LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article ; Online: High-Temporal-Resolution Kinetic Modeling of Lung Tumors with Dual-Blood Input Function Using Total-Body Dynamic PET.

Wang, Yiran / Abdelhafez, Yasser G / Spencer, Benjamin A / Verma, Rashmi / Parikh, Mamta / Stollenwerk, Nicholas / Nardo, Lorenzo / Jones, Terry / Badawi, Ramsey D / Cherry, Simon R / Wang, Guobao

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 5, Page(s) 714–721

Abstract: The lungs are supplied by both the pulmonary arteries carrying deoxygenated blood originating from the right ventricle and the bronchial arteries carrying oxygenated blood downstream from the left ventricle. However, this effect of dual blood supply has ... ...

Abstract	The lungs are supplied by both the pulmonary arteries carrying deoxygenated blood originating from the right ventricle and the bronchial arteries carrying oxygenated blood downstream from the left ventricle. However, this effect of dual blood supply has never been investigated using PET, partially because the temporal resolution of conventional dynamic PET scans is limited. The advent of PET scanners with a long axial field of view, such as the uEXPLORER total-body PET/CT system, permits dynamic imaging with high temporal resolution (HTR). In this work, we modeled the dual-blood input function (DBIF) and studied its impact on the kinetic quantification of normal lung tissue and lung tumors using HTR dynamic PET imaging.
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/metabolism ; Male ; Female ; Middle Aged ; Kinetics ; Positron-Emission Tomography/methods ; Models, Biological ; Adult ; Fluorodeoxyglucose F18 ; Aged ; Whole Body Imaging ; Positron Emission Tomography Computed Tomography ; Image Processing, Computer-Assisted ; Time Factors ; Radiopharmaceuticals/pharmacokinetics
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.267036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Stability of Whole Blood Lactate Specimens at Room Temperature Versus Slushed Ice Conditions.

Zavorsky, Gerald S / Gasparyan, Samuel / Stollenwerk, Nicholas S / Brooks, Rebecca A

Respiratory care

2020 Volume 66, Issue 3, Page(s) 494–500

Abstract: Background: There are limited data on lactate stability in whole blood. The purpose of this study was to determine whole blood lactate stability at room temperature and in slushed ice conditions.: Methods: An equal number of arterial and venous ... ...

Abstract	Background: There are limited data on lactate stability in whole blood. The purpose of this study was to determine whole blood lactate stability at room temperature and in slushed ice conditions. Methods: An equal number of arterial and venous samples were obtained from 202 subjects hospitalized for various pathophysiological conditions. Whole blood lactate concentration was measured over 5 different times spanning 80-90 min in a blood gas lab at a major hospital center. Samples were stored at room temperature (22-24°C) or in slushed ice conditions (0.1-0.2°C) before analysis. Results: The mean increase in lactate concentration was 0.001 mmol/L/min in samples on slushed ice over 90 min. However, at room temperature conditions, the mean increase in lactate concentration was 0.008 mmol/L/min regardless of whether the sample was arterial or venous. An increase in whole blood lactate concentration of ≥ 0.4 mmol/L occured after 45 min at room temperature, with 5% of all whole blood specimens demonstrating a meaningful change at ≤ 20 min. The ≥ 0.4 mmol/L change in whole blood lactate is considered significant based on the College of American Pathologists instrument peer-group standards. Conclusions: Considering that a change in whole blood lactate concentration of ≥ 0.4 mmol/L is unacceptable instrument peer-group variation as defined by the College of American Pathologists, ice is no longer needed to stabilize whole blood lactate specimens when the draw time to analyze time is < 45 min. Samples remain stable even at 90 min when left on ice.
MeSH term(s)	Humans ; Ice ; Lactic Acid ; Temperature
Chemical Substances	Ice ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.08023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2285: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Case of Osimertinib-Induced Eosinophilic Pneumonia.

Patel, Kanishka G / Corbett, Rebecca L / Karanjawala, Zarir E / Kelly, Karen A / Stollenwerk, Nicholas / Riess, Jonathan W

Clinical lung cancer

2022 Volume 23, Issue 7, Page(s) 639–642

MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; Pulmonary Eosinophilia/chemically induced ; Pulmonary Eosinophilia/diagnosis ; Acrylamides/adverse effects ; Aniline Compounds/adverse effects ; Protein Kinase Inhibitors/adverse effects
Chemical Substances	osimertinib (3C06JJ0Z2O) ; Acrylamides ; Aniline Compounds ; Protein Kinase Inhibitors
Language	English
Publishing date	2022-08-07
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2022.07.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 440: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions.

Zavorsky, Gerald S / van Wijk, Xander M R / Gasparyan, Samuel / Stollenwerk, Nicholas S / Brooks, Rebecca A

The journal of applied laboratory medicine

2021 Volume 7, Issue 2, Page(s) 541–554

Abstract: Background: Data on the stability of whole blood electrolytes is limited to small sample sizes. We sought to determine the stability of whole blood electrolytes under room temperature and slushed iced conditions in human patients at a major hospital ... ...

