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Article: Micro-Spherical BiOI Photocatalysts for Efficient Degradation of Residual Xanthate and Gaseous Nitric Oxide.

Nie, Qianqian / Jia, Liuhu / Zhang, Guoqing / Xie, Jiewei / Liu, Jiayou

2024 Volume 14, Issue 7

Abstract: BiOI microspheres were synthesized using the solvothermal method for the degradation of residual xanthate and gaseous nitric oxide (NO) under visible light irradiation. The as-prepared BiOI nanomaterials were then characterized using various technologies, ...

Abstract	BiOI microspheres were synthesized using the solvothermal method for the degradation of residual xanthate and gaseous nitric oxide (NO) under visible light irradiation. The as-prepared BiOI nanomaterials were then characterized using various technologies, including XRD, FE-SEM, TEM, UV-Vis DRS, and XPS. The photodegradation results show that the removal efficiency of isobutyl sodium xanthate can reach 98.08% at an initial xanthate concentration of 120 mg/L; that of NO is as high as 96.36% at an inlet NO concentration of 11 ppm. Moreover, the effects of operational parameters such as catalyst dosage, initial xanthate concentration, and pH value of wastewater on the removal of xanthate were investigated. The results of scavenging tests and full-spectrum scanning indicate that ·O
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14070576
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Article ; Online: How should China set ethical guardrails for medical research?

Xu, Jingyi / Liu, Zhongxuan / Shi, Jiayou / Wang, Yue

Journal of medical ethics

2023

Abstract: Ethics first' reform in China significantly changes the governance framework for the research of emerging technologies. The misapplication of human genome editing technology reflects the urgent need to reform the governance framework. Strengthening ... ...

Abstract	'Ethics first' reform in China significantly changes the governance framework for the research of emerging technologies. The misapplication of human genome editing technology reflects the urgent need to reform the governance framework. Strengthening ethics governance in medical research has become a consensus in China, where legal and ethical reforms are proceeding in parallel. The protection of human dignity, the prevention of biosafety risks, as well as the regulation of technological crimes are at the core of the legal system, which has been embodied in numerous fundamental legislations following the CRISPR-babies incident. Establishing a national ethics committee to coordinate ethics governance, and reinforcing ethics review and external oversight are significant steps in ethical reform. Essentially, ethics governance requires implementing the basic concept of 'ethics first', focusing on forward-looking and preventive governance rather than delayed intervention, while maintaining openness and collaboration.
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	194927-5
ISSN	1473-4257 ; 0306-6800
ISSN (online)	1473-4257
ISSN	0306-6800
DOI	10.1136/jme-2023-109621
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Zs.A 1163: Show issues

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Article ; Online: An updated meta-analysis of effectiveness and safety of mTOR inhibitors in the management of tuberous sclerosis complex patients.

Liu, Mengling / Ye, Jiayou / You, Xiaoling

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2023 Volume 40, Issue 3, Page(s) 823–829

Abstract: Purpose: Tuberculous sclerosis complex (TSC) is an autosomal dominant multi-system disease. In TSC patients, the inhibition of mTOR pathway is weakened, which leads to the uncontrolled proliferation of normal resting cells. Therefore, mTOR inhibitors ... ...

Abstract	Purpose: Tuberculous sclerosis complex (TSC) is an autosomal dominant multi-system disease. In TSC patients, the inhibition of mTOR pathway is weakened, which leads to the uncontrolled proliferation of normal resting cells. Therefore, mTOR inhibitors have many therapeutic potentials in the treatment of TSC. However, there is no consensus on the safety and efficacy of mTOR inhibitors so far. This article aimed to present new evidence for the efficacy and safety of mTOR inhibitors in the treatment of TSC by evaluating published clinical trials. Methods: A systemic search of online databases, such as Cochrane Library, Embase, PubMed, and the US National Institutes of Health Clinical Trials Registry, was conducted. The researchers selected studies that met the following entry criteria: randomized, double-blinded or single-blinded, placebo-controlled, parallel-group studies with active and control arms receiving rapamycin or everolimus and matched placebo, respectively. The meta-analysis included seven studies. Tumor response or epilepsy seizure frequency response rates were considered efficacy outcomes. Results: In seven studies involving 877 patients, using of mTOR inhibitors therapy showed an improvement in both tumor response and seizure frequency outcomes in TSC. In combination of AML (angiomyolipomas), SEGA (subependymal giant cell astrocytoma), epilepsy, and facial angiofibroma subjects, the RR is 3.01 (95% CI 2.03 to 4.45, p = 0.000) with observed heterogeneity (I-squared = 55.4%). The main side effect of mTOR inhibitors was stomatitis. Conclusion: The updated meta-analysis suggests that the use of mTOR inhibitors is an effective therapy for patients with TSC.
MeSH term(s)	Humans ; MTOR Inhibitors ; Tuberous Sclerosis/drug therapy ; Sirolimus/adverse effects ; Epilepsy/drug therapy ; Seizures/drug therapy ; Astrocytoma/pathology
Chemical Substances	MTOR Inhibitors ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2023-10-31
Publishing country	Germany
Document type	Meta-Analysis ; Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-06200-y
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Zs.A 2036: Show issues

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Article ; Online: Microwave-Assisted Rapid Substitution of Ti for Zr to Produce Bimetallic (Zr/Ti)UiO-66-NH

Liu, Jiayou / Huang, Xiaoxiang / Jia, Liuhu / Liu, Linfeng / Nie, Qianqian / Tan, Zhongchao / Yu, Hesheng

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 20, Page(s) e2207198

Abstract: Efficient nitric oxide (NO) removal without nitrogen dioxide ( ... ...

Abstract	Efficient nitric oxide (NO) removal without nitrogen dioxide (NO
Language	English
Publishing date	2023-02-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202207198
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Article: Influencing factors and risk prediction model for cervical cancer recurrence.

Li, Jina / Luo, Jiayou / Liu, Gaoming / Yan, Shipeng

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2023 Volume 47, Issue 12, Page(s) 1711–1720

Abstract: Objectives: Cervical cancer is the most common malignant tumor in the female reproductive system worldwide. The recurrence rate for the treated cervical cancer patients is high, which seriously threatens women's lives and health. At present, the risk ... ...

Title translation	宫颈癌复发的影响因素及风险预测模型.
Abstract	Objectives: Cervical cancer is the most common malignant tumor in the female reproductive system worldwide. The recurrence rate for the treated cervical cancer patients is high, which seriously threatens women's lives and health. At present, the risk prediction study of cervical cancer has not been reported. Based on the influencing factors of cervical cancer recurrence, we aim to establish a risk prediction model of cervical cancer recurrence to provide a scientific basis for the prevention and treatment of cervical cancer recurrence. Methods: A total of 4 358 cervical cancer patients admitted to the Hunan Cancer Hospital from January 1992 to December 2005 were selected as research subjects, and the recurrence of cervical cancer patients after treatment was followed up. Univariate analysis was used to analyze the possible influencing factors. Variables that were significant in univariate analysis or those that were not significant in univariate analysis but may be considered significant were included in multivariate Cox regression analysis to establish a cervical cancer recurrence risk prediction model. Line graphs was used to show the model and it was evaluated by using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis. Results: Univariate analysis showed that the recurrence rates of cervical cancer patients with different age, age of menarche, parity, miscarriage, clinical stage, and treatment method were significantly different (all P<0.05). Multivariate Cox regression analysis showed that RR=-0.489×(age≥55 years old)+0.481×(age at menarche >15 years old)+0.459×(number of miscarriages≥3)+0.416×(clinical stage II)+0.613×(clinical stage III/IV)+0.366×(the treatment method was surgery + chemotherapy) + 0.015×(the treatment method was chemotherapy alone). The area under the ROC curve (AUC) of the Cox risk prediction model for cervical cancer recurrence constructed was 0.736 (95% CI 0.684 to 0.789), the best prediction threshold was 0.857, the sensitivity was 0.576, and the specificity was 0.810. The accuracy of the Cox risk model constructed by this model was good. From the clinical decision curve, the net benefit value was high and the validity was good. Conclusions: Patient age, age at menarche, miscarriages, clinical stages, and treatment methods are independent factors affecting cervical cancer recurrence. The Cox proportional hazards prediction model for cervical cancer recurrence constructed in this study can be better used for predicting the risk of cervical cancer recurrence.
MeSH term(s)	Pregnancy ; Humans ; Female ; Middle Aged ; Adolescent ; Prognosis ; Uterine Cervical Neoplasms/epidemiology ; Abortion, Spontaneous ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Proportional Hazards Models ; Risk Factors ; Retrospective Studies
Language	Chinese
Publishing date	2023-01-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2022.210722
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Zs.B 2681: Show issues

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Article: QTL-seq analysis identified the genomic regions of plant height and days to heading in high-latitude rice.

Wang, Rongsheng / Li, Kun / Zhang, Wei / Liu, Hui / Tao, Yongqing / Liu, Yuming / Ding, Guohua / Yang, Guang / Zhou, Yuanhang / Wang, Jiayou / Wu, Licheng / Liu, Baohai / Mu, Fengchen

Frontiers in genetics

2024 Volume 15, Page(s) 1305681

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1305681
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Article ; Online: Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis.

Yang, Siyu / Sun, Yaochuan / Luo, Yajun / Liu, Yingyi / Jiang, Mengyu / Li, Jiayou / Zhang, Qibing / Bai, Jun

Ecotoxicology and environmental safety

2024 Volume 272, Page(s) 116068

Abstract: The inflammatory response induced by fine particulate matter ( ... ...

Abstract	The inflammatory response induced by fine particulate matter (PM
MeSH term(s)	Rats ; Humans ; Animals ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Particulate Matter/toxicity ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; PPAR gamma ; HMGB1 Protein/genetics ; DNA
Chemical Substances	Particulate Matter ; NLR Family, Pyrin Domain-Containing 3 Protein ; PPAR gamma ; HMGB1 Protein ; DNA (9007-49-2)
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116068
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Zs.A 1418: Show issues

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Article ; Online: Clinical treatment procedure and experience of six gene-edited pig-rhesus monkey heterotopic heart xenotransplantation.

Zhang, Bing / Ji, Pengfei / Peng, Langang / Zhai, Mengen / Tang, Jiayou / Zhao, Lin / Jin, Yan / Xu, Baoling / Lyu, Xiangni / Lu, Linhe / Zhou, Yenong / Jin, Zhenxiao / Duan, Weixun / Yang, Xiuling / Yi, Wei / Liu, Jincheng

Chinese medical journal

2024 Volume 137, Issue 8, Page(s) 997–999

MeSH term(s)	Animals ; Transplantation, Heterologous/methods ; Swine ; Heart Transplantation/methods ; Macaca mulatta ; Humans ; Male ; Gene Editing/methods ; Female
Language	English
Publishing date	2024-02-29
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000003030
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Zs.B 1207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.425: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A comprehensive bioinformatics analysis identifies mitophagy biomarkers and potential Molecular mechanisms in hypertensive nephropathy.

Liu, Jiayou / Feng, Luda / Jia, Qi / Meng, Jia / Zhao, Yun / Ren, Lei / Yan, Ziming / Wang, Manrui / Qin, Jianguo

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–20

Abstract: Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To address this gap, we investigated mitophagy-related genes in HTN, ... ...

Abstract	Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To address this gap, we investigated mitophagy-related genes in HTN, identifying potential biomarkers for diagnosis and treatment. Transcriptome datasets from the Gene Expression Omnibus database were analyzed, resulting in the identification of seven mitophagy related differentially expressed genes (MR-DEGs), namely PINK1, ULK1, SQSTM1, ATG5, ATG12, MFN2, and UBA52. Further, we explored the correlation between MR-DEGs, immune cells, and inflammatory factors. The identified genes demonstrated a strong correlation with Mast cells, T-cells, TGFβ3, IL13, and CSF3. Machine learning techniques were employed to screen important genes, construct diagnostic models, and evaluate their accuracy. Consensus clustering divided the HTN patients into two mitophagy subgroups, with Subgroup 2 showing higher levels of immune cell infiltration and inflammatory factors. The functions of their proteins primarily involve complement, coagulation, lipids, and vascular smooth muscle contraction. Single-cell RNA sequencing revealed that mitophagy was most significant in proximal tubule cells (PTC) in HTN patients. Pseudotime analysis of PTC confirmed the expression changes observed in the transcriptome. Intercellular communication analysis suggested that mitophagy might regulate PTC's participation in intercellular crosstalk. Notably, specific transcription factors such as HNF4A, PPARA, and STAT3 showed strong correlations with mitophagy-related genes in PTC, indicating their potential role in modulating PTC function and influencing the onset and progression of HTN. This study offers a comprehensive analysis of mitophagy in HTN, enhancing our understanding of the pathogenesis, diagnosis, and treatment of HTN.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2311344
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Zs.A 2093: Show issues

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Article: An Electrolyte with Elevated Average Valence for Suppressing the Capacity Decay of Vanadium Redox Flow Batteries.

Wang, Zhenyu / Guo, Zixiao / Ren, Jiayou / Li, Yiju / Liu, Bin / Fan, Xinzhuang / Zhao, Tianshou

ACS central science

2022 Volume 9, Issue 1, Page(s) 56–63

Abstract: Nafion series membranes are widely used in vanadium redox flow batteries (VRFBs). However, the poor ion selectivity of the membranes to vanadium ions, especially for ... ...

Abstract	Nafion series membranes are widely used in vanadium redox flow batteries (VRFBs). However, the poor ion selectivity of the membranes to vanadium ions, especially for V
Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.2c01112
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