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  1. Book: The Rose and Mackay Textbook of Autoimmune Diseases

    Gershwin, Eric / Tsokos, George / Diamond, Betty / Mackay, Charles

    2024  

    Abstract: In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive ... ...

    Abstract In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.The new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.
    Keywords autoimmune disease; cancer; COVID; autoinflammation; T-cells; B-cells ; Immunologie ; Immunology ; Life Sciences ; Single-item retail product ; Rheumatologie, Muskelerkrankungen
    Language English
    Dates of publication 2024-2024
    Size 276 mm.
    Publisher Elsevier Science & Technology
    Publishing country United States
    Document type Book
    HBZ-ID HT030071462
    ISBN 9780443186479 ; 9780443186486 ; 0443186472 ; 0443186480
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Letter by Diamond regarding article, "Bayesian methods affirm the use of percutaneous coronary intervention to improve survival in patients with unprotected left main coronary artery disease".

    Diamond, George A

    Circulation

    2014  Volume 129, Issue 4, Page(s) e308

    MeSH term(s) Coronary Artery Bypass/mortality ; Coronary Artery Disease ; Female ; Humans ; Male ; Percutaneous Coronary Intervention/mortality ; Stents
    Language English
    Publishing date 2014-01-28
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.113.004321
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  3. Article ; Online: Randomized trials, observational registries, and the foundations of evidence-based medicine.

    Diamond, George A

    The American journal of cardiology

    2014  Volume 113, Issue 8, Page(s) 1436–1441

    Abstract: Although randomized trials and observational studies are used as the evidentiary basis of clinical practice guidelines, they are not always in agreement. Limitations in the process of randomization in the former and the selective referral of patients for ...

    Abstract Although randomized trials and observational studies are used as the evidentiary basis of clinical practice guidelines, they are not always in agreement. Limitations in the process of randomization in the former and the selective referral of patients for treatment as a consequence of clinical "risk stratification" in the latter are underappreciated causes for these disagreements. As a result, neither is guaranteed to correctly quantify treatment benefit. This essay reviews the operational differences between these alternative evidentiary sources and shows how these differences can affect individual clinical decisions, population-based practice guidelines, and national health policy. In conclusion, the process of evidence-based medicine can be improved by independent agencies charged with the responsibility to identify and resolve these differences.
    MeSH term(s) Cardiovascular Diseases/therapy ; Evidence-Based Medicine/organization & administration ; Humans ; Randomized Controlled Trials as Topic/methods ; Registries
    Language English
    Publishing date 2014-04-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2014.01.420
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  4. Article ; Online: A kinetic model for the integrated assessment of safety and efficacy in clinical trials.

    Diamond, George A

    The American journal of cardiology

    2014  Volume 114, Issue 9, Page(s) 1456–1463

    Abstract: Regulatory agencies, professional societies, and clinical trialists commonly base judgments of treatment benefit on separate assessments of efficacy and safety. When separate assessments were compared with an integrated assessment using a kinetic model ... ...

    Abstract Regulatory agencies, professional societies, and clinical trialists commonly base judgments of treatment benefit on separate assessments of efficacy and safety. When separate assessments were compared with an integrated assessment using a kinetic model of a hypothetical randomized trial of antiplatelet agents in patients with acute coronary syndrome, the former showed treatment A to be superior to treatment B, whereas the latter showed treatment B to be superior to treatment A. In conclusion, comparative judgments regarding the balance between efficacy and safety depend on the model chosen for analysis; kinetic models are particularly suited to the integrated assessment of efficacy and safety relative to regulatory decisions, public policy, guideline development, and clinical care.
    MeSH term(s) Clinical Trials as Topic/standards ; Humans ; Myocardial Ischemia/therapy ; Myocardial Revascularization/standards ; Outcome Assessment (Health Care) ; Risk Assessment/methods ; United States
    Language English
    Publishing date 2014-11-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2014.07.080
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  5. Article ; Online: Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Vision and refractive error results.

    Diamond, Daniel F / Kresch, Yocheved S / Gorroochurn, Prakash / Park, Lisa / Horowitz, Jason D / Wang, Qing / Maruri, Stefania C / Henriquez, Desiree R / Harizman, Noga / Carrion, Jailine / Liebmann, Jeffrey M / Cioffi, George A / Hark, Lisa A

    Clinical & experimental optometry

    2024  , Page(s) 1–8

    Abstract: Clinical relevance: Optometrists can play a key role in providing access to eye care in underserved populations by organising community-based eye health screenings that include optometric exams to detect vision impairment and uncorrected refractive ... ...

    Abstract Clinical relevance: Optometrists can play a key role in providing access to eye care in underserved populations by organising community-based eye health screenings that include optometric exams to detect vision impairment and uncorrected refractive error.
    Background: Community-based eye health screenings and optometric exams were conducted in the NYC-SIGHT Study.
    Methods: A sub-analysis of vision impairment and refractive error results within a 5-year prospective, cluster-randomised clinical trial. Eligible individuals (age ≥40 years) were recruited from 10 affordable housing developments in Upper Manhattan. Developments were randomised into usual care (received glasses prescription only) and intervention (free glasses) groups. Participants with 6/12 visual acuity or worse, intraocular pressure 23-29 mmHg, or an unreadable fundus image were scheduled with the study optometrist for refraction and a non-dilated exam. Visual improvement data were obtained by comparing the presenting acuity at screening compared to the best corrected acuity after refraction by the optometrist. Chi-square, two-sample t-tests, and a stepwise multivariate logistic regression model were used to determined factors associated with improvable visual impairment.
    Results: Seven hundred and eight participants completed screening, 308 received an optometric exam. Those with improvable vision impairment (
    Conclusion: This innovative, targeted community-based study included an optometrist who detected high rates of refractive error and improvable vision impairment in an underserved population living in New York City.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2024.2322523
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  6. Article ; Online: Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT): optometric exam improves access and utilization of eye care services.

    Diamond, Daniel F / Hirji, Sitara / Xing, Samantha X / Gorroochurn, Prakash / Horowitz, Jason D / Wang, Qing / Park, Lisa / Harizman, Noga / Maruri, Stefania C / Henriquez, Desiree R / Liebmann, Jeffrey M / Cioffi, George A / Hark, Lisa A

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  Volume 262, Issue 5, Page(s) 1619–1631

    Abstract: Purpose: To describe the benefits of optometric evaluation for detection of vision-affecting conditions in the context of community-based eye health screenings and identify factors associated with having a recent dilated eye exam.: Methods: Enrolled ... ...

    Abstract Purpose: To describe the benefits of optometric evaluation for detection of vision-affecting conditions in the context of community-based eye health screenings and identify factors associated with having a recent dilated eye exam.
    Methods: Enrolled participants were age 40 and older, living independently in affordable housing developments in New York City. Eye health screening failure and criteria for seeing the on-site study optometrist were defined as visual acuity 20/40 or worse in either eye, intraocular pressure 23-29 mmHg, or an unreadable fundus image. The optometrist conducted a manifest refraction using loose lenses and used a portable slit lamp and ophthalmoscope to perform a non-dilated anterior and posterior segment ocular health evaluation. Demographics, social determinants of health, eye health screening results, and rates of suspected ophthalmic conditions were recorded. To determine factors associated with having a recent dilated eye exam, which was the main outcome for this statistical analysis, a stepwise multivariate logistic regression was performed.
    Results: A total of 708 participants were screened, 308 attended the optometric exam; mean age 70.7 ± 11.7 [standard deviation (SD)] years. Among this subgroup, 70.1% identified as female, 54.9% self-identified as African American, 39% as Hispanic/Latino, and 26.6% Dominican ethnicity; 78.2% (241/308) had not undergone a dilated eye exam within the last year, 71.4% reported they did not have an eye care provider. Stepwise multivariate logistic regression analysis indicated that participants who self-reported having cataracts (odds ratio (OR) 2.15; 95% confidence interval (CI) 1.03-4.47; p = 0.041), self-reported having glaucoma/glaucoma suspect (OR 5.60; 95% CI 2.02-15.43; p = 0.001), or spoke Spanish as their primary language (OR 3.25; 95% CI 1.48-7.11; p = 0.003) had higher odds of having a recent dilated eye exam.
    Conclusions: This community-based screening initiative demonstrated the effectiveness of optometric exams in detecting vision-affecting conditions and identified factors associated with having a recent dilated eye exam. Optometrists play a vital role in increasing access to eye care for high-risk, underserved populations.
    Trial registration: ClinicalTrials.gov (NCT04271709).
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Middle Aged ; Cataract ; Follow-Up Studies ; Glaucoma ; Ocular Hypertension ; Vision Disorders ; Vision Screening
    Language English
    Publishing date 2024-01-08
    Publishing country Germany
    Document type Clinical Study ; Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06344-2
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  7. Article ; Online: Right answer, wrong question: on the clinical relevance of the cardiovascular history.

    Diamond, George A

    Circulation

    2011  Volume 124, Issue 22, Page(s) 2377–2379

    MeSH term(s) Coronary Angiography/standards ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Female ; Guidelines as Topic/standards ; Humans ; International Cooperation ; Male ; Multidetector Computed Tomography/standards ; Registries
    Language English
    Publishing date 2011-11-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.111.068718
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  8. Article ; Online: Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT): Subanalysis of Referral to Ophthalmology.

    Hark, Lisa A / Lin, Weijie Violet / Hirji, Sitara / Gorroochurn, Prakash / Horowitz, Jason D / Diamond, Daniel F / Park, Lisa / Wang, Qing / Auran, James D / Maruri, Stefania C / Henriquez, Desiree R / Sharma, Tarun / Valenzuela, Ives / Liebmann, Jeffrey M / Cioffi, George A / Friedman, David S / Harizman, Noga

    Current eye research

    2024  Volume 49, Issue 2, Page(s) 197–206

    Abstract: Purpose: The Manhattan Vision Screening and Follow-up Study aims to provide access to eye care for underserved populations, detect native rates of ocular pathology, and refer participants with eye disease to ophthalmology. This subanalysis describes the ...

    Abstract Purpose: The Manhattan Vision Screening and Follow-up Study aims to provide access to eye care for underserved populations, detect native rates of ocular pathology, and refer participants with eye disease to ophthalmology. This subanalysis describes the reasons for referral to ophthalmology and identifies risk factors associated with being referred.
    Methods: Enrolled participants were aged ≥40 years, living independently in public housing developments and able to provide consent for eye health screenings. Those with habitual visual acuity 20/40 or worse, intraocular pressure (IOP) 23-29 mmHg, or an unreadable fundus image failed and were scheduled with the on-site optometrist. The optometric exam determined whether further referral to ophthalmology for a clinic exam was warranted. Those with an abnormal image or IOP ≥30 mmHg were referred directly to ophthalmology. Main outcome was factors associated with referral to ophthalmology.
    Results: A total of 708 individuals completed the eye health screening over 15 months. A total of 468 participants were referred to ophthalmology (250 had an abnormal image and 218 were referred by the optometrist). Those referred were predominantly older adults (mean age 70.0 ± 11.4 years), female (66.7%), African American (55.1%) and Hispanic (39.5%). Seventy percent of participants had not had a recent eye exam. Stepwise multivariate logistic regression analysis showed that participants with pre-existing glaucoma (OR 3.14, 95% CI 1.62 to 6.08,
    Conclusion: This targeted community-based study in Upper Manhattan provided access to eye care and detected a significant amount of ocular pathology requiring referral to ophthalmology in this high-risk population.
    MeSH term(s) Humans ; Female ; Aged ; Middle Aged ; Aged, 80 and over ; Vision Screening ; Ophthalmology/methods ; Follow-Up Studies ; Glaucoma/diagnosis ; Intraocular Pressure ; Referral and Consultation
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 82079-9
    ISSN 1460-2202 ; 0271-3683
    ISSN (online) 1460-2202
    ISSN 0271-3683
    DOI 10.1080/02713683.2023.2269614
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  9. Article ; Online: Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): a nested cross-sectional assessment of falls risk within a cluster randomised trial.

    Hark, Lisa A / Wang, Yujia / Gorroochurn, Prakash / Simon, Phyllis R / Maruri, Stefania C / Henriquez, Desiree R / Diamond, Daniel F / Horowitz, Jason D / Park, Lisa / Wang, Qing / Auran, James D / Carrion, Jailine / Friedman, David S / Liebmann, Jeffrey L / Cioffi, George A / Harizman, Noga

    The British journal of ophthalmology

    2024  

    Abstract: Background: To investigate the feasibility of using the Stopping Elderly Accidents, Deaths and Injuries (STEADI) Falls Risk Tool Kit during community-based eye health screenings to assess falls risk of participants enrolled in the Manhattan Vision ... ...

    Abstract Background: To investigate the feasibility of using the Stopping Elderly Accidents, Deaths and Injuries (STEADI) Falls Risk Tool Kit during community-based eye health screenings to assess falls risk of participants enrolled in the Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT).
    Methods: Cross-sectional analysis of data from a 5-year prospective, cluster-randomised clinical trial conducted in affordable housing developments in New York City in adults age 40 years and older. Prescreening questions determined whether participants were at risk of falling. STEADI tests classified participants at low, moderate or high risk of falling. Multivariate logistic regression determined odds of falls risk of all enrolled participants.
    Results: 708 participants completed the eye health screening; 351 (49.6%) performed STEADI tests; mean age: 71.0 years (SD±11.3); 72.1% female; 53.6% Black, non-Hispanic, 37.6% Hispanic/Latino. Level of falls risk: 32 (9.1%) low, 188 (53.6%) moderate and 131 (37.3%) high. Individuals age >80 (OR 5.921, 95% CI (2.383 to 14.708), p=0.000), had blurry vision (OR 1.978, 95% CI (1.186 to 3.300), p=0.009), high blood pressure (OR 2.131, 95% CI (1.252 to 3.628), p=0.005), arthritis (OR 2.29876, 95% CI (1.362 to 3.875), p=0.002) or foot problems (OR 5.239, 95% CI (2.947 to 9.314), p=0.000) had significantly higher odds of falling, emergency department visits or hospitalisation due to falling.
    Conclusion: This study detected a significant amount of falls risk in an underserved population. The STEADI Falls Risk screening questions were easy for eye care providers to ask, were highly predictive of falls risk and may be adequate for referral to occupational health and/or physical therapy.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjo-2022-323052
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  10. Article ; Online: Correlation of Rehabilitation and Throwing Program Milestones With Outcomes After Ulnar Collateral Ligament Reconstruction: An Analysis of 717 Professional Baseball Pitchers.

    Griffith, Timothy B / Conte, Stan / Poulis, George C / Diamond, Adam / D'Angelo, John / Camp, Christopher L

    The American journal of sports medicine

    2022  Volume 50, Issue 7, Page(s) 1990–1996

    Abstract: Background: There remains room for improvement in surgical outcomes after medial ulnar collateral ligament reconstruction (MUCLR) in professional pitchers. The role and influence of postoperative rehabilitation on the outcomes of MUCLR are unknown. ... ...

    Abstract Background: There remains room for improvement in surgical outcomes after medial ulnar collateral ligament reconstruction (MUCLR) in professional pitchers. The role and influence of postoperative rehabilitation on the outcomes of MUCLR are unknown. There is a paucity of clinical data in the current literature comparing the success of various postsurgical rehabilitation protocols after MUCLR.
    Purpose: To summarize the current rehabilitation process for professional pitchers recovering from MUCLR, evaluates what player and surgical factors correlate with outcomes, and determines whether rehabilitation timing and milestones correlate with successful outcomes.
    Study design: Case series; Level of evidence, 4.
    Methods: 717 professional baseball pitchers who underwent MUCLR between 2010 and 2016 were identified and included in the analysis. Player characteristics evaluated included age at the time of surgery, throwing side dominance, primary pitching role (starter vs reliever), and level of play (MLB, AAA, AA, A). Surgical factors studied included date of surgery, graft type (palmaris longus autograft vs gracilis autograft), and surgical technique (figure of 8 vs docking vs other). The rehabilitation and throwing progression details were as follows: initiation date; first throw date; dates to start throwing from various distances; longest distance thrown; first flat ground throw date; first mound throw date; and first live batting practice (BP) date. The primary outcomes of interest were the ability to return to play at any level (RTP), the ability to return to the same level (RSL), and the time to RTP/RSL.
    Results: On average, pitchers threw a baseball for the first time 4.9 months after surgery, with a broad range (2.8-14.9 months). For the 675 (94%) pitchers who were able to progress to mound throwing, the first throws off a mound occurred at a mean of 9.4 months after surgery. Before progressing to the mound, the mean longest long-toss distance reached was 137.5 feet, with a broad range (105-300 feet). A high variation in the time to RTP (7.6-53.9 months) and RSL (8.6-60.7 months) was noted. A total of 599 (84%) pitchers were able to RTP at a mean time of 14.9 ± 4.9 months after surgery (range, 7.6-53.9 months). Also, 528 (74%) pitchers were able to RSL after MUCLR at a mean of 17.4 ± 7 months (range, 8.6-60.7 months) postoperatively. Age was the most significant predictor of RTP (hazard ratio [HR], 1.03 [95% CI, 1.01-1.05];
    Conclusion: Significant variability in the postoperative rehabilitation protocols after MUCLR was observed in 717 professional baseball pitchers. The timing of achievement of throwing progression and rehabilitation milestones postoperatively varied widely but did not correlate with outcomes. Player characteristics-except for player age and professional pitching level-did not correlate with RTP and RSL outcomes. Older pitchers and MLB pitchers were more likely to RTP, but younger players were more likely to RSL. Surgical factors did not correlate with rehabilitation outcomes.
    MeSH term(s) Baseball ; Collateral Ligament, Ulnar/surgery ; Collateral Ligaments/surgery ; Elbow/surgery ; Elbow Joint/surgery ; Humans ; Treatment Outcome ; Ulnar Collateral Ligament Reconstruction/methods
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465221093995
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