Abstract	Background: Data on the stability of whole blood electrolytes is limited to small sample sizes. We sought to determine the stability of whole blood electrolytes under room temperature and slushed iced conditions in human patients at a major hospital center. Methods: Whole blood samples were obtained from 203 patients hospitalized for various pathophysiological conditions. Electrolyte concentrations of sodium, potassium [K+], ionized calcium, and chloride were measured at 5 different timepoints spanning 3 h. Samples were stored at room temperature (22-24 °C) or under slushed ice conditions (0.1-0.2 °C) before analysis. Results: Under both conditions, sodium, ionized calcium, and chloride did not show a measurable change up to 109 min compared to baseline; however, the mean increase in [K+] over 138 min of storage in slushed ice was 0.0032 (0.0021 [5th percentile] to 0.0047 [95th percentile]) mmol/L/min (adjusted R2 = 0.62, P < 0.001). Five percent of the specimens demonstrated a ≥0.3 mmol/L change in [K+] from baseline after 67 min of storage in slushed ice. In contrast, 1% of the specimens stored at room temperature showed the same change at the same timepoint. Conclusions: Whole blood sodium, [K+], ionized calcium, and chloride concentrations remain stable for at least 109 min at room temperature. However, whole blood specimens stored in slushed ice for not more than 67 min exhibit a 5% probability that the [K+] concentration will increase by at least 0.3 mmol/L compared to baseline. The other analytes do not destabilize for up to 178 min of slushed ice storage.
MeSH term(s)	Calcium ; Chlorides ; Electrolytes ; Humans ; Ice ; Sodium ; Temperature
Chemical Substances	Chlorides ; Electrolytes ; Ice ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-08-27
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfab089
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Emerging precision neoadjuvant systemic therapy for patients with resectable non-small cell lung cancer: current status and perspectives.

Godoy, Luis A / Chen, Joy / Ma, Weijie / Lally, Jag / Toomey, Kyra A / Rajappa, Prabhu / Sheridan, Roya / Mahajan, Shirish / Stollenwerk, Nicholas / Phan, Chinh T / Cheng, Danny / Knebel, Robert J / Li, Tianhong

Biomarker research

2023 Volume 11, Issue 1, Page(s) 7

Abstract: Over the past decade, targeted therapy for oncogene-driven NSCLC and immune checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved the survival and quality of life for patients with unresectable NSCLC. Increasingly, ... ...

Abstract	Over the past decade, targeted therapy for oncogene-driven NSCLC and immune checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved the survival and quality of life for patients with unresectable NSCLC. Increasingly, these biomarker-guided systemic therapies given before or after surgery have been used in patients with early-stage NSCLC. In March 2022, the US FDA granted the approval of neoadjuvant nivolumab and chemotherapy for patients with stage IB-IIIA NSCLC. Several phase II/III trials are evaluating the clinical efficacy of various neoadjuvant immune checkpoint inhibitor combinations for non-oncogene-driven NSCLC and neoadjuvant molecular targeted therapies for oncogene-driven NSCLC, respectively. However, clinical application of precision neoadjuvant treatment requires a paradigm shift in the biomarker testing and multidisciplinary collaboration at the diagnosis of early-stage NSCLC. In this comprehensive review, we summarize the current diagnosis and treatment landscape, recent advances, new challenges in biomarker testing and endpoint selections, practical considerations for a timely multidisciplinary collaboration at diagnosis, and perspectives in emerging neoadjuvant precision systemic therapy for patients with resectable, early-stage NSCLC. These biomarker-guided neoadjuvant therapies hold the promise to improve surgical and pathological outcomes, reduce systemic recurrences, guide postoperative therapy, and improve cure rates in patients with resectable NSCLC.
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-022-00444-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Safety and Efficacy of Osimertinib in the Treatment of a Patient With Metastatic Lung Cancer and Concurrent Somatic

Ma, Weijie / Gong, Jay / Shan, Jidong / Lewis, Debbie / Xiao, Wenwu / Moore, Elizabeth H / Zhang, Yanhong / Hung, Jamie / Mans, Nicole Z / Wei, Sixi / Welborn, Jenna / Stollenwerk, Nicholas S / Lam, Kit S / Li, Tianhong

JCO precision oncology

2022 Volume 2, Page(s) 1–7

Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.18.00076
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A fresh look at paralytics in the critically ill: real promise and real concern.

Price, David / Kenyon, Nicholas J / Stollenwerk, Nicholas

Annals of intensive care

2012 Volume 2, Issue 1, Page(s) 43

Abstract: Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails. Despite the publication of guidelines on the use of NMBAs in the ICU in 2002, clinicians have ... ...

