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  1. Article ; Online: Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline.

    Titanji, Boghuma K / Sereti, Irini / Singer, Benjamin D

    The Journal of infectious diseases

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae074
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  2. Article ; Online: Finding Facts in Postacute Sequelae of COVID-19: Clinical, Radiographic, and Histopathologic Markers of Disease.

    Pickens, Chiagozie I / Singer, Benjamin D

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 5, Page(s) 521–523

    MeSH term(s) Humans ; COVID-19 ; Diagnostic Imaging ; Disease Progression
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202306-1043ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and the next influenza season.

    Singer, Benjamin D

    Science advances

    2020  Volume 6, Issue 31, Page(s) eabd0086

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coinfection/epidemiology ; Coinfection/transmission ; Coinfection/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Healthcare Disparities ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Seasons ; Vaccination
    Chemical Substances Influenza Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Editorial ; Portrait
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abd0086
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  5. Article ; Online: COVID-19 and the next influenza season

    Singer, Benjamin D.

    Science Advances

    2020  Volume 6, Issue 31, Page(s) eabd0086

    Keywords covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2810933-8
    ISSN 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abd0086
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Practical Guide to the Measurement and Analysis of DNA Methylation.

    Singer, Benjamin D

    American journal of respiratory cell and molecular biology

    2019  Volume 61, Issue 4, Page(s) 417–428

    Abstract: DNA methylation represents a fundamental epigenetic mark that is associated with transcriptional repression during development, maintenance of homeostasis, and disease. In addition to methylation-sensitive PCR and targeted deep-amplicon bisulfite ... ...

    Abstract DNA methylation represents a fundamental epigenetic mark that is associated with transcriptional repression during development, maintenance of homeostasis, and disease. In addition to methylation-sensitive PCR and targeted deep-amplicon bisulfite sequencing to measure DNA methylation at defined genomic loci, numerous unsupervised techniques exist to quantify DNA methylation on a genome-wide scale, including affinity enrichment strategies and methods involving bisulfite conversion. Both affinity-enriched and bisulfite-converted DNA can serve as input material for array hybridization or sequencing using next-generation technologies. In this practical guide to the measurement and analysis of DNA methylation, the goal is to convey basic concepts in DNA methylation biology and explore genome-scale bisulfite sequencing as the current gold standard for assessment of DNA methylation. Bisulfite conversion chemistry and library preparation are discussed in addition to a bioinformatics approach to quality assessment, trimming, alignment, and methylation calling of individual cytosine residues. Bisulfite-converted DNA presents challenges for standard next-generation sequencing library preparation protocols and data-processing pipelines, but these challenges can be met with elegant solutions that leverage the power of high-performance computing systems. Quantification of DNA methylation, data visualization, statistical approaches to compare DNA methylation between sample groups, and examples of integrating DNA methylation data with other -omics data sets are also discussed. The reader is encouraged to use this article as a foundation to pursue advanced topics in DNA methylation measurement and data analysis, particularly the application of bioinformatics and computational biology principles to generate a deeper understanding of mechanisms linking DNA methylation to cellular function.
    MeSH term(s) 5-Methylcytosine/analysis ; 5-Methylcytosine/immunology ; 5-Methylcytosine/isolation & purification ; Base Sequence ; Computational Biology/methods ; CpG Islands ; DNA/chemistry ; DNA/drug effects ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA Methylation ; High-Throughput Nucleotide Sequencing ; Immunoprecipitation ; Methylation ; Molecular Structure ; Nucleic Acid Hybridization ; Quality Control ; Sequence Alignment ; Sulfites/pharmacology
    Chemical Substances Sulfites ; 5-Methylcytosine (6R795CQT4H) ; DNA (9007-49-2) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNMT1 protein, human (EC 2.1.1.37) ; hydrogen sulfite (OJ9787WBLU)
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0150TR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Toward a Paradigm to Distinguish Distinct Functions of FOXP3

    Weinberg, Samuel E / Singer, Benjamin D

    ImmunoHorizons

    2021  Volume 5, Issue 12, Page(s) 944–952

    Abstract: ... ...

    Abstract FOXP3
    MeSH term(s) Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Animals ; Forkhead Transcription Factors/immunology ; Forkhead Transcription Factors/metabolism ; Homeostasis/immunology ; Humans ; Immune Tolerance ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2100046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply: Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs.

    Mikacenic, Carmen / Fussner, Lynn A / Simpson, A John / Singer, Benjamin D / Files, D Clark

    Annals of the American Thoracic Society

    2023  Volume 21, Issue 1, Page(s) 184–185

    MeSH term(s) Humans ; Bronchoscopy ; Lung/diagnostic imaging
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202309-811LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differential roles of regulatory T cells in acute respiratory infections.

    Jovisic, Milica / Mambetsariev, Nurbek / Singer, Benjamin D / Morales-Nebreda, Luisa

    The Journal of clinical investigation

    2023  Volume 133, Issue 14

    Abstract: Acute respiratory infections trigger an inflammatory immune response with the goal of pathogen clearance; however, overexuberant inflammation causes tissue damage and impairs pulmonary function. CD4+FOXP3+ regulatory T cells (Tregs) interact with cells ... ...

    Abstract Acute respiratory infections trigger an inflammatory immune response with the goal of pathogen clearance; however, overexuberant inflammation causes tissue damage and impairs pulmonary function. CD4+FOXP3+ regulatory T cells (Tregs) interact with cells of both the innate and the adaptive immune system to limit acute pulmonary inflammation and promote its resolution. Tregs also provide tissue protection and coordinate lung tissue repair, facilitating a return to homeostatic pulmonary function. Here, we review Treg-mediated modulation of the host response to respiratory pathogens, focusing on mechanisms underlying how Tregs promote resolution of inflammation and repair of acute lung injury. We also discuss potential strategies to harness and optimize Tregs as a cellular therapy for patients with severe acute respiratory infection and discuss open questions in the field.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Lung ; Acute Lung Injury/therapy ; Pneumonia ; Inflammation ; Forkhead Transcription Factors
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI170505
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  10. Article ; Online: Opening the Regulatory T Cell Toolbox.

    Singer, Benjamin D

    American journal of respiratory cell and molecular biology

    2017  Volume 57, Issue 2, Page(s) 137–138

    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/pathology ; Humans ; Influenza A virus/immunology ; Influenza, Human/immunology ; Influenza, Human/pathology ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2017-0130ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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