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  1. Article ; Online: Voices in Molecular Pharmaceutics: Meet Dr. Swati Biswas, an Academic Developing Therapeutic Weapons To Kill Cancer Cells.

    Biswas, Swati

    Molecular pharmaceutics

    2022  Volume 19, Issue 4, Page(s) 1031–1032

    MeSH term(s) Biopharmaceutics ; Neoplasms/drug therapy
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00128
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  2. Article ; Online: Polymeric micelles as drug-delivery systems in cancer: challenges and opportunities.

    Biswas, Swati

    Nanomedicine (London, England)

    2021  Volume 16, Issue 18, Page(s) 1541–1544

    Abstract: Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation. ...

    Abstract Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.
    MeSH term(s) Drug Carriers ; Drug Delivery Systems ; Humans ; Micelles ; Neoplasms/drug therapy ; Polyethylene Glycols ; Polymers
    Chemical Substances Drug Carriers ; Micelles ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2021-0081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Bivariate quantitative Bayesian LASSO for detecting association of rare haplotypes with two correlated continuous phenotypes.

    Sajal, Ibrahim Hossain / Biswas, Swati

    Frontiers in genetics

    2023  Volume 14, Page(s) 1104727

    Abstract: In genetic association studies, the multivariate analysis of correlated phenotypes offers statistical and biological advantages compared to analyzing one phenotype at a time. The joint analysis utilizes additional information contained in the correlation ...

    Abstract In genetic association studies, the multivariate analysis of correlated phenotypes offers statistical and biological advantages compared to analyzing one phenotype at a time. The joint analysis utilizes additional information contained in the correlation and avoids multiple testing. It also provides an opportunity to investigate and understand shared genetic mechanisms of multiple phenotypes. Bivariate logistic Bayesian LASSO (LBL) was proposed earlier to detect rare haplotypes associated with two binary phenotypes or one binary and one continuous phenotype jointly. There is currently no haplotype association test available that can handle multiple continuous phenotypes. In this study, by employing the framework of bivariate LBL, we propose bivariate quantitative Bayesian LASSO (QBL) to detect rare haplotypes associated with two continuous phenotypes. Bivariate QBL removes unassociated haplotypes by regularizing the regression coefficients and utilizing a latent variable to model correlation between two phenotypes. We carry out extensive simulations to investigate the performance of bivariate QBL and compare it with that of a standard (univariate) haplotype association test, Haplo.score (applied twice to two phenotypes individually). Bivariate QBL performs better than Haplo.score in all simulations with varying degrees of power gain. We analyze Genetic Analysis Workshop 19 exome sequencing data on systolic and diastolic blood pressures and detect several rare haplotypes associated with the two phenotypes.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1104727
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  4. Article ; Online: Introducing the

    Ueda, Keisuke / Cai, Ting / Biswas, Swati / Kim, Sun Hwa

    Molecular pharmaceutics

    2023  Volume 20, Issue 8, Page(s) 3694–3695

    MeSH term(s) Biopharmaceutics ; Pharmaceutical Research ; Asia ; Pharmacy
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00534
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  5. Article: Unveiling the Nexus: Cellular Metabolomics Unravels the Impact of Estrogen on Nicotinamide Metabolism in Mitigating Rheumatoid Arthritis Pathogenesis.

    Malik, Swati / Chakraborty, Debolina / Agnihotri, Prachi / Kumar, Vijay / Biswas, Sagarika

    Metabolites

    2024  Volume 14, Issue 4

    Abstract: Rheumatoid arthritis (RA) is a metabolic joint disorder influenced by hormonal regulation, notably estrogen, which plays a cytoprotective role against inflammation. While estrogen's impact on RA pathogenesis has been studied, the altered metabolite ... ...

    Abstract Rheumatoid arthritis (RA) is a metabolic joint disorder influenced by hormonal regulation, notably estrogen, which plays a cytoprotective role against inflammation. While estrogen's impact on RA pathogenesis has been studied, the altered metabolite expression under estrogen's influence remains unexplored. This study investigated the changes in the metabolome of synovial fibroblasts isolated from RA patients under 17β-estradiol (E2) using the liquid chromatography with tandem mass spectrometry (LC-MS/MS) approach followed by multivariate and biological pathway analysis along with in vitro validation. Results identified 3624
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14040214
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  6. Article ; Online: Mitochondrial functioning in Rheumatoid arthritis modulated by estrogen: Evidence-based insight into the sex-based influence on mitochondria and disease.

    Malik, Swati / Chakraborty, Debolina / Agnihotri, Prachi / Sharma, Alankrita / Biswas, Sagarika

    Mitochondrion

    2024  Volume 76, Page(s) 101854

    Abstract: Alteration of immune response and synovium microvasculature in Rheumatoid arthritis (RA) progression has been suggested to be associated with mitochondrial functioning. Mitochondria, with maternally inherited DNA, exhibit differential response to the ... ...

    Abstract Alteration of immune response and synovium microvasculature in Rheumatoid arthritis (RA) progression has been suggested to be associated with mitochondrial functioning. Mitochondria, with maternally inherited DNA, exhibit differential response to the female hormone estrogen. Various epidemiological evidence has also shown the prominence of RA in the female population, depicting the role of estrogen in modulating the pathogenesis of RA. As estrogen regulates the expression of differential proteins and associated signaling pathways of RA, its influence on mitochondrial functioning seems evident. Thus, in this review, the studies related to mitochondria and their relation with estrogen and Rheumatoid arthritis were retrieved. We analyzed the different mitochondrial activities that are altered in RA and the possibility of their estrogenic control. The study expands to in silico analysis, revealing the differential mitochondrial proteins expressed in RA and examining these proteins as potential estrogenic targets. It was found that ALDH2, CASP3, and SOD2 are the major mitochondrial proteins involved in RA progression and are also potent estradiol targets. The analysis establishes the role of mitochondrial proteins in RA progression, which were found to be direct or indirect targets of estrogen, depicting its potential for regulating mitochondrial functions in RA.
    Language English
    Publishing date 2024-02-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2024.101854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Meta-Analysis of Breast Cancer Risk for Individuals with PALB2 Pathogenic Variants.

    Ruberu, Thanthirige Lakshika M / Braun, Danielle / Parmigiani, Giovanni / Biswas, Swati

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Pathogenic variants in cancer susceptibility genes can now be tested efficiently and economically with the wide availability of multi-gene panel testing. This has resulted in an unprecedented rate of identifying individuals carrying ... ...

    Abstract Background: Pathogenic variants in cancer susceptibility genes can now be tested efficiently and economically with the wide availability of multi-gene panel testing. This has resulted in an unprecedented rate of identifying individuals carrying pathogenic variants. These carriers need to be counselled about their future cancer risk conferred by the specific gene mutation. An important cancer susceptibility gene is PALB2. Several studies reported risk estimates for breast cancer (BC) associated with pathogenic variants in PALB2. Because of the variety of modalities (age specific risk, odds ratio, relative risk, and standardized incidence ratio) and effect sizes of these risk estimates, a meta-analysis of all of these estimates of BC risk is necessary to provide accurate counseling of patients with pathogenic variants in PALB2. The challenge, though, in combining these estimates is the heterogeneity of studies in terms of study design and risk measure.
    Methods: We utilized a recently proposed novel Bayesian random-effects meta-analysis method that can synthesize and combine information from such heterogeneous studies. We applied this method to combine estimates from twelve different studies on BC risk for carriers of pathogenic PALB2 mutations, out of which two report age-specific penetrance, one reports relative risk, and nine report odds ratios.
    Results: The estimated overall (meta-analysis based) risk of BC is 12.80% by age 50 (6.11%
    Conclusion: Pathogenic mutations in PALB2 makes women more susceptible to BC. Our risk estimates can help clinically manage patients carrying pathogenic variants in PALB2.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.31.23290791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Meta-analysis of breast cancer risk for individuals with PALB2 pathogenic variants.

    Ruberu, Thanthirige L M / Braun, Danielle / Parmigiani, Giovanni / Biswas, Swati

    Genetic epidemiology

    2024  

    Abstract: Multigene panel testing now allows efficient testing of many cancer susceptibility genes leading to a larger number of mutation carriers being identified. They need to be counseled about their cancer risk conferred by the specific gene mutation. An ... ...

    Abstract Multigene panel testing now allows efficient testing of many cancer susceptibility genes leading to a larger number of mutation carriers being identified. They need to be counseled about their cancer risk conferred by the specific gene mutation. An important cancer susceptibility gene is PALB2. Multiple studies reported risk estimates for breast cancer (BC) conferred by pathogenic variants in PALB2. Due to the diverse modalities of reported risk estimates (age-specific risk, odds ratio, relative risk, and standardized incidence ratio) and effect sizes, a meta-analysis combining these estimates is necessary to accurately counsel patients with this mutation. However, this is not trivial due to heterogeneity of studies in terms of study design and risk measure. We utilized a recently proposed Bayesian random-effects meta-analysis method that can synthesize estimates from such heterogeneous studies. We applied this method to combine estimates from 12 studies on BC risk for carriers of pathogenic PALB2 mutations. The estimated overall (meta-analysis-based) risk of BC is 12.80% (6.11%-22.59%) by age 50 and 48.47% (36.05%-61.74%) by age 80. Pathogenic mutations in PALB2 makes women more susceptible to BC. Our risk estimates can help clinically manage patients carrying pathogenic variants in PALB2.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.22561
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1969: Show issues Location:
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  9. Article ; Online: Human Serum Albumin-Oxaliplatin (Pt(IV)) prodrug nanoparticles with dual reduction sensitivity as effective nanomedicine for triple-negative breast cancer.

