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Article ; Online: Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography.

Wang, Jeffrey B / Hassan, Umair / Bruss, Joel E / Oya, Hiroyuki / Uitermarkt, Brandt D / Trapp, Nicholas T / Gander, Phillip E / Howard, Matthew A / Keller, Corey J / Boes, Aaron D

Molecular psychiatry

2024

Abstract: Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the neurophysiological effects of TMS using ... ...

Abstract	Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the neurophysiological effects of TMS using intracranial electrocorticography (iEEG) in neurosurgical patients. We first evaluated safety in a gel-based phantom. We then performed TMS-iEEG in 22 neurosurgical participants with no adverse events. We next evaluated intracranial responses to single pulses of TMS to the dorsolateral prefrontal cortex (dlPFC) (N = 10, 1414 electrodes). We demonstrate that TMS is capable of inducing evoked potentials both locally within the dlPFC and in downstream regions functionally connected to the dlPFC, including the anterior cingulate and insular cortex. These downstream effects were not observed when stimulating other distant brain regions. Intracranial dlPFC electrical stimulation had similar timing and downstream effects as TMS. These findings support the safety and promise of TMS-iEEG in humans to examine local and network-level effects of TMS with higher spatiotemporal resolution than currently available methods.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02405-y
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Zs.A 4812: Show issues

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Article ; Online: Advances in analytical chemistry?

Corey, Howard E

American journal of physiology. Renal physiology

2010 Volume 298, Issue 2, Page(s) F474

MeSH term(s)	Chemistry, Analytic/history ; Chemistry, Analytic/trends ; History, 19th Century
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Historical Article ; Letter
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00235.2009
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Article: The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA).

Corey, Howard E

The Journal of laboratory and clinical medicine

2006 Volume 147, Issue 3, Page(s) 121–125

Abstract: Although "unmeasured" anions contribute to metabolic acidosis in a variety of disease states, they are generally not measured directly but estimated from the calculation of "gaps." Among the most commonly used method, the anion gap (AG) is not only a ... ...

Abstract	Although "unmeasured" anions contribute to metabolic acidosis in a variety of disease states, they are generally not measured directly but estimated from the calculation of "gaps." Among the most commonly used method, the anion gap (AG) is not only a function of "unmeasured" anions, but also it is a function of plasma non-carbonate buffers (albumin and phosphate), the plasma pH, and the method of measurement. To clarify the contribution of non-carbonate buffers to the AG, the Figge-Fencl-Waston model of human plasma was applied to laboratory values obtained from two novel populations, patients with nephrotic syndrome and patients with diabetic ketoacidosis (DKA). The model performed adequately, justifying the common clinical practice of correcting the AG for the net protein charge.
MeSH term(s)	Acetoacetates/blood ; Acid-Base Equilibrium ; Adolescent ; Adult ; Anions/metabolism ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/metabolism ; Diabetic Ketoacidosis/metabolism ; Female ; Humans ; Infant ; Male ; Nephrotic Syndrome/metabolism ; Regression Analysis ; Sensitivity and Specificity
Chemical Substances	Acetoacetates ; Anions ; acetoacetic acid (4ZI204Y1MC)
Language	English
Publishing date	2006-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	80208-6
ISSN	1532-6543 ; 0022-2143
ISSN (online)	1532-6543
ISSN	0022-2143
DOI	10.1016/j.lab.2005.10.004
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Article ; Online: Bench-to-bedside review: Fundamental principles of acid-base physiology.

Corey, Howard E

Critical care (London, England)

2005 Volume 9, Issue 2, Page(s) 184–192

Abstract: Complex acid-base disorders arise frequently in critically ill patients, especially in those with multiorgan failure. In order to diagnose and treat these disorders better, some intensivists have abandoned traditional theories in favor of revisionist ... ...

Abstract	Complex acid-base disorders arise frequently in critically ill patients, especially in those with multiorgan failure. In order to diagnose and treat these disorders better, some intensivists have abandoned traditional theories in favor of revisionist models of acid-base balance. With claimed superiority over the traditional approach, the new methods have rekindled debate over the fundamental principles of acid-base physiology. In order to shed light on this controversy, we review the derivation and application of new models of acid-base balance.
MeSH term(s)	Acid-Base Equilibrium/physiology ; Buffers ; Humans ; Hydrogen-Ion Concentration ; Infant, Newborn ; Ions ; Models, Biological ; Software
Chemical Substances	Buffers ; Ions
Language	English
Publishing date	2005-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2051256-9
ISSN	1466-609X ; 1466-609X
ISSN (online)	1466-609X
ISSN	1466-609X
DOI	10.1186/cc2985
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Article ; Online: Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth.

The Journal of clinical investigation

2021 Volume 131, Issue 12

Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI151719
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Article: Stewart and beyond: new models of acid-base balance.

Corey, Howard E

Kidney international

2003 Volume 64, Issue 3, Page(s) 777–787

Abstract: The Henderson-Hasselbalch equation and the base excess have been used traditionally to describe the acid-base balance of the blood. In 1981, Stewart proposed a new model of acid-base balance based upon three variables, the "strong ion difference" (SID), ... ...

Abstract	The Henderson-Hasselbalch equation and the base excess have been used traditionally to describe the acid-base balance of the blood. In 1981, Stewart proposed a new model of acid-base balance based upon three variables, the "strong ion difference" (SID), the total weak acids (ATot), and the partial pressure of carbon dioxide (Pco2). Over 20 years later, Stewart's physiochemical model still remains largely unknown. In this review, we will present both the traditional and the Stewart models of acid-base balance and then derive each using an "ion equilibrium method." Modern theories of acid-base balance may be useful toward the understanding of complex acid-base disorders.
MeSH term(s)	Acid-Base Equilibrium ; Animals ; Humans ; Ions ; Models, Biological ; Nephrology/trends
Chemical Substances	Ions
Language	English
Publishing date	2003-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1046/j.1523-1755.2003.00177.x
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Zs.A 797: Show issues

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Article ; Online: Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience.

Rosenberg, Ari J / Agrawal, Nishant / Pearson, Alexander / Gooi, Zhen / Blair, Elizabeth / Cursio, John / Juloori, Aditya / Ginat, Daniel / Howard, Adam / Chin, Jeffrey / Kochanny, Sara / Foster, Corey / Cipriani, Nicole / Lingen, Mark / Izumchenko, Evgeny / Seiwert, Tanguy Y / Haraf, Daniel / Vokes, Everett E

Oral oncology

2021 Volume 122, Page(s) 105566

Abstract: Background: Favorable prognosis for Human papillomavirus-associated (HPV+) oropharyngeal cancer (OPC) led to investigation of response-adaptive de-escalation, yet long-term outcomes are unknown. We present expanded experience and follow-up of risk/ ... ...

Abstract	Background: Favorable prognosis for Human papillomavirus-associated (HPV+) oropharyngeal cancer (OPC) led to investigation of response-adaptive de-escalation, yet long-term outcomes are unknown. We present expanded experience and follow-up of risk/response adaptive treatment de-intensification in HPV+ OPC. Methods: A phase 2 trial (OPTIMA) and subsequent cohort of sequential off-protocol patients treated from September 2014 to November 2018 at the University of Chicago were reviewed. Eligible patients had T3-T4 or N2-3 (AJCC 7th edition) HPV+ OPC. Patients were stratified by risk: High-risk (HR) (T4, ≥N2c, or >10PYH), all others low-risk (LR). Induction chemotherapy (IC) included 3 cycles of carboplatin and nab-paclitaxel (OPTIMA) or paclitaxel (off-protocol). LR with ≥50% response received low-dose radiotherapy (RT) alone to 50 Gy (RT50). LR with 30-50% response and HR with ≥50% response received intermediate-dose chemoradiotherapy (CRT) to 45 Gy (CRT45). All others received full-dose CRT to 75 Gy (CRT75). Results: 91 patients consented and 90 patients were treated, of which 31% had >10PYH, 34% had T3/4 disease, and 94% had N2b/N2c/N3 disease. 49% were LR and 51% were HR. Overall response rate to induction was 88%. De-escalated treatment was administered to 83%. Median follow-up was 4.2 years. Five-year OS, PFS, LRC, and DC were 90% (95% CI 81,95), 90% (95% CI 80,95), 96% (95% CI 90,99), and 96% (88,99) respectively. G-tube placement rates in RT50, CRT45, and CRT75 were 3%, 33%, and 80% respectively (p < 0.05). Conclusion: Risk/response adaptive de-escalated treatment for an inclusive cohort of HPV+ OPC demonstrates excellent survival with reduced toxicity with long-term follow-up.
MeSH term(s)	Alphapapillomavirus ; Chemoradiotherapy ; Humans ; Oropharyngeal Neoplasms/therapy ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/complications ; Papillomavirus Infections/therapy
Language	English
Publishing date	2021-10-18
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2021.105566
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth.

The Journal of clinical investigation

2021 Volume 131, Issue 10

Abstract: Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR of the activating ligands testosterone (T) and dihydrotestosterone (DHT) ... ...

Abstract	Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR of the activating ligands testosterone (T) and dihydrotestosterone (DHT) by limiting their biosynthesis or blocking AR binding. Notably, AR signaling is dichotomous, inducing growth at lower activity levels, while suppressing growth at higher levels. Recent clinical studies have exploited this effect by administration of supraphysiological concentrations of T, resulting in clinical responses and improvements in quality of life. However, the use of T as a therapeutic agent in oncology is limited by poor drug-like properties as well as rapid and variable metabolism. Here, we investigated the antitumor effects of selective AR modulators (SARMs), which are small-molecule nonsteroidal AR agonists developed to treat muscle wasting and cachexia. Several orally administered SARMs activated the AR program in PC models. AR cistromes regulated by steroidal androgens and SARMs were superimposable. Coregulatory proteins including HOXB13 and GRHL2 comprised AR complexes assembled by both androgens and SARMs. At bioavailable concentrations, SARMs repressed MYC oncoprotein expression and inhibited the growth of castration-sensitive and castration-resistant PC in vitro and in vivo. These results support further clinical investigation of SARMs for treating advanced PC.
MeSH term(s)	Androgens/pharmacology ; Animals ; Cell Line, Tumor ; Dihydrotestosterone/metabolism ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Proteins/agonists ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics
Chemical Substances	Androgens ; Neoplasm Proteins ; Receptors, Androgen ; Dihydrotestosterone (08J2K08A3Y)
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI146777
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Book: Planning for locational change in the delivery of medical care

Corey, Kenneth E. / Stafford, Howard A.

a selected bibliography

(Exchange bibliography ; 100)

1969

Author's details	by Kenneth E. Corey and Howard A. Stafford
Series title	Exchange bibliography ; 100
Collection
Language	English
Publisher	Council of Planning Librarians
Publishing place	Monticello, Ill
Publishing country	United States
Document type	Book
HBZ-ID	HT008226060
Database	Catalogue ZB MED Medicine, Health

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1980 A 989	order for loan	Magazin

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Article ; Online: Follistatin and Soluble Endoglin Predict 1-Year Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation.

Newell, Laura F / DeFor, Todd E / Cutler, Corey / Verneris, Michael R / Blazar, Bruce R / Miller, Jeff S / Antin, Joseph H / Howard, Alan / Wu, Juan / MacMillan, Margaret L / Panoskaltsis-Mortari, Angela / Weisdorf, Daniel J / Holtan, Shernan G

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2019 Volume 26, Issue 3, Page(s) 606–611

Abstract: Damage-associated angiogenic factors (AFs), including follistatin (FS) and soluble endoglin (sEng), are elevated in circulation at the onset of acute graft-versus-host disease (GVHD). We hypothesized that regimen-related tissue injury also might be ... ...

Abstract	Damage-associated angiogenic factors (AFs), including follistatin (FS) and soluble endoglin (sEng), are elevated in circulation at the onset of acute graft-versus-host disease (GVHD). We hypothesized that regimen-related tissue injury also might be associated with aberrant AF levels and sought to determine the relevance of these AF on nonrelapse mortality (NRM) in patients with acute GVHD and those without acute GVHD. To test our hypothesis, we analyzed circulating levels of FS, sEng, angiopoietin-2 (Ang2), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) A and B, placental growth factor (PlGF), and soluble VEGF receptor (sVEGFR)-1 and -2, in plasma samples from patients enrolled on Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0402 (n = 221), which tested GVHD prophylaxis after myeloablative hematopoietic stem cell transplantation (HCT). We found that the interaction between FS and sEng had an additive effect in their association with 1-year NRM. In multivariate analysis, patients with the highest levels of day +28 FS and sEng had a 14.9-fold greater hazard ratio (HR) of NRM (95% confidence interval, 3.2 to 69.4; P < .01) when compared with low levels of FS and sEng. We validated these findings using an external cohort of patients (n = 106). Pre-HCT measurements of FS and sEng were not associated with NRM, suggesting that elevations in these factors early post-HCT may be consequences of early regimen-related toxicity. Determining the mechanisms responsible for patient-specific vulnerability to treatment toxicities and endothelial damage associated with specific AF elevation may guide interventions to reduce NRM post-HCT.
MeSH term(s)	Endoglin ; Female ; Follistatin ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Placenta Growth Factor ; Transplantation Conditioning ; Vascular Endothelial Growth Factor A
Chemical Substances	Endoglin ; Follistatin ; Vascular Endothelial Growth Factor A ; Placenta Growth Factor (144589-93-5)
Language	English
Publishing date	2019-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2019.11.006
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Zs.A 5082: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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