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Article ; Online: Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology.

Du, Kuo / Jun, Ji Hye / Dutta, Rajesh K / Diehl, Anna Mae

Hepatology communications

2024 Volume 8, Issue 5

Abstract: HSCs, the resident pericytes of the liver, have consistently been at the forefront of liver research due to their crucial roles in various hepatic pathological processes. Prior literature often depicted HSCs in a binary framework, categorizing them as ... ...

Abstract	HSCs, the resident pericytes of the liver, have consistently been at the forefront of liver research due to their crucial roles in various hepatic pathological processes. Prior literature often depicted HSCs in a binary framework, categorizing them as either quiescent or activated. However, recent advances in HSC research, particularly the advent of single-cell RNA-sequencing, have revolutionized our understanding of these cells. This sophisticated technique offers an unparalleled, high-resolution insight into HSC populations, uncovering a spectrum of diversity and functional heterogeneity across various physiological states of the liver, ranging from liver development to the liver aging process. The single-cell RNA-sequencing revelations have also highlighted the intrinsic plasticity of HSCs and underscored their complex roles in a myriad of pathophysiological processes, including liver injury, repair, and carcinogenesis. This review aims to integrate and clarify these recent discoveries, focusing on how the inherent plasticity of HSCs is central to their dynamic roles both in maintaining liver homeostasis and orchestrating responses to liver injury. Future research will clarify whether findings from rodent models can be translated to human livers and guide how these insights are harnessed to develop targeted therapeutic interventions.
MeSH term(s)	Humans ; Hepatic Stellate Cells ; Liver ; Carcinogenesis ; Homeostasis ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Review ; Journal Article
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000411
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Article ; Online: Withdrawal:

Sun, Lin / Dutta, Rajesh K / Xie, Ping / Kanwar, Yashpal S

The Journal of biological chemistry

2019 Volume 294, Issue 26, Page(s) 10380

Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.W119.009586
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Article ; Online: Pneumopericardium after minimally invasive atrial septal defect closure.

Lamba, Aditya / Dutta, Rahul / Chand, Rajesh K

Annals of cardiac anaesthesia

2018 Volume 21, Issue 1, Page(s) 99–100

Abstract: Minimally invasive atrial septal defect (ASD) closure is a commonly performed cardiac surgical procedure and has good outcome. We report an interesting chest X-ray showing pneumopericardium in a patient who underwent ASD closure using a minimally ... ...

Abstract	Minimally invasive atrial septal defect (ASD) closure is a commonly performed cardiac surgical procedure and has good outcome. We report an interesting chest X-ray showing pneumopericardium in a patient who underwent ASD closure using a minimally invasive approach.
MeSH term(s)	Adult ; Female ; Heart Septal Defects, Atrial/surgery ; Humans ; Minimally Invasive Surgical Procedures/adverse effects ; Pneumopericardium/etiology ; Pneumopericardium/therapy ; Postoperative Complications/etiology ; Postoperative Complications/therapy
Language	English
Publishing date	2018-01-16
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	2106866-5
ISSN	0974-5181 ; 0971-9784
ISSN (online)	0974-5181
ISSN	0971-9784
DOI	10.4103/aca.ACA_37_17
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Article ; Online: Density Functional Theory-Guided Photo-Triggered Anticancer Activity of Curcumin-Based Zinc(II) Complexes.

Kushwaha, Rajesh / Singh, Virendra / Peters, Silda / Yadav, Ashish K / Dolui, Dependu / Saha, Sukanta / Sarkar, Sujit / Dutta, Arnab / Koch, Biplob / Sadhukhan, Tumpa / Banerjee, Samya

The journal of physical chemistry. B

2023 Volume 127, Issue 48, Page(s) 10266–10278

Abstract: Photodynamic therapy (PDT) has evolved as a new therapeutic modality for cancer treatment with fewer side effects and drug resistance. Curcumin exhibits PDT activity, but its low bioavailability restricts its clinical application. Here, the ... ...

Abstract	Photodynamic therapy (PDT) has evolved as a new therapeutic modality for cancer treatment with fewer side effects and drug resistance. Curcumin exhibits PDT activity, but its low bioavailability restricts its clinical application. Here, the bioavailability of curcumin was increased by its complex formation with the Zn(II) center. For a structure-activity relationship study, Zn(II)-based complexes (
MeSH term(s)	Humans ; Curcumin/pharmacology ; Density Functional Theory ; Zinc/chemistry ; Caspase 9/metabolism ; Molecular Docking Simulation ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Coordination Complexes/chemistry ; Antineoplastic Agents/chemistry ; Photochemotherapy
Chemical Substances	Curcumin (IT942ZTH98) ; Zinc (J41CSQ7QDS) ; Caspase 9 (EC 3.4.22.-) ; Photosensitizing Agents ; Coordination Complexes ; Antineoplastic Agents
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c02382
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Article: Cholera outbreak associated with contaminated water sources in paddy fields, Mandla District, Madhya Pradesh, India.

Dutta, Biswa Prakash / Kumar, Nishant / Meshram, K C / Yadav, Rajesh / Sodha, Samir V / Gupta, Sonia

Indian journal of public health

2021 Volume 65, Issue Supplement, Page(s) S46–S50

Abstract: Background: Mandla District in Madhya Pradesh, India, reported a suspected cholera outbreak from Ghughri subdistrict on August 18, 2016.: Objective: We investigated to determine risk factors and recommend control and prevention measures.: Methods: ...

Abstract	Background: Mandla District in Madhya Pradesh, India, reported a suspected cholera outbreak from Ghughri subdistrict on August 18, 2016. Objective: We investigated to determine risk factors and recommend control and prevention measures. Methods: We defined a case as >3 loose stools in 24 h in a Ghughri resident between July 20 and August 19, 2016. We identified cases by passive surveillance in health facilities and by a house-to-house survey in 28 highly affected villages. We conducted a 1:2 unmatched case-control study, collected stool samples for culture, and tested water sources for fecal contamination. Results: We identified 628 cases (61% female) from 96 villages; the median age was 27 years (range: 1 month-76 years). Illnesses began 7 days after rainfall with 259 (41%) hospitalizations and 14 (2%) deaths in people from remote villages who died before reaching a health facility; 12 (86%) worked in paddy fields. Illness was associated with drinking well water within paddy fields (odds ratio [OR] = 4.0, 95% confidence interval [CI] = 1.4-8.0) and not washing hands with soap after defecation (OR = 6.1, CI = 1.7-21). Of 34 stool cultures, 11 (34%) tested positive for Vibrio cholerae O1 Ogawa. We observed open defecation in affected villages around paddy fields. Of 16 tested water sources in paddy fields, eight (50%) were protected, but 100% had fecal contamination. Conclusion: We recommended education regarding pit latrine sanitation and safe water, especially in paddy fields, provision of oral rehydration solution in remote villages, and chlorