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Article ; Online: D-

Yang, Qiong / Zhang, Yao / Li, Luqi / Li, Jia / Li, Yunlong / Han, Lin / Wang, Min

2022 Volume 13, Issue 13, Page(s) 7192–7203

Abstract: D- ...

Abstract	D-
MeSH term(s)	AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adiponectin/metabolism ; Animals ; Body Weight ; Diet, High-Fat ; Fatty Liver/metabolism ; Glucose/metabolism ; Inositol/pharmacology ; Lipid Metabolism ; Lipids/pharmacology ; Liver/metabolism ; Mammals/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Peroxisome Proliferator-Activated Receptors/metabolism ; Tandem Mass Spectrometry
Chemical Substances	Adiponectin ; Lipids ; Peroxisome Proliferator-Activated Receptors ; Inositol (4L6452S749) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo00869f
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Article ; Online: d

Wei, Si Yue / Wang, Jian Ling / Zhang, Cai Shun / Xu, Xue-Ting / Zhang, Xiao Xi / Wang, Ji Xiao / Xing, Yong-Heng

ChemPlusChem

2014 Volume 80, Issue 3, Page(s) 549–558

Abstract: By introducing 2,6-bis(2-benzimidazolyl)pyridyl and 2,6-di-(pyrazol-3-yl)pyridine derivatives as ligand in the reaction system, three new transition-metal coordination complexes have been successfully synthesized, namely, [Co( ... ...

Abstract	By introducing 2,6-bis(2-benzimidazolyl)pyridyl and 2,6-di-(pyrazol-3-yl)pyridine derivatives as ligand in the reaction system, three new transition-metal coordination complexes have been successfully synthesized, namely, [Co(HL
Language	English
Publishing date	2014-11-17
Publishing country	Germany
Document type	Journal Article
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.201402255
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Article: Current status of vitamin D

Liu, Jia / An, Zhihua / An, Na / Zhao, Yile / Zhang, Guying / Zhao, Deyun

Frontiers in pediatrics

2024 Volume 12, Page(s) 1333769

Abstract: Background: The aim of this study was to explore the current status of vitamin D: Methods ... The instances of detection of vitamin D (VD) and VD: Results: Among the different age groups, children aged ...

Abstract	Background: The aim of this study was to explore the current status of vitamin D Methods: The instances of detection of vitamin D (VD) and VD Results: Among the different age groups, children aged 11-15 years exhibited the most severe VD Conclusions: Children who came to the hospital were severely deficient in VD
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1333769
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Article ; Online: Vitamin D

Zhang, Minping / Chen, Li / Xu, Qunping / Yang, Xiaohua / Liu, Xiang / Liu, Luanmei

In vitro cellular & developmental biology. Animal

2024

Abstract: ... to investigate the mechanism underlying the effect of vitamin D ...

Abstract	It has been reported that the effective inhibition of vascular endothelial growth factor (VEGF) can prevent the progression of ovarian hyperstimulation syndrome (OHSS). The present study aimed to investigate the mechanism underlying the effect of vitamin D
Language	English
Publishing date	2024-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-024-00898-z
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Prostaglandin D

Bao, Haixia / Gong, Zhiguo / Zhao, Jiamin / Ren, Peipei / Yu, Zhuoya / Su, Niri / Gong, Linlin / Mao, Wei / Liu, Bo / Zhang, Shuangyi / Yang, Yinfeng / Cao, Jinshan

International immunopharmacology

2024 Volume 129, Page(s) 111526

Abstract: ... prostaglandin D ...

Abstract	Staphylococcus aureus (S. aureus) is one of the most infamous and widespread bacterial pathogens, causing a hard-to-estimate number of uncomplicated skin infections and probably hundreds of thousands to millions of more severe, invasive infections globally per year. S. aureus may also be acquired from animals, especially in the livestock industry. The interaction mechanism of host and S. aureus has significance for finding ways to against S. aureus infection and control inflammatory response of host, while the molecular biological activities after S. aureus infection, particular in inflammatory and immune cells are not fully clear. The present study aimed to explore whether pattern recognition receptors (PRRs) mediate prostaglandin D
MeSH term(s)	Animals ; Mice ; Toll-Like Receptor 2 ; Staphylococcus aureus ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Macrophages ; NF-kappa B/metabolism ; Cytokines/metabolism
Chemical Substances	Toll-Like Receptor 2 ; NLR Family, Pyrin Domain-Containing 3 Protein ; NF-kappa B ; Cytokines
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111526
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Zs.A 5408: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Vitamin D

Chen, Zhichu / Huang, Dong / Yongyut, Prakaiwan / Li, Guangbin / Esteban, María Ángeles / Jintasataporn, Orapint / Deng, Junming / Zhang, Wenbing / Ai, Qinghui / Mai, Kangsen / Zhang, Yanjiao

Frontiers in immunology

2022 Volume 13, Page(s) 986593

Abstract: Vitamin D ...