Abstract	Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails. Despite the publication of guidelines on the use of NMBAs in the ICU in 2002, clinicians have needed more direction to determine which patients would benefit from NMBAs and which patients would be harmed. Recently, new evidence has shown that paralytics hold more promise when used in carefully selected lung injury patients for brief periods of time. When used in early acute respiratory distress syndrome (ARDS), NMBAs assist to establish a lung protective strategy, which leads to improved oxygenation, decreased pulmonary and systemic inflammation, and potentially improved mortality. It also is increasingly recognized that NMBAs can cause harm, particularly critical illness polyneuromyopathy (CIPM), when used for prolonged periods or in septic shock. In this review, we address several practical considerations for clinicians who use NMBAs in their practice. Ultimately, we conclude that NMBAs should be considered a lung protective adjuvant in early ARDS and that clinicians should consider using an alternative NMBA to the aminosteroids in septic shock with less severe lung injury pending further studies.
Language	English
Publishing date	2012-10-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820 ; 2110-5820
ISSN (online)	2110-5820
ISSN	2110-5820
DOI	10.1186/2110-5820-2-43
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Simulation in procedural training: at the tipping point.

Murin, Susan / Stollenwerk, Nicholas S

Chest

2010 Volume 137, Issue 5, Page(s) 1009–1011

MeSH term(s)	Bronchoscopy ; Catheterization, Central Venous ; Clinical Competence/standards ; Humans ; Manikins ; Medical Staff/education ; Pulmonary Medicine/education ; Pulmonary Medicine/instrumentation
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.10-0199
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 349: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Acute febrile respiratory illness in the ICU: reducing disease transmission.

Sandrock, Christian / Stollenwerk, Nicholas

Chest

2008 Volume 133, Issue 5, Page(s) 1221–1231

Abstract: Acute febrile respiratory illness (FRI) leading to respiratory failure is a common reason for admission to the ICU. Viral pneumonia constitutes a portion of these cases, and often the viral etiology goes undiagnosed. Emerging viral infectious diseases ... ...

Abstract	Acute febrile respiratory illness (FRI) leading to respiratory failure is a common reason for admission to the ICU. Viral pneumonia constitutes a portion of these cases, and often the viral etiology goes undiagnosed. Emerging viral infectious diseases such as severe acute respiratory syndrome and avian influenza present with acute FRIs progressing to respiratory failure and ARDS. Therefore, early recognition of a viral cause of acute FRI leading to ARDS becomes important for protection of health-care workers (HCWs), lessening spread to other patients, and notification of public health officials. These patients often have longer courses of viral shedding and undergo higher-risk procedures that may potentially generate aerosols, such as intubation, bronchoscopy, bag-valve mask ventilation, noninvasive positive pressure ventilation, and medication nebulization, further illustrating the importance of early detection and isolation. A small number of viral agents lead to acute FRI, respiratory failure, and ARDS: seasonal influenza, avian influenza, coronavirus associated with severe ARDS, respiratory syncytial virus, adenovirus, varicella, human metapneumovirus, and hantavirus. A systematic approach to early isolation, testing for these agents, and public health involvement becomes important in dealing with acute FRI. Ultimately, this approach will lead to improved HCW protection, reduction of transmission to other patients, and prevention of transmission in the community.
MeSH term(s)	Disease Outbreaks ; Humans ; Infection Control/methods ; Intensive Care Units ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/transmission ; Respiratory Tract Infections/virology
Keywords	covid19
Language	English
Publishing date	2008-05-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.07-0778
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 349: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.

O'Hara, Steven P / Splinter, Patrick L / Trussoni, Christy E / Guicciardi, Maria Eugenia / Splinter, Noah P / Al Suraih, Mohammed S / Nasser-Ghodsi, Navine / Stollenwerk, Deborah / Gores, Gregory J / LaRusso, Nicholas F

The Journal of biological chemistry

2019 Volume 294, Issue 49, Page(s) 18698–18713

Abstract: Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS proto-oncogene 1 ( ... ...

Abstract	Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS proto-oncogene 1 (ETS1) and associated with overexpression of BCL2 like 1 (BCL2L1 or BCL-xL), an anti-apoptotic BCL2-family member. Here, we further explored the mechanisms regulating BCL-xL-mediated, apoptosis resistance in senescent cholangiocytes and uncovered that ETS1 and the histone acetyltransferase E1A-binding protein P300 (EP300 or p300) both promote
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Lipopolysaccharides/pharmacology ; Liver/drug effects ; Liver/metabolism ; Mice ; Proto-Oncogene Mas ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-1/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism ; ATP-Binding Cassette Sub-Family B Member 4
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B ; Lipopolysaccharides ; MAS1 protein, human ; Proto-Oncogene Mas ; Proto-Oncogene Protein c-ets-1 ; Transcription Factors ; bcl-X Protein
Language	English
Publishing date	2019-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.010176
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito