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Article ; Online: C.E.R.A. maintains stable control of hemoglobin in patients with chronic kidney disease on dialysis when administered once every two weeks.

Spinowitz, Bruce / Coyne, Daniel W / Lok, Charmaine E / Fraticelli, Mario / Azer, Maher / Dalal, Sanjay / Villa, Giuseppe / Rosansky, Steven / Adamis, Helena / Beyer, Ulrich

American journal of nephrology

2008 Volume 28, Issue 2, Page(s) 280–289

Abstract: Background/aims: This Phase III study examined the efficacy and safety of C.E.R.A., a continuous ... TIW)), or receive C.E.R.A. Q2W by the same route as previous epoetin treatment for 36 weeks. Dosage ... Results: Mean change in Hb for C.E.R.A. and epoetin was 0.088 and -0.030 g/dl, respectively (endpoint Hb ...

Abstract	Background/aims: This Phase III study examined the efficacy and safety of C.E.R.A., a continuous erythropoietin receptor activator, given once every 2 weeks (Q2W) via subcutaneous or intravenous injection using pre-filled syringes, for maintaining hemoglobin (Hb) levels in patients with chronic kidney disease (CKD) on dialysis who converted directly from epoetin therapy. Methods: Patients (n = 336) were randomized 1:1 to continue epoetin at their current dose, route and administration interval (once to three times weekly (QW-TIW)), or receive C.E.R.A. Q2W by the same route as previous epoetin treatment for 36 weeks. Dosage was adjusted to maintain patients' Hb within +/-1.0 g/dl of baseline value and within 10.0-13.5 g/dl. Primary endpoint was mean change in Hb between baseline and the evaluation period (weeks 29-36). Results: Mean change in Hb for C.E.R.A. and epoetin was 0.088 and -0.030 g/dl, respectively (endpoint Hb 11.93 and 11.86 g/dl, respectively). Analysis showed that C.E.R.A. was as effective as epoetin in maintaining Hb (p < 0.0001), and was well tolerated. The administration route had no impact on primary endpoint. Conclusion: Q2W C.E.R.A. administered using pre-filled syringes effectively maintains stable control of Hb in patients on dialysis who convert directly from epoetin QW-TIW.
MeSH term(s)	Adult ; Aged ; Drug Administration Schedule ; Epoetin Alfa ; Erythropoietin/administration & dosage ; Erythropoietin/therapeutic use ; Female ; Hemoglobins/metabolism ; Humans ; Injections, Intravenous ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins ; Renal Dialysis/methods ; Syringes ; Treatment Outcome
Chemical Substances	Hemoglobins ; Recombinant Proteins ; continuous erythropoietin receptor activator ; Erythropoietin (11096-26-7) ; Polyethylene Glycols (30IQX730WE) ; Epoetin Alfa (64FS3BFH5W)
Language	English
Publishing date	2008
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000111115
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Article: C.E.R.A. Maintains Stable Control of Hemoglobin in Patients with Chronic Kidney Disease on Dialysis when Administered Once Every Two Weeks

Spinowitz, Bruce / Coyne, Daniel W. / Lok, Charmaine E. / Fraticelli, Mario / Azer, Maher / Dalal, Sanjay / Villa, Giuseppe / Rosansky, Steven / Adamis, Helena / Beyer, Ulrich

American Journal of Nephrology

2007 Volume 28, Issue 2, Page(s) 280–289

Abstract: Background/Aims: This Phase III study examined the efficacy and safety of C.E.R.A., a continuous ... TIW)), or receive C.E.R.A. Q2W by the same route as previous epoetin treatment for 36 weeks. Dosage ... Mean change in Hb for C.E.R.A. and epoetin was 0.088 and –0.030 g/dl, respectively (endpoint Hb 11.93 ...