Abstract	Vitamin D
MeSH term(s)	Animals ; Apoptosis ; Autophagy ; Cholecalciferol ; Flatfishes ; Inflammasomes ; Inflammation/metabolism ; NF-kappa B/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Vitamin D Deficiency
Chemical Substances	Inflammasomes ; NF-kappa B ; Receptors, Calcitriol ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.986593
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Article: Vitamin D

Chen, Xiaoqi / An, Zhifang / Wei, Linna / Zhang, Jiayu / Li, Jimei / Wang, Zhijie / Gao, Conghui / Wei, Dengbang

Animals : an open access journal from MDPI

2022 Volume 12, Issue 18

Abstract: ... intestinal paracellular calcium absorption in a vitamin D receptor-dependent manner in vitamin D-deficient ...

Abstract	Vitamin D3 (D3) is produced endogenously from 7-dehydrocholesterol by irradiation and is an important secosteroid for the absorption of calcium and phosphate. Lithocholic acid (LCA) increases intestinal paracellular calcium absorption in a vitamin D receptor-dependent manner in vitamin D-deficient rats. The plateau zokor (Myospalax baileyi), a strictly subterranean species, and plateau pika are endemic to the Qinghai-Tibet Plateau. To verify whether the zokors were deficient in D3 and reveal the effects of hypoxia on D3 metabolism in the zokors and pikas, we measured the levels of 25(OH)D3, calcium, and LCA, and quantified the expression levels of D3 metabolism-related genes. The results showed an undetectable serum level of 25(OH)D3 and a significantly higher concentration of LCA in the serum of plateau zokor, but its calcium concentration was within the normal range compared with that of plateau pika and Sprague-Dawley rats. With increasing altitude, the serum 25(OH)D3 levels in plateau pika decreased significantly, and the mRNA and protein levels of CYP2R1 (in the liver) and CYP27B1 (in the kidney) in plateau pika decreased significantly. Our results indicate that plateau zokors were deficient in D3 and abundant in LCA, which might be a substitution of D3 in the zokor. Furthermore, hypoxia suppresses the metabolism of D3 by down-regulating the expression of CYP2R1 and CYP27B1 in plateau pika.
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12182371
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Article ; Online: Cathepsin D

Cheng, Dan / Zhang, Wenyi / Jiang, Sufei / Xiong, Yiwei / Jin, Shubo / Pan, Fangyan / Zhu, Junpeng / Gong, Yongsheng / Wu, Yan / Qiao, Hui / Fu, Hongtuo

Genes

2022 Volume 13, Issue 8

Abstract: ... farming. Cathepsin D is a lysosomal protease involved in the ovarian maturation of M. nipponense ... In the current study, the cDNA of the gene encoding cathepsin D (Mn-CTSD) was cloned from M. nipponense ... sequences of nondigestive cathepsin D. The qPCR analysis indicated that Mn-CTSD was highly expressed ...

Abstract	The oriental river prawn Macrobrachium nipponense is an economically important aquacultural species. However, its aquaculture is negatively impacted by the rapid sexual maturation of female M. nipponense. The fast sexual maturation produces a large number of offspring which leads to a reduction in resilience, a low survival rate, and an increased risk of hypoxia, this in turn, seriously affects the economic benefits of prawn farming. Cathepsin D is a lysosomal protease involved in the ovarian maturation of M. nipponense. In the current study, the cDNA of the gene encoding cathepsin D (Mn-CTSD) was cloned from M. nipponense. The total length was 2391 bp and consisted of an open reading frame (ORF) of 1158 bp encoding 385 amino acids. Sequence analysis confirmed the presence of conserved N-glycosylation sites and characteristic sequences of nondigestive cathepsin D. The qPCR analysis indicated that Mn-CTSD was highly expressed in all tissues tested, most significantly in the ovaries, whereas in situ hybridization showed that expression occurred mainly in oocyte nuclei. Analysis of its expression during development showed that Mn-CTSD peaked during the O-IV stage of ovarian maturation. For the RNAi interference experiment, female M. nipponense specimens in the ovary stage I were selected. Injection of Mn-CTSD double-stranded (ds)RNA into female M. nipponense decreased the expression of Mn-CTSD in the ovaries, such that the Gonad Somatic Index (GSI) of the experimental group was significantly lower than that of the control group (1.79% versus 4.57%; p < 0.05). Ovary development reached the O-III stage in 80% of the control group, compared with 0% in the experimental group. These results suggest that Mn-CTSD dsRNA inhibits ovarian maturation in M. nipponense, highlighting its important role in ovarian maturation in this species and suggesting an approach to controlling ovarian maturation during M. nipponense aquaculture.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Female ; Ovary/metabolism ; Palaemonidae/genetics ; Palaemonidae/metabolism ; RNA, Double-Stranded/metabolism
Chemical Substances	RNA, Double-Stranded ; Cathepsin D (EC 3.4.23.5)
Language	English
Publishing date	2022-08-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13081495
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Article ; Online: 1,25-Dihydroxyvitamin D

Wei, Yujia / Wang, Tingmei / Nie, Xiaoqi / Shi, Zeqi / Liu, Zhong / Zeng, Ying / Pan, Ronghua / Zhang, Ri / Deng, Yunhua / Li, Dong

Nutrients

2023 Volume 15, Issue 21

Abstract: ... effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made ... to elucidate the immunomodulatory effects of 1,25(OH)₂D₃ in vitiligo. Cross-sectional relationships between ... serum 1,25(OH)₂D₃ levels and disease characteristics were investigated in 327 patients with vitiligo ...

Abstract	Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study aimed to elucidate the immunomodulatory effects of 1,25(OH)₂D₃ in vitiligo. Cross-sectional relationships between serum 1,25(OH)₂D₃ levels and disease characteristics were investigated in 327 patients with vitiligo. The immunomodulatory and therapeutic effects of 1,25(OH)₂D₃ were then investigated in vivo and in vitro, respectively. We found that 1,25(OH)₂D₃ deficiency was associated with hyperactivity of CD8+ T cells in the vitiligo cohort. In addition, 1,25(OH)₂D₃ suppressed glycolysis by activating the AMP-activated protein kinase (AMPK) signaling pathway, thereby inhibiting the proliferation, cytotoxicity and aberrant activation of CD8+ T cells. Finally, the in vivo administration of 1,25(OH)₂D₃ to melanocyte-associated vitiligo (MAV) mice reduced the infiltration and function of CD8+ T cells and promoted repigmentation. In conclusion, 1,25(OH)₂D₃ may serve as an essential biomarker of the progression and severity of vitiligo. The modulation of autoreactive CD8+ T cell function and glycolysis by 1,25(OH)₂D₃ may be a novel approach for treating vitiligo.
MeSH term(s)	Humans ; Mice ; Animals ; Vitiligo/drug therapy ; Vitiligo/complications ; Calcitriol/metabolism ; CD8-Positive T-Lymphocytes
Chemical Substances	1,25-dihydroxyvitamin D (66772-14-3) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214697
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Article ; Online: Primary Structural Units "D

Zhang, Meng-Meng / Chen, Shun-Li / Huang, Siya / Zheng, Dexin / Liang, Hui / Ye, Bowei / Chen, Jiecheng / Song, Xinluo / Liu, Lishan / Li, Jiayu / Chen, Wenbin / Ji, Shaomin / Dang, Li / Li, Ming-De

The journal of physical chemistry letters

2023 Volume 15, Issue 1, Page(s) 68–75

Abstract: The specific stacking mode of D/A blocks is often considered to largely determine ... with distinct stacking modes display analogous D-A interactions, broad red-shift absorption, ultrafast (1-3 ps ... relaxation dynamics of excited states, and excellent NIR-PTC properties. This supports that the resulting "D ...

Abstract	The specific stacking mode of D/A blocks is often considered to largely determine the physicochemical properties of cocrystals. However, this rule may fail when encountering a large degree of (integer or near-integer) charge transfer situations. Herein, we explore the extensive correlations between the possible smallest structural units, stacking modes, and near-infrared photothermal conversion (NIR-PTC) properties of F4TCNQ-based cocrystals with typical features of integer-charge-transfer. Surprisingly, these cocrystals with distinct stacking modes display analogous D-A interactions, broad red-shift absorption, ultrafast (1-3 ps) relaxation dynamics of excited states, and excellent NIR-PTC properties. This supports that the resulting "D
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03366
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