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Article: A new brain CT reference line: the lower eyelid to the inner occipital base line closely parallels the Talairach-Tournoux line.

Ishizaka, Hiroshi / Naka, Minoru / Nagase, Hiroyuki / Yanagisawa, Katsumi / Kubota, Toshio / Morita, Hideo / Tsushima, Yoshito

Acta radiologica open

2020 Volume 9, Issue 1, Page(s) 2058460120902406

Abstract: Background: There is no standardized brain computed tomography (CT) reference line that can be determined on both scout and reformatted sagittal CT images. Here, a tangential line from the anterior edge of the lower eyelid to the inner table of the ... ...

Abstract	Background: There is no standardized brain computed tomography (CT) reference line that can be determined on both scout and reformatted sagittal CT images. Here, a tangential line from the anterior edge of the lower eyelid to the inner table of the occipital base (LEL/O line) appears nearly parallel to the Talairach-Tournoux (T/T) line, which shows a consistent intracranial anatomical relationship among subjects, and acts as a standard reference line for magnetic resonance (MR) imaging. Purpose: To quantitatively validate the LEL/O line as a new standard brain CT reference line. Material and methods: We measured: angle 1 = the LEL/O line on scout images from the LEL/O line on parasagittal CT images (n=93); and angle 2 = the LEL/O line on scout images from the T/T line on high resolution midsagittal MR images (n=97). Angles in a clockwise direction were defined as positive and were expressed as mean±SD with the 95% confidence interval (CI) of the SD. Angle 2 was measured independently by two observers and intraclass correlation coefficients (ICCs) were calculated. Results: Angle 1 was -0.4°±1.2° (95% CI of SD 1.1°-1.5°); angle 2 was -0.4°±2.0° (95% CI of SD, 1.8°-2.4°). The ICC in the angle 2 measurement was 0.780 ( Conclusion: The LEL/O lines on scout and parasagittal CT images show practically the same gradient, and these LEL/O lines are almost parallel to the T/T line. Use of the LEL/O line either for direct scanning or reformation can minimize intra- and inter-subject variations on CT images and mismatch between CT and MR images.
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2818429-4
ISSN	2058-4601
ISSN	2058-4601
DOI	10.1177/2058460120902406
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Article ; Online: Estimation of the physiologic ability and surgical stress scoring system as a useful predictor of postoperative recurrence in patients with stage II colorectal cancer: a multicenter study.

Tanio, Akimitsu / Saito, Hiroaki / Hara, Kazushi / Sugezawa, Ken / Uejima, Chihiro / Kihara, Kyoichi / Tatebe, Shigeru / Kurisu, Yasuro / Shibata, Shunsuke / Yamamoto, Toshio / Nishie, Hiroshi / Shiota, Setsujo / Naka, Takuji / Sugamura, Kenji / Katano, Kuniyuki / Yamamoto, Manabu / Fujiwara, Yoshiyuki

Surgery today

2023 Volume 53, Issue 8, Page(s) 949–956

Abstract: Purpose: We determined the usefulness of the estimation of physiologic ability and surgical stress (E-PASS), initially reported as a predictive factor for postoperative morbidity and mortality, as a prognostic indicator in stage II colorectal cancer ( ... ...

Abstract	Purpose: We determined the usefulness of the estimation of physiologic ability and surgical stress (E-PASS), initially reported as a predictive factor for postoperative morbidity and mortality, as a prognostic indicator in stage II colorectal cancer (CRC). Methods: Overall, 739 patients who underwent proctocolectomy for CRC at Tottori University Hospital and affiliated hospitals and histologically diagnosed with stage II CRC were included in the current study. Results: A receiver operating characteristic (ROC) analysis of the five-year recurrence-free survival indicated that the comprehensive risk score (CRS) of E-PASS predicted postoperative recurrence. A multivariate analysis revealed that the presence of preoperative perforation, T4, v ≥ 2, and CRS Conclusions: The CRS predicts postoperative recurrence in patients with stage II CRC.
MeSH term(s)	Humans ; Postoperative Complications/epidemiology ; Neoplasm Recurrence, Local/epidemiology ; Risk Factors ; Prognosis ; Colorectal Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2023-02-15
Publishing country	Japan
Document type	Multicenter Study ; Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-023-02656-2
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Article ; Online: Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells.

Yahata, Takashi / Ibrahim, Abd Aziz / Hirano, Ken-Ichi / Muguruma, Yukari / Naka, Kazuhito / Hozumi, Katsuto / Vaughan, Douglas E / Miyata, Toshio / Ando, Kiyoshi

Haematologica

2021 Volume 106, Issue 2, Page(s) 483–494

Abstract: Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility ... ...

Abstract	Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSCs to tyrosine kinase inhibitor (TKI), which facilitates the eradication of CML-LSCs and leads to sustained remission of the disease. We demonstrated for the first time that TGF-β-PAI-1 axis was selectively augmented in CML-LSCs in the bone marrow (BM), whereby protecting CML-LSCs from TKI treatment. Furthermore, the combined administration of TKI plus a PAI-1 inhibitor, in a mouse model of CML, significantly enhanced the eradication of CML cells in the BM and prolonged the survival of CML mice. The combined therapy of imatinib and a PAI-1 inhibitor prevented the recurrence of CML-like disease in serially transplanted recipients, indicating the elimination of CML-LSCs. Interestingly, PAI-1 inhibitor treatment augmented membrane-type matrix metalloprotease-1 (MT1-MMP)-dependent motility of CML-LSCs, and the anti-CML effect of PAI-1 inhibitor was extinguished by the neutralizing antibody for MT1-MMP, underlining the mechanistic importance of MT1-MMP. Our findings provide evidence of, and a rationale for, a novel therapeutic tactic, based on the blockade of PAI-1 activity, for CML patients.
MeSH term(s)	Animals ; Fusion Proteins, bcr-abl ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Mice ; Neoplastic Stem Cells ; Plasminogen Activator Inhibitor 1 ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Serpin E2
Chemical Substances	Plasminogen Activator Inhibitor 1 ; Protein Kinase Inhibitors ; SERPINE1 protein, human ; Serpin E2 ; Serpine2 protein, mouse ; Imatinib Mesylate (8A1O1M485B) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
Language	English
Publishing date	2021-02-01
Publishing country	Italy
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2019.230227
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Article ; Online: Case Report: Pulmonary Tumor Thrombotic Microangiopathy in a Cervical Cancer Patient.

Tsujimoto, Naoya / Miyoshi, Ai / Mimura, Mayuko / Naka, Toshio / Yamasaki, Masaru / Yokoi, Takeshi

Gynecologic and obstetric investigation

2018 Volume 83, Issue 1, Page(s) 99–104

Abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most ... ...

Abstract	Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most cases of PTTM are caused by an adenocarcinoma of the stomach. We present the first case report of PTTM caused by cervical squamous cell carcinoma. An 82-year-old woman presented with vaginal bleeding and exertional dyspnea. A cervical mass biopsy showed squamous cell carcinoma. Computed tomography revealed ground glass opacity of the bilateral peripheral lung fields. Hypoxia and pulmonary hypertension gradually worsened after admission. Treatment for acute heart failure was started, but was ineffective. She died of respiratory failure 31 days after admission. She was diagnosed at autopsy as having PTTM induced by cervical squamous cell carcinoma. PTTM needs to be considered in any patient with advanced cancer and lung-related issues to rule out metastatic disease, even in the absence of imaging findings.
MeSH term(s)	Aged, 80 and over ; Autopsy ; Carcinoma, Squamous Cell/secondary ; Fatal Outcome ; Female ; Humans ; Hypertension, Pulmonary/etiology ; Lung/pathology ; Lung Neoplasms/secondary ; Neoplastic Cells, Circulating ; Thrombotic Microangiopathies/etiology ; Tomography, X-Ray Computed ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/pathology
Language	English
Publishing date	2018
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	800003-7
ISSN	1423-002X ; 0378-7346
ISSN (online)	1423-002X
ISSN	0378-7346
DOI	10.1159/000480400
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Zs.A 688: Show issues

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Article ; Online: Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study.

Yagyu, Takuki / Yamamoto, Manabu / Tanio, Akimitsu / Hara, Kazushi / Sugezawa, Ken / Uejima, Chihiro / Kihara, Kyoichi / Tatebe, Shigeru / Kurisu, Yasuro / Shibata, Shunsuke / Yamamoto, Toshio / Nishie, Hiroshi / Shiota, Setsujo / Saito, Hiroaki / Naka, Takuji / Sugamura, Kenji / Katano, Kuniyuki / Fujiwara, Yoshiyuki

BMC cancer

2022 Volume 22, Issue 1, Page(s) 390

Abstract: Background: Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurrence remain controversial, and ... ...

Abstract	Background: Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurrence remain controversial, and there is limited information, especially for elderly patients. The Geriatric Nutritional Risk Index (GNRI) is widely used as a simple nutritional screening tool in the elderly and is associated with cancer prognosis and recurrence. This study aimed to investigate the risk factors for recurrence in the elderly with stage II CRC, focusing on the GNRI. Methods: We enrolled 348 elderly patients (≥ 75 years) with stage II CRC who underwent curative resection at the Department of Surgery, Tottori University and our 10 affiliated institutions. The patients were divided into GNRI Results: The GNRI Conclusions: GNRI
MeSH term(s)	Aged ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Geriatric Assessment ; Humans ; Neoplasm Recurrence, Local/epidemiology ; Nutrition Assessment ; Nutritional Status ; Prognosis ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09501-8
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Article ; Online: Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.

Maeba, Takaki / Hirata, Kazuyuki / Kotoku, Masayuki / Seki, Noriyoshi / Maeda, Katsuya / Hirashima, Shintaro / Yamanaka, Hiroshi / Sakai, Takayuki / Obika, Shingo / Hori, Akimi / Hara, Yoshinori / Noji, Satoru / Suwa, Yoshihiro / Yokota, Masahiro / Fujioka, Shingo / Yamaguchi, Takayuki / Katsuda, Yoshiaki / Hata, Takahiro / Miyagawa, Naoki /

Journal of medicinal chemistry

2024 Volume 67, Issue 2, Page(s) 952–970

Abstract: A number of RORγ inhibitors have been reported over the past decade. There were also several examples advancing to human clinical trials, however, none of them has reached the market yet, suggesting that there could be common obstacles for their future ... ...

Abstract	A number of RORγ inhibitors have been reported over the past decade. There were also several examples advancing to human clinical trials, however, none of them has reached the market yet, suggesting that there could be common obstacles for their future development. As was expected from the general homology of nuclear receptor ligands, insufficient selectivity as well as poor physicochemical properties were identified as potential risks for a RORγ program. Based on such considerations, we conducted a SAR investigation by prioritizing drug-like properties to mitigate such potential drawbacks. After an intensive SAR exploration with strong emphasis on "drug-likeness" indices, an orally available RORγ inhibitor, JTE-151, was finally generated and was advanced to a human clinical trial. The compound was confirmed to possess highly selective profiles along with good metabolic stability, and most beneficially, no serious adverse events (SAE) and good PK profiles were observed in the human clinical trial.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01933
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Article ; Online: Influence of incomplete neoadjuvant chemotherapy on esophageal carcinoma.

Fujiwara, Yushi / Lee, Shigeru / Kishida, Satoru / Hashiba, Ryoya / Gyobu, Ken / Naka, Ryoko / Nishiyama, Masaki / Ihara, Toshio / Takemura, Masashi / Osugi, Harushi

International journal of clinical oncology

2018 Volume 23, Issue 5, Page(s) 877–885

Abstract: Background: Neoadjuvant chemotherapy (NAC) involving two cycles of cisplatin plus fluorouracil is recommended in Japan as a standard treatment for resectable, locally advanced esophageal squamous cell carcinoma (ESCC). We have encountered patients who ... ...

Abstract	Background: Neoadjuvant chemotherapy (NAC) involving two cycles of cisplatin plus fluorouracil is recommended in Japan as a standard treatment for resectable, locally advanced esophageal squamous cell carcinoma (ESCC). We have encountered patients who were administered incomplete chemotherapy because of adverse events or the patient's refusal of treatment. Here, we retrospectively investigated the influence on perioperative outcomes and long-term prognosis of patients with ESCC who underwent complete (two cycles) or incomplete (one cycle) NAC. Methods: We retrospectively investigated 133 patients with locally advanced ESCC of the thoracic esophagus who underwent NAC. We compared the perioperative results and prognoses of patients who underwent complete or incomplete NAC because of adverse events or the patient's refusal of treatment. Results: Of 133 patients, 37 patients did not receive the second cycle of NAC; the remaining 96 patients received the second cycle of NAC as scheduled. There were no significant differences in the clinical backgrounds, surgical results, or operative morbidity rates between the groups. Patients in both groups were similarly administered postoperative chemotherapy regimens. There was no significant difference in disease-free survival or overall survival. Conclusions: We suggest that perioperative outcomes and long-term prognosis of patients with locally advanced ESCC were not significantly influenced, even if the patients did not receive a complete cycle of NAC. When certain adverse events occur after the first cycle of NAC, we believe that it is nevertheless possible to discontinue chemotherapy.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Disease-Free Survival ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/surgery ; Female ; Fluorouracil/administration & dosage ; Humans ; Japan ; Male ; Middle Aged ; Neoadjuvant Therapy ; Prognosis ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2018-05-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-018-1291-6
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Article: Whole-body vibration training improves the walking ability of a moderately impaired child with cerebral palsy: a case study.

Yabumoto, Tamotsu / Shin, Sohee / Watanabe, Tsuneo / Watanabe, Yusuke / Naka, Toru / Oguri, Kazuo / Matsuoka, Toshio

Journal of physical therapy science

2015 Volume 27, Issue 9, Page(s) 3023–3025

Abstract: Purpose] Strength training is recommended for children with cerebral palsy. However, it is difficult for moderately impaired children with cerebral palsy, who require crutches for ambulation, to participate in this type of training. The purpose of this ... ...

Abstract	[Purpose] Strength training is recommended for children with cerebral palsy. However, it is difficult for moderately impaired children with cerebral palsy, who require crutches for ambulation, to participate in this type of training. The purpose of this study was to investigate whether whole-body vibration training is an effective method of strengthening in a moderately impaired child with cerebral palsy. [Subject and Methods] This report describes an 8-year-old Japanese boy with cerebral palsy, who was ambulatory with crutches. The subject participated in physical therapy twice a week for 5 weeks. Whole-body vibration training was selected to complement the standing practice. The patient's crutch-walking ability, gross motor function, and spasticity were evaluated. [Results] The number of steps and walking duration were reduced in a 5-m walk test with crutches and gross motor function was improved. Further, the spasticity was reduced. [Conclusion] Whole-body vibration training is an effective physical therapy intervention in moderately impaired children with cerebral palsy, who are unable to walk without crutches.
Language	English
Publishing date	2015-09-30
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.27.3023
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Article ; Online: 'Super high-flux' or 'high cut-off' hemofiltration and hemodialysis.

Naka, Toshio / Haase, Michael / Bellomo, Rinaldo

Contributions to nephrology

2010 Volume 166, Page(s) 181–189

Abstract: Recently, 'super high-flux' (SHF) or 'high cut-off' (HCO) membranes have been developed to increase the clearance of inflammatory mediators. In the experimental and clinical settings, SHF/HCO membranes appear to achieve greater clearance of inflammatory ... ...

Abstract	Recently, 'super high-flux' (SHF) or 'high cut-off' (HCO) membranes have been developed to increase the clearance of inflammatory mediators. In the experimental and clinical settings, SHF/HCO membranes appear to achieve greater clearance of inflammatory cytokines than conventional high-flux membranes. SHF/HCO membranes also restore immune cell function, attenuate hemodynamic instability and decrease plasma IL-6 levels. Moreover, SHF/HCO membranes can eliminate larger late-phase inflammatory mediators such as HMGB-1. Although albumin sieving coefficients with SHF/HCO membranes are greater than with conventional high-flux membranes, the daily amount lost is limited and can be replaced. Hemodialysis with SHF/HCO membranes can also achieve similar cytokine removal to hemofiltration with acceptable albumin losses. When strategies for sepsis or systemic inflammation treatment target middle molecular mediators, both SHF/HCO hemofiltration and hemodialysis appear feasible and safe and require further clinical investigation.
MeSH term(s)	Cytokines/blood ; Cytokines/isolation & purification ; Hemodynamics ; Hemofiltration/instrumentation ; Humans ; Immunity ; Inflammation Mediators/blood ; Inflammation Mediators/isolation & purification ; Membranes, Artificial ; Renal Dialysis/instrumentation
Chemical Substances	Cytokines ; Inflammation Mediators ; Membranes, Artificial
Language	English
Publishing date	2010-05-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000314871
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Article ; Online: Surgically Diagnosed Primary Hepatic Angiosarcoma.

Tsunematsu, Seiji / Muto, Shuichi / Oi, Hiroki / Naka, Tomoaki / Kitagataya, Takashi / Sasaki, Rui / Taya, Yoko / Baba, Urara / Tsukamoto, Yuki / Uemura, Kazuhito / Kimura, Toshio / Ohara, Yukio

Internal medicine (Tokyo, Japan)

2018 Volume 57, Issue 5, Page(s) 687–691

Abstract: Primary hepatic angiosarcoma is a rare tumor originating from endothelial cells in the liver and accounts for approximately 1% of all hepatic malignant tumors. It is difficult to diagnose due to the lack of specific symptoms or tumor markers. No ... ...

Abstract	Primary hepatic angiosarcoma is a rare tumor originating from endothelial cells in the liver and accounts for approximately 1% of all hepatic malignant tumors. It is difficult to diagnose due to the lack of specific symptoms or tumor markers. No effective treatment exists, but complete surgical resection may achieve a good outcome. Since most primary hepatic angiosarcomas are already at an advanced stage at diagnosis, few reports describe tumors smaller than 2 cm. We report a case of surgery for a 1.7-cm sized primary hepatic angiosarcoma. Further studies are required to improve the preoperative diagnosis of primary hepatic angiosarcoma.
MeSH term(s)	Aged ; Biomarkers, Tumor ; Female ; Hemangiosarcoma/diagnosis ; Hemangiosarcoma/pathology ; Hemangiosarcoma/surgery ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2018-03-01
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9318-17
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