LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48

Search options

  1. Article ; Online: Seizures Cause Prolonged Impairment of Ventilation, CO

    Teran, Frida A / Sainju, Rup K / Bravo, Eduardo / Wagnon, Jacy / Kim, YuJaung / Granner, Alex / Gehlbach, Brian K / Richerson, George B

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 27, Page(s) 4959–4971

    Abstract: Sudden unexpected death in epilepsy (SUDEP) has been linked to respiratory dysfunction, but the mechanisms underlying this association remain unclear. Here we found that both focal and generalized convulsive seizures (GCSs) in epilepsy patients caused a ... ...

    Abstract Sudden unexpected death in epilepsy (SUDEP) has been linked to respiratory dysfunction, but the mechanisms underlying this association remain unclear. Here we found that both focal and generalized convulsive seizures (GCSs) in epilepsy patients caused a prolonged decrease in the hypercapnic ventilatory response (HCVR; a measure of respiratory CO
    MeSH term(s) Male ; Female ; Mice ; Animals ; Sudden Unexpected Death in Epilepsy ; Serotonin/pharmacology ; Carbon Dioxide/pharmacology ; Hypothermia/complications ; Seizures ; Respiration ; Epilepsy ; Respiration Disorders ; Death, Sudden/etiology ; Fenfluramine/pharmacology ; Serotonergic Neurons/physiology ; Body Temperature Regulation ; NAV1.6 Voltage-Gated Sodium Channel
    Chemical Substances Serotonin (333DO1RDJY) ; Carbon Dioxide (142M471B3J) ; Fenfluramine (2DS058H2CF) ; Scn8a protein, mouse ; NAV1.6 Voltage-Gated Sodium Channel ; Scn1a protein, mouse
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0450-23.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Erratum to "Looking for light in the din: An examination of the circadian-disrupting properties of a medical intensive care unit" [Intensive Crit. Care Nurs. 46 (2018) 57-63].

    Danielson, Samantha J / Rappaport, Charles A / Loher, Michael K / Gehlbach, Brian K

    Intensive & critical care nursing

    2020  Volume 59, Page(s) 102834

    Language English
    Publishing date 2020-04-07
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2020.102834
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2818: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Corrigendum to "Looking for light in the din: An examination of the circadian-disrupting properties of a medical intensive care unit" [Intensive Crit. Care Nurs. 46 (2018) 57-63].

    Danielson, Samantha J / Rappaport, Charles A / Loher, Michael K / Gehlbach, Brian K

    Intensive & critical care nursing

    2020  Volume 59, Page(s) 102832

    Language English
    Publishing date 2020-04-07
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2020.102832
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2818: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Use of Fluoxetine to Augment the Inter-Ictal Hypercapnic Ventilatory Response in Patients with Epilepsy: A Pilot Study.

    Sainju, Rup K / Dragon, Deidre N / Winnike, Harold B / Eyck, Patrick Ten / Granner, Mark A / Gehlbach, Brian K / Richerson, George B

    Neurology India

    2022  Volume 70, Issue 5, Page(s) 2125–2129

    Abstract: Background: Severe peri-ictal respiratory dysfunction is a potential biomarker for high SUDEP risk and correlates with an attenuated hypercapnic ventilatory response (HCVR). Prior studies suggest a potential role for selective serotonergic reuptake ... ...

    Abstract Background: Severe peri-ictal respiratory dysfunction is a potential biomarker for high SUDEP risk and correlates with an attenuated hypercapnic ventilatory response (HCVR). Prior studies suggest a potential role for selective serotonergic reuptake inhibitors in modifying the HCVR, but this approach has not been studied in the epilepsy population.
    Objectives: To assess the feasibility of using fluoxetine to augment HCVR in epilepsy patients.
    Methods and material: An inter-ictal HCVR was measured using a CO
    Results: Of the 30 subjects enrolled, 22 were randomized (mean: 3.8 subjects/3 months), with a retention rate of 100% in fluoxetine and 95% in placebo.
    Conclusions: Our results demonstrate feasibility for a larger definitive future study to assess the efficacy of fluoxetine in augmenting HCVR.
    MeSH term(s) Humans ; Fluoxetine/therapeutic use ; Pilot Projects ; Carbon Dioxide/physiology ; Hypercapnia/drug therapy ; Epilepsy/drug therapy
    Chemical Substances Fluoxetine (01K63SUP8D) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-11-09
    Publishing country India
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.359160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Prevalence and Risk Factors of Poor Sleep Quality in Collegiate Athletes during COVID-19 Pandemic: A Cross-Sectional Study.

    Melone, Marie-Anne / Tourny, Claire / Gehlbach, Brian K / Schmidt, Eli L / Lalevée, Matthieu / L'Hermette, Maxime

    International journal of environmental research and public health

    2022  Volume 19, Issue 5

    Abstract: The COVID-19 pandemic has changed our lifestyle, sleep and physical activity habits. This study evaluated the prevalence of poor sleep quality, its disrupters, and the impact of the pandemic in collegiate athletes. We performed a cross-sectional study of ...

    Abstract The COVID-19 pandemic has changed our lifestyle, sleep and physical activity habits. This study evaluated the prevalence of poor sleep quality, its disrupters, and the impact of the pandemic in collegiate athletes. We performed a cross-sectional study of collegiate athletes (N = 339, median age: 20 (IQR,19−21) years old, 48.5% female, 47% individual sports) who received a web-based questionnaire in April 2021. This survey included subject characteristics, chronotype, sleep disrupters, the changes due to the pandemic and sleep quality (Pittsburg Sleep Quality Index [PSQI]). A multivariate linear regression was performed to assess the relationship between sleep quality, gender, chronotype, sleep disrupters and the changes to training volume or sleep. Results showed a disrupted sleep quality in 63.7%. One in five students had a total sleep time under 6.5 h per night. Poor sleep quality was significantly correlated with nocturnal concerns related to the pandemic, evening chronotype, female gender, third year of study, caffeine consumption and lack of sleep routine (all p < 0.05). To conclude, poor sleep quality is common in collegiate athletes. Sleep disrupters remain prevalent in the lifestyle habits of this population and may have been exacerbated by changes related to the COVID-19 pandemic. Sleep hygiene should become a major aspect of sports education during the return to post-covid normality.
    MeSH term(s) Adult ; Athletes ; COVID-19/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Pandemics ; Prevalence ; Risk Factors ; SARS-CoV-2 ; Sleep Quality ; Young Adult
    Language English
    Publishing date 2022-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19053098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Response.

    Hansdottir, Sif / Gehlbach, Brian K

    Chest

    2014  Volume 145, Issue 2, Page(s) 420–421

    MeSH term(s) Humans ; Hypertension, Pulmonary/classification ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/drug therapy
    Language English
    Publishing date 2014-02-03
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.13-2519
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Response.

    Hansdottir, Sif / Gehlbach, Brian K

    Chest

    2014  Volume 145, Issue 2, Page(s) 433

    MeSH term(s) Humans ; Hypertension, Pulmonary/classification ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/drug therapy
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.13-2694
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Interictal respiratory variability predicts severity of hypoxemia after generalized convulsive seizures.

    Sainju, Rup K / Dragon, Deidre N / Winnike, Harold B / Vilella, Laura / Li, Xiaojin / Lhatoo, Samden / Ten Eyck, Patrick / Wendt, Linder H / Richerson, George B / Gehlbach, Brian K

    Epilepsia

    2023  Volume 64, Issue 9, Page(s) 2373–2384

    Abstract: Objective: Severe respiratory dysfunction induced by generalized convulsive seizures (GCS) is now thought to be a common mechanism for sudden unexpected death in epilepsy (SUDEP). In a mouse model of seizure-induced death, increased interictal ... ...

    Abstract Objective: Severe respiratory dysfunction induced by generalized convulsive seizures (GCS) is now thought to be a common mechanism for sudden unexpected death in epilepsy (SUDEP). In a mouse model of seizure-induced death, increased interictal respiratory variability was reported in mice that later died of respiratory arrest after GCS. We studied respiratory variability in epilepsy patients as a predictive tool for severity of postictal hypoxemia, a potential biomarker for SUDEP risk. We then explored the relationship between respiratory variability and central CO
    Methods: We reviewed clinical, video-electroencephalography, and respiratory (belts, airflow, pulse oximeter, and HCVR) data of epilepsy patients. Mean, SD, and coefficient of variation (CV) of interbreath interval (IBI) were calculated. Primary outcomes were: (1) nadir of capillary oxygen saturation (SpO
    Results: Of 66 GCS recorded in 131 subjects, 30 had interpretable respiratory data. In the multivariate model with the lowest AIC value, duration of epilepsy was a significant predictor of duration of oxygen desaturation. Duration of tonic phase and CV of IBI during the third postictal minute correlated with SpO
    Significance: These results indicate that interictal respiratory variability predicts severity of postictal oxygen desaturation, suggesting its utility as a potential biomarker. They also suggest that interictal respiratory control may be abnormal in some patients with epilepsy.
    MeSH term(s) Humans ; Electroencephalography/methods ; Epilepsy ; Epilepsy, Generalized ; Hypercapnia ; Hypoxia ; Oxygen ; Respiration Disorders ; Seizures ; Sudden Unexpected Death in Epilepsy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17691
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Sudden unexpected death in epilepsy: basic mechanisms and clinical implications for prevention.

    Dlouhy, Brian J / Gehlbach, Brian K / Richerson, George B

    Journal of neurology, neurosurgery, and psychiatry

    2016  Volume 87, Issue 4, Page(s) 402–413

    Abstract: Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with intractable epilepsy. The substantial lifetime risk of SUDEP and the lack of a clear pathophysiological connection between epilepsy itself and sudden death ... ...

    Abstract Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with intractable epilepsy. The substantial lifetime risk of SUDEP and the lack of a clear pathophysiological connection between epilepsy itself and sudden death have fuelled increased attention to this phenomenon. Understanding the mechanisms underlying SUDEP is paramount to developing preventative strategies. In this review, we discuss SUDEP population studies, case-control studies, witnessed and monitored cases, as well as human seizure cardiorespiratory findings related to SUDEP, and SUDEP animal models. We integrate these data to suggest the most probable mechanisms underlying SUDEP. Understanding the modifiable risk factors and pathophysiology allows us to discuss potential preventative strategies.
    MeSH term(s) Death, Sudden/epidemiology ; Death, Sudden/etiology ; Death, Sudden/prevention & control ; Epilepsy/complications ; Epilepsy/therapy ; Humans ; Risk Factors
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2013-307442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.93: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.

    Knauert, Melissa P / Ayas, Najib T / Bosma, Karen J / Drouot, Xavier / Heavner, Mojdeh S / Owens, Robert L / Watson, Paula L / Wilcox, M Elizabeth / Anderson, Brian J / Cordoza, Makayla L / Devlin, John W / Elliott, Rosalind / Gehlbach, Brian K / Girard, Timothy D / Kamdar, Biren B / Korwin, Amy S / Lusczek, Elizabeth R / Parthasarathy, Sairam / Spies, Claudia /
    Sunderram, Jag / Telias, Irene / Weinhouse, Gerald L / Zee, Phyllis C

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 7, Page(s) e49–e68

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; United States ; Sleep ; Polysomnography ; Societies, Medical
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202301-0184ST
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top