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  1. Article ; Online: High-density neonatal electroencephalography provides biomarkers for developmental trajectories.

    Pelc, Karine

    Developmental medicine and child neurology

    2023  Volume 65, Issue 10, Page(s) 1274–1275

    MeSH term(s) Infant, Newborn ; Humans ; Electroencephalography ; Infant, Premature ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.15569
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  2. Article ; Online: Ethics of human enhancement in cerebral palsy.

    Dan, Bernard / Pelc, Karine

    Annals of physical and rehabilitation medicine

    2019  Volume 63, Issue 5, Page(s) 389–390

    MeSH term(s) Cerebral Palsy ; Humans ; Quality of Life
    Language English
    Publishing date 2019-04-09
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2480363-7
    ISSN 1877-0665 ; 1877-0657
    ISSN (online) 1877-0665
    ISSN 1877-0657
    DOI 10.1016/j.rehab.2019.03.002
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  3. Article ; Online: Nocturnal Transcutaneous Blood Gas Measurements in a Pediatric Neurologic Population: A Quality Assessment.

    Toussaint, Michel / Buggenhoudt, Lori / Pelc, Karine

    Developmental neurorehabilitation

    2021  Volume 24, Issue 5, Page(s) 303–310

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Adolescent ; Blood Gas Monitoring, Transcutaneous/standards ; Carbon Dioxide/blood ; Central Nervous System Diseases/blood ; Central Nervous System Diseases/physiopathology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Neuromuscular Diseases/blood ; Neuromuscular Diseases/physiopathology ; Oxygen/blood ; Partial Pressure ; Positive-Pressure Respiration ; Quality Assurance, Health Care ; Sleep Apnea Syndromes/blood ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/therapy
    Chemical Substances Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280007-4
    ISSN 1751-8431 ; 1751-8423
    ISSN (online) 1751-8431
    ISSN 1751-8423
    DOI 10.1080/17518423.2020.1869336
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  4. Article ; Online: Application of touch screen technology for early assessment of executive function.

    Dan, Bernard / Pelc, Karine

    Archives of disease in childhood

    2018  Volume 104, Issue 2, Page(s) 108–109

    MeSH term(s) Child ; Cognition ; Executive Function ; Feasibility Studies ; Humans ; Surveys and Questionnaires ; User-Computer Interface
    Language English
    Publishing date 2018-08-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2018-315272
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  5. Article ; Online: Multiscale entropy as a metric of brain maturation in a large cohort of typically developing children born preterm using longitudinal high-density EEG in the first two years of life.

    Pelc, Karine / Gajewska, Aleksandra / Napiórkowski, Natan / Dan, Jonathan / Verhoeven, Caroline / Dan, Bernard

    Physiological measurement

    2022  Volume 43, Issue 12

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Infant, Newborn ; Brain/diagnostic imaging ; Brain/growth & development ; Infant ; Infant, Premature ; Entropy ; Electroencephalography
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1149545-5
    ISSN 1361-6579 ; 0967-3334
    ISSN (online) 1361-6579
    ISSN 0967-3334
    DOI 10.1088/1361-6579/aca26c
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  6. Article ; Online: Early intervention and environmental factors: optimizing the development of infants born preterm.

    Pelc, Karine / Gajewska, Aleksandra

    Developmental medicine and child neurology

    2017  

    Language English
    Publishing date 2017-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.13626
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  7. Article ; Online: Prevalence of cerebral palsy and factors associated with cerebral palsy subtype: A population-based study in Belgium.

    Dhondt, Evy / Dan, Bernard / Plasschaert, Frank / Degelaen, Marc / Dielman, Charlotte / Dispa, Delphine / Ebetiuc, Iulia / Hasaerts, Danielle / Kenis, Sandra / Lombardo, Costanza / Pelc, Karine / Wermenbol, Vanessa / Ortibus, Els

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2023  Volume 46, Page(s) 8–23

    Abstract: Aim: To report on the prevalence, neuroimaging patterns, and function of children with cerebral palsy (CP) in Belgium for birth years 2007-2012, and identify distinctive risk indicators and differences in outcome between CP subtypes.: Methods: ... ...

    Abstract Aim: To report on the prevalence, neuroimaging patterns, and function of children with cerebral palsy (CP) in Belgium for birth years 2007-2012, and identify distinctive risk indicators and differences in outcome between CP subtypes.
    Methods: Antenatal and perinatal/neonatal factors, motor and speech function, associated impairments, and neuroimaging patterns were extracted from the Belgian Cerebral Palsy Register. Prevalence was estimated per 1000 (overall, ante/perinatal, spastic, dyskinetic CP) or 10,000 (post-neonatal, ataxic CP) live births. Multinomial logistic regression analyses were performed to ascertain the effects of antenatal/perinatal/neonatal factors and neuroimaging patterns on the likelihood of dyskinetic or ataxic CP relative to spastic CP, and test the likelihood of the occurrence of impaired motor and speech function and associated impairments in dyskinetic or ataxic CP relative to spastic CP.
    Results: In total, 1127 children with CP were identified in Belgium. The birth prevalence of overall CP was 1.48 per 1000 live births. The likelihood of dyskinetic CP increases if the child was born to a mother aged ≥35 years, mechanically ventilated, and had predominant grey matter injury, while an increased likelihood of ataxic CP is associated with ≥2 previous deliveries. Children with dyskinetic and ataxic CP are more likely to function with impairments in motor, speech, and intellectual abilities.
    Conclusion: Distinctive risk indicators and differences in outcome between CP subtypes were identified. These factors can be incorporated into clinical practice to facilitate early, accurate, and reliable classification of CP subtype, and may lead to individually tailored neonatal care and other (early) intervention options.
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2023.06.003
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  8. Article ; Online: Multicentre prospective randomised single-blind controlled study protocol of the effect of an additional parent-administered sensorimotor stimulation on neurological development of preterm infants: Primebrain.

    Pelc, Karine / Daniel, Irit / Wenderickx, Bernard / Dan, Bernard

    BMJ open

    2017  Volume 7, Issue 12, Page(s) e018084

    Abstract: Introduction: Preterm and very low birthweight infants are at increased risk for neurodevelopmental disorders, including cerebral palsy, sensory impairment and intellectual disability. Several early intervention approaches have been designed in the hope ...

    Abstract Introduction: Preterm and very low birthweight infants are at increased risk for neurodevelopmental disorders, including cerebral palsy, sensory impairment and intellectual disability. Several early intervention approaches have been designed in the hope of optimising neurological development in this context. It seems important that the intervention takes into account parental mental health, focuses on parent-child interactions and lasts sufficiently long. This study aims to evaluate the effects of a stimulation programme administered by parents until 6 months post-term on motor and neurophysiological development of infants born preterm.
    Methods and analysis: Participants will be infants born <32 weeks' gestation and/or with a birth weight <1500 g recruited prospectively from two tertiary neonatal intensive care units. They will be randomly assigned to receive nationally recommended follow-up only (control group) or also a stimulation programme between 37 weeks' gestation and 6 months' corrected age. Perinatal, clinical neurodevelopmental, socio-demographic and neuroimaging (ultrasonography or MRI) data will be collected. Bayley Scales of Infant Development will be used up to 24 months' corrected age and Parental Stress Index at 6, 12, 18 and 24 months' corrected age. High-density (64 or 128 electrodes) EEG, visual, somatosensory and long latency auditory evoked potentials will be recorded at term age, 3, 6, 12, 18 and 24 months' corrected age. They will be analysed for spatiotemporal frequency bands contents and source localisation.
    Ethics and dissemination: The study was approved by the Ethics Committees of the Hôpital Universitaire des Enfants Reine Fabiola and CHU Saint-Pierre. Results dissemination will be made for stakeholders and families, reports will be written for parents, healthcare providers and policymakers, and scientific papers will be published.
    Trial registration number: NCT02159534; Pre-results.
    MeSH term(s) Belgium ; Developmental Disabilities/physiopathology ; Developmental Disabilities/prevention & control ; Developmental Disabilities/therapy ; Early Intervention, Educational ; Electroencephalography ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Neuroimaging ; Parent-Child Relations ; Parents/education ; Program Evaluation ; Prospective Studies ; Somatosensory Cortex/physiopathology ; Transcutaneous Electric Nerve Stimulation ; Treatment Outcome
    Language English
    Publishing date 2017-12-03
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2017-018084
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  9. Article ; Online: Postural cortical myoclonus during gait in Rett syndrome.

    Pelc, Karine / Dan, Bernard

    Epilepsy & behavior : E&B

    2009  Volume 16, Issue 1, Page(s) 188

    MeSH term(s) Child ; Electroencephalography ; Female ; Gait/physiology ; Humans ; Myoclonus/complications ; Myoclonus/physiopathology ; Rett Syndrome/complications ; Rett Syndrome/physiopathology
    Language English
    Publishing date 2009-09
    Publishing country United States
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2009.06.024
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  10. Article ; Online: Phenotypic plasticity and the perception-action-cognition-environment paradigm in neurodevelopmental genetic disorders.

    Dan, Bernard / Pelc, Karine / de Meirleir, Linda / Cheron, Guy

    Developmental medicine and child neurology

    2015  Volume 57 Suppl 2, Page(s) 52–54

    Abstract: Careful study of the phenotype can have implications at several levels, namely clinical diagnosis, pathophysiological reasoning, management planning, and outcome measurement. Behavioural phenotypes involve cognition, communication, social skills, and ... ...

    Abstract Careful study of the phenotype can have implications at several levels, namely clinical diagnosis, pathophysiological reasoning, management planning, and outcome measurement. Behavioural phenotypes involve cognition, communication, social skills, and motor control. They can be documented in a host of neurodevelopmental conditions and approached with the recently refined perception-action-cognition-environment (PACE) paradigm, which focuses on the neurodevelopmental processes that underlie learning and adaption to the environment through perception, action, and cognitive processing. Although this paradigm was originally developed in the context of cerebral palsy, it can be applied along developmental trajectories in several neurogenetic conditions, including Down syndrome, fragile X syndrome, Rett syndrome, Angelman syndrome, and Williams syndrome, to name but a few. It must be recognized, however, that relevant, valid tools for assessment and management strategies still need to be developed.
    MeSH term(s) Child ; Child Behavior/physiology ; Cognition/physiology ; Environment ; Humans ; Intellectual Disability/genetics ; Intellectual Disability/physiopathology ; Perception/physiology ; Phenotype
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.12694
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