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Article ; Online: Idiopathic Left-Bundle Branch Block and Unexplained Symptom At Exercise: A Case Report.

Guimarães, Guilherme Veiga / Bocchi, Edimar Alcides

2020 Volume 115, Issue 1 suppl 1, Page(s) 10–13

Title translation	Bloqueio do Ramo Esquerdo Idiopático e Sintomas Inexplicáveis Durante o Exercício: Um Relato de Caso.
MeSH term(s)	Arrhythmias, Cardiac ; Bundle-Branch Block/diagnosis ; Electrocardiography ; Exercise ; Exercise Test ; Humans
Language	Portuguese
Publishing date	2020-09-16
Publishing country	Brazil
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20190363
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Article ; Online: Reply: Sacubitril/valsartan for Chagas' heart disease heart failure?

Bocchi, Edimar Alcides / Rassi, Salvador / Veiga Guimarães, Guilherme

ESC heart failure

2018 Volume 5, Issue 6, Page(s) 1072–1073

MeSH term(s)	Aminobutyrates ; Chagas Cardiomyopathy ; Drug Combinations ; Heart Failure ; Humans ; Ivabradine ; Tetrazoles ; Valsartan
Chemical Substances	Aminobutyrates ; Drug Combinations ; Tetrazoles ; Ivabradine (3H48L0LPZQ) ; Valsartan (80M03YXJ7I) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2018-10-09
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.12344
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Article ; Online: Resurgence of human respiratory syncytial virus during COVID-19 pandemic in Southern Brazil.

Fröhlich, Guilherme C / Gregianini, Tatiana S / Pinheiro, Felipe G / Nascimento, Rodrigo / Cezar, Thiago M / Pscheidt, Veridiane M / Selayaran, Tainá / Martins, Letícia G / Gomes, Marcelo Ferreira da Costa / Salvato, Richard S / Pereira, Elisa C / Guimarães-Ribeiro, Victor / Scalioni, Letícia de Paula / Siqueira, Marilda M / Resende, Paola C / Veiga, Ana B G

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29551

Abstract: Respiratory Syncytial Virus (RSV) is an important cause of respiratory infection in humans. Severe cases are common in children ≤2 years old, immunocompromised individuals, and the elderly. In 2020, RSV infection reduced in Rio Grande do Sul (RS), ... ...

Abstract	Respiratory Syncytial Virus (RSV) is an important cause of respiratory infection in humans. Severe cases are common in children ≤2 years old, immunocompromised individuals, and the elderly. In 2020, RSV infection reduced in Rio Grande do Sul (RS), southern Brazil; however, in 2021 resurgence of RSV was observed. This study analyzed epidemiological and genetic features of RSV infection cases reported in 2021 in RS. Nasopharyngeal samples collected from individuals with respiratory infection negative for SARS-CoV-2, Influenza A and B viruses were assessed for the presence of RSV by real time RT-qPCR. RSV-A and RSV-B genomic sequencing and phylogenetic reconstructions were performed for genotyping and clade characterization. Among 21,035 respiratory samples analyzed, 2,947 were positive for RSV, 947 of which were hospitalized patients. Positive cases were detected year-round, with the highest number in June-July (winter). Children <1 year comprised 56.28% (n = 533) of the hospitalized patients infected with RSV, whereas 14.46% (n = 137) were individuals >60 years. Of a total of 361 deaths, 14.68% (n = 53) were RSV positive, mostly patients >60 years old (73.58%, n = 39). Chronic kidney disease, cardiopathy, Down syndrome and neurological diseases were associated with RSV infection. RSV-A was identified in 58.5% (n = 117/200) of the patients, and RSV-B in 41.5% (n = 83/200). Of 95 RSV genomes recovered from SARI cases, 66 were RSV-A GA.2.3.5 genotype, while 29 were RSV-B GB.5.0.5a genotype. This study provides epidemiological and molecular data on RSV cases in RS during the COVID-19 pandemic and highlights that investigation of different respiratory viruses is essential for decision-making and disease prevention and control measures.
MeSH term(s)	Child ; Humans ; Infant ; Aged ; Child, Preschool ; Middle Aged ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus Infections/epidemiology ; Phylogeny ; Brazil/epidemiology ; Pandemics ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Influenza, Human/epidemiology ; Respiratory Tract Infections
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29551
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Zs.A 1320: Show issues

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Article ; Online: Hypotensive Effect of Heated Water-based Exercise in Older Individuals with Hypertension.

Ngomane, Awassi Yophiwa / Fernandes, Bianca / Guimarães, Guilherme Veiga / Ciolac, Emmanuel Gomes

International journal of sports medicine

2019 Volume 40, Issue 4, Page(s) 283–291

Abstract: Blood pressure (BP) and hemodynamic response to heated water-based (HEx) ...

Abstract	Blood pressure (BP) and hemodynamic response to heated water-based (HEx)
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Endothelium, Vascular/physiology ; Exercise Therapy/methods ; Female ; Heart Rate ; Hot Temperature ; Humans ; Hydrotherapy/methods ; Hypertension/drug therapy ; Hypertension/physiopathology ; Hypertension/therapy ; Male ; Middle Aged ; Vascular Stiffness
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2019-02-21
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603122-5
ISSN	1439-3964 ; 0172-4622 ; 0943-917X
ISSN (online)	1439-3964
ISSN	0172-4622 ; 0943-917X
DOI	10.1055/a-0828-8017
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Zs.A 1561: Show issues

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Article ; Online: Contemporary review of exercise in heart transplant recipients.

Guimarães, Guilherme Veiga / Ribeiro, Fernando / Arthuso, Fernanda Zane / Castro, Rafael Ertner / Cornelissen, Véronique / Ciolac, Emmanuel Gomes

Transplantation reviews (Orlando, Fla.)

2021 Volume 35, Issue 2, Page(s) 100597

Abstract: Heart transplantation (HTx) is a therapeutic option for a selected group of patients with end-stage heart failure. Although secondary prevention including exercise therapy is recommended in the management of patients following HTx, little information is ... ...

Abstract	Heart transplantation (HTx) is a therapeutic option for a selected group of patients with end-stage heart failure. Although secondary prevention including exercise therapy is recommended in the management of patients following HTx, little information is available on their metabolic and physiological consequences in HTx. Therefore, we aimed to conduct a contemporary review the effectiveness of exercise therapy on functional capacity, cardiovascular health and health-related quality of life for adult HTx patients. We searched the database MEDLINE for articles published between January 2015 and October 2020 and were able to include 6 studies involving 202 patients. Larger improvements in exercise capacity were seen after high-intensity interval training and in patients with evidence of cardiac reinnervation. Clinically relevant reductions were observed for daytime and 24 h ambulatory blood pressure after exercise training and following a single bout of aerobic exercise. Finally, limited data suggest that quality of life is higher in HTx patients following high-intensity training. In summary, the available evidence shows the potential for exercise as a vital treatment in patients following HTx. Yet, the scant data calls for more well-designed and adequately powered studies to support its effectiveness and to unravel optimal exercise characteristics, which would allow for more effective and person-tailored exercise prescription.
MeSH term(s)	Blood Pressure Monitoring, Ambulatory ; Exercise ; Heart Failure/therapy ; Heart Transplantation ; Humans ; Quality of Life ; Transplant Recipients
Language	English
Publishing date	2021-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639400-0
ISSN	1557-9816 ; 0955-470X
ISSN (online)	1557-9816
ISSN	0955-470X
DOI	10.1016/j.trre.2021.100597
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Se 1072: Show issues

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Article ; Online: Effects of β-blocker therapy on exercise oscillatory ventilation in reduced ejection fraction heart failure patients: A case series study.

Belli-Marin, Juliana Fernanda Calhado / Bocchi, Edimar Alcides / Ayub-Ferreira, Silvia / Junior, Nelson Carvas / Guimarães, Guilherme Veiga

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 152, Page(s) 113106

Abstract: Background: Exercise oscillatory ventilation (EOV) is an abnormal breathing pattern that occurs in ~20% of patients with heart failure (HF) and is associated with poor prognosis and exercise intolerance. β-blockers (βb) are prescribed for most HF ... ...

Abstract	Background: Exercise oscillatory ventilation (EOV) is an abnormal breathing pattern that occurs in ~20% of patients with heart failure (HF) and is associated with poor prognosis and exercise intolerance. β-blockers (βb) are prescribed for most HF patients; however, their effect on EOV remains unclear. We evaluated the effect of βb on EOV in HF patients with reduced ejection fraction (HFrEF). Methods: Fifteen patients diagnosed with HF, ejection fraction < 45%, aged from 18 to 65 years, were included before starting βb therapy. Patients underwent clinical evaluation, cardiopulmonary exercise testing, echocardiography, laboratory exams (norepinephrine levels, B type natriuretic peptide) at baseline and after βb therapy optimized for six months. Presence of exercise oscillatory breathing was determined by two experienced observers who were blinded to the moment of the test (pre or post). Results: Fifteen patients (1 female), aged 49.5 ± 2.5 years, with HFrEF, NYHA I-III enrolled in the study. The etiologies of the HFrEF were idiopathic (n = 8) and hypertensive (n = 7). LVEF increased after βb therapy from 25.9 ± 2.5% to 33 ± 2.6%, P = 0.02; peak VO Conclusion: In patients with HF, medical therapy with βb can reverse EOV. This may explain why these patients experience symptom improvement after βb therapy.
MeSH term(s)	Exercise Test ; Female ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Oxygen Consumption ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-06-03
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113106
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Ud II Zs.198: Show issues

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Article ; Online: Analysis of Cardiovascular Hemodynamic and Autonomic Variables in Individuals with Systemic Arterial Hypertension, Type 2 Diabetes Mellitus, and Parkinson's Disease: A Comparative Study.

Yuphiwa Ngomane, Awassi / Martins de Abreu, Raphael / Fernandes, Bianca / Roque Marçal, Isabela / Veiga Guimarães, Guilherme / Gomes Ciolac, Emmanuel

Clinical and experimental hypertension (New York, N.Y. : 1993)

2021 Volume 44, Issue 2, Page(s) 119–126

Abstract: Background: Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system.: Aim: The aim of this study was to compare ... ...

Abstract	Background: Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system. Aim: The aim of this study was to compare hemodynamic and autonomic variables at rest in individuals with SAH, T2DM, or PD. Methods: Fifty sedentary or insufficiently active individuals (22 men) with SAH (age = 66 ± 5.0 yr), T2DM (age = 52 ± 10 yr) or PD (age = 68 ± 8.0 yr) had their resting blood pressure (BP), arterial stiffness, endothelial function, and heart rate variability (HRV) assessed and compared. Results: Systolic and diastolic BP were higher in SAH (130 ± 10 / 80 ± 10 mmHg) than T2DM (110 ± 14 / 75 ± 11 mmHg) and PD, and (123 ± 20 / 70 ± 11 mmHg) respectively. T2DM individuals showed lower arterial stiffness (8.4 ± 1.1 m/s), when compared to SAH (10.3 ± 2.3 m/s) and PD (10.6 ± 3.0 m/s). T2DM had greater resting tachycardia showed by the mean RR (759 ± 79 ms), than SAH (962 ± 169 ms) and PD (976 ± 134 ms), which was accompanied by higher sympathetic modulation (low frequency [LF]: 62 ± 19 nu) and lower parasympathetic modulation (high frequency [HF]: 32 ± 16 nu) when compared to SAH (LF: 40 ± 16 nu; HF: 61 ± 33 nu). No differences among groups were found on non-linear HRV markers and endothelial reactivity indexes. Conclusions: Individuals with T2DM showed impaired levels of cardiac autonomic markers when compared to individuals with SAH and PD, despite of having lower levels of BP and arterial stiffness.
MeSH term(s)	Adult ; Aged ; Blood Pressure ; Diabetes Mellitus, Type 2/complications ; Heart ; Heart Rate ; Hemodynamics ; Humans ; Hypertension ; Male ; Middle Aged ; Parkinson Disease
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2021.2001480
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Zs.A 1429: Show issues

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Article ; Online: Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension.

Roque Marçal, Isabela / Teixeira Do Amaral, Vanessa / Fernandes, Bianca / Martins de Abreu, Raphael / Alvarez, Cristian / Veiga Guimarães, Guilherme / Cornelissen, Véronique A / Gomes Ciolac, Emmanuel

Clinical and experimental hypertension (New York, N.Y. : 1993)

2022 Volume 44, Issue 5, Page(s) 427–435

Abstract: Objectives: This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension.: Methods: Twenty ...

Abstract	Objectives: This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension. Methods: Twenty (67 ± 7 y) older individuals with hypertension were randomly assigned to perform HIIE, MICE, or control (CON) sessions in the heated swimming pool (30-32°C). Blood pressure (BP), arterial stiffness, endothelial reactivity, and heart rate variability (HRV) were measured pre, post, and 45 min (recovery) after each intervention followed by 24-h ambulatory BP and HRV. Results: One single aerobic exercise session was not effective to provoke post-exercise hypotension and vascular improvements. HIIE was superior to MICE and CON to increasing parasympathetic modulation at post and recovery. Exercise sessions showed to disturb the autonomic system at nighttime compared to CON. Conclusions: These results may have important implications in water-based therapy and the elderly with hypertension.
MeSH term(s)	Aged ; Aquatic Therapy/methods ; Autonomic Nervous System/physiopathology ; Blood Pressure/physiology ; Blood Vessels/physiopathology ; Cross-Over Studies ; Exercise/physiology ; Heart/innervation ; Heart/physiopathology ; Heart Rate/physiology ; Heating ; Hemodynamics/physiology ; High-Intensity Interval Training/methods ; Humans ; Hypertension/physiopathology ; Hypertension/therapy ; Middle Aged
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2022.2065288
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Article: Physical activity: practice this idea.

Guimarães, Guilherme Veiga / Ciolac, Emmanuel Gomes

American journal of cardiovascular disease

2014 Volume 4, Issue 1, Page(s) 31–33

Abstract: Sedentary habits or insufficient activities to promote health benefits can influence the occurrence of chronic diseases. The cardiovascular risk factors arise, at least partially, from the individual-environment interaction during life, and worsen with ... ...

Abstract	Sedentary habits or insufficient activities to promote health benefits can influence the occurrence of chronic diseases. The cardiovascular risk factors arise, at least partially, from the individual-environment interaction during life, and worsen with aging and lack of physical exercise. Health promotion and prevention are among the greatest challenges of public health policies. However, physical activity turns out to be rarely recommended and, thus have a very poor adhesion. In spite of consensus about the benefits of physical activity in both primary and secondary prevention, only 32% of adults and 66% of children and adolescents, according to Healthy People 2010 guideline, practice leisure-time physical activity. Thus, the regular practice of physical activity and healthy habits require changes in basic concepts in government and social policies. The higher involvement of public and private sectors related to health and education, the more expressive would be the reduction in socioeconomic costs and the improvement in quality of life.
Language	English
Publishing date	2014-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2616844-3
ISSN	2160-200X
ISSN	2160-200X
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Article ; Online: Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial.

Bocchi, Edimar Alcides / Rassi, Salvador / Guimarães, Guilherme Veiga

ESC heart failure

2017 Volume 5, Issue 3, Page(s) 249–256

Abstract: Aims: The SHIFT trial showed that ivabradine reduced heart rate (HR) and the risk of cardiovascular outcomes. Concerns remain over the efficacy and safety of ivabradine on heart failure (HF) due to Chagas disease (ChD). We therefore conducted a post hoc ...

Abstract	Aims: The SHIFT trial showed that ivabradine reduced heart rate (HR) and the risk of cardiovascular outcomes. Concerns remain over the efficacy and safety of ivabradine on heart failure (HF) due to Chagas disease (ChD). We therefore conducted a post hoc analysis of the SHIFT trial to investigate the effect of ivabradine in these patients. Methods and results: SHIFT was a randomized, double-blind, placebo-controlled trial in symptomatic systolic stable HF, HR ≥ 70 b.p.m., and in sinus rhythm. The ChD HF subgroup included 38 patients, 20 on ivabradine, and 18 on placebo. The ChD HF subgroup showed high prevalence of bundle branch right block and, compared with the overall SHIFT population, lower systolic blood pressure; higher use of diuretics, cardiac glycosides, and antialdosterone agents; and lower use of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker or target daily dose of beta-blocker. ChD HF presented a poor prognosis (all-cause mortality at 2 years was ~60%). The mean twice-daily dose of ivabradine was 6.26 ± 1.15 mg and placebo 6.43 ± 1.55 mg. Ivabradine reduced HR from 77.9 ± 3.8 to 62.3 ± 10.1 b.p.m. (P = 0.005) and improved functional class (P = 0.02). A trend towards reduction in all-cause death was observed in ivabradine arm vs. placebo (P = 0.07). Ivabradine was not associated with serious bradycardia, atrioventricular block, hypotension, or syncope. Conclusions: ChD HF is an advanced form of HF with poor prognosis. Ivabradine was effective in reducing HR in these patients and improving functional class. Although our results are based on a very limited sample and should be interpreted with caution, they suggest that ivabradine may have a favourable benefit-risk profile in ChD HF patients.
MeSH term(s)	Argentina/epidemiology ; Brazil/epidemiology ; Cardiovascular Agents/administration & dosage ; Chagas Disease/complications ; Chagas Disease/diagnosis ; Chagas Disease/physiopathology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Heart Failure, Systolic/drug therapy ; Heart Failure, Systolic/etiology ; Heart Failure, Systolic/physiopathology ; Heart Rate/drug effects ; Humans ; Ivabradine/administration & dosage ; Male ; Middle Aged ; Stroke Volume/drug effects ; Survival Rate/trends ; Treatment Outcome ; Ventricular Function, Left
Chemical Substances	Cardiovascular Agents ; Ivabradine (3H48L0LPZQ)
Language	English
Publishing date	2017-12-20
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.12240
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