LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 57

Search options

  1. Article ; Online: Solution-Processed Sb

    Vishwanathan Vidyanagar, Akshay / Bhat, S Venkataprasad

    ACS applied materials & interfaces

    2024  Volume 16, Issue 3, Page(s) 3631–3639

    Abstract: Antimony sulfide ( ... ...

    Abstract Antimony sulfide (Sb
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c13051
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Disaggregation of amyloid-beta fibrils via natural metabolites using long timescale replica exchange molecular dynamics simulation studies.

    Uttarkar, Akshay / Rao, Vibha / Bhat, Dhrithi / Niranjan, Vidya

    Journal of molecular modeling

    2024  Volume 30, Issue 3, Page(s) 61

    Abstract: Context: Amyloid fibrils are self-assembled fibrous protein aggregates that are associated with several presently incurable diseases such as Alzheimer's. disease that is characterized by the accumulation of amyloid fibrils in the brain, which leads to ... ...

    Abstract Context: Amyloid fibrils are self-assembled fibrous protein aggregates that are associated with several presently incurable diseases such as Alzheimer's. disease that is characterized by the accumulation of amyloid fibrils in the brain, which leads to the formation of plaques and the death of brain cells. Disaggregation of amyloid fibrils is considered a promising approach to cure Alzheimer's disease. The mechanism of amyloid fibril formation is complex and not fully understood, making it difficult to develop drugs that can target the process. Diacetonamine and cystathionine are potential lead compounds to induce disaggregation of amyloid fibrils.
    Methods: In the current research, we have used long timescale molecular simulation studies and replica exchange molecular dynamics (REMD) for 1000 ns (1 μs) to examine the mechanisms by which natural metabolites can disaggregate amyloid-beta fibrils. Molecular docking was carried out using Glide and with prior protein minimization and ligand preparation. We focused on a screening a database of natural metabolites, as potential candidates for disaggregating amyloid fibrils. We used Desmond with OPLS 3e as a force field. MM-GBSA calculations were performed. Blood-brain barrier permeability, SASA, and radius of gyration parameters were calculated.
    MeSH term(s) Humans ; Amyloid/metabolism ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/metabolism
    Chemical Substances Amyloid ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-02-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-024-05860-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Azolla Pinnata

    Mohd, Ghulam / Bhat, Irfan Majeed / Kakroo, Insha / Balachandran, Akshay / Tabasum, Ruheena / Majid, Kowsar / Wani, Mohammad Farooq / Manna, Uttam / Ghodake, Gajanan / Lone, Saifullah

    ACS omega

    2024  Volume 9, Issue 11, Page(s) 12725–12733

    Abstract: Various plant-based materials effectively absorb oil contaminants at the water/air interface. These materials showcase unparalleled efficiency in purging oil contaminants, encompassing rivers, lakes, and boundless oceans, positioning them as integral ... ...

    Abstract Various plant-based materials effectively absorb oil contaminants at the water/air interface. These materials showcase unparalleled efficiency in purging oil contaminants, encompassing rivers, lakes, and boundless oceans, positioning them as integral components of environmental restoration endeavors. In addition, they are biodegradable, readily available, and eco-friendly, thus making them a preferable choice over traditional oil cleaning materials. This study explores the phenomenal properties of the floating Azolla fern (
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08417
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online ; Thesis: Bioinformatics modeling of proteomics changes in muscle invasive bladder cancer

    Bhat, Akshay [Verfasser]

    2016  

    Author's details Akshay Bhat
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s).

    Chaudhari, Sima / Ware, Akshay Pramod / Jasti, Dushyanth Babu / Gorthi, Sankar Prasad / Acharya, Lavanya Prakash / Bhat, Manoj / Mallya, Sandeep / Satyamoorthy, Kapaettu

    Molecular genetics and genomics : MGG

    2023  Volume 298, Issue 4, Page(s) 965–976

    Abstract: Choreoacanthocytosis, one of the forms of neuroacanthocytosis, is caused by mutations in vacuolar protein sorting-associated protein A (VPS13A), and is often misdiagnosed with other form of neuroacanthocytosis with discrete genetic defects. The ... ...

    Abstract Choreoacanthocytosis, one of the forms of neuroacanthocytosis, is caused by mutations in vacuolar protein sorting-associated protein A (VPS13A), and is often misdiagnosed with other form of neuroacanthocytosis with discrete genetic defects. The phenotypic variations among the patients with VPS13A mutations significantly obfuscates the understanding of the disease and treatment strategies. In this study, two unrelated cases were identified, exhibiting the core phenotype of neuroacanthocytosis but with considerable clinical heterogeneity. Case 1 presented with an additional Parkinsonism phenotype, whereas seizures were evident in case 2. To decipher the genetic basis, whole exome sequencing followed by validation with Sanger sequencing was performed. A known homozygous pathogenic nonsense mutation (c.799C > T; p.R267X) in exon 11 of the VPS13A gene was identified in case 1 that resulted in a truncated protein. A novel missense mutation (c.9263T > G; p.M3088R) in exon 69 of VPS13A identified in case 2 was predicted as pathogenic. In silico analysis of the p.M3088R mutation at the C-terminus of VPS13A suggests a loss of interaction with TOMM40 and may disrupt mitochondrial localization. We also observed an increase in mitochondrial DNA copy numbers in case 2. Mutation analysis revealed benign heterozygous variants in interacting partners of VPS13A such as VAPA in case 1. Our study confirmed the cases as ChAc and identified the novel homozygous variant of VPS13A (c.9263T > G; p.M3088R) within the mutation spectrum of VPS13A-associated ChAc. Furthermore, mutations in VPS13A and co-mutations in its potential interacting partner(s) might contribute to the diverse clinical manifestations of ChAc, which requires further study.
    MeSH term(s) Humans ; Neuroacanthocytosis/genetics ; Neuroacanthocytosis/pathology ; Exome Sequencing ; Genes, Modifier ; Mutation ; Codon, Nonsense/genetics ; Vesicular Transport Proteins/genetics
    Chemical Substances Codon, Nonsense ; VPS13A protein, human ; Vesicular Transport Proteins
    Language English
    Publishing date 2023-05-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2044817-X
    ISSN 1617-4623 ; 1617-4615
    ISSN (online) 1617-4623
    ISSN 1617-4615
    DOI 10.1007/s00438-023-02032-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A new comprehensive grading for giant pituitary adenomas: SLAP grading.

    Shukla, Dhaval / Konar, Subhas / Kulkarni, Akshay / Bhat, Dhananjaya I / Sadashiva, Nishanth / Devi, Bhagavatula Indira / Dikshit, Priyadarshi / Mehta, Sarthak / Jain, Chirag

    British journal of neurosurgery

    2022  Volume 36, Issue 3, Page(s) 377–384

    Abstract: ... ...

    Abstract Aim
    MeSH term(s) Adenoma/complications ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Humans ; Magnetic Resonance Imaging ; Neoplasm, Residual ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2057432
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Conference proceedings: Novel Comprehensive Grading for Giant Pituitary Adenomas: Slap Grading

    Sadashiva, Nishanth / Shukla, Dhaval / Konar, Subhas / Kulkarni, Akshay / Bhat, Dhananjay / Devi, Bhagavatula I.

    Journal of Neurological Surgery Part B: Skull Base

    2022  Volume 83, Issue S 01

    Event/congress 31st Annual Meeting North American Skull Base Society, Online, 2022-02-18
    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0042-1743685
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Orbitofrontal Extradural Hematoma: Unusual Cause of Proptosis.

    Kulkarni, Akshay V / Mishra, Tejesh / Devi, B Indira / Bhat, Dhananjaya I / Konar, Subhas / Sadashiva, Nishanth

    Pediatric neurosurgery

    2021  Volume 56, Issue 4, Page(s) 369–372

    Abstract: Introduction: Frontal extradural hematoma (EDH) extending into orbit is an uncommon entity. Clinical presentation can be subacutely progressive proptosis following head injury.: Case presentation: We present a case of frontal EDH with orbital ... ...

    Abstract Introduction: Frontal extradural hematoma (EDH) extending into orbit is an uncommon entity. Clinical presentation can be subacutely progressive proptosis following head injury.
    Case presentation: We present a case of frontal EDH with orbital extension which had delayed progressive proptosis. The patient improved clinically after surgical evacuation of EDH.
    Conclusion: It is important to look for orbital roof fractures, orbital hematoma in cases of head injury. Such cases should be treated surgically at the earliest.
    MeSH term(s) Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnostic imaging ; Craniocerebral Trauma/surgery ; Exophthalmos/etiology ; Hematoma ; Hematoma, Epidural, Cranial/diagnostic imaging ; Hematoma, Epidural, Cranial/etiology ; Hematoma, Epidural, Cranial/surgery ; Humans
    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000515518
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Online: VAKTA-SETU

    Mhaskar, Shivam / Bhat, Vineet / Batheja, Akshay / Deoghare, Sourabh / Choudhary, Paramveer / Bhattacharyya, Pushpak

    A Speech-to-Speech Machine Translation Service in Select Indic Languages

    2023  

    Abstract: In this work, we present our deployment-ready Speech-to-Speech Machine Translation (SSMT) system for English-Hindi, English-Marathi, and Hindi-Marathi language pairs. We develop the SSMT system by cascading Automatic Speech Recognition (ASR), Disfluency ... ...

    Abstract In this work, we present our deployment-ready Speech-to-Speech Machine Translation (SSMT) system for English-Hindi, English-Marathi, and Hindi-Marathi language pairs. We develop the SSMT system by cascading Automatic Speech Recognition (ASR), Disfluency Correction (DC), Machine Translation (MT), and Text-to-Speech Synthesis (TTS) models. We discuss the challenges faced during the research and development stage and the scalable deployment of the SSMT system as a publicly accessible web service. On the MT part of the pipeline too, we create a Text-to-Text Machine Translation (TTMT) service in all six translation directions involving English, Hindi, and Marathi. To mitigate data scarcity, we develop a LaBSE-based corpus filtering tool to select high-quality parallel sentences from a noisy pseudo-parallel corpus for training the TTMT system. All the data used for training the SSMT and TTMT systems and the best models are being made publicly available. Users of our system are (a) Govt. of India in the context of its new education policy (NEP), (b) tourists who criss-cross the multilingual landscape of India, (c) Indian Judiciary where a leading cause of the pendency of cases (to the order of 10 million as on date) is the translation of case papers, (d) farmers who need weather and price information and so on. We also share the feedback received from various stakeholders when our SSMT and TTMT systems were demonstrated in large public events.
    Keywords Computer Science - Computation and Language
    Subject code 410
    Publishing date 2023-05-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Unusual Complication of a Neglected Growing Skull Fracture.

    Kulkarni, Akshay Vijay / Dikshit, Priyadarshi / Devi, B Indira / Sadashiva, Nishanth / Shukla, Dhaval / Bhat, Dhananjaya I

    Pediatric neurosurgery

    2021  Volume 56, Issue 2, Page(s) 179–183

    Abstract: Introduction: The growing skull fracture (GSF) is a rare complication seen after head injury in infants and young children. It occurs due to a wide skull defect with underlying dural defect and changes in pressure gradients within skull cavity. ... ...

    Abstract Introduction: The growing skull fracture (GSF) is a rare complication seen after head injury in infants and young children. It occurs due to a wide skull defect with underlying dural defect and changes in pressure gradients within skull cavity. Neglected cases may develop progressive neurological deficits and complications after second head trauma. Case Discussion: We present a 14-year-old child who developed sudden-onset, diffuse, soft, fluctuant, circumferential swelling of the head after a road traffic accident. He had sustained a head injury at the age of 3-months leading to an asymptomatic soft swelling over the skull which was left untreated. Present CT scan of the brain showed a bony defect with ragged edges and cerebrospinal fluid (CSF) collection in subgaleal space circumferentially. He underwent exploration, duroplasty, and cranioplasty and had a good outcome.
    Conclusion: Neglected GSF can rupture and cause diffuse subgaleal CSF collection. It should be managed with dural repair and cranioplasty.
    MeSH term(s) Adolescent ; Brain ; Child ; Child, Preschool ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnostic imaging ; Craniocerebral Trauma/surgery ; Humans ; Infant ; Male ; Skull/diagnostic imaging ; Skull/surgery ; Skull Fractures/diagnostic imaging ; Skull Fractures/etiology ; Skull Fractures/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000513102
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top