23 ; NOD2 protein, human ; Nod2 Signaling Adaptor Protein ; Receptors, Calcitriol ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2007-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v13.i42.5560
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