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  1. Book ; Online ; E-Book: Studies of epithelial transporters and ion channels / Vol. 3 /

    Hamilton, Kirk L. / Devor, Daniel C.

    ion channels and transporters of epithelia in health and disease

    (Physiology in health and disease)

    2020  

    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters ... ...

    Author's details Kirk L. Hamilton, Daniel C. Devor, editors
    Series title Physiology in health and disease
    Abstract This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
    Keywords Epithelium ; Epiteli ; Canals iònics ; Farmacologia
    Subject code 574.821
    Language English
    Size 1 online resource (XXI, 1244 p. 256 illus., 203 illus. in color.)
    Edition Second edition.
    Publisher Springer ; American Physiological Society
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-55454-6 ; 3-030-55453-8 ; 978-3-030-55454-5 ; 978-3-030-55453-8
    DOI 10.1007/978-3-030-55454-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Ion transport across epithelial tissues and disease

    Devor, Daniel C. / Hamilton, Kirk L.

    ion channels and transporters of epithelia in health and disease - vol. 2

    (Physiology in Health and Disease,)

    2020  

    Abstract: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these ... ...

    Author's details edited by Kirk L. Hamilton, Daniel C. Devor
    Series title Physiology in Health and Disease,
    Abstract This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
    Keywords Molecular Medicine ; Protein Science ; Human physiology
    Subject code 361
    Language English
    Size 1 online resource (XIX, 382 p. 77 illus., 62 illus. in color.)
    Edition 2nd ed. 2020.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-55310-8 ; 3-030-55309-4 ; 978-3-030-55310-4 ; 978-3-030-55309-8
    DOI 10.1007/978-3-030-55310-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Basic epithelial ion transport principles and function / Volume 1 /

    Devor, Daniel C. / Hamilton, Kirk L.

    (Physiology in health and disease)

    2020  

    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles ...

    Author's details Kirk L. Hamilton, Daniel C. Devor, editors
    Series title Physiology in health and disease
    Abstract This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike. .
    Keywords Human physiology
    Subject code 612
    Language English
    Size 1 online resource (XIX, 563 p. 106 illus., 71 illus. in color.)
    Edition Second edition.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-52780-8 ; 3-030-52779-4 ; 978-3-030-52780-8 ; 978-3-030-52779-2
    DOI 10.1007/978-3-030-52780-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Ion channels and transporters of epithelia in health and disease

    Hamilton, Kirk L. / Devor, Daniel C.

    (Physiology in health and disease)

    2016  

    Author's details Kirk L. Hamilton ; Daniel C. Devor ed
    Series title Physiology in health and disease
    Keywords Chloride channels and transport ; Maintaining homeostasis ; Bicarbonate secretion ; Transepithelial secretion ; Cystic fibrosis ; Sodium channels and absorption ; Epithelial ion transport ; Membrane protein folding and structure ; Potassium channels ; Kidney transport processes
    Language English
    Size XIV, 1019 S. : Ill. graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018862623
    ISBN 978-1-4939-3364-8 ; 978-1-4939-3366-2 ; 1-4939-3364-7 ; 1-4939-3366-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 144 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: AJP-Cell Physiology

    Hamilton, Kirk L

    American journal of physiology. Cell physiology

    2020  Volume 319, Issue 2, Page(s) C402–C403

    MeSH term(s) Cell Physiological Phenomena ; Cilia ; Endosomes ; GTP Phosphohydrolases ; Protein Transport
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00347.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New life in overactive bladder. Focus on "Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function".

    Hamilton, Kirk L

    American journal of physiology. Cell physiology

    2016  Volume 310, Issue 7, Page(s) C597–9

    MeSH term(s) Animals ; Female ; Humans ; Male ; Muscle Contraction/physiology ; Muscle, Smooth/metabolism ; TRPM Cation Channels/metabolism ; Urinary Bladder/metabolism
    Chemical Substances TRPM Cation Channels
    Language English
    Publishing date 2016-02-17
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00039.2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reproducibility and intratumoral heterogeneity of the PAM50 breast cancer assay.

    Hurson, Amber N / Hamilton, Alina M / Olsson, Linnea T / Kirk, Erin L / Sherman, Mark E / Calhoun, Benjamin C / Geradts, Joseph / Troester, Melissa A

    Breast cancer research and treatment

    2023  Volume 199, Issue 1, Page(s) 147–154

    Abstract: Background: The PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how technical variation and intratumoral heterogeneity contribute to misclassification and ... ...

    Abstract Background: The PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how technical variation and intratumoral heterogeneity contribute to misclassification and reproducibility of these tests is limited.
    Methods: We evaluated the impact of intratumoral heterogeneity on the reproducibility of results for the PAM50 assay by testing RNA extracted from formalin-fixed paraffin embedded breast cancer blocks sampled at distinct spatial locations. Samples were classified according to intrinsic subtype (Luminal A, Luminal B, HER2-enriched, Basal-like, or Normal-like) and risk of recurrence with proliferation score (ROR-P, high, medium, or low). Intratumoral heterogeneity and technical reproducibility (replicate assays on the same RNA) were assessed as percent categorical agreement between paired intratumoral and replicate samples. Euclidean distances between samples, calculated across the PAM50 genes and the ROR-P score, were compared for concordant vs. discordant samples.
    Results: Technical replicates (N = 144) achieved 93% agreement for ROR-P group and 90% agreement on PAM50 subtype. For spatially distinct biological replicates (N = 40 intratumoral replicates), agreement was lower (81% for ROR-P and 76% for PAM50 subtype). The Euclidean distances between discordant technical replicates were bimodal, with discordant samples showing higher Euclidian distance and biologic heterogeneity.
    Conclusion: The PAM50 assay achieved very high technical reproducibility for breast cancer subtyping and ROR-P, but intratumoral heterogeneity is revealed by the assay in a small proportion of cases.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Reproducibility of Results ; Prognosis ; Breast ; RNA ; Biomarkers, Tumor/genetics ; Receptor, ErbB-2
    Chemical Substances RNA (63231-63-0) ; Biomarkers, Tumor ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-03-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-06888-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1655: Show issues Location:
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  8. Article ; Online: BIRC5 expression by race, age and clinical factors in breast cancer patients.

    Hamilton, Alina M / Walens, Andrea / Van Alsten, Sarah C / Olsson, Linnea T / Nsonwu-Farley, Joseph / Gao, Xiaohua / Kirk, Erin L / Perou, Charles M / Carey, Lisa A / Troester, Melissa A / Abdou, Yara

    Breast cancer research : BCR

    2024  Volume 26, Issue 1, Page(s) 50

    Abstract: Purpose: Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not been well studied among racially diverse populations where aggressive breast cancers ... ...

    Abstract Purpose: Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not been well studied among racially diverse populations where aggressive breast cancers are prevalent.
    Experimental design: We studied BIRC5 expression in association with clinical and demographic variables and as a predictor of recurrence in 2174 participants in the Carolina Breast Cancer Study (CBCS), a population-based study that oversampled Black (n = 1113) and younger (< 50 years; n = 1137) participants with breast cancer. For comparison, similar analyses were conducted in The Cancer Genome Atlas [TCGA N = 1094, Black (n = 183), younger (n = 295)]. BIRC5 was evaluated as a continuous and categorical variable (highest quartile vs. lower three quartiles).
    Results: Univariate, continuous BIRC5 expression was higher in breast tumors from Black women relative to non-Black women in both estrogen receptor (ER)-positive and ER-negative tumors and in analyses stratified by stage (i.e., within Stage I, Stage II, and Stage III/IV tumors). Within CBCS and TCGA, BIRC5-high was associated with young age (< 50 years) and Black race, as well as hormone receptor-negative tumors, non-Luminal A PAM50 subtypes, advanced stage, and larger tumors (> 2 cm). Relative to BIRC5-low, BIRC5-high tumors were associated with poor 5-year recurrence-free survival (RFS) among ER-positive tumors, both in unadjusted models [HR (95% CI): 2.7 (1.6, 4.6)] and after adjustment for age and stage [Adjusted HR (95% CI): 1.87 (1.07, 3.25)]. However, this relationship was not observed among ER-negative tumors [Crude HR (95% CI): 0.7 (0.39, 1.2); Adjusted HR (95% CI): 0.67 (0.37, 1.2)].
    Conclusion: Black and younger women with breast cancer have a higher burden of BIRC5-high tumors than older and non-Black women. Emerging anti-survivin treatment strategies may be an important future direction for equitable breast cancer outcomes.
    MeSH term(s) Female ; Humans ; Middle Aged ; Breast Neoplasms/pathology ; Survivin/genetics ; Black or African American
    Chemical Substances BIRC5 protein, human ; Survivin
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-024-01792-y
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    Zs.A 5494: Show issues Location:
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  9. Article ; Online: Cleavage: what's up with prostasin and ENaC these days?

    Hamilton, Kirk L

    American journal of physiology. Renal physiology

    2014  Volume 307, Issue 11, Page(s) F1196–7

    MeSH term(s) Animals ; Epithelial Sodium Channels/metabolism ; Female ; Humans ; Male ; Protein Subunits/metabolism ; Serine Endopeptidases/metabolism
    Chemical Substances Epithelial Sodium Channels ; Protein Subunits ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2014-12-01
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00522.2014
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  10. Article ; Online: Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status.

    Van Alsten, Sarah C / Dunn, Matthew R / Hamilton, Alina M / Ivory, Joannie M / Gao, Xiaohua / Kirk, Erin L / Nsonwu-Farley, Joseph S / Carey, Lisa A / Abdou, Yara / Reeder-Hayes, Katherine E / Roberson, Mya L / Wheeler, Stephanie B / Emerson, Marc A / Hyslop, Terry / Troester, Melissa A

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2024  Volume 33, Issue 5, Page(s) 654–661

    Abstract: Background: OncotypeDx is a prognostic and predictive genomic assay used in early-stage hormone receptor-positive, HER2- (HR+/HER2-) breast cancer. It is used to inform adjuvant chemotherapy decisions, but not all eligible women receive testing. We ... ...

    Abstract Background: OncotypeDx is a prognostic and predictive genomic assay used in early-stage hormone receptor-positive, HER2- (HR+/HER2-) breast cancer. It is used to inform adjuvant chemotherapy decisions, but not all eligible women receive testing. We aimed to assess variation in testing by demographics and geography, and to determine whether testing was associated with chemotherapy.
    Methods: For 1,615 women in the Carolina Breast Cancer Study with HR+/HER2-, Stage I-II tumors, we estimated prevalence differences (PD) and 95% confidence intervals (CI) for receipt of OncotypeDx genomic testing in association with and sociodemographic characteristics. We assessed associations between testing and chemotherapy receipt overall and by race. Finally, we calculated the proportion of eligible women receiving OncotypeDx by county-level rurality, census tract-level socioeconomic status, and Area Health Education Center regions.
    Results: 38% (N = 609) of potentially eligible women were tested, with lower testing prevalences in Black (31%; PD, -11%; 95% CI, -16%-6%) and low-income women (24%; PD, -20%; 95% CI, -29% to -11%) relative to non-Black and higher income women. Urban participants were less likely to be tested than rural participants, though this association varied by region. Among women with low genomic risk tumors, tested participants were 29% less likely to receive chemotherapy than untested participants (95% CI, -40% to -17%). Racial differences in chemotherapy were restricted to untested women.
    Conclusions: Both individual and area-level socioeconomics predict likelihood of OncotypeDx testing.
    Impact: Variable adoption of OncotypeDx by socioeconomics and across geographic settings may contribute to excess chemotherapy among patients with HR+/HER2- cancers. See related In the Spotlight, p. 635.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Middle Aged ; Adult ; Aged ; Social Class ; Healthcare Disparities/statistics & numerical data ; Genetic Testing/statistics & numerical data ; Genetic Testing/methods ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/genetics
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-1201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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