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Book ; Online: Kinder- und Jugendhilfereport 2018

Tabel, Agathe / Feller, Nadine / Schilling, Matthias / Rauschenbach, Thomas / Pothmann, Jens / Müller, Sylvia / Mühlmann, Thomas / Meiner- Teubner, Christiane / Kopp, Katharina / Fendrich, Sandra / Böwing-Schmalenbrock, Melanie

2019

Abstract: The Children and Youth Welfare Report 2018, comprehensively describes the current situation and the more recent development of child and youth welfare in Germany. It is based on the data of the official child and youth welfare statistics. For the first ... ...

Abstract	The Children and Youth Welfare Report 2018, comprehensively describes the current situation and the more recent development of child and youth welfare in Germany. It is based on the data of the official child and youth welfare statistics. For the first time, child and youth welfare is presented and analysed on the basis of indicators. The report provides a quick and reliable overview of central fields of work and important areas of responsibility.; Der Kinder- und Jugendhilfereport 2018, die zentrale Publikation der Dortmunder Arbeitsstelle Kinder- und Jugendhilfestatistik, beschreibt umfassend die aktuelle Situation und die neuere Entwicklung der Kinder- und Jugendhilfe. Grundlage sind die Daten der amtlichen Kinder- und Jugendhilfestatistik. Erstmals wird die Kinder- und Jugendhilfe auf der Basis von Indikatoren dargestellt und analysiert. Der Report ermöglicht einen schnellen und zuverlässigen Überblick über zentrale Arbeitsfelder und wichtige Aufgabengebiete
Keywords	Social pathology. Social and public welfare. Criminology
Size	1 electronic resource (224 pages)
Publisher	Verlag Barbara Budrich
Document type	Book ; Online
Note	German ; Open Access
HBZ-ID	HT020310467
ISBN	9783847413400 ; 9783847422402 ; 3847413406 ; 3847422405
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Interpretation of azimuthal angle dependence of periodic gratings in Mueller matrix spectroscopic ellipsometry.

Heinrich, Anett / Bischoff, Jörg / Meiner, Kurt / Richter, Uwe / Mikolajick, Thomas / Dirnstorfer, Ingo

Journal of the Optical Society of America. A, Optics, image science, and vision

2015 Volume 32, Issue 4, Page(s) 604–610

Abstract: Mueller matrix spectroscopic ellipsometry becomes increasingly important for determining structural parameters of periodic line gratings. Because of the anisotropic character of gratings, the measured Mueller matrix elements are highly azimuthal angle ... ...

Abstract	Mueller matrix spectroscopic ellipsometry becomes increasingly important for determining structural parameters of periodic line gratings. Because of the anisotropic character of gratings, the measured Mueller matrix elements are highly azimuthal angle dependent. Measurement results are interpreted by basic principles of diffraction on gratings. The spectral and azimuthal angle dependent intensity changes are correlated to so-called Rayleigh singularities, i.e., wavelengths where the number of diffraction orders changes. The positions of the Rayleigh singularities are calculated analytically and overlapped with measured spectra of two different types of photomasks with transparent and reflecting substrates. For both types of gratings, the Rayleigh singularities reproduce the contours of the spectra. Increasing grating periods result in a shift of these contours to longer wavelengths. Characteristic differences between the two photomasks are explained by the influence of the transmission orders, which are determined by the substrate transparency.
Language	English
Publishing date	2015-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	283633-6
ISSN	1520-8532 ; 1084-7529 ; 0740-3232
ISSN (online)	1520-8532
ISSN	1084-7529 ; 0740-3232
DOI	10.1364/JOSAA.32.000604
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Article ; Online: Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood.

Wander, Pandora L / Hochner, Hagit / Sitlani, Colleen M / Enquobahrie, Daniel A / Lumley, Thomas / Lawrence, Gabriela M / Burger, Ayala / Savitsky, Bella / Manor, Orly / Meiner, Vardiella / Hesselson, Stephanie / Kwok, Pui Y / Siscovick, David S / Friedlander, Yechiel

PloS one

2014 Volume 9, Issue 3, Page(s) e91835

Abstract: Background: Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is ... ...

Abstract	Background: Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown. Methods/results: In 1249 mother-offspring pairs recruited from the Jerusalem Perinatal Study, we used archival data to characterize ppBMI and GWG and follow-up data from offspring to assess CMR, including body mass index (BMI), waist circumference, glucose, insulin, blood pressure, and lipid levels, at an average age of 32. Maternal genetic risk scores (GRS) were created using a subset of SNPs most predictive of ppBMI, GWG, and each CMR trait, selected among 1384 single-nucleotide polymorphisms (SNPs) characterizing variation in 170 candidate genes potentially related to fetal development and/or metabolic risk. We fit linear regression models to examine the associations of ppBMI and GWG with CMR traits with and without adjustment for GRS. Compared to unadjusted models, the coefficient for the association of a one-standard-deviation (SD) difference in GWG and offspring BMI decreased by 41% (95%CI -81%, -11%) from 0.847 to 0.503 and the coefficient for a 1SD difference in GWG and WC decreased by 63% (95%CI -318%, -11%) from 1.196 to 0.443. For other traits, there were no statistically significant changes in the coefficients for GWG with adjustment for GRS. None of the associations of ppBMI with CMR traits were significantly altered by adjustment for GRS. Conclusions: Maternal genetic variation may account in part for associations of GWG with offspring BMI and WC in young adults.
MeSH term(s)	Adult ; Body Mass Index ; Body Size/genetics ; Cardiovascular Diseases/genetics ; Female ; Genetic Variation ; Humans ; Male ; Metabolic Syndrome/genetics ; Phenotype ; Pregnancy ; Risk Factors ; Weight Gain
Language	English
Publishing date	2014-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0091835
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.

Hochner, Hagit / Allard, Catherine / Granot-Hershkovitz, Einat / Chen, Jinbo / Sitlani, Colleen M / Sazdovska, Sandra / Lumley, Thomas / McKnight, Barbara / Rice, Kenneth / Enquobahrie, Daniel A / Meigs, James B / Kwok, Pui / Hivert, Marie-France / Borecki, Ingrid B / Gomez, Felicia / Wang, Ting / van Duijn, Cornelia / Amin, Najaf / Rotter, Jerome I /

Stamatoyannopoulos, John / Meiner, Vardiella / Manor, Orly / Dupuis, Josée / Friedlander, Yechiel / Siscovick, David S

PLoS genetics

2015 Volume 11, Issue 10, Page(s) e1005573

Abstract: Loci identified in genome-wide association studies (GWAS) of cardio-metabolic traits account for a small proportion of the traits' heritability. To date, most association studies have not considered parent-of-origin effects (POEs). Here we report ... ...

Abstract	Loci identified in genome-wide association studies (GWAS) of cardio-metabolic traits account for a small proportion of the traits' heritability. To date, most association studies have not considered parent-of-origin effects (POEs). Here we report investigation of POEs on adiposity and glycemic traits in young adults. The Jerusalem Perinatal Family Follow-Up Study (JPS), comprising 1250 young adults and their mothers was used for discovery. Focusing on 18 genes identified by previous GWAS as associated with cardio-metabolic traits, we used linear regression to examine the associations of maternally- and paternally-derived offspring minor alleles with body mass index (BMI), waist circumference (WC), fasting glucose and insulin. We replicated and meta-analyzed JPS findings in individuals of European ancestry aged ≤50 belonging to pedigrees from the Framingham Heart Study, Family Heart Study and Erasmus Rucphen Family study (total N≅4800). We considered p<2.7x10-4 statistically significant to account for multiple testing. We identified a common coding variant in the 4th exon of APOB (rs1367117) with a significant maternally-derived effect on BMI (β = 0.8; 95%CI:0.4,1.1; p = 3.1x10-5) and WC (β = 2.7; 95%CI:1.7,3.7; p = 2.1x10-7). The corresponding paternally-derived effects were non-significant (p>0.6). Suggestive maternally-derived associations of rs1367117 were observed with fasting glucose (β = 0.9; 95%CI:0.3,1.5; p = 4.0x10-3) and insulin (ln-transformed, β = 0.06; 95%CI:0.03,0.1; p = 7.4x10-4). Bioinformatic annotation for rs1367117 revealed a variety of regulatory functions in this region in liver and adipose tissues and a 50% methylation pattern in liver only, consistent with allelic-specific methylation, which may indicate tissue-specific POE. Our findings demonstrate a maternal-specific association between a common APOB variant and adiposity, an association that was not previously detected in GWAS. These results provide evidence for the role of regulatory mechanisms, POEs specifically, in adiposity. In addition this study highlights the benefit of utilizing family studies for deciphering the genetic architecture of complex traits.
MeSH term(s)	Adiposity/genetics ; Adult ; Apolipoprotein B-100/genetics ; Body Mass Index ; Cholesterol/genetics ; Female ; Genome-Wide Association Study ; Genomic Imprinting ; Glucose/metabolism ; Humans ; Insulin/genetics ; Male ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Polymorphism, Single Nucleotide ; Waist Circumference/genetics ; Waist-Hip Ratio ; Young Adult
Chemical Substances	APOB protein, human ; Apolipoprotein B-100 ; Insulin ; Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2015-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1005573
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood.

Pandora L Wander / Hagit Hochner / Colleen M Sitlani / Daniel A Enquobahrie / Thomas Lumley / Gabriela M Lawrence / Ayala Burger / Bella Savitsky / Orly Manor / Vardiella Meiner / Stephanie Hesselson / Pui Y Kwok / David S Siscovick / Yechiel Friedlander

PLoS ONE, Vol 9, Iss 3, p e

2014 Volume 91835

Abstract: Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown.In 1249 ... ...

Abstract	Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown.In 1249 mother-offspring pairs recruited from the Jerusalem Perinatal Study, we used archival data to characterize ppBMI and GWG and follow-up data from offspring to assess CMR, including body mass index (BMI), waist circumference, glucose, insulin, blood pressure, and lipid levels, at an average age of 32. Maternal genetic risk scores (GRS) were created using a subset of SNPs most predictive of ppBMI, GWG, and each CMR trait, selected among 1384 single-nucleotide polymorphisms (SNPs) characterizing variation in 170 candidate genes potentially related to fetal development and/or metabolic risk. We fit linear regression models to examine the associations of ppBMI and GWG with CMR traits with and without adjustment for GRS. Compared to unadjusted models, the coefficient for the association of a one-standard-deviation (SD) difference in GWG and offspring BMI decreased by 41% (95%CI -81%, -11%) from 0.847 to 0.503 and the coefficient for a 1SD difference in GWG and WC decreased by 63% (95%CI -318%, -11%) from 1.196 to 0.443. For other traits, there were no statistically significant changes in the coefficients for GWG with adjustment for GRS. None of the associations of ppBMI with CMR traits were significantly altered by adjustment for GRS.Maternal genetic variation may account in part for associations of GWG with offspring BMI and WC in young adults.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Short-term administration of ethanol does not affect functional recovery from myocardial stunning in awake dogs.

Weber, Thomas Peter / Hartlage, Maike Anja Groe / Rolf, Norbert / Booke, Michael / Berendes, Elmar / Van Aken, Hugo / Meiner, Andreas

Anesthesia and analgesia

2001 Volume 96, Issue 3, Page(s) 665–672

Abstract: Unlabelled: Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized ... ...

Abstract	Unlabelled: Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs in awake dogs. Therefore, we investigated the effects of SAE on regional myocardial stunning in awake dogs. Thirty-six dogs were chronically instrumented for measurement of heart rate, left atrial, aortic, and left ventricular pressure, left systolic ventricular contactility (dP/dt(max)) and diastolic ventricular function (dP/dt(min)), and regional myocardial wall-thickening fraction (WTF). Occluders around the left anterior descending (LAD) artery allowed the induction of reversible ischemia in the LAD-perfused myocardium. The dogs were assigned to one of three groups that differed in the dose of ethanol administered in the ethanol experiment (I, 0.125 g/kg [n = 12]; II, 0.25 g/kg [n = 12]; III, 0.5 g/kg [n = 12]). In each group, the dogs underwent two ischemic episodes (randomized crossover fashion; separate days): 10 min of LAD occlusion after the application of ethanol IV over 30 min (ethanol group) and without ethanol (control). WTF and hemodynamic variables were measured at baseline and at predetermined time points until complete recovery of myocardial stunning occurred. LAD-ischemia led to a significant decrease of LAD-WTF in all groups. There was no difference in WTF and hemodynamic variables with or without SAE during reperfusion. We conclude that SAE (0.125 g/kg, 0.25 g/kg, and 0.5 g/kg) does not significantly affect myocardial stunning in conscious dogs. Implications: In contrast to previous experiments in anesthetized dogs, short-term administration of ethanol does not alter myocardial stunning in conscious dogs.
MeSH term(s)	Animals ; Central Nervous System Depressants/blood ; Central Nervous System Depressants/pharmacology ; Coronary Circulation/drug effects ; Coronary Circulation/physiology ; Dogs ; Electrophysiology ; Ethanol/blood ; Ethanol/pharmacology ; Female ; Male ; Manometry ; Myocardial Reperfusion Injury/physiopathology ; Myocardial Stunning/pathology ; Myocardial Stunning/physiopathology ; Myocardium/pathology ; Ventricular Function, Left/physiology
Chemical Substances	Central Nervous System Depressants ; Ethanol (3K9958V90M)
Language	English
Publishing date	2001-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/01.ANE.0000048712.95074.CD
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Article ; Online: De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

Fry, Andrew E / Fawcett, Katherine A / Zelnik, Nathanel / Yuan, Hongjie / Thompson, Belinda A N / Shemer-Meiri, Lilach / Cushion, Thomas D / Mugalaasi, Hood / Sims, David / Stoodley, Neil / Chung, Seo-Kyung / Rees, Mark I / Patel, Chirag V / Brueton, Louise A / Layet, Valérie / Giuliano, Fabienne / Kerr, Michael P / Banne, Ehud / Meiner, Vardiella /

Brain : a journal of neurology

2017 Volume 141, Issue 3, Page(s) 698–712

Abstract: Polymicrogyria is a malformation of cortical development. The aetiology of polymicrogyria remains poorly understood. Using whole-exome sequencing we found de novo heterozygous missense GRIN1 mutations in 2 of 57 parent-offspring trios with polymicrogyria. ...

Abstract	Polymicrogyria is a malformation of cortical development. The aetiology of polymicrogyria remains poorly understood. Using whole-exome sequencing we found de novo heterozygous missense GRIN1 mutations in 2 of 57 parent-offspring trios with polymicrogyria. We found nine further de novo missense GRIN1 mutations in additional cortical malformation patients. Shared features in the patients were extensive bilateral polymicrogyria associated with severe developmental delay, postnatal microcephaly, cortical visual impairment and intractable epilepsy. GRIN1 encodes GluN1, the essential subunit of the N-methyl-d-aspartate receptor. The polymicrogyria-associated GRIN1 mutations tended to cluster in the S2 region (part of the ligand-binding domain of GluN1) or the adjacent M3 helix. These regions are rarely mutated in the normal population or in GRIN1 patients without polymicrogyria. Using two-electrode and whole-cell voltage-clamp analysis, we showed that the polymicrogyria-associated GRIN1 mutations significantly alter the in vitro activity of the receptor. Three of the mutations increased agonist potency while one reduced proton inhibition of the receptor. These results are striking because previous GRIN1 mutations have generally caused loss of function, and because N-methyl-d-aspartate receptor agonists have been used for many years to generate animal models of polymicrogyria. Overall, our results expand the phenotypic spectrum associated with GRIN1 mutations and highlight the important role of N-methyl-d-aspartate receptor signalling in the pathogenesis of polymicrogyria.
MeSH term(s)	Animals ; Child ; Child, Preschool ; DNA Mutational Analysis ; Excitatory Amino Acid Agonists/pharmacology ; Family Health ; Female ; Glutamic Acid/pharmacology ; Glycine/metabolism ; Glycine/pharmacology ; HEK293 Cells ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Membrane Potentials/genetics ; Models, Molecular ; Mutagenesis/genetics ; Mutation/genetics ; N-Methylaspartate/pharmacology ; Nerve Tissue Proteins/genetics ; Patch-Clamp Techniques ; Polymicrogyria/diagnostic imaging ; Polymicrogyria/genetics ; Rats ; Receptors, N-Methyl-D-Aspartate/genetics ; Transfection
Chemical Substances	Excitatory Amino Acid Agonists ; GRIN1 protein, human ; Nerve Tissue Proteins ; Receptors, N-Methyl-D-Aspartate ; Glutamic Acid (3KX376GY7L) ; N-Methylaspartate (6384-92-5) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2017-12-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awx358
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Book ; Online: Kinder- und Jugendhilfereport 2018

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Article ; Online: Interpretation of azimuthal angle dependence of periodic gratings in Mueller matrix spectroscopic ellipsometry.

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Article ; Online: Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood.

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Article ; Online: Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.

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Article ; Online: Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood.

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Article: Short-term administration of ethanol does not affect functional recovery from myocardial stunning in awake dogs.

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Article ; Online: De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

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