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  1. Article ; Online: Retraction Note: m

    Zhang, Yi / Kang, Min / Zhang, Bin / Meng, Fanchao / Song, Jun / Kaneko, Hiroshi / Shimamoto, Fumio / Tang, Bo

    Molecular cancer

    2023  Volume 22, Issue 1, Page(s) 166

    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2091373-4
    ISSN 1476-4598 ; 1476-4598
    ISSN (online) 1476-4598
    ISSN 1476-4598
    DOI 10.1186/s12943-023-01874-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mucocutaneous Manifestations of Behçet's Disease.

    Nakamura, Koichiro / Tsunemi, Yuichiro / Kaneko, Fumio / Alpsoy, Erkan

    Frontiers in medicine

    2021  Volume 7, Page(s) 613432

    Abstract: Behçet's disease (BD) is a chronic, relapsing, systemic inflammatory disease with clinical features showing mucocutaneous lesions involving the ocular, articular, and further miscellaneous organs. Mucocutaneous manifestations, one of the most ... ...

    Abstract Behçet's disease (BD) is a chronic, relapsing, systemic inflammatory disease with clinical features showing mucocutaneous lesions involving the ocular, articular, and further miscellaneous organs. Mucocutaneous manifestations, one of the most characteristic signs of BD, have been most commonly observed upon onset or at any disease stage and are exceptionally important in its diagnosis. Given the lack of specific diagnostic laboratory tests for BD, diagnosis has been based on clinical findings. All diagnostic criteria published have thus far relied heavily on mucocutaneous manifestations, particularly oral ulcers (OU), genital ulcers (GU), cutaneous lesions, and pathergy test positivity. Worldwide, OU, GU, cutaneous lesions, and ocular and articular manifestations have been the most common symptoms, with erythema nodosum (EN)-like lesions and papulopustular lesions being the most prevalent cutaneous manifestations. While majority of the patients worldwide have reported OU as the most frequent symptom upon disease onset, GU, and EN-like lesions have also been identified upon onset. Considering that mucocutaneous symptoms precede severe organ involvement in most patients, familiarity with such symptoms is imperative for early diagnosis and prevention of potentially serious organ involvement through appropriate management.
    Language English
    Publishing date 2021-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.613432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Random Transfer of

    Seike, Taisuke / Narazaki, Yuki / Kaneko, Yoshinobu / Shimizu, Hiroshi / Matsuda, Fumio

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 4

    Abstract: Horizontal gene transfer, a process through which an organism acquires genes from other organisms, is a rare evolutionary event in yeasts. Artificial random gene transfer can emerge as a valuable tool in yeast bioengineering to investigate the background ...

    Abstract Horizontal gene transfer, a process through which an organism acquires genes from other organisms, is a rare evolutionary event in yeasts. Artificial random gene transfer can emerge as a valuable tool in yeast bioengineering to investigate the background of complex phenotypes, such as heat tolerance. In this study, a cDNA library was constructed from the mRNA of a methylotrophic yeast,
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7040302
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  4. Article ; Online: Mucocutaneous manifestations of Behçet’s disease

    Doyoung Kim / Koichiro Nakamura / Fumio Kaneko / Erkan Alpsoy / Dongsik Bang

    Frontiers in Medicine, Vol

    Pathogenesis and management from perspectives of vasculitis

    2022  Volume 9

    Abstract: Behçet’s disease (BD) is a systemic inflammatory disorder characterized by vasculitis affecting blood vessels of any caliber or type. It can present with a wide spectrum of vasculitic lesions, including erythema nodosum-like lesions and retinal ... ...

    Abstract Behçet’s disease (BD) is a systemic inflammatory disorder characterized by vasculitis affecting blood vessels of any caliber or type. It can present with a wide spectrum of vasculitic lesions, including erythema nodosum-like lesions and retinal vasculitis, and may also lead to larger vessel diseases, such as aortic aneurysm and deep vein thrombosis. The full etiology of BD remains unclear, but it is considered a polygenetic disease with multiple genetic risk factors that promote immune dysregulation and thrombophilia. Inflammation can be triggered by environmental factors, such as bacteria or viruses, and the dysregulation of innate and adaptive immune cell subsets. Neutrophils and lymphocytes are the primary players involved in BD pathogenesis, with specific innate (i.e., neutrophil-derived reactive oxygen species and neutrophil extracellular traps) and adaptive (i.e., anti-endothelial cell antibodies) processes inducing endothelial cell activation and chemotaxis of inflammatory cells, leading to coagulation and vasculitis. These inflammation-induced vasculitic or vasculopathic features are observed in most mucocutaneous BD lesions, although vasculitis per se is often pathologically evident only during a brief period of the disease process. Due to the multifactorial nature of BD-associated inflammation, broad-spectrum anti-inflammatory medications, including glucocorticoids and immunosuppressive drugs, have been the mainstay for managing BD. In addition, inhibitors of interleukin (IL)-1, tumor necrosis factor (TNF)-α, and IL-17, which target innate and adaptive immune functions dysregulated in BD, have emerged as promising new therapeutics. In this review, we discuss the muco-cutaneous manifestations of BD by focusing on the underlying vasculitic components in their pathologies, as well as the current array of treatment options.
    Keywords Behçet’s disease ; vasculitis ; mucocutaneous ; pathogenesis ; thrombosis ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mucocutaneous Manifestations of Behçet's Disease

    Koichiro Nakamura / Yuichiro Tsunemi / Fumio Kaneko / Erkan Alpsoy

    Frontiers in Medicine, Vol

    2021  Volume 7

    Abstract: Behçet's disease (BD) is a chronic, relapsing, systemic inflammatory disease with clinical features showing mucocutaneous lesions involving the ocular, articular, and further miscellaneous organs. Mucocutaneous manifestations, one of the most ... ...

    Abstract Behçet's disease (BD) is a chronic, relapsing, systemic inflammatory disease with clinical features showing mucocutaneous lesions involving the ocular, articular, and further miscellaneous organs. Mucocutaneous manifestations, one of the most characteristic signs of BD, have been most commonly observed upon onset or at any disease stage and are exceptionally important in its diagnosis. Given the lack of specific diagnostic laboratory tests for BD, diagnosis has been based on clinical findings. All diagnostic criteria published have thus far relied heavily on mucocutaneous manifestations, particularly oral ulcers (OU), genital ulcers (GU), cutaneous lesions, and pathergy test positivity. Worldwide, OU, GU, cutaneous lesions, and ocular and articular manifestations have been the most common symptoms, with erythema nodosum (EN)-like lesions and papulopustular lesions being the most prevalent cutaneous manifestations. While majority of the patients worldwide have reported OU as the most frequent symptom upon disease onset, GU, and EN-like lesions have also been identified upon onset. Considering that mucocutaneous symptoms precede severe organ involvement in most patients, familiarity with such symptoms is imperative for early diagnosis and prevention of potentially serious organ involvement through appropriate management.
    Keywords Behçet's disease ; erythema nodosum-like lesion ; papulopustular lesion ; oral ulcer ; genital ulcer ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Is it truly atrial tachycardia?

    Kaneko, Yoshiaki / Suzuki, Fumio

    Journal of arrhythmia

    2016  Volume 32, Issue 6, Page(s) 502

    Language English
    Publishing date 2016-04-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1016/j.joa.2016.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mandibular premolar identification system based on a deep learning model.

    Igarashi, Yuriko / Kondo, Shintaro / Kida, Sora / Aibara, Megumi / Kaneko, Minami / Uchikoba, Fumio

    Journal of oral biosciences

    2022  Volume 64, Issue 3, Page(s) 321–328

    Abstract: Objectives: For constructing an isolated tooth identification system using deep learning, Igarashi et al. (2021) began constructing a learning model as basic research to identify the left and right mandibular first and second premolars. These teeth were ...

    Abstract Objectives: For constructing an isolated tooth identification system using deep learning, Igarashi et al. (2021) began constructing a learning model as basic research to identify the left and right mandibular first and second premolars. These teeth were chosen for analysis because they are difficult to identify from one another. The learning method itself was proven appropriate but presented low accuracy. Therefore, further improvement in the learning data should increase the accuracy of the model. The study objectives were to modify the learning data and increase the learning model accuracy for enabling the identification of isolated lower premolars.
    Methods: Static images of the occlusal surface of the premolars made from the dental plaster casts of dental students were used as the training, validation, and test data. A convolutional neural network with 32 hidden layers, AlexNet, convolutional architecture for fast feature embedding, and stochastic gradient descent was used to construct four learning models.
    Results: The accuracy of the identification model increased using static images of the occlusal surface of the teeth with the adjacent teeth deleted as the training and validation data; however, a learning model that could perfectly identify the teeth could not be realized.
    Conclusions: Static images of the occlusal surface of the teeth with the adjacent teeth deleted should be used as both training and validation data. The ratio of the numbers of training, validation, and test data should be optimized.
    MeSH term(s) Artificial Intelligence ; Bicuspid ; Deep Learning ; Humans ; Mandible ; Neural Networks, Computer
    Language English
    Publishing date 2022-05-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2022.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Random Transfer of Ogataea polymorpha Genes into Saccharomyces cerevisiae Reveals a Complex Background of Heat Tolerance

    Taisuke Seike / Yuki Narazaki / Yoshinobu Kaneko / Hiroshi Shimizu / Fumio Matsuda

    Journal of Fungi, Vol 7, Iss 302, p

    2021  Volume 302

    Abstract: Horizontal gene transfer, a process through which an organism acquires genes from other organisms, is a rare evolutionary event in yeasts. Artificial random gene transfer can emerge as a valuable tool in yeast bioengineering to investigate the background ...

    Abstract Horizontal gene transfer, a process through which an organism acquires genes from other organisms, is a rare evolutionary event in yeasts. Artificial random gene transfer can emerge as a valuable tool in yeast bioengineering to investigate the background of complex phenotypes, such as heat tolerance. In this study, a cDNA library was constructed from the mRNA of a methylotrophic yeast, Ogataea polymorpha , and then introduced into Saccharomyces cerevisiae . Ogataea polymorpha was selected because it is one of the most heat-tolerant species among yeasts. Screening of S. cerevisiae populations expressing O. polymorpha genes at high temperatures identified 59 O. polymorpha genes that contribute to heat tolerance. Gene enrichment analysis indicated that certain S. cerevisiae functions, including protein synthesis, were highly temperature-sensitive. Additionally, the results confirmed that heat tolerance in yeast is a complex phenotype dependent on multiple quantitative loci. Random gene transfer would be a useful tool for future bioengineering studies on yeasts.
    Keywords Saccharomyces cerevisiae ; cDNA library ; heat tolerance ; random gene transfer ; Ogataea polymorpha ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Immunocytochemical Analysis of DGKη in Cultured Cells Using a Monoclonal Antibody DhMab-4.

    Nakano, Tomoyuki / Tanaka, Toshiaki / Sakane, Fumio / Kaneko, Mika K / Kato, Yukinari / Goto, Kaoru

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2021  Volume 40, Issue 6, Page(s) 261–265

    Abstract: Diacylglycerol kinase (DGK) is a lipid kinase that converts diacylglycerol (DG) to phosphatidic acid (PA). Since both DG and PA serve as intracellular second messenger molecules, DGK plays a pivotal role in balancing these two signaling pathways. Of the ... ...

    Abstract Diacylglycerol kinase (DGK) is a lipid kinase that converts diacylglycerol (DG) to phosphatidic acid (PA). Since both DG and PA serve as intracellular second messenger molecules, DGK plays a pivotal role in balancing these two signaling pathways. Of the DGK family, DGKη is classified as a type II DGK. Reportedly, DGKη is expressed ubiquitously through mammalian tissues and cells. Previous studies using cDNA transfection methods reported cytoplasmic localization of DGKη in cultured human cells. However, subcellular localization of native protein is still unknown. Recently, we established a human DGKη-specific monoclonal antibody, DhMab-4. In this study, we examined subcellular localization of native protein of DGKη using DhMab-4 by immunocytochemistry in human cultured cells.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Cell Line ; Cells, Cultured ; Diacylglycerol Kinase/genetics ; Humans ; Immunohistochemistry ; Phosphatidic Acids
    Chemical Substances Antibodies, Monoclonal ; Phosphatidic Acids ; Diacylglycerol Kinase (EC 2.7.1.107)
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2021.0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The walking and running control of a human musculoskeletal model using a low-power consumption hardware central pattern generator model

    Kenji Takeda / Mikihito Hayakawa / Motokuni Ishibashi / Minori Ishihara / Takumi Ishihama / Megumi Aibara / Minami Kaneko / Fumio Uchikoba

    International Journal of Advanced Robotic Systems, Vol

    2022  Volume 19

    Abstract: Applying a control system with low energy consumption and low load of motion control to robots, similar to living organisms, is considered to be one of the most important issues in robot development. We have been studying systems that use pulse-type ... ...

    Abstract Applying a control system with low energy consumption and low load of motion control to robots, similar to living organisms, is considered to be one of the most important issues in robot development. We have been studying systems that use pulse-type hardware neural networks to control robotic motion with a small number of control signals, as is the case in living organisms. In particular, it has been mimicking the function of the central pattern generator localized in the spinal cord of living organisms to generate motion patterns. In the present article, a new biomimetic control system using pulse-type hardware neural networks for biped gait control is reported.
    Keywords Electronics ; TK7800-8360 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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