Institution	Division of Nephrology, New York Hospital Queens, Nephrology Associates, Flushing, N.Y., and Renal Division, Department of Internal Medicine, Washington University, St. Louis, Mo., USA Department of Medicine, Division of Nephrology, Toronto General Hospital and University of Toronto, Toronto, Ont., Canada Division of Nephrology, S. Anna Hospital, Como, Italy Renal Research Center, Los Alamitos, Calif., and Department of Medicine, MSU/KCMS, Kalamazoo, Mich., USA Divisione di Nefrologia ed Emodialisi, Fondazione ‘S. Maugeri’ IRCCS, Pavia, Italy Pharma Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Abstract	Background/Aims: This Phase III study examined the efficacy and safety of C.E.R.A., a continuous erythropoietin receptor activator, given once every 2 weeks (Q2W) via subcutaneous or intravenous injection using pre-filled syringes, for maintaining hemoglobin (Hb) levels in patients with chronic kidney disease (CKD) on dialysis who converted directly from epoetin therapy. Methods: Patients (n = 336) were randomized 1:1 to continue epoetin at their current dose, route and administration interval (once to three times weekly (QW–TIW)), or receive C.E.R.A. Q2W by the same route as previous epoetin treatment for 36 weeks. Dosage was adjusted to maintain patients’ Hb within ±1.0 g/dl of baseline value and within 10.0–13.5 g/dl. Primary endpoint was mean change in Hb between baseline and the evaluation period (weeks 29–36). Results: Mean change in Hb for C.E.R.A. and epoetin was 0.088 and –0.030 g/dl, respectively (endpoint Hb 11.93 and 11.86 g/dl, respectively). Analysis showed that C.E.R.A. was as effective as epoetin in maintaining Hb (p < 0.0001), and was well tolerated. The administration route had no impact on primary endpoint. Conclusion: Q2W C.E.R.A. administered using pre-filled syringes effectively maintains stable control of Hb in patients on dialysis who convert directly from epoetin QW–TIW.
Keywords	Pre-filled syringe ; Renal anemia ; Chronic kidney disease ; Hemoglobin ; Epoetin ; Continuous erythropoietin receptor activator
Language	English
Publishing date	2007-11-13
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Report: Laboratory Investigation
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000111115
Database	Karger publisher's database

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Article ; Online: Effect of pH variation and temperature on pesticides sorption characteristics in calcareous soil

Mohamed R. Fouad / Ahmed F. El-Aswad / Mohamed E. I. Badawy / Maher I. Aly

Current Chemistry Letters, Vol 13, Iss 1, Pp 141-

2024 Volume 150

Abstract: The effect of pH value at three levels (5, 7, and 9) and temperature at two levels (25 and 50ºC) on the sorption properties of chlorantraniliprole-CAP, dinotefuran-DNF, bispyribac-sodium-BPS, and metribuzin-MBZ were studied in calcareous soil. The ... ...

Abstract	The effect of pH value at three levels (5, 7, and 9) and temperature at two levels (25 and 50ºC) on the sorption properties of chlorantraniliprole-CAP, dinotefuran-DNF, bispyribac-sodium-BPS, and metribuzin-MBZ were studied in calcareous soil. The sorption of CAP at pH 5 (38.2%) was significantly higher than that at pH 7 (32.4%) and 9 (28.4%), whereas the sorption of DNF at pH 5 was lower than that at pH 7. The adsorption of BPS at pH 9 was statistically significantly higher than that at pH 5 and pH 7. Regarding the herbicide MBZ adsorption percentages were 47.0, 61.1 and 57.1 % at pH 5, 7 and 9. The number of tested pesticides adsorbed by the soil was significantly influenced by the temperature. The adsorbed amount of CAP was decreased from 37% to 33% as the temperature was increased from 25˚C to 50 ˚C, while no significant differences of adsorbed DNF. Data showed that the adsorption of BPS and MBZ statistically decreases with temperature. The data from the adsorption behaviour of CAP, DNF, BPS, and MBZ in tested soil at different temperatures correspond well with the Freundlich isotherm. The negative ΔG˚ indicated that the adsorption of CAP, DNF, BPS, and MBZ were spontaneous at different temperatures. There was an increase in the entropy of the pesticide-soil systems as shown by the positive values of ΔS˚.
Keywords	Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Growing Science
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Children's Health, Wellbeing and Academic Outcomes over the Summer Holidays: A Scoping Review.

Eglitis, Emily / Miatke, Aaron / Virgara, Rosa / Machell, Amanda / Olds, Timothy / Richardson, Mandy / Maher, Carol

Children (Basel, Switzerland)

2024 Volume 11, Issue 3

Abstract: Background: The school day provides a supportive and stimulating environment that may protect children and adolescents (5-18 years) from behaviours that are adverse for health and wellbeing.: Objective: To review the literature regarding changes in ... ...

Abstract	Background: The school day provides a supportive and stimulating environment that may protect children and adolescents (5-18 years) from behaviours that are adverse for health and wellbeing. Objective: To review the literature regarding changes in children's academic achievement or overall wellbeing during the extended school summer break and evaluate if the outcomes are different for children experiencing disadvantage. Methods: The peer-reviewed literature was searched across six electronic databases for studies tracking changes in any academic, health or wellbeing outcome in children over the summer holidays. Studies were screened in duplicate for inclusion. Data were extracted using a standardized data extraction form. Outcomes were coded as decline (suggestive or significant), increase (suggestive or significant) or mixed/neutral and then compared to the school year or according to disadvantaged. Results: Seventy-six studies ( Conclusions: Over the summer break, children's academic and health outcomes decline. Children experiencing disadvantage display magnified losses that warrant further investigation. The summer holidays present an opportunity to improve children's health and wellbeing.
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11030287
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Article: Treatment of Apathy in Parkinson's Disease and Implications for Underlying Pathophysiology.

Maher, Senan / Donlon, Eoghan / Mullane, Gerard / Walsh, Richard / Lynch, Tim / Fearon, Conor

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: Apathy is a prevalent and highly debilitating non-motor symptom of Parkinson's disease (PD) that is often overlooked in clinical practice due to its subtle nature. This review aims to provide a comprehensive overview of the current evidence for the ... ...

Abstract	Apathy is a prevalent and highly debilitating non-motor symptom of Parkinson's disease (PD) that is often overlooked in clinical practice due to its subtle nature. This review aims to provide a comprehensive overview of the current evidence for the treatment of apathy in PD, highlighting recent advancements and emerging therapeutic avenues. In this review, we analyse a diverse array of treatment strategies for apathy in PD, including pharmacological interventions, non-pharmacological approaches, and emerging neuromodulation techniques. We evaluate the efficacy, safety, and limitations of established pharmacotherapies, such as dopaminergic agents, antidepressants, and cognitive enhancers. Additionally, we examine the promising role of non-pharmacological interventions, encompassing psychotherapies and behavioural interventions, in ameliorating apathetic symptoms. Furthermore, this review explores the effects of neuromodulation techniques on apathy, including the modulation of apathy via deep brain stimulation and emerging data on the potential influence of transcranial magnetic stimulation (TMS) on apathy in PD. Ultimately, a deeper understanding of effective treatment strategies for apathy has the potential to significantly improve the quality of life and overall well-being of individuals living with PD.
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082216
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Article ; Online: The Adductor Sling Technique for Pediatric Medial Patellofemoral Ligament Reconstruction Better Resists Dislocation Loads When Compared With Adductor Transfer at Time Zero in a Cadaveric Model.

Balazs, George C / Meyers, Kathleen N / Dennis, Elizabeth R / Maher, Suzanne A / Shubin Stein, Beth E

Arthroscopy, sports medicine, and rehabilitation

2023 Volume 6, Issue 1, Page(s) 100831

Abstract: Purpose: To characterize the ability of the intact medial patellofemoral ligament (MPFL) and the adductor transfer and adductor sling MPFL reconstruction techniques to resist subluxation and dislocation in a cadaveric model.: Methods: Nine fresh- ... ...

Abstract	Purpose: To characterize the ability of the intact medial patellofemoral ligament (MPFL) and the adductor transfer and adductor sling MPFL reconstruction techniques to resist subluxation and dislocation in a cadaveric model. Methods: Nine fresh-frozen cadaveric knees were placed on a custom testing fixture with the femur fixed parallel to the floor, the tibia placed in 20° of flexion, and the patella attached to a load cell. The patella was displaced laterally, and subluxation load (in newtons), dislocation load (in newtons), maximum failure load (in newtons), patellar displacement at failure, and mode of failure were recorded. Testing was conducted with the MPFL intact and after the adductor sling and adductor transfer reconstruction techniques. Statistical analysis was completed using 1-way repeated-measures analysis of variance with the Holm-Šidák post hoc test. Results: The subluxation load was not significantly different between groups. The native MPFL dislocation load was significantly higher than the dislocation loads of both reconstruction techniques, but no significant difference between the dislocation loads of the 2 reconstruction techniques occurred. The native MPFL failure load was significantly higher than the failure loads of both reconstruction techniques. The adductor sling failure load was significantly higher than the adductor transfer failure load. The mode of failure varied across groups. The native MPFL failed by femoral avulsion, patellar avulsion, and midsubstance tear. The main mode of failure for adductor transfer was pullout, whereas failure for the adductor sling technique most often occurred at the sutures. Most of the native MPFLs and all adductor sling reconstructions failed after dislocation. The adductor transfer reconstructions were much more variable, with failures spanning from before subluxation through dislocation. Conclusions: Our cadaveric model showed that neither the adductor transfer technique nor the adductor sling technique restored failure load to that of the native condition. There was no significant difference in the subluxation or dislocation loads between the 2 MPFL reconstructions, but the adductor sling technique resulted in a higher load to failure. The adductor transfer technique frequently failed before subluxation or dislocation when compared with the adductor sling technique and the native MPFL. Clinical relevance: The best technique for MPFL reconstruction in patients with open physes is a topic of debate. Given the long-term consequences of MPFL injury and potential for growth plate disturbance, it is important to study MPFL reconstruction techniques thoroughly, including in the laboratory setting.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ISSN	2666-061X
ISSN (online)	2666-061X
DOI	10.1016/j.asmr.2023.100831
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Article ; Online: Effect of functional appliances on sleep-disordered breathing in Class II division 1 malocclusion children: Randomized controlled trial.

Radwan, E S / Maher, A / Montasser, M A

Orthodontics & craniofacial research

2023 Volume 27, Issue 1, Page(s) 126–138

Abstract: ... correlation (r = -.589; P = .006) could be found between the total volume of the oropharynx and ODI. No ...

Abstract	Objectives: A randomized controlled trial was undertaken to investigate the orthopaedic effect of functional appliances on the pharyngeal airway space and nocturnal breathing of children with skeletal class II due to mandibular retrusion. Materials and methods: Forty patients were randomized into a 1:1 ratio study (Twin block) group and a control (fixed appliance) group. Each group included equal numbers of boys and girls. Diagnosis with sleep-disordered breathing was not an inclusion criterion. The duration of the trial was 12 months (T0 - T12). Eligibility criteria included skeletal Class II division 1 malocclusion with mandibular retrognathism, SNA ≥82, SNB ≤78, ANB ≥4, overjet ≥6 mm, and patients in circumpubertal stage CVM2 and CVM3. The main outcomes were pharyngeal airway volume, oxygen desaturation index (ODI), and maximum expiratory pressure (MEP), while the secondary outcomes were skeletal and dental changes of the maxilla and mandible. Randomization was accomplished with random blocks of 20 patients with allocation concealed in sequentially numbered, opaque, and sealed envelopes. Blinding was only applicable for data analysis of radiographic measurements and data extracted from the pulse oximeter. Results: The mean age of the patients was 10 ± 1.5 and 10 ± 1.2 at (T0) for the Twin Block and the control groups, respectively. The changes in the oropharyngeal (2.66 cc and 0.056; P = .03) and nasopharyngeal (1.3 cc and 0.84; P = .053) airway volumes for the Twin block and control groups, respectively, were significantly different for the oropharynx. There was a significant decrease in ODI by [median -3.55 (-5.05 to 0.50); P ≤ .001] and a significant increase [median 45 (0.0-110); P ≤ .001] in MEP for the Twin block group. A significant inverse correlation (r = -.589; P = .006) could be found between the total volume of the oropharynx and ODI. No serious harm was observed. Conclusions: The Twin block group showed significant change in oropharyngeal airway volume and improvement of nocturnal breathing. Registration: This trial was registered at https://www. Clinicaltrials: gov, registration number NCT04255511.
MeSH term(s)	Male ; Child ; Female ; Humans ; Malocclusion, Angle Class II/therapy ; Overbite ; Malocclusion ; Mandible ; Sleep Apnea Syndromes/therapy ; Maxilla ; Orthodontic Appliances, Functional ; Cephalometry
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2076514-9
ISSN	1601-6343 ; 1601-6335
ISSN (online)	1601-6343
ISSN	1601-6335
DOI	10.1111/ocr.12696
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Zs.A 5412: Show issues

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Article ; Online: Decoupling body shape and mass distribution in birds and their dinosaurian ancestors.

Macaulay, Sophie / Hoehfurtner, Tatjana / Cross, Samuel R R / Marek, Ryan D / Hutchinson, John R / Schachner, Emma R / Maher, Alice E / Bates, Karl T

Nature communications

2023 Volume 14, Issue 1, Page(s) 1575

Abstract: It is accepted that non-avian theropod dinosaurs, with their long muscular tails and small forelimbs, had a centre-of-mass close to the hip, while extant birds, with their reduced tails and enlarged wings have their mass centred more cranially. ... ...

Abstract	It is accepted that non-avian theropod dinosaurs, with their long muscular tails and small forelimbs, had a centre-of-mass close to the hip, while extant birds, with their reduced tails and enlarged wings have their mass centred more cranially. Transition between these states is considered crucial to two key innovations in the avian locomotor system: crouched bipedalism and powered flight. Here we use image-based models to challenge this dichotomy. Rather than a phylogenetic distinction between 'dinosaurian' and 'avian' conditions, we find terrestrial versus volant taxa occupy distinct regions of centre-of-mass morphospace consistent with the disparate demands of terrestrial bipedalism and flight. We track this decoupled evolution of body shape and mass distribution through bird evolution, including the origin of centre-of-mass positions more advantageous for flight and major reversions coincident with terrestriality. We recover modularity in the evolution of limb proportions and centre-of-mass that suggests fully crouched bipedalism evolved after powered flight.
MeSH term(s)	Animals ; Phylogeny ; Biological Evolution ; Somatotypes ; Birds ; Dinosaurs/anatomy & histology ; Fossils
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37317-y
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Article ; Online: Hereditary renal cell carcinoma syndromes: diagnosis, surveillance and management.

Maher, Eamonn R

World journal of urology

2018 Volume 36, Issue 12, Page(s) 1891–1898

Abstract: ... Though screening and management guidelines for some inherited RCC syndromes (e.g. von Hippel-Lindau disease ... Birt-Hogg-Dube syndrome, hereditary leiomyomatosis) are well defined for rare cause of inherited RCC (e.g. germline BAP1 ...

Abstract	Purpose: Genetic factors have been implicated in the pathogenesis of renal cell carcinoma (RCC), with around 3% of cases having a family history. A greater knowledge of the genetics of inherited RCC has the potential to translate into novel therapeutic targets for sporadic RCC. Methods: A literature review was performed summarising the current knowledge on hereditary RCC diagnosis, surveillance and management. Results: Familial RCC is usually inherited in an autosomal dominant manner, although inherited RCC may present without a relevant family history. A number of familial RCC syndromes have been identified. Familial non-syndromic RCC is suspected when ≥ 2 relatives are affected in the absence of syndromic features, although clear diagnostic criteria are lacking. Young age at onset and bilateral/multicentric tumours are recognised characteristics which should prompt molecular genetic analysis. Surveillance in individuals at risk of inherited RCC aims to prevent morbidity and mortality via early detection of tumours. Though screening and management guidelines for some inherited RCC syndromes (e.g. von Hippel-Lindau disease, Birt-Hogg-Dube syndrome, hereditary leiomyomatosis) are well defined for rare cause of inherited RCC (e.g. germline BAP1 mutations), there is limited information regarding the lifetime RCC risks and the most appropriate screening modalities. Conclusion: Increasing knowledge of the natural history and genetic basis has led to characterisation and tailored management of hereditary RCC syndromes. International data sharing of inherited RCC gene variant information may enable evidence-based improvements in the diagnosis, surveillance protocols and management of these rare conditions.
MeSH term(s)	Age of Onset ; Birt-Hogg-Dube Syndrome/diagnosis ; Birt-Hogg-Dube Syndrome/genetics ; Birt-Hogg-Dube Syndrome/therapy ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; Disease Management ; Early Detection of Cancer ; Fumarate Hydratase/genetics ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/therapy ; Leiomyomatosis/diagnosis ; Leiomyomatosis/genetics ; Leiomyomatosis/therapy ; Neoplasms, Multiple Primary/diagnosis ; Neoplasms, Multiple Primary/genetics ; Neoplasms, Multiple Primary/therapy ; Neoplastic Syndromes, Hereditary/diagnosis ; Neoplastic Syndromes, Hereditary/genetics ; Neoplastic Syndromes, Hereditary/therapy ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-met/genetics ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/therapy ; Succinate Dehydrogenase/genetics ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/genetics ; Uterine Neoplasms/therapy ; Von Hippel-Lindau Tumor Suppressor Protein/genetics ; von Hippel-Lindau Disease/diagnosis ; von Hippel-Lindau Disease/genetics ; von Hippel-Lindau Disease/therapy
Chemical Substances	BAP1 protein, human ; FLCN protein, human ; Proto-Oncogene Proteins ; Tumor Suppressor Proteins ; Succinate Dehydrogenase (EC 1.3.99.1) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Fumarate Hydratase (EC 4.2.1.2) ; VHL protein, human (EC 6.3.2.-)
Language	English
Publishing date	2018-04-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-018-2288-5
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Article: Are Tidal Salt Marshes Exposed to Nutrient Pollution more Vulnerable to Sea Level Rise?

Krause, J R / Watson, E / Wigand, C / Maher, N

Wetlands (Wilmington, N.C.)

2021 Volume 40, Page(s) 1–10

Abstract: Over the past four decades, Long Island, NY, USA, has lost coastal wetlands at a rate of 4% per decade due to submergence. In this study, we examined relationships between the rate of tidal salt marsh loss and environmental factors, including marsh ... ...

Abstract	Over the past four decades, Long Island, NY, USA, has lost coastal wetlands at a rate of 4% per decade due to submergence. In this study, we examined relationships between the rate of tidal salt marsh loss and environmental factors, including marsh elevation, tidal range, and wastewater exposure through analysis of stable isotope ratios of marsh soils and biota. Our goal was to identify factors that increase vulnerability of marshes to sea level rise, with a specific emphasis on the potential role of poor water quality in hastening marsh loss. Our results suggest that wastewater exposure may accelerate loss of intertidal marsh, but does not negatively impact high tidal marsh resilience to sea level rise. And while marsh elevation and tidal range were statistically significant predictors of marsh loss, they similarly displayed opposite relationships among marsh zones. This study suggests that different functional zones of coastal salt marshes may not respond similarly to global change factors, and that elevation may be an important factor mediating eutrophication effects to coastal salt marshes.
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1097341-2
ISSN	1943-6246 ; 0277-5212
ISSN (online)	1943-6246
ISSN	0277-5212
DOI	10.1007/s13157-019-01254-8
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