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  1. Article: Synthesis, crystal structure and photoluminescence of the salts Cation+ [M(caffeine)Cl]− with Cation+=NnBu4+, AsPh4+ and M==Zn(II), Pt(II)

    Vogler, Arnd / Hischa, Birgit / Stempfhuber, Sabine

    Zeitschrift für Naturforschung. 2019 Dec. 18, v. 74, no. 11-12

    2019  

    Abstract: ... anions [M(II)(caffeine)Cl3]− with M = Zn and Pt show an absorption spectrum with an intense band at λmax ...

    Abstract The salts (NnBu4)[Zn(caffeine)Cl3] and (AsPh4)[Pt(caffeine)Cl3] were prepared and their crystal structures determined by single crystal X-ray diffraction. The free ligand caffeine, as well as the complex anions [M(II)(caffeine)Cl3]− with M = Zn and Pt show an absorption spectrum with an intense band at λmax = 275 nm, which is attributed to an IL π–π* transition of the caffeine. A second band at ca. 300 nm is much weaker and largely obscured by the π–π* band. This second band is assigned to an IL n–π* transition. Both complex anions exhibit a photoluminescence (fluorescence), which originates from the n–π* state. The position of the n–π* state is recognized by the excitation band which distinctly overlaps with the fluorescence band.
    Keywords anions ; caffeine ; crystal structure ; fluorescence ; ligands ; photoluminescence ; platinum ; salts ; spectral analysis ; X-ray diffraction ; zinc
    Language English
    Dates of publication 2019-1218
    Size p. 885-889.
    Publishing place De Gruyter
    Document type Article
    ISSN 1865-7117
    DOI 10.1515/znb-2019-0141
    Database NAL-Catalogue (AGRICOLA)

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  2. Book ; Thesis: Das Auftreten eines postthrombotischen Syndroms nach Beinvenenthrombose - Vergleich von Villalta-Score, Duplexsonographie und Lichtreflexionsrheographie (PTS VILDER)

    Vogler, Mirko / Weiss, Norbert / Reeps, Christian Georg Horst

    2021  

    Institution Medizinische Klinik und Poliklinik III
    Author's details von Mirko Vogler aus Freital ; Medizinische Klinik und Poliklinik III [Dresden]
    Language German
    Size 93 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021732760
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: 1 M Gd-chelate (gadobutrol) for multislice first-pass magnetic resonance myocardial perfusion imaging.

    Fenchel, M / Franow, A / Martirosian, P / Engels, M / Kramer, U / Stauder, N I / Helber, U / Vogler, H / Claussen, C D / Miller, S

    The British journal of radiology

    2007  Volume 80, Issue 959, Page(s) 884–892

    Abstract: The aim of the study was to evaluate a 1 M gadolinium-chelate (gadobutrol) for first-pass MR ... examinations using 1 M gadobutrol yielded high sensitivity and specificity in detection of malperfused areas ... 82% and 91%, respectively). This is comparable with recently published perfusion data using 0.5 M ...

    Abstract The aim of the study was to evaluate a 1 M gadolinium-chelate (gadobutrol) for first-pass MR myocardial perfusion examinations in patients with suspected coronary artery disease (CAD). In phantom studies, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) values of gadobutrol were compared with gadopentetate (Gd-DTPA). 25 consecutive patients with clinically suspected CAD were examined with dynamic rest/stress MR perfusion examinations using 0.05 mmol kg(-1) gadobutrol. Semi-quantitative evaluation of the myocardial perfusion was performed by calculating the myocardial perfusion reserve index (MPRI). Hypoperfused regions were correlated with data from X-ray coronary angiography. In phantom studies, SNR/CNR of gadobutrol-doped blood samples were consistently higher for all applied flip angles at concentrations < or =1.0 mmol L(-1) compared with Gd-DTPA. Assessment of 81 stress perfusion series with gadobutrol in 25 patients yielded a sensitivity of 82% and specificity of 91% for significant CAD. Combining the information from all perfusion series of one patient yielded a sensitivity of 89% and specificity of 94% on a per-vessel basis. Gadobutrol exhibited favourable signal properties in phantom studies. Rest/stress myocardial perfusion examinations using 1 M gadobutrol yielded high sensitivity and specificity in detection of malperfused areas (82% and 91%, respectively). This is comparable with recently published perfusion data using 0.5 M Gd-DTPA.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Contrast Media ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Female ; Gadolinium DTPA ; Humans ; Magnetic Resonance Angiography/methods ; Magnetic Resonance Angiography/standards ; Male ; Middle Aged ; Organometallic Compounds ; Sensitivity and Specificity
    Chemical Substances Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L) ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2007-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/34610669
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  4. Book ; Online: Avaliação das aquisições centralizadas dos medicamentos em Portugal

    Vogler, Sabine / Habimana, Katharina / Schneider, Peter / Haasis, Manuel Alexander

    relatório síntese

    2021  

    Abstract: O presente estudo avalia as aquisições centralizadas dos medicamentos (ACM) em Portugal numa perspetiva de saúde pública e desenvolve recomendações políticas. A "Metodologia para a avaliação dos sistemas de aquisição" (MAPS, na sigla em inglês) da OCDE ... ...

    Institution Gesundheit Österreich GmbH
    Europäische Union
    Author's details autores: Sabine Vogler, Katharina Habimana, Eveli Bauer, Peter Schneider, Manuel Alexander Haasis ; assistente do projeto: Monika Schintlmeister ; tradução em português: A. Sousa Coutinho ; com o financiamento da União Europeia ; EMSPOS - Estrutura de Missão para a Sustentabilidade do Programa Orçamental da Saúde ; Gesundheit Österreich Forschungs- und Planungs GmbH
    Abstract O presente estudo avalia as aquisições centralizadas dos medicamentos (ACM) em Portugal numa perspetiva de saúde pública e desenvolve recomendações políticas. A "Metodologia para a avaliação dos sistemas de aquisição" (MAPS, na sigla em inglês) da OCDE foi aplicada de forma adaptada. As informações foram obtidas da literatura e de documentos de aquisições, incluindo propostas de procedimentos de aquisição selecionados, e de 42 entrevistas, das quais 37 realizadas no local com representantes de autoridades públicas, hospitais e administrações regionais de saúde, pacientes e indústria farmacêutica. O input de especialistas em aquisições de 5 países europeus, de participantes portugueses num seminário de pessoas interessadas e de académicos num inquérito Delphi contribuiu para a garantia de qualidade, participação e aceitação. A Serviços Partilhados do Ministério da Saúde (SPMS) é responsável pela realização dos processos de aquisições centralizadas, os quais compreendem procedimentos abertos (Aquisições centralizadas / AC) com um (ou dois) fornecedores e processos de Acordos Quadros / AQ) de duas fases. A aplicação jurídica das ACM está em conformidade com as normas europeias, e concluiu-se que o sistema português tem várias forças. Trata-se nomeadamente da sua contribuição para preços mais baixos (em comparação com aquisições individuais) em vários casos (mas não todos) e, por conseguinte, de poupanças para o sector público, de uma maior transparência dos processos e da governação, de uma maior equidade no acesso aos medicamentos em Portugal, e de um menor volume de trabalho para os adquirentes individuais. Contudo, foram também identificadas as fraquezas. [...]
    Keywords Aquisições públicas ; farmacêutica ; avaliação ; acesso aos medicamentos ; processos ; Portugal
    Subject code 610
    Language Portuguese
    Size 1 Online-Ressource (III, 12 Seiten), Diagramme
    Publisher Gesundheit Österreich Forschungs- und Planungs GmbH
    Publishing place Viena
    Publishing country Austria
    Document type Book ; Online
    Note realizado com o financiamento da União Europeia através do Programa de Apoio às Reformas Estruturais e em cooperação com a Direção-Geral do Apoio às Reformas Estruturais da Comissão Europeia ; Open Access
    HBZ-ID HT020934073
    DOI 10.4126/FRL01-006427713
    Database Repository for Life Sciences

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  5. Book ; Online: Assessment of centralised procurement of medicines in Portugal

    Vogler, Sabine / Habimana, Katharina / Schneider, Peter / Haasis, Manuel Alexander

    full report

    2021  

    Abstract: This study assesses the performance of centralised procurement of medicines (CPM) in Portugal from a public health perspective and develops policy recommendations. The OECD “Methodology for Assessing Procurement Systems” (MAPS) was applied in an adapted ... ...

    Institution Gesundheit Österreich GmbH
    Europäische Union
    Author's details authors: Sabine Vogler, Katharina Habimana, Eveli Bauer, Peter Schneider, Manuel Alexander Haasis ; project assistant: Monika Schintlmeister ; translation of abstract and executive summary: A. Sousa Coutinho ; funding by the European Union ; Gesundheit Österreich Forschungs- und Planungs GmbH
    Abstract This study assesses the performance of centralised procurement of medicines (CPM) in Portugal from a public health perspective and develops policy recommendations. The OECD “Methodology for Assessing Procurement Systems” (MAPS) was applied in an adapted manner. Information was retrieved from the literature and procurement documents, including bids of selected procurement procedures, and from 42 interviews, thereof 37 on-site interviews with representatives of public authorities, hospitals and regional health administrations, patients and the pharmaceutical industry. Input of procurement experts of five European countries, of Portuguese participants in a stakeholder workshop and of academics in a Delphi survey have contributed to quality-assurance, participation and acceptance. The Shared Services of the Ministry of Health (SPMS) is responsible for performing centralised procurement processes, which comprise both open procedures (Aquisições centralizadas / AC) with one (or two) suppliers and the two-stage processes of framework agreements (Acordos Quadros / AQ). Legal implementation of CPM is compliant with European standards, and the Portuguese system was found to have several strengths. These include its contribution to lower prices (compared to individual purchases) in several (but not all) cases and thus to savings for the public sector, to improved transparency of processes and governance, to more equity in access to medicines across Portugal and to a lower workload for individual procurers. However, weaknesses were also identified. There is a lack of strategy related to CPM and a lack of clarity related to the roles and responsibilities of SPMS and further relevant public institutions and stakeholders with regard to their CPM activities. [...]
    Keywords Public procurement ; pharmaceutical ; evaluation ; access to medicines ; processes ; Portugal
    Subject code 610
    Language English
    Size 1 Online-Ressource (XXV, 58, LXIV Seiten), Diagramme
    Publisher Gesundheit Österreich Forschungs- und Planungs GmbH
    Publishing place Vienna
    Publishing country Austria
    Document type Book ; Online
    Note carried out with funding by the European Union via the Structural Reform Support Programme and in cooperation with the Directorate-General for Structural Reform Support of the European Commission ; inhaltliche Zusammenfassung in portugiesischer und englischer Sprache ; Open Access
    HBZ-ID HT020933833
    DOI 10.4126/FRL01-006427709
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  6. Book ; Online: Assessment of centralised procurement of medicines in Portugal

    Vogler, Sabine / Habimana, Katharina / Schneider, Peter / Haasis, Manuel Alexander

    summary report

    2021  

    Abstract: This study assesses the performance of centralised procurement of medicines (CPM) in Portugal from a public health perspective and develops policy recommendations. The OECD “Methodology for Assessing Procurement Systems” (MAPS) was applied in an adapted ... ...

    Institution Gesundheit Österreich GmbH
    Europäische Union
    Author's details authors: Sabine Vogler, Katharina Habimana, Eveli Bauer, Peter Schneider, Manuel Alexander Haasis ; project assistant: Monika Schintlmeister ; translation of abstract and executive summary: A. Sousa Coutinho ; funding by the European Union ; EMSPOS - Estrutura de Missão para a Sustentabilidade do Programa Orçamental da Saúde ; Gesundheit Österreich Forschungs- und Planungs GmbH
    Abstract This study assesses the performance of centralised procurement of medicines (CPM) in Portugal from a public health perspective and develops policy recommendations. The OECD “Methodology for Assessing Procurement Systems” (MAPS) was applied in an adapted manner. Information was retrieved from the literature and procurement documents, including bids of selected procurement procedures, and from 42 interviews, thereof 37 on-site interviews with representatives of public authorities, hospitals and regional health administrations, patients and the pharmaceutical industry. Input of procurement experts of five European countries, of Portuguese participants in a stakeholder workshop and of academics in a Delphi survey have contributed to quality-assurance, participation and acceptance. The Shared Services of the Ministry of Health (SPMS) is responsible for performing centralised procurement processes, which comprise both open procedures (Aquisições centralizadas / AC) with one (or two) suppliers and the two-stage processes of framework agreements (Acordos Quadros / AQ). Legal implementation of CPM is compliant with European standards, and the Portuguese system was found to have several strengths. These include its contribution to lower prices (compared to individual purchases) in several (but not all) cases and thus to savings for the public sector, to improved transparency of processes and governance, to more equity in access to medicines across Portugal and to a lower workload for individual procurers. However, weaknesses were also identified. There is a lack of strategy related to CPM and a lack of clarity related to the roles and responsibilities of SPMS and further relevant public institutions and stakeholders with regard to their CPM activities. [...]
    Keywords Public procurement ; pharmaceutical ; evaluation ; access to medicines ; processes ; Portugal
    Subject code 610
    Language English
    Size 1 Online-Ressource (III, 11 Seiten), Diagramme
    Publisher Gesundheit Österreich Forschungs- und Planungs GmbH
    Publishing place Vienna
    Publishing country Austria
    Document type Book ; Online
    Note carried out with funding by the European Union via the Structural Reform Support Programme and in cooperation with the Directorate-General for Structural Reform Support of the European Commission ; Open Access
    HBZ-ID HT020933838
    DOI 10.4126/FRL01-006427711
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  7. Article: Infection with HIV type 1 group M non-B subtypes in individuals living in New York City.

    Achkar, Jacqueline M / Burda, Sherri T / Konings, Frank A J / Urbanski, Mateusz M / Williams, Constance A U / Seifen, Dorothee / Kahirimbanyi, Martha N / Vogler, Mary / Parta, Mark / Lupatkin, Helene C / Zolla-Pazner, Susan / Nyambi, Phillipe N

    Journal of acquired immune deficiency syndromes (1999)

    2004  Volume 36, Issue 3, Page(s) 835–844

    Abstract: Objective: To document infection with HIV type 1 (HIV-1) group M non-B subtypes in individuals ... genes were amplified by PCR analysis. The infecting HIV-1 group M subtype was determined based ... unclassifiable. HIV-1 infections were classified as those due to the following group M subtypes: A (n = 4; 7%), B ...

    Abstract Objective: To document infection with HIV type 1 (HIV-1) group M non-B subtypes in individuals living in New York City.
    Design: From October 1999 through April 2003, HIV-1-seropositive individuals were selected from 3 clinics in New York City based on having risk factors for infection with HIV-1 non-B subtypes.
    Methods: HIV-1 RNA was extracted from plasma samples, and partial gag, pol, or env genes were amplified by PCR analysis. The infecting HIV-1 group M subtype was determined based on results of either heteroduplex mobility assay or sequencing and phylogenetic analysis.
    Results: Ninety-seven subjects were enrolled in the study. Of the 97 subjects, 91 (94%) were selected based on having emigrated from a non-European country, while 6 (6%) were native United States citizens. Subtypes were successfully determined in 53 (55%) of the 97 plasma samples tested. The subtypes in 2 plasma samples were unclassifiable. HIV-1 infections were classified as those due to the following group M subtypes: A (n = 4; 7%), B (n = 12; 22%), C (n = 8; 15%), F (n = 2; 4%), CRF01_AE-like (n = 7; 13%), CRF02_AG-like (n = 19; 34%), an intersubtype recombinant form G/A (n = 1; 2%), and unclassifiable viruses (n = 2; 4%).
    Conclusion: This study reveals infection with a broad variety of HIV-1 group M subtypes mostly in the immigrant population of New York City as well as how several non-B subtypes are being introduced into the United States.
    MeSH term(s) Adult ; Base Sequence ; Emigration and Immigration ; Female ; Genes, env ; Genes, gag ; Genes, pol ; Genotype ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; New York City/epidemiology ; Phylogeny ; RNA, Viral/blood ; RNA, Viral/genetics ; Risk Factors ; Travel
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2004-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 1525-4135 ; 0897-5965 ; 0894-9255
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 1525-4135 ; 0897-5965 ; 0894-9255
    DOI 10.1097/00126334-200407010-00011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2442: Show issues Location:
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  8. Book ; Thesis: Gefühlte Wirksamkeit und Präferenz von Verkehrssicherheitsmaßnahmen in Abhängigkeit von Risikofaktoren und Unfallanamnese

    Vogler, Michael

    eine Fragebogenuntersuchung

    2010  

    Author's details vorgelegt von Michael Vogler
    Language German
    Size 81 Bl., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Greifswald, Univ., Diss., 2010
    HBZ-ID HT016970629
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 E 3325 order for loan Magazin

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  9. Article ; Online: [No title information]

    Vogler, Brigitte

    Medecine sciences : M/S

    2021  Volume 37 Hors série n° 2, Page(s) 17–18

    Title translation AXEL et les fées cachées de m/s.
    Language French
    Publishing date 2021-12-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021219
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  10. Book ; Online: Novel policy options for reimbursement, pricing and procurement of AMR health technologies

    Vogler, Sabine / Habimana, Katharina / Fischer, Stefan / Haasis, Manuel Alexander

    final report

    2021  

    Abstract: Antimicrobial resistance (AMR) is a global health threat. A key pillar in the multi-faceted approach to tackle AMR includes the development and commercialisation of novel antibiotics to replace those to which patients are increasingly becoming resistant. ...

    Institution Gesundheit Österreich GmbH
    Author's details authors: Sabine Vogler, Katharina Habimana, Stefan Fischer, Manuel Alexander Haasis ; project assistant: Monika Schintlmeister ; commissioned by the Global AMR R&D Hub ; Gesundheit Österreich Forschungs- und Planungs GmbH
    Abstract Antimicrobial resistance (AMR) is a global health threat. A key pillar in the multi-faceted approach to tackle AMR includes the development and commercialisation of novel antibiotics to replace those to which patients are increasingly becoming resistant. Another approach is focused on diagnostics, which, among others, help decide whether or not the prescription of an antibiotic is required, thus reducing antibiotic consumption. Medicines and medical devices, hereinafter referred to as health technologies, usually enter the market of a country after the public authority has decided whether, and to what extent, the cost of the specific health technology will be paid for by the public payer. Linked to these reimbursement and procurement decisions, the price of the health technologies can also be determined by authorities. AMR health technologies have special characteristics such as a dearth of data and evidence, a value to society higher than added therapeutic benefit, and comparably low prices of antibiotics compared to diagnostics. These considerations are not yet well captured by the current standard policies on reimbursement, pricing and procurement. There is a need for a more finely tuned set of specific policy options. Against this backdrop, the study aimed to identify specific policy options in reimbursement, pricing and procurement that are able to incentivise production and market entry of AMR health technologies (novel antibiotics and diagnostics). Included are examples of national policies already in place for AMR health technologies as well as for health technologies with similar characteristics.
    Subject code 610
    Language English
    Size 1 Online-Ressource (XVIII, 171 Seiten), Diagramme
    Publisher Gesundheit Österreich Forschungs- und Planungs GmbH
    Publishing place Wien
    Publishing country Austria
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020934113
    DOI 10.4126/FRL01-006427715
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