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  1. Article: Ben Pimlott Memorial Lecture 2018The Women's Suffrage Movement in the Balfour Family.

    Pedersen, Susan

    20 century British history

    2019  Volume 30, Issue 3, Page(s) 299–320

    Abstract: Given on the centenary of women's suffrage, this lecture explores the tensions and conflicts the claim for the vote raised among elite women already enmeshed in parliamentary and political circles. Drawing on the unbuttoned and sometimes angry ... ...

    Abstract Given on the centenary of women's suffrage, this lecture explores the tensions and conflicts the claim for the vote raised among elite women already enmeshed in parliamentary and political circles. Drawing on the unbuttoned and sometimes angry correspondence among A.J. Balfour's suffragist sisters-in-law Lady Frances Balfour and Lady Betty Balfour, Frances' collaborator (and suffragist leader) Millicent Fawcett, Lady Betty's militant suffragette sister Lady Constance Lytton, and their old friend (and wife of the anti-suffragist Prime Minister) Margot Asquith, it explores the appeal but also the costs of this democratic claim for such "incorporated" women - and explains why some nevertheless supported it.
    MeSH term(s) History, 20th Century ; Politics ; United Kingdom ; Women's Rights/history
    Language English
    Publishing date 2019-07-12
    Publishing country England
    Document type Historical Article ; Journal Article ; Lecture
    ZDB-ID 2077480-1
    ISSN 1477-4674 ; 0955-2359
    ISSN (online) 1477-4674
    ISSN 0955-2359
    DOI 10.1093/tcbh/hwz010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Urgent action is required to increase sustainability in in vitro modelling.

    Pedersen, Katarina / Vanhoestenberghe, Anne / Heavey, Susan

    In vitro models

    2022  Volume 1, Issue 2, Page(s) 115–117

    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Editorial
    ISSN 2731-3441
    ISSN (online) 2731-3441
    DOI 10.1007/s44164-022-00011-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Factors affecting driving performance in patients with Multiple Sclerosis - still an open question.

    Seddiq Zai, Susan / das Nair, Roshan / Heesen, Christoph / Buhmann, Carsten / Pedersen, Anya / Pöttgen, Jana

    Frontiers in neurology

    2024  Volume 15, Page(s) 1369143

    Abstract: Background and objectives: Research on driving ability in people with multiple sclerosis (MS) suggests that they might be at risk for unsafe driving due to MS-related motor, visual, and cognitive impairment. Our first aim was to investigate differences ... ...

    Abstract Background and objectives: Research on driving ability in people with multiple sclerosis (MS) suggests that they might be at risk for unsafe driving due to MS-related motor, visual, and cognitive impairment. Our first aim was to investigate differences in driving ability and performance between people with MS (PwMS) and those without any neurologic or psychiatric disease ("controls"). Secondly, we determined disease-related factors influencing driving ability in PwMS.
    Methods: We prospectively compared standardized performance in a driving simulator between 97 persons with early MS [mean (SD) = 6.4 (7.3) years since diagnosis, mean (SD) Expanded Disability Status Scale (EDSS) = 2.5 (1.4)] and 94 group-matched controls. Participants completed an extensive examination comprising questionnaires and assessments regarding driving, cognitive and psychological factors, as well as demographic and disease-related measures. Between-group comparisons of driving-relevant neuropsychological tests and driving performance were done. Correlations were performed to define demographic and disease-related factors on driving performance in MS.
    Results: In a driving simulator setting, PwMS had more driving accidents [T(188) = 2.762,
    Conclusion: Driving performance in a simulator seems to be reduced in PwMS at an early stage of disease compared to controls, as a result of increased erroneous driving, reduced reaction time and higher accident rate. MS-related impairment in mobility, vision, cognition, and in psychological and demographic aspects showed no or only minimal association to driving ability, but impairment in different areas of cognition such as spatial short-term memory, working memory and selective attention correlated with the number of accidents, and might indicate a higher risk for driving errors and worse performance. These results show that driving ability is a complex skill with involvement of many different domains, which need further research.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1369143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer.

    Al Naji, Hiba / Winter, Jean M / Pedersen, Susanne K / Roy, Amitesh / Byrne, Susan E / Young, Graeme P / Symonds, Erin L

    Biomarker insights

    2024  Volume 19, Page(s) 11772719241232870

    Abstract: Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor DNA (ctDNA) at diagnosis could be ...

    Abstract Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor DNA (ctDNA) at diagnosis could be used to improve the prediction for disease recurrence.
    Objectives: To assess the impact of detecting methylated
    Design: A retrospective cohort study.
    Methods: The cohort included 180 patients (36 with recurrent CRC), who had undergone complete treatment and surveillance for a minimum of 3 years. Participant clinical details and ctDNA methylated
    Results: Clinical factors independently associated with reduced disease-free survival included nodal involvement (HR = 3.83, 95% CI 1.56-9.43,
    Conclusions: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.
    Registration: Australian and New Zealand Clinical Trials Registry #12611000318987.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2256754-9
    ISSN 1177-2719
    ISSN 1177-2719
    DOI 10.1177/11772719241232870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder.

    Mizzi, Simone / Pedersen, Mangor / Rossell, Susan L / Rendell, Peter / Terrett, Gill / Heinrichs, Markus / Labuschagne, Izelle

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 147

    Abstract: Social anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to ... ...

    Abstract Social anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to understand the neurobiological underpinnings of SAD in the absence of threat-related stimuli. Previous studies have primarily focused on the role of the amygdala in SAD. However, the amygdala consists of functionally and structurally distinct subregions, and recent studies have highlighted the importance of investigating the role of these subregions independently. Using multiband fMRI, we analyzed resting-state data from 135 participants (42 SAD, 93 healthy controls). By employing voxel-wise permutation testing, we examined group differences of fMRI connectivity and associations between fMRI connectivity and social anxiety symptoms to further investigate the classification of SAD as a categorical or dimensional construct. Seed-to-whole brain functional connectivity analysis using multiple 'seeds' including the amygdala and its subregions and the precuneus, revealed no statistically significant group differences. However, social anxiety severity was significantly negatively correlated with functional connectivity of the precuneus - perigenual anterior cingulate cortex and positively correlated with functional connectivity of the amygdala (specifically the superficial subregion) - parietal/cerebellar areas. Our findings demonstrate clear links between symptomatology and brain connectivity in the absence of diagnostic differences, with evidence of amygdala subregion-specific alterations. The observed brain-symptom associations did not include disturbances in the brain's fear circuitry (i.e., disturbances in connectivity between amygdala - prefrontal regions) likely due to the absence of threat-related stimuli.
    MeSH term(s) Humans ; Phobia, Social ; Amygdala/diagnostic imaging ; Anxiety Disorders/diagnostic imaging ; Brain ; Parietal Lobe/diagnostic imaging ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02844-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Experimental assessment of cross-species transmission in a natural multihost-multivector-multipathogen community.

    Fenton, Andy / Withenshaw, Susan M / Devevey, Godefroy / Morris, Alexandra / Erazo, Diana / Pedersen, Amy B

    Proceedings. Biological sciences

    2023  Volume 290, Issue 2011, Page(s) 20231900

    Abstract: Vector-borne pathogens, many of which cause major suffering worldwide, often circulate in diverse wildlife communities comprising multiple reservoir host and/or vector species. However, the complexities of these systems make it challenging to determine ... ...

    Abstract Vector-borne pathogens, many of which cause major suffering worldwide, often circulate in diverse wildlife communities comprising multiple reservoir host and/or vector species. However, the complexities of these systems make it challenging to determine the contributions these different species make to transmission. We experimentally manipulated transmission within a natural multihost-multipathogen-multivector system, by blocking flea-borne pathogen transmission from either of two co-occurring host species (bank voles and wood mice). Through genetic analysis of the resulting infections in the hosts and vectors, we show that both host species likely act together to maintain the overall flea community, but cross-species pathogen transmission is relatively rare-most pathogens were predominantly found in only one host species, and there were few cases where targeted treatment affected pathogens in the other host species. However, we do provide experimental evidence of some reservoir-spillover dynamics whereby reductions of some infections in one host species are achieved by blocking transmission from the other host species. Overall, despite the apparent complexity of such systems, we show there can be 'covert simplicity', whereby pathogen transmission is primarily dominated by single host species, potentially facilitating the targeting of key hosts for control, even in diverse ecological communities.
    MeSH term(s) Animals ; Mice ; Siphonaptera ; Arvicolinae ; Host Specificity ; Animals, Wild ; Insect Vectors
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.1900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: The guardians

    Pedersen, Susan

    the League of Nations and the crisis of empire

    2015  

    Institution League of Nations
    Author's details Susan Pedersen
    Keywords Anti-imperialist movements/History ; Colonies/History ; Imperialism/History ; International relations/History ; Internationalism/History ; Mandates/History ; World politics
    Language English
    Size Online-Ressource, maps
    Edition First edition
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0191009407 ; 9780191009402 ; 9780199570485 ; 0199570485
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Substance Use Descriptive Norms and Behaviors among US College Students: Findings from the Healthy Minds Study.

    Oh, Hans / Besecker, Megan / Huh, Jimi / Zhou, Sasha / Luczak, Susan E / Pedersen, Eric R

    Epidemiolgia (Basel, Switzerland)

    2022  Volume 3, Issue 1, Page(s) 42–48

    Abstract: Background: Social norms have been associated with alcohol use in college populations; however, more research is needed to confirm the associations between social norms and a range of substance use behaviors during the COVID-19 pandemic.: Methods: We ...

    Abstract Background: Social norms have been associated with alcohol use in college populations; however, more research is needed to confirm the associations between social norms and a range of substance use behaviors during the COVID-19 pandemic.
    Methods: We analyzed data from the Healthy Minds Study (September 2020-December 2020), a non-probability sample administered online to college students. We used multivariable logistic regression to test for associations between respondents' perceptions of substance use behaviors in their respective colleges and their own substance use behaviors, adjusting for age, gender, race/ethnicity, and international student status.
    Results: We found that those who overestimated the prevalence of alcohol use, cigarette use, cannabis use, and vaping were significantly more likely to use these substances when compared with those who did not overestimate. These associations persisted even when using different prevalence estimates of substance use, though some associations lost statistical significance when applying the survey weights to account for non-response.
    Conclusion: College students overestimated the prevalence of substance use in their respective colleges, even during the early stages of the pandemic when social interactions were limited, and these beliefs were associated with substance use. Future studies may test the utility of campaigns to alter perceptions of social norms and interventions that use personalized normative feedback to reduce substance use during pandemics.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3986
    ISSN (online) 2673-3986
    DOI 10.3390/epidemiologia3010005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: The guardians

    Pedersen, Susan

    the League of Nations and the crisis of empire

    2015  

    Abstract: ... haunting."-- ... and institutions, structures and contingencies, Pedersen demonstrates how imperial ambitions ... that internationalism set in train, the book is bracing. The histories Pedersen tells, both human and institutional, are ...

    Institution League of Nations
    Author's details Susan Pedersen
    Abstract "A landmark work of global history, powerfully argued and superbly researched, "The Guardians" explains how the modern international order of normative statehood came to be. In an account rich in people and institutions, structures and contingencies, Pedersen demonstrates how imperial ambitions, nationalist claims, revanchism, and idealism collided and combined in Geneva and on the ground in the Middle East, Africa, and the Pacific in the 1920s and 1930s. As an analysis of the unintended consequences that internationalism set in train, the book is bracing. The histories Pedersen tells, both human and institutional, are haunting."--

    "It is not just the staggering research in this book, both far-flung across the globe and incomparably deep; it is not just its exemplary and unprecedented success in combining the stories of great politicians in imperial capitals and international bureaucrats in Geneva with those of ordinary people making claims the world over; it is not just the unending drama of the tumultuous era and the lovely prose in which it is presented. For Susan Pedersen does nothing less than reconstruct the making of our times, as the struggle to continue intolerable empire in the name of paternalism and progress set off unexpected forces that created our unhappy world of nation states, rich and poor. With "The Guardians", international history reaches its contemporary pinnacle."--
    Keywords Anti-imperialist movements/History ; Colonies/History ; Imperialism/History ; International relations/History ; Internationalism/History ; Mandates/History ; World politics
    Language English
    Size XIV, 571 S., Ill., graph. Darst., Kt.
    Edition 1. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Document type Book
    Note Literaturverz. S. [519] - 546
    ISBN 9780199570485 ; 0199570485
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book: The guardians

    Pedersen, Susan

    the League of Nations and the crisis of empire

    2015  

    Abstract: ... te and far-flung territories became the site and the vehicle of global transformation. In this ma ... sterful history of the mandates system, Susan Pedersen illuminates the role the League of Nations played in cr ... over ideas of civilization, independence, economic relations, and sovereignty in the Geneva headquarters. ...

    Institution League of Nations
    Author's details Susan Pedersen
    Abstract "A sweeping global history of the League of Nations' mandates system and the limits of imperial order"--

    "At the end of the First World War, the Paris Peace Conference saw a battle over the future of empire. The victorious allied powers wanted to annex the Ottoman territories and German colonies they had occupied; Woodrow Wilson and a groundswell of anti-imperialist activism stood in their way. France, Belgium, Japan and the British dominions reluctantly agreed to an Anglo-American proposal to hold and administer those allied conquests under 'mandate' from the new League of Nations. In the end, fourteen mandated territories were set up across the Middle East, Africa and the Pacific. Against all odds, these disparate and far-flung territories became the site and the vehicle of global transformation. In this masterful history of the mandates system, Susan Pedersen illuminates the role the League of Nations played in creating the modern world. Tracing the system from its creation in 1920 until its demise in 1939, Pedersen examines its workings from the realm of international diplomacy; the viewpoints of the League's experts and officials; and the arena of local struggles within the territories themselves. Featuring a cast of larger-than-life figures, including Lord Lugard, King Faisal, Chaim Weizmann and Ralph Bunche, the narrative sweeps across the globe--from windswept scrublands along the Orange River to famine-blighted hilltops in Rwanda to Damascus under French bombardment--but always returns to Switzerland and the sometimes vicious battles over ideas of civilization, independence, economic relations, and sovereignty in the Geneva headquarters. As Pedersen shows, although the architects and officials of the mandates system always sought to uphold imperial authority, colonial nationalists, German revisionists, African-American intellectuals and others were able to use the platform Geneva offered to challenge their claims. Amid this cacophony, imperial statesmen began exploring new means--client states, economic concessions--of securing Western hegemony. In the end, the mandate system helped to create the world in which we now live. A riveting work of global history, The Guardians enables us to look back at the League with new eyes, and in doing so, appreciate how complex, multivalent, and consequential this first great experiment in internationalism really was"--
    Keywords Anti-imperialist movements/History ; Colonies/History ; Imperialism/History ; International relations/History ; Internationalism/History ; Mandates/History ; World politics
    Language English
    Size XIV, 571 S, Ill., graph. Darst., Kt
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Document type Book
    Note Includes bibliographical references S. [519] - 546 and index
    ISBN 9780199730032 ; 0199730032
    Database Former special subject collection: coastal and deep sea fishing

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