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  1. Article ; Online: A live-cell ergosterol reporter for visualization of the effects of fluconazole on the human fungal pathogen

    Serrano, Antonio / Basante-Bedoya, Miguel A / Bassilana, Martine / Arkowitz, Robert A

    mBio

    2023  , Page(s) e0249323

    Abstract: Importance: Ergosterol is a critical membrane lipid in fungi. ... ...

    Abstract Importance: Ergosterol is a critical membrane lipid in fungi. In
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02493-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recent advances in understanding

    Arkowitz, Robert A / Bassilana, Martine

    F1000Research

    2019  Volume 8

    Abstract: Morphological changes are critical for the virulence of a range of plant and human fungal pathogens. ...

    Abstract Morphological changes are critical for the virulence of a range of plant and human fungal pathogens.
    MeSH term(s) Candida albicans/growth & development ; Candida albicans/pathogenicity ; Humans ; Hyphae/growth & development ; Virulence
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.18546.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cell polarity inside-out.

    Etienne-Manneville, Sandrine / Arkowitz, Robert

    Current opinion in cell biology

    2020  Volume 62, Page(s) iii–iv

    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Editorial
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2020.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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  4. Article ; Online: Cell polarity: wanderful exploration in yeast sex.

    Arkowitz, Robert A

    Current biology : CB

    2013  Volume 23, Issue 1, Page(s) R10–2

    Abstract: Chemical gradients are used by cells to provide positional information. Two new studies reveal that polarity proteins are highly dynamic in yeast cells responding to a pheromone gradient and suggest that this behavior is important for robust directional ... ...

    Abstract Chemical gradients are used by cells to provide positional information. Two new studies reveal that polarity proteins are highly dynamic in yeast cells responding to a pheromone gradient and suggest that this behavior is important for robust directional growth.
    MeSH term(s) Cell Polarity ; Saccharomyces cerevisiae/cytology ; Schizosaccharomyces/cytology ; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae/physiology
    Chemical Substances cdc42 GTP-Binding Protein, Saccharomyces cerevisiae (EC 3.6.5.2)
    Language English
    Publishing date 2013-01-07
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2012.11.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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  5. Article ; Online: Recent advances in understanding Candida albicans hyphal growth [version 1; peer review

    Robert A. Arkowitz / Martine Bassilana

    F1000Research, Vol

    4 approved]

    2019  Volume 8

    Abstract: Morphological changes are critical for the virulence of a range of plant and human fungal pathogens. Candida albicans is a major human fungal pathogen whose ability to switch between different morphological states is associated with its adaptability and ... ...

    Abstract Morphological changes are critical for the virulence of a range of plant and human fungal pathogens. Candida albicans is a major human fungal pathogen whose ability to switch between different morphological states is associated with its adaptability and pathogenicity. In particular, C. albicans can switch from an oval yeast form to a filamentous hyphal form, which is characteristic of filamentous fungi. What mechanisms underlie hyphal growth and how are they affected by environmental stimuli from the host or resident microbiota? These questions are the focus of intensive research, as understanding C. albicans hyphal growth has broad implications for cell biological and medical research.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: External signal-mediated polarized growth in fungi.

    Bassilana, Martine / Puerner, Charles / Arkowitz, Robert A

    Current opinion in cell biology

    2019  Volume 62, Page(s) 150–158

    Abstract: As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in ... ...

    Abstract As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in response to external signals has commonalities with polarization during mitotic division, during budding, and fission growth, the importance of diverse feedback loops regulating external signal-mediated polarized growth is likely to be distinct and uniquely adapted to a dynamic environment. Here, we highlight recent advances in our understanding of the mechanisms that are crucial for polarity in response to external signals in fungi, with particular focus on the roles of membrane traffic, small GTPases, and lipids, as well as the interplay between cell shape and cell growth.
    MeSH term(s) Cell Polarity/physiology ; Fungi/chemistry ; Saccharomyces cerevisiae/chemistry
    Language English
    Publishing date 2019-12-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2019.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Polarized growth and movement: how to generate new shapes and structures.

    Arkowitz, Robert A

    Seminars in cell & developmental biology

    2011  Volume 22, Issue 8, Page(s) 789

    MeSH term(s) Animals ; Bacteria/cytology ; Bacteria/growth & development ; Bacteria/metabolism ; Cell Adhesion ; Cell Movement ; Cell Polarity ; Cell Shape ; Humans ; Neurons/cytology ; Neurons/metabolism ; Pollen Tube/cytology ; Pollen Tube/metabolism
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2011.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: In Situ Assays of Chemotropism During Yeast Mating.

    Stone, David E / Arkowitz, Robert A

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1407, Page(s) 1–12

    Abstract: Virtually all eukaryotic cells can grow in a polarized fashion in response to external signals. Cells can respond to gradients of chemoattractants or chemorepellents by directional growth, a process referred to as chemotropism. The budding yeast ... ...

    Abstract Virtually all eukaryotic cells can grow in a polarized fashion in response to external signals. Cells can respond to gradients of chemoattractants or chemorepellents by directional growth, a process referred to as chemotropism. The budding yeast Saccharomyces cerevisiae undergoes chemotropic growth during mating, in which two haploid cells of opposite mating type grow towards one another. Mating pheromone gradients are essential for efficient mating in yeast and different yeast mutants are defective in chemotropism. Two methods of assessing the ability of yeast strains to respond to pheromone gradients are presented here.
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3480-5_1
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  9. Article ; Online: A Myosin Light Chain Is Critical for Fungal Growth Robustness in Candida albicans.

    Puerner, Charles / Serrano, Antonio / Wakade, Rohan S / Bassilana, Martine / Arkowitz, Robert A

    mBio

    2021  Volume 12, Issue 5, Page(s) e0252821

    Abstract: In a number of elongated cells, such as fungal hyphae, a vesicle cluster is observed at the growing tip. This cluster, called a Spitzenkörper, has been suggested to act as a vesicle supply center, yet analysis of its function is challenging, as a ... ...

    Abstract In a number of elongated cells, such as fungal hyphae, a vesicle cluster is observed at the growing tip. This cluster, called a Spitzenkörper, has been suggested to act as a vesicle supply center, yet analysis of its function is challenging, as a majority of components identified thus far are essential for growth. Here, we probe the function of the Spitzenkörper in the human fungal pathogen Candida albicans, using genetics and synthetic physical interactions (SPI). We show that the C. albicans Spitzenkörper is comprised principally of secretory vesicles. Mutant strains lacking the Spitzenkörper component myosin light chain 1 (Mlc1) or having a SPI between Mlc1 and either another Spitzenkörper component, the Rab GTPase Sec4, or prenylated green fluorescent protein (GFP), are viable and still exhibit a Spitzenkörper during filamentous growth. Strikingly, all of these mutants formed filaments with increased diameters and extension rates, indicating that Mlc1 negatively regulates myosin V, Myo2, activity. The results of our quantitative studies reveal a strong correlation between filament diameter and extension rate, which is consistent with the vesicle supply center model for fungal tip growth. Together, our results indicate that the Spitzenkörper protein Mlc1 is important for growth robustness and reveal a critical link between filament morphology and extension rate.
    MeSH term(s) Candida albicans/genetics ; Candida albicans/growth & development ; Candida albicans/pathogenicity ; Cell Polarity ; Cytoskeleton/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Humans ; Hyphae/genetics ; Hyphae/growth & development ; Myosin Light Chains/genetics ; Myosin Light Chains/metabolism
    Chemical Substances Fungal Proteins ; Myosin Light Chains ; myosin light chain I
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02528-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection.

    Garcia-Rodas, Rocio / Labbaoui, Hayet / Orange, François / Solis, Norma / Zaragoza, Oscar / Filler, Scott G / Bassilana, Martine / Arkowitz, Robert A

    mBio

    2022  Volume 13, Issue 1, Page(s) e0387321

    Abstract: Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles, including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI(4)P] at the Golgi apparatus is required for the budding-to-filamentous-growth ... ...

    Abstract Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles, including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI(4)P] at the Golgi apparatus is required for the budding-to-filamentous-growth transition in the human-pathogenic fungus Candida albicans; however, the role of plasma membrane PI(4)P is unclear. We have investigated the importance of this phospholipid in C. albicans growth, stress response, and virulence by generating mutant strains with decreased levels of plasma membrane PI(4)P, via deletion of components of the PI-4-kinase complex, i.e., Efr3, Ypp1, and Stt4. The amounts of plasma membrane PI(4)P in the
    MeSH term(s) Animals ; Mice ; Candida albicans/genetics ; Candidiasis/microbiology ; Cell Membrane/metabolism ; Cell Wall/metabolism ; Disease Models, Animal ; Fungal Proteins/genetics ; Hyphae ; Phosphatidylinositol Phosphates/metabolism
    Chemical Substances Fungal Proteins ; phosphatidylinositol 4-phosphate ; Phosphatidylinositol Phosphates
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03873-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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