LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article ; Online: Oleander attenuates hepatic inflammation in a TLR4-independent manner and by favorable modulation of hepatocellular global metabolome that supports cytoprotection.

Dey, Priyankar / Tewari, Nisha / Dutta, Somit / Newman, Robert A / Chaudhuri, Tapas Kumar

2024 Volume 323, Page(s) 117717

Abstract: Ethnopharmacological relevance: Nerium oleander is used to treat liver-associated chronic metabolic diseases in traditional medicinal systems across the globe. The hepatoprotective effects of oleander are mentioned in Indian and Chinese traditional ... ...

Abstract	Ethnopharmacological relevance: Nerium oleander is used to treat liver-associated chronic metabolic diseases in traditional medicinal systems across the globe. The hepatoprotective effects of oleander are mentioned in Indian and Chinese traditional medicinal literature. Aim of the study: The present study aimed to investigate the cellular mechanisms behind the hepatoprotective effects of a non-toxic dose of oleander (NO). Materials and methods: The hepatoprotective effects of NO were tested against lipopolysaccharide (LPS)-treated HepG2 cells. Oxidative stress response was studied using cellular enzymatic assays, and gene expression was analyzed using qRT-PCR. HepG2 cells were pretreated with TAK-242 (pharmacological inhibitor of TLR4) to decipher the anti-inflammatory mechanisms of NO. Cell-free metabolites were analyzed using GCMS and were subjected to pathway enrichment analysis. Results: NO reduced systemic inflammation, serum lipid peroxidation byproducts, and glucose without affecting serum transaminase levels and hepatic histopathological features. NO attenuated the inflammation-induced loss of antioxidant enzyme activities and mRNA expressions of toll-like receptor-4 (TLR4)/nuclear factor κβ (NFκβ)-dependent inflammatory genes. In TAK-242 pretreated cells, LPS was unable to induce inflammatory and oxidative responses. However, NO treatment in TAK-242 pretreated cells with LPS stimulation further reduced the signs of inflammation and improved hepatoprotective activities. A comparative analysis of the intracellular global metabolome from HepG2 cells with and without NO treatment indicated NO-mediated favorable modulation of intracellular metabolic pathways that support cytoprotective activities. Conclusion: NO protects HepG2 cells from LPS-induced oxidative and inflammatory injury. The hepatoprotective effects of NO are mediated by a TLR4-independent process and through a favorable modulation of the intracellular global metabolome that supports cytoprotection.
MeSH term(s)	Humans ; Nerium ; Lipopolysaccharides/toxicity ; Lipopolysaccharides/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Cytoprotection ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Metabolome ; Sulfonamides
Chemical Substances	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate ; Lipopolysaccharides ; Toll-Like Receptor 4 ; Antioxidants ; TLR4 protein, human ; Sulfonamides
Language	English
Publishing date	2024-01-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117717
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Before the "cytokine storm": Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications.

Dutta, Somit / Mukherjee, Amartya / Nongthomba, Upendra

Cytokine & growth factor reviews

2022 Volume 63, Page(s) 108–118

Abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding ... ...

Abstract	The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding the immunological routes underlying the clinical manifestations of COVID-19 is important for developing effective therapeutic interventions. The clearance of SARS-CoV-2-infected apoptotic cells by professional efferocytes, through a process termed as 'efferocytosis', is essential for maintaining tissue homeostasis, and reducing the chances of health complications caused by SARS-CoV-2 infection. In this review, we focus on the cellular events leading to engagement of the SARS-CoV-2 with type 2 alveolar cells, and how SARS-COV-2 infection impairs the macrophage anti-inflammatory programming. We also discuss accounts of impaired efferocytosis, and the "cytokine storm" which occur concomitantly with the SARS-CoV-2 infection. Finally, we propose how targeting impaired efferocytosis, due to the SARS-CoV-2 infection, may be a beneficial therapeutic strategy to combat COVID-19, and its complications.
MeSH term(s)	COVID-19 ; Cytokine Release Syndrome ; Humans ; Macrophages ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330534-7
ISSN	1879-0305 ; 1359-6101
ISSN (online)	1879-0305
ISSN	1359-6101
DOI	10.1016/j.cytogfr.2022.01.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2653: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparative

Chauhan, Vipin / Chauhan, Nitin K / Dutta, Somit / Pathak, Dhruv / Nongthomba, Upendra

Frontiers in neuroscience

2023 Volume 17, Page(s) 1153422

Abstract: A healthy gut flora contains a diverse and stable commensal group of microorganisms, whereas, in disease conditions, there is a shift toward pathogenic microbes, termed microbial dysbiosis. Many studies associate microbial dysbiosis with ... ...

Abstract	A healthy gut flora contains a diverse and stable commensal group of microorganisms, whereas, in disease conditions, there is a shift toward pathogenic microbes, termed microbial dysbiosis. Many studies associate microbial dysbiosis with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Multiple sclerosis (MS), and Amyotrophic lateral sclerosis (ALS). Although, an overall comparative analysis of microbes and their metabolic involvement in these diseases is still lacking. In this study, we have performed a comparative analysis of microbial composition changes occurring in these four diseases. Our research showed a high resemblance of microbial dysbiosis signatures between AD, PD, and MS. However, ALS appeared dissimilar. The most common population of microbes to show an increase belonged to the phyla,
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1153422
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Evaluation of cytogenotoxic potential and embryotoxicity of KRS-Cauvery River water in zebrafish (Danio rerio)

Abass Toba Anifowoshe / Debasish Roy / Somit Dutta / Upendra Nongthomba

Ecotoxicology and Environmental Safety, Vol 233, Iss , Pp 113320- (2022)

2022

Abstract: In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the ... ...

Abstract	In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the water and then evaluated the toxicity effects on the zebrafish (Danio rerio) model. The zebrafish were treated with KRS-CR water samples collected from three stations (fast-flowing water [X], slow-flowing [Y], and stagnant [Z] water), before and after filtration. Firstly, we detected microscopic organisms (MO) such as Cyclops, Daphnia, Spirogyra, Spirochaeta, and total coliform (Escherichia coli), which are bioindicators of water pollution present in the samples. All physicochemical parameters analyzed, including heavy metals before and after filtration of the water with Millipore filter paper (0.45 µm), were within the acceptable limits set by standard organizations, except for decreased dissolved oxygen (DO), and increased biochemical oxygen demand (BOD), and chemical oxygen demand (COD), which are indicators of hypoxic water conditions, as well as the presence of microplastics (polybutene (< 15 µm), polyisobutene (≤ 20 µm), and polymethylpentene (≤3 mm)) and cyclohexyl in CR water samples. Zebrafish embryos treated with the water samples, both before and after filtration exerts the same cytogenotoxic effects by inducing increased reactive oxygen species (ROS) production, which triggers subcellular organelle dysfunctions, DNA damage, apoptosis, pericardial edema, skeletal deformities, and increased mortality. As a result, we observed that both water samples and zebrafish larvae had significantly less oxygen using SEM and EDS. Our findings show that KRS-CR water can induce cytogenotoxic and embryotoxic defects in zebrafish due to hypoxic water conditions triggered by the microplastics influx. The present study would provide valuable insights for health hazards evaluation and future river water treatment strategies.
Keywords	Confocal microscopy ; Developmental defects ; Microplastics ; Oxidative stress ; ROS (Reactive oxygen species) ; Zebrafish ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Evaluation of cytogenotoxic potential and embryotoxicity of KRS-Cauvery River water in zebrafish (Danio rerio).

Anifowoshe, Abass Toba / Roy, Debasish / Dutta, Somit / Nongthomba, Upendra

Ecotoxicology and environmental safety

2022 Volume 233, Page(s) 113320

Abstract	In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the water and then evaluated the toxicity effects on the zebrafish (Danio rerio) model. The zebrafish were treated with KRS-CR water samples collected from three stations (fast-flowing water [X], slow-flowing [Y], and stagnant [Z] water), before and after filtration. Firstly, we detected microscopic organisms (MO) such as Cyclops, Daphnia, Spirogyra, Spirochaeta, and total coliform (Escherichia coli), which are bioindicators of water pollution present in the samples. All physicochemical parameters analyzed, including heavy metals before and after filtration of the water with Millipore filter paper (0.45 µm), were within the acceptable limits set by standard organizations, except for decreased dissolved oxygen (DO), and increased biochemical oxygen demand (BOD), and chemical oxygen demand (COD), which are indicators of hypoxic water conditions, as well as the presence of microplastics (polybutene (< 15 µm), polyisobutene (≤ 20 µm), and polymethylpentene (≤3 mm)) and cyclohexyl in CR water samples. Zebrafish embryos treated with the water samples, both before and after filtration exerts the same cytogenotoxic effects by inducing increased reactive oxygen species (ROS) production, which triggers subcellular organelle dysfunctions, DNA damage, apoptosis, pericardial edema, skeletal deformities, and increased mortality. As a result, we observed that both water samples and zebrafish larvae had significantly less oxygen using SEM and EDS. Our findings show that KRS-CR water can induce cytogenotoxic and embryotoxic defects in zebrafish due to hypoxic water conditions triggered by the microplastics influx. The present study would provide valuable insights for health hazards evaluation and future river water treatment strategies.
MeSH term(s)	Animals ; Embryo, Nonmammalian ; Microplastics ; Plastics/toxicity ; Rivers ; Water Pollutants, Chemical/analysis ; Zebrafish
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2022-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113320
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1418: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluation of cytogenotoxic potential and embryotoxicity of KRS-Cauvery River water in zebrafish (Danio rerio)

Anifowoshe, Abass Toba / Roy, Debasish / Dutta, Somit / Nongthomba, Upendra

Ecotoxicology and Environmental Safety. 2022 Mar., v. 233 p.113320-

2022

Abstract	In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the water and then evaluated the toxicity effects on the zebrafish (Danio rerio) model. The zebrafish were treated with KRS-CR water samples collected from three stations (fast-flowing water [X], slow-flowing [Y], and stagnant [Z] water), before and after filtration. Firstly, we detected microscopic organisms (MO) such as Cyclops, Daphnia, Spirogyra, Spirochaeta, and total coliform (Escherichia coli), which are bioindicators of water pollution present in the samples. All physicochemical parameters analyzed, including heavy metals before and after filtration of the water with Millipore filter paper (0.45 µm), were within the acceptable limits set by standard organizations, except for decreased dissolved oxygen (DO), and increased biochemical oxygen demand (BOD), and chemical oxygen demand (COD), which are indicators of hypoxic water conditions, as well as the presence of microplastics (polybutene (< 15 µm), polyisobutene (≤ 20 µm), and polymethylpentene (≤3 mm)) and cyclohexyl in CR water samples. Zebrafish embryos treated with the water samples, both before and after filtration exerts the same cytogenotoxic effects by inducing increased reactive oxygen species (ROS) production, which triggers subcellular organelle dysfunctions, DNA damage, apoptosis, pericardial edema, skeletal deformities, and increased mortality. As a result, we observed that both water samples and zebrafish larvae had significantly less oxygen using SEM and EDS. Our findings show that KRS-CR water can induce cytogenotoxic and embryotoxic defects in zebrafish due to hypoxic water conditions triggered by the microplastics influx. The present study would provide valuable insights for health hazards evaluation and future river water treatment strategies.
Keywords	DNA damage ; Danio rerio ; Daphnia ; Escherichia coli ; Spirochaeta ; Spirogyra ; apoptosis ; biochemical oxygen demand ; chemical oxygen demand ; coliform bacteria ; dissolved oxygen ; ecotoxicology ; edema ; embryotoxicity ; filtration ; fish ; microplastics ; models ; mortality ; oxygen ; pericardium ; reactive oxygen species ; river water ; rivers ; water pollution ; water treatment ; KRS-CRW ; DO ; BOD ; COD ; SEM-EDS ; WHO ; BIS ; C ; TR ; HR ; YS ; PC ; YSE ; HW ; PE ; DE ; DL ; SC ; BT ; ST ; UHE ; Confocal microscopy ; Developmental defects ; Oxidative stress ; ROS (Reactive oxygen species) ; Zebrafish
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113320
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3684: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Wild raspberry: Antioxidant fruits from Eastern Himalaya

Basak, Mridushree / Somit Dutta / Monoranjan Chowdhury

Journal of food biochemistry. 2018 Oct., v. 42, no. 5

2018

Abstract: Raspberry fruits were used to investigate their possible activity against free radicals with possible implication in alleviating oxidative stress. A detailed in vitro antioxidant profiling, has been executed with a motive to evaluate the free radical ... ...

Abstract	Raspberry fruits were used to investigate their possible activity against free radicals with possible implication in alleviating oxidative stress. A detailed in vitro antioxidant profiling, has been executed with a motive to evaluate the free radical scavenging activity of raspberry fruits extract. The immune cell proliferative properties (MTT) and in vitro assay for evaluation of their antioxidant activities including hydroxyl radical, nitric oxide, singlet oxygen, peroxynitrite and hydrogen peroxide were investigated. GC‐MS and FTIR analysis have been performed for the proper identification of active biological compounds. The results showed that raspberry fruit extracts have potent free radical scavenging capacity. ROS generated due to H₂O₂ in HEK‐293 cell line were normalized in the highest group (200 µg/mL) when compared with control group. MTT assay also proved that raspberry fruit extracts have the potentiality to modulate the immune system. In the present study, the peak characteristics of FTIR revealed that raspberry fruit extracts might be a probable source of many natural phyto‐compounds. The compounds identified by the GC‐MS analysis are known to have potent antioxidant activity. The present study clearly demonstrates that raspberry fruit extracts (Rubus lineatus and Rubus treutleri) are effective in alleviating ROS and RNS related complexities while being absolutely safe for human consumption and beneficial for the immune system. PRACTICAL APPLICATIONS: Naturally occurring antioxidants have become increasingly popular over its synthetic counterpart in food, pharmaceutical and even in cosmetic industries due to its minimal side effects and ease in absorbance in physiological environment namely human body. Local people of Darjeeling Hills consume raspberry unaware of its medicinal properties. The aim of our study is to establish the medicinal properties of raspberry fruits through the antioxidant and cytotoxic activity.
Keywords	Fourier transform infrared spectroscopy ; Rubus moluccanus ; absorbance ; adverse effects ; antioxidant activity ; biochemical compounds ; cell lines ; cytotoxicity ; free radical scavengers ; free radicals ; fruit extracts ; fruits ; gas chromatography-mass spectrometry ; humans ; hydrogen peroxide ; hydroxyl radicals ; immune system ; in vitro studies ; industry ; medicinal properties ; nitric oxide ; oxidative stress ; raspberries ; singlet oxygen ; toxicity testing ; Himalayan region
Language	English
Dates of publication	2018-10
Size	p. e12560.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.12560
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correlative metabolomic fingerprinting and molecular docking studies of dermatological phytotherapeutics of South-Eastern Himalaya

Priyankar Dey / Indrani Sarkar / Somit Dutta / Manas Ranjan Saha / Tapas Kumar Chaudhuri

Journal of Traditional and Complementary Medicine, Vol 9, Iss 4, Pp 243-

2019 Volume 248

Abstract: Viburnum erubescens Wall., Rhododendron arboretum Sm., Eurya japonica Thumb., Symplocos lucida (Thunb.) Siebold & Zucc, and Symplocos pyrifolia Wall. ex G. Don are extensively used by the native and ethnic populations of the South-Eastern Himalayan ... ...

Abstract	Viburnum erubescens Wall., Rhododendron arboretum Sm., Eurya japonica Thumb., Symplocos lucida (Thunb.) Siebold & Zucc, and Symplocos pyrifolia Wall. ex G. Don are extensively used by the native and ethnic populations of the South-Eastern Himalayan region for several dermatological conditions, yet their phytochemical composition remained largely unknown. Therefore, the aim of the study was to explore the therapeutically relevant volatile phytochemical compositions and study the molecular interactions against intracellular cytoregulatory transcription factors. Leaves of the five plants were subjected to Gas chromatography-Mass spectrometry (GCMS) post silylation derivation. The results were further analyzed using multivariate statistical methods such as Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). A total of 115 compounds were identified in the five plants. Multivariate analysis revealed optimum metabolomic correlation between S. pyrifolia and S. lucida (0.876), whereas lowest correlation was found between E. japonica and V. erubescens (−0.242). Arbutin, β-amyrin, betulin, β-sitosterol and stigmasterol demonstrated highest interaction with the molecular targets. Collectively, the present study revealed the bioactive volatile phytochemicals responsible the therapeutic uses against diverse skin conditions. Keywords: Gas chromatography-Mass spectrometry, Molecular docking, Multivariate statistics, Silylation, Volatiles
Keywords	Medicine ; R
Subject code	580
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Fruit juice of silverberry (Elaeagnus) and bayberry (Myrica) may help in combating against kidney dysfunctions

Pallab Kar / Arnab Kumar Chakraborty / Somit Dutta / Malay Bhattacharya / Tapas Kumar Chaudhuri / Arnab Sen

Clinical Phytoscience, Vol 5, Iss 1, Pp 1-

2019 Volume 9

Abstract: Abstract Background Elaeagnus pyriformis, Myrica nagi and Myrica esculenta are prominent actinorhizal plants of North-East India which produce juicy edible fruits. Native people of this region consume these fruits for nutritional enhancement. Apart from ... ...

Abstract	Abstract Background Elaeagnus pyriformis, Myrica nagi and Myrica esculenta are prominent actinorhizal plants of North-East India which produce juicy edible fruits. Native people of this region consume these fruits for nutritional enhancement. Apart from having immense nutritional value, fruits of these plants have been utilized in traditional medicine for providing protection against various ailments. In our previous study on antioxidant activity and phytochemical fingerprints using GC-MS method; many medicinally potent compounds in fresh fruit juice of the three plants were revealed. We reported the presence of several compounds used to cure renal ailments. In the present study we reported the efficacy of these juices to alleviate nephrotoxicity in rat model. We intend to understand to what extent these fruits could be beneficial. Within the same scope we tried to evaluate whether the bioactive compounds present in the fruits could be responsible for reducing nephrotoxicity by in-silico molecular docking approaches. Methods In this study, three fruit juices namely Elaeagnus pyriformis, Myrica nagi and M. esculenta were evaluated on gentamicin induced nephrotoxicity in rat model. Nephrotoxicity was induced in wistar albino rats by intraperitoneal administration of gentamicin (100 mg/kg/day body weight) for 7 days. The study included a control group which received oral saline only, negative control group received gentamicin, positive control group received gentamicin and cystone, low dose group received gentamicin along with juice (200 mg/kg/day) and high dose group received gentamicin along with juice (400 mg/kg/day). Various enzymatic and biochemical parameters were assessed to study the protective effect of fruit juices in kidney disorders. Results Among the three fruits M. esculenta showed promising result in all in-vivo enzymatic assays (Superoxide dismutase, Glutathione reductase, Lipid peroxidation and catalase). Nevertheless, all the three fruit juice showed high significance value with encouraging range ...
Keywords	Actinorhizal plants ; Gentamicin ; Catalase ; Histology ; Molecular docking ; Medicine ; R ; Homeopathy ; RX1-681
Subject code	630
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Correlative metabolomic fingerprinting and molecular docking studies of dermatological phytotherapeutics of South-Eastern Himalaya.

Dey, Priyankar / Sarkar, Indrani / Dutta, Somit / Saha, Manas Ranjan / Chaudhuri, Tapas Kumar

Journal of traditional and complementary medicine

2018 Volume 9, Issue 4, Page(s) 243–248

Abstract: ... Viburnum ... ...

Abstract	Viburnum erubescens
Language	English
Publishing date	2018-08-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2709698-1
ISSN	2225-4110
ISSN	2225-4110
DOI	10.1016/j.jtcme.2018.08.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito