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  1. Article: [Psychiatry: the last outpost of medicine?]

    Strous, R / Belmaker, H

    Harefuah

    2019  Volume 158, Issue 7, Page(s) 415–417

    MeSH term(s) Humans ; Psychiatry
    Language Hebrew
    Publishing date 2019-07-23
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
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  2. Article ; Online: Lurasidone and bipolar disorder.

    Belmaker, R H

    The American journal of psychiatry

    2014  Volume 171, Issue 2, Page(s) 131–133

    MeSH term(s) Bipolar Disorder/drug therapy ; Female ; Humans ; Isoindoles/therapeutic use ; Lithium Compounds/therapeutic use ; Lurasidone Hydrochloride ; Male ; Thiazoles/therapeutic use ; Valproic Acid/therapeutic use
    Chemical Substances Isoindoles ; Lithium Compounds ; Thiazoles ; Valproic Acid (614OI1Z5WI) ; Lurasidone Hydrochloride (O0P4I5851I)
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2013.13091240
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  3. Article: Successful cultural change: the example of female circumcision among Israeli Bedouins and Israeli Jews from Ethiopia.

    Belmaker, R H

    The Israel journal of psychiatry and related sciences

    2012  Volume 49, Issue 3, Page(s) 178–183

    Abstract: Female genital mutilation (FGM) is practiced in many areas of the world, including the Middle East, Africa and Australia. Although it is most common in Muslim populations it is not a dictate of Islam. In the 1980s this practice was reported among Bedouin ...

    Abstract Female genital mutilation (FGM) is practiced in many areas of the world, including the Middle East, Africa and Australia. Although it is most common in Muslim populations it is not a dictate of Islam. In the 1980s this practice was reported among Bedouin tribes, originally nomadic, in the southern area of Israel. Almost all of the women interviewed in the first study intended to continue the practice by performing FGM on their daughters including educated women who were teachers, dental assistants or university students. A second study was therefore done based in the obstetrical clinic where only women from tribes reporting to undergo FGM were examined for signs of FGM by an experienced gynecologist, in the presence of an Arabic-speaking female nurse and translator, as part of a gynecologic examination that was indicated for other reasons. In no cases was clitoridectomy or any damage to the labia found. All women had a small scar from a 1cm. incision somewhere on the labia or prepuce of the clitoris. this study concluded that the importance of the ritual in this population was unrelated to its severity. the ritual had apparently become over time a small symbolic scar, even though this population continued to believe in its importance. By contrast, a group of Ethiopian Jews who had immigrated to Israel was interviewed by an Amharic translator, and examined during routine gynecological examination in the same manner as the Bedouin group above. In Ethiopia, FGM is universal among Christian, Muslim and Jewish groups. All women interviewed reported that FGM was universal in Ethiopia, but none intended to continue this practice with their daughters. All stated that this was a practice that would be left behind in their country of origin. On physical examination many of the women had amputation of the clitoris. The conclusion of this study was that the severity of the operation performed had no relation to the social and cultural adherence to the operation, since the Ethiopian Jews who practiced a more severe form of the operation intended to abandon this practice while the Muslim Bedouin who had a much milder form intended to continue it. A follow-up study in 2009 of the Bedouin population of southern Israel has found that FGM had disappeared, both by self-report of women under the age of 30, and by physical examination of women under the age of 30 in an obstetrical clinic. These results suggest an optimistic approach toward cultural change involving unhealthy cultural practices and emphasize the importance of cognitive approaches to cultural change.
    MeSH term(s) Adolescent ; Adult ; Arabs/ethnology ; Circumcision, Female/ethnology ; Cross-Cultural Comparison ; Ethiopia/ethnology ; Female ; Follow-Up Studies ; Humans ; Israel/ethnology ; Jews/ethnology ; Middle Aged ; Social Change ; Young Adult
    Language English
    Publishing date 2012
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 604431-1
    ISSN 0333-7308
    ISSN 0333-7308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comment on: 'antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence'.

    Belmaker, R H

    The international journal of neuropsychopharmacology

    2008  Volume 11, Issue 4, Page(s) 577–8; author reply 579–82

    MeSH term(s) Antidepressive Agents/therapeutic use ; Biomedical Research/ethics ; Depressive Disorder/drug therapy ; Depressive Disorder/psychology ; Humans ; Research Design ; Selection Bias
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2008-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1017/S1461145708008705
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  5. Article: The future of depression psychopharmacology.

    Belmaker, R H

    CNS spectrums

    2008  Volume 13, Issue 8, Page(s) 682–687

    Abstract: Along with the development of selective serotonin reuptake inhibitors there has been a tremendous widening of the definition of depression and an impressive decrease in the placebo-drug difference in controlled studies. In the early 1960s, about one ... ...

    Abstract Along with the development of selective serotonin reuptake inhibitors there has been a tremendous widening of the definition of depression and an impressive decrease in the placebo-drug difference in controlled studies. In the early 1960s, about one third of depressed patients improved with placebo and two thirds with active compounds. Current controlled studies suggest that the situation has certainly not improved. The Sequenced Treatment Alternatives to Relieve Depression Study found that response rates to new compounds after the failure of the first antidepressant are low. The monoamine hypothesis of depression was formulated in the mid 1960s based on the antidepressant efficacy of the monoamine reuptake inhibitors, monoamine oxidase inhibitors, and the depressogenic effects of reserpine as a monoamine depleter. However, no monoamine-related finding has been found that is diagnostic for depression. A second major hypothesis regarding depression has been the stress cortisol hypothesis. However, blood cortisol levels are not diagnostic of depression. Psychiatric clinicians are convinced that there are patients for whom antidepressants have made the difference between life and death. However, physicians may generalize unjustifiably based on single dramatic cases to a much larger diagnostic group. Perhaps there are many causes of different types of human sadness, and perhaps only some of these involve mechanisms related to monoamines. Thus, perhaps only some kinds of depression are responsive to monoamine affecting antidepressants..
    MeSH term(s) Biogenic Monoamines/blood ; Brain/metabolism ; Depression/drug therapy ; Depression/metabolism ; Forecasting ; Humans ; Hydrocortisone/blood ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Psychopharmacology/methods ; Psychopharmacology/trends
    Chemical Substances Biogenic Monoamines ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2008-08-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900013766
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  6. Article ; Online: Treatment of bipolar depression.

    Belmaker, R H

    The New England journal of medicine

    2007  Volume 356, Issue 17, Page(s) 1771–1773

    MeSH term(s) Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Antimanic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Drug Therapy, Combination ; Humans ; Selection Bias
    Chemical Substances Antidepressive Agents ; Antimanic Agents
    Language English
    Publishing date 2007-04-26
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe078042
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  7. Article ; Online: Deep brain drug delivery.

    Belmaker, R H / Agam, G

    Brain stimulation

    2013  Volume 6, Issue 3, Page(s) 455–456

    MeSH term(s) Animals ; Brain/drug effects ; Brain/physiology ; Deep Brain Stimulation ; Humans ; Psychotropic Drugs/administration & dosage
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2012.05.001
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  8. Article: Modafinil add-on in the treatment of bipolar depression.

    Belmaker, R H

    The American journal of psychiatry

    2007  Volume 164, Issue 8, Page(s) 1143–1145

    MeSH term(s) Antidepressive Agents/therapeutic use ; Benzhydryl Compounds/therapeutic use ; Bipolar Disorder/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Humans ; Placebos ; Randomized Controlled Trials as Topic/statistics & numerical data ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Benzhydryl Compounds ; Central Nervous System Stimulants ; Placebos ; modafinil (R3UK8X3U3D)
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2007.07050749
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  9. Article ; Online: Normobaric oxygen treatment for mild-to-moderate depression: a randomized, double-blind, proof-of-concept trial.

    Bloch, Yehudit / Belmaker, R H / Shvartzman, Pesach / Romem, Pnina / Bolotin, Arkady / Bersudsky, Yuly / Azab, Abed N

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 18911

    Abstract: Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects even in subjects without lung disease. Consistently, several studies demonstrated that normobaric oxygen treatment has clinical benefits in some neurological ... ...

    Abstract Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects even in subjects without lung disease. Consistently, several studies demonstrated that normobaric oxygen treatment has clinical benefits in some neurological conditions. This study examined the efficacy of normobaric oxygen treatment in subjects with depression. In a randomized, double-blind trial, 55 participants aged 18-65 years with mild to moderate depression (had a Hamilton Rating Scale for Depression [HRSD] score of ≥ 8) were recruited to the study from the Southern district in Israel. Participants underwent a psychiatric inclusion assessment at baseline and then were randomly assigned to either normobaric oxygen treatment of 35% fraction of inspired oxygen or 21% fraction of inspired oxygen (room air) through a nasal tube, for 4 weeks, during the night. Evaluations were performed at baseline, 2 and 4 weeks after commencement of study interventions, using the following tools: HRSD; Clinical Global Impression (CGI) questionnaire; World Health Organization-5 questionnaire for the estimation of Quality of Life (WHO-5-QOL); Sense of Coherence (SOC) 13-item questionnaire; and, Sheehan Disability Scale (SDS). A multivariate regression analysis showed that the mean ± standard deviation [SD] changes in the HRSD scores from baseline to week four were - 4.2 ± 0.3 points in the oxygen-treated group and - 0.7 ± 0.6 in the control group, for a between-group difference of 3.5 points (95% confidence interval [CI] - 5.95 to - 1.0; P = 0.007). Similarly, at week four there was a between-group difference of 0.71 points in the CGI score (95% CI - 1.00 to - 0.29; P = 0.001). On the other hand, the analysis revealed that there were no significant differences in WHO-5-QOL, SOC-13 or SDS scores between the groups. This study showed a significant beneficial effect of oxygen treatment on some symptoms of depression.Trial registration: NCT02149563 (29/05/2014).
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adult ; Aged ; Depression/diagnosis ; Depression/therapy ; Double-Blind Method ; Female ; Humans ; Israel ; Male ; Middle Aged ; Oxygen/administration & dosage ; Proof of Concept Study ; Quality of Life ; Severity of Illness Index ; Treatment Outcome ; Young Adult
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98245-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sex work during the World Cup in Germany.

    Belmaker, R H

    Lancet (London, England)

    2006  Volume 368, Issue 9538, Page(s) 841

    MeSH term(s) Germany ; Gonorrhea/transmission ; Humans ; Sex Work/legislation & jurisprudence ; Soccer
    Language English
    Publishing date 2006-09-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(06)69325-2
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