    Paul, Milan / Ghosh, Balaram / Biswas, Swati

    International journal of biological macromolecules

    2023  Volume 256, Issue Pt 1, Page(s) 128281

    Abstract: Nanomedicines have emerged as a potential strategy to reduce the toxic effect of drugs administered via conventional approaches. Nanomedicines undergo passive and active targeting of the tumor tissues, thereby causing localized drug delivery and reducing ...

    Abstract Nanomedicines have emerged as a potential strategy to reduce the toxic effect of drugs administered via conventional approaches. Nanomedicines undergo passive and active targeting of the tumor tissues, thereby causing localized drug delivery and reducing drug demand and side effects. Here, we prepared reduction-sensitive oxaliplatin-conjugated human serum albumin nanoparticles with a small size, uniform surfaces, and a satisfactory encapsulation coefficient. The findings of cellular studies demonstrate that utilizing human serum albumin is effective for active tumor targeting. The presence of glutathione-sensitive disulfide linkers in the crosslinking agent and between Pt(IV) and HSA provided dual reduction sensitivity. Cytotoxicity and cell death were enhanced compared to free Oxaliplatin. The outcomes demonstrate that the approach maximized Oxaliplatin's ability to control tumor growth, induced apoptosis, and reduced drug resistance. Therefore, for the first time, our results imply that OXA-SS-HSA NPs were biocompatible, smart, and effective anticancer nanomedicine for triple-negative breast cancer therapy.
    MeSH term(s) Humans ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Serum Albumin, Human/therapeutic use ; Nanomedicine ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Nanoparticles ; Cell Line, Tumor
    Chemical Substances Prodrugs ; Oxaliplatin (04ZR38536J) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2023-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128281
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  10. Article ; Online: A Case Study on PPM1D and 9 Other Shared Germline Alterations in a Family.

    Biswas, Shristi / Manekar, Swati / Bakshi, Sonal Rajiv

    Asian Pacific journal of cancer prevention : APJCP

    2023  Volume 24, Issue 6, Page(s) 2129–2134

    Abstract: Background: The use of high-throughput genotyping techniques has enabled us to identify the rare germline genetic variants with different pathogenicity and penetrance, and understand their role in cancer predisposition. We report here a familial cancer ... ...

    Abstract Background: The use of high-throughput genotyping techniques has enabled us to identify the rare germline genetic variants with different pathogenicity and penetrance, and understand their role in cancer predisposition. We report here a familial cancer case, a study from Western Indian.
    Methods: NGS-WES was carried out in a lung cancer patient who has a family history of multiple cancers across generations, including tongue, lung, brain, cervical, urothelial, and esophageal cancer. The results were validated by data mining from available data bases. I-TASSER, RasMol and PyMol were used for protein structure modelling.
    Results: The sequencing by NGS-WES revealed PPM1D c.1654C>T (p.Arg552Ter) mutation in hotspot region exon 6 leading to sudden protein truncation and loss of the C-terminal, due to the substitution of C>T. This mutation was classified as a variant of uncertain significance (VUS), due to limited data on lung cancer, The three unaffected siblings of proband did not show any pathogenic variants and comparative analysis of the four siblings indicate 9 shared genetic variants, classified as benign as per ClinVar.
    Conclusion: PPM1D constitutional genetic alterations are rare and uncommon in different ethnic populations. This gene encodes a phosphatase playing role in regulating the P53 tumor suppressor pathway and DNA damage response. Genetic alterations in the PPM1D gene maybe linked to history of gliomas, breast cancer, and ovarian cancer onset in the proband's family.
    .
    MeSH term(s) Female ; Humans ; Breast Neoplasms/genetics ; Exons ; Genetic Predisposition to Disease ; Germ-Line Mutation/genetics ; Lung Neoplasms/genetics ; Mutation ; Ovarian Neoplasms/genetics ; Protein Phosphatase 2C/genetics
    Chemical Substances PPM1D protein, human (EC 3.1.3.16) ; Protein Phosphatase 2C (EC 3.1.3.16)
    Language English
    Publishing date 2023-06-01
    Publishing country Thailand
    Document type Case Reports ; Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2023.24.6.2129
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