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Article ; Online: Which lymphoid cells express MHC class II antigens; are TCRs encoded within the MHC?

Hansen, Ted H

Journal of immunology (Baltimore, Md. : 1950)

2011 Volume 187, Issue 5, Page(s) 2043–2044

MeSH term(s)	Allergy and Immunology/history ; Animals ; B-Lymphocytes/immunology ; Isoantigens/immunology ; Major Histocompatibility Complex/immunology
Chemical Substances	Isoantigens
Language	English
Publishing date	2011-09-01
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1101982
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Article ; Online: Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women.

Dam, Tine Vrist / Dalgaard, Line Barner / Johansen, Frank Ted / Bengtsen, Mads Bisgaard / Mose, Maike / Lauritsen, Katrine Meyer / Gravholt, Claus H / Hansen, Mette

European journal of applied physiology

2022 Volume 123, Issue 3, Page(s) 667–681

Abstract: Purpose: To investigate the effects of resistance training with or without transdermal estrogen therapy (ET) on satellite cell (SC) number and molecular markers for muscle hypertrophy in early postmenopausal women.: Methods: Using a double-blinded ... ...

Abstract	Purpose: To investigate the effects of resistance training with or without transdermal estrogen therapy (ET) on satellite cell (SC) number and molecular markers for muscle hypertrophy in early postmenopausal women. Methods: Using a double-blinded randomized controlled design, we allocated healthy, untrained postmenopausal women to perform 12 weeks of resistance training with placebo (PLC, n = 16) or ET (n = 15). Muscle biopsies obtained before and after the intervention, and two hours after the last training session were analyzed for fiber type, SC number and molecular markers for muscle hypertrophy and degradation (real-time PCR, western blotting). Results: The analysis of SCs per Type I fiber showed a time x treatment interaction caused by a 47% decrease in PLC, and a 26% increase after ET after the training period. Also, SCs per Type II fiber area was lower after the intervention driven by a 57% decrease in PLC. Most molecular markers changed similarly in the two groups. Conclusion: A decline in SC per muscle fiber was observed after the 12-week training period in postmenopausal women, which was counteracted when combined with use of transdermal ET. Clinical trial registration number: nct03020953.
MeSH term(s)	Female ; Humans ; Estrogens ; Hypertrophy/pathology ; Muscle Fibers, Skeletal/physiology ; Muscle, Skeletal/physiology ; Postmenopause ; Resistance Training ; Satellite Cells, Skeletal Muscle/metabolism ; Double-Blind Method
Chemical Substances	Estrogens
Language	English
Publishing date	2022-12-31
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-022-05093-0
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Article ; Online: Immunology: Vitamins prime immunity.

Chua, Wei-Jen / Hansen, Ted H

Nature

2012 Volume 491, Issue 7426, Page(s) 680–681

MeSH term(s)	Folic Acid/metabolism ; Histocompatibility Antigens Class I/chemistry ; Histocompatibility Antigens Class I/immunology ; Humans ; Minor Histocompatibility Antigens ; Pterins/chemistry ; Pterins/immunology ; T-Lymphocytes/immunology
Chemical Substances	Histocompatibility Antigens Class I ; MR1 protein, human ; Minor Histocompatibility Antigens ; Pterins ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2012-11-28
Publishing country	England
Document type	News ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/491680a
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Article ; Online: Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial.

Dam, Tine Vrist / Dalgaard, Line Barner / Thomsen, Christian Bejlegaard / Hjortebjerg, Rikke / Ringgaard, Steffen / Johansen, Frank Ted / Bengtsen, Mads Bisgaard / Mose, Maike / Lauritsen, Katrine Meyer / Søndergaard, Esben / Gravholt, Claus H / Hansen, Mette

Menopause (New York, N.Y.)

2022 Volume 28, Issue 11, Page(s) 1214–1224

Abstract: Objective: Women experience an unhealthy change in metabolic risk profile at menopause. The purpose of the present study was to determine effects of resistance training with or without transdermal estrogen therapy (ET) on adipose tissue mass and ... ...

Abstract	Objective: Women experience an unhealthy change in metabolic risk profile at menopause. The purpose of the present study was to determine effects of resistance training with or without transdermal estrogen therapy (ET) on adipose tissue mass and metabolic risk profile in early postmenopausal women. Methods: A double-blinded randomized controlled trial, where healthy, untrained postmenopausal women were allocated to supervised resistance training with placebo (PLC, n = 16) or transdermal ET (n = 15) for 12 weeks. Endpoints with prespecified hypotheses were the change in total fat mass (FM) (main endpoint) and the change in visceral FM (secondary endpoint) from before to after the intervention. Additionally, prespecified endpoints of body composition, metabolic health-related blood markers, fat%, fat cell size, and lipogenic markers in subcutaneous adipose tissue (SAT) from abdominal and femoral region were explored. Results: Compared with the ET group, the PLC group experienced a greater reduction (time × treatment interaction P < 0.05) in total FM (PLC vs ET: -5.6% vs -1.1%) and visceral FM (-18.6% vs -6.8%), and femoral SAT (-5.6% vs 1.0%), but not abdominal SAT mass (-8.5% vs -2.8%, P = 0.15).The ET group improved their metabolic blood profile by reduced low-density lipoprotein, glucose and hemoglobin A1c compared with PLC (time × treatment interaction P < 0.05). The intervention induced changes in lipolytic markers of abdominal SAT, whereas no changes were detected in femoral SAT. Conclusion: Use of transdermal ET reduced adipose tissue loss, but improved metabolic blood markers when combined with 12 weeks of progressive resistance training in early postmenopausal women.
MeSH term(s)	Body Composition ; Estrogens ; Female ; Humans ; Intra-Abdominal Fat ; Postmenopause ; Resistance Training
Chemical Substances	Estrogens
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000001841
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Article: No Added Neuroprotective Effect of Remote Ischemic Postconditioning and Therapeutic Hypothermia After Mild Hypoxia-Ischemia in a Piglet Model.

Andelius, Ted C K / Pedersen, Mette V / Andersen, Hannah B / Andersen, Mads / Hjortdal, Vibeke E / Pedersen, Michael / Ringgaard, Steffen / Hansen, Lærke H / Henriksen, Tine B / Kyng, Kasper J

Frontiers in pediatrics

2020 Volume 8, Page(s) 299

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2020-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.00299
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Article: Transdermal Estrogen Therapy Improves Gains in Skeletal Muscle Mass After 12 Weeks of Resistance Training in Early Postmenopausal Women.

Dam, Tine Vrist / Dalgaard, Line Barner / Ringgaard, Steffen / Johansen, Frank Ted / Bisgaard Bengtsen, Mads / Mose, Maike / Lauritsen, Katrine Meyer / Ørtenblad, Niels / Gravholt, Claus H / Hansen, Mette

Frontiers in physiology

2021 Volume 11, Page(s) 596130

Abstract: Context: Women show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women.: Objective: We aimed to test ...

Abstract	Context: Women show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women. Objective: We aimed to test the hypothesis that transdermal estrogen therapy (ET) amplifies the skeletal muscle response to resistance training in early postmenopausal women. Design: A double-blinded randomized controlled study. Setting: Department of Public Health, Aarhus University, Denmark. Participants: Thirty-one healthy, untrained postmenopausal women no more than 5 years past menopause. Interventions: Supervised resistance training with placebo (PLC, Main outcome measures: The primary outcome parameter was a cross-sectional area of quadriceps femoris measured by magnetic resonance imaging, and secondary parameters were fat-free mass (dual-energy X-ray absorptiometry), muscle strength, and functional tests. Results: The increase in muscle cross-sectional area was significantly greater in the ET group (7.9%) compared with the PLC group (3.9%) ( Conclusion: The use of transdermal ET enhanced the increase in muscle mass in response to 12 weeks of progressive resistance training in early postmenopausal women.
Language	English
Publishing date	2021-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.596130
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Article ; Online: Bacteria, mucosal-associated invariant T cells and MR1.

Chua, Wei-Jen / Hansen, Ted H

Immunology and cell biology

2010 Volume 88, Issue 8, Page(s) 767–769

MeSH term(s)	Animals ; Antigens, Bacterial/immunology ; Antigens, Bacterial/metabolism ; Bacterial Infections/immunology ; Cytokines/metabolism ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunity, Mucosal ; Lymphocyte Activation/genetics ; Mice ; Mice, Knockout ; Mice, Transgenic ; Minor Histocompatibility Antigens ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Natural Killer T-Cells/pathology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Pattern Recognition/metabolism
Chemical Substances	Antigens, Bacterial ; Cytokines ; Histocompatibility Antigens Class I ; MR1 protein, human ; Minor Histocompatibility Antigens ; Receptors, Antigen, T-Cell ; Receptors, Pattern Recognition
Language	English
Publishing date	2010-08-24
Publishing country	United States
Document type	News
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1038/icb.2010.104
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Article ; Online: A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

Xiaoli Wang / Sytse J Piersma / Christopher A Nelson / Ya-Nan Dai / Ted Christensen / Eric Lazear / Liping Yang / Marjolein Sluijter / Thorbald van Hall / Ted H Hansen / Wayne M Yokoyama / Daved H Fremont

eLife, Vol

2018 Volume 7

Abstract: A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report ... ...

Abstract	A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report that rodent herpesvirus Peru (RHVP) encodes a Qa-1 like protein (pQa-1) via RNA splicing to counteract NK activation. While pQa-1 surface expression is stabilized by the same canonical peptides presented by murine Qa-1, pQa-1 is GPI-anchored and resistant to the activity of RHVP pK3, a ubiquitin ligase that targets MHC-I for degradation. pQa-1 tetramer staining indicates that it recognizes CD94/NKG2A receptors. Consistently, pQa-1 selectively inhibits NKG2A+ NK cells and expression of pQa-1 can protect tumor cells from NK control in vivo. Collectively, these findings reveal an innovative NK evasion strategy wherein RHVP encodes a modified Qa-1 mimic refractory to MHC-I sabotage and capable of specifically engaging inhibitory receptors to circumvent NK activation.
Keywords	viral immune evasion ; NK cell receptor ; non-classical MHC protein ; missing-self recognition ; herpesvirus ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement.

Wang, Xiaoli / Piersma, Sytse J / Nelson, Christopher A / Dai, Ya-Nan / Christensen, Ted / Lazear, Eric / Yang, Liping / Sluijter, Marjolein / van Hall, Thorbald / Hansen, Ted H / Yokoyama, Wayne M / Fremont, Daved H

eLife

2018 Volume 7

Abstract: A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of 'missing-self' recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report ... ...

Abstract	A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of 'missing-self' recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report that rodent herpesvirus Peru (RHVP) encodes a Qa-1 like protein (pQa-1) via RNA splicing to counteract NK activation. While pQa-1 surface expression is stabilized by the same canonical peptides presented by murine Qa-1, pQa-1 is GPI-anchored and resistant to the activity of RHVP pK3, a ubiquitin ligase that targets MHC-I for degradation. pQa-1 tetramer staining indicates that it recognizes CD94/NKG2A receptors. Consistently, pQa-1 selectively inhibits NKG2A
MeSH term(s)	Amino Acid Sequence ; Animals ; Antigen Presentation/immunology ; Base Sequence ; Cytotoxicity, Immunologic/genetics ; Cytotoxicity, Immunologic/immunology ; HEK293 Cells ; Herpesviridae/genetics ; Herpesviridae/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Mimicry/genetics ; Molecular Mimicry/immunology ; NK Cell Lectin-Like Receptor Subfamily C/genetics ; NK Cell Lectin-Like Receptor Subfamily C/immunology ; NK Cell Lectin-Like Receptor Subfamily C/metabolism ; NK Cell Lectin-Like Receptor Subfamily D/genetics ; NK Cell Lectin-Like Receptor Subfamily D/immunology ; NK Cell Lectin-Like Receptor Subfamily D/metabolism ; Protein Binding/immunology ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid
Chemical Substances	Histocompatibility Antigens Class I ; NK Cell Lectin-Like Receptor Subfamily C ; NK Cell Lectin-Like Receptor Subfamily D ; Q surface antigens
Language	English
Publishing date	2018-12-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.38667
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Article ; Online: MHC class I antigen presentation: learning from viral evasion strategies.

Hansen, Ted H / Bouvier, Marlene

Nature reviews. Immunology

2009 Volume 9, Issue 7, Page(s) 503–513

Abstract: The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various ... ...

Abstract	The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides. This Review highlights how the elucidation of mechanisms of viral immune evasion is important for advancing our understanding of virus-host interactions and can further our knowledge of the MHC class I presentation pathway as well as other cellular pathways.
MeSH term(s)	ATP-Binding Cassette Transporters/immunology ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Antigen Presentation ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/virology ; Enzyme Inhibitors/immunology ; Enzyme Inhibitors/metabolism ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Membrane Transport Proteins/immunology ; Membrane Transport Proteins/metabolism ; Proteasome Endopeptidase Complex/immunology ; Proteasome Endopeptidase Complex/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/virology ; Ubiquitin/immunology ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/immunology ; Ubiquitin-Protein Ligases/metabolism ; Viral Proteins/immunology ; Viral Proteins/metabolism ; Viruses/immunology
Chemical Substances	ATP-Binding Cassette Transporters ; Enzyme Inhibitors ; Histocompatibility Antigens Class I ; Membrane Transport Proteins ; Ubiquitin ; Viral Proteins ; tapasin ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2009-06-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/nri2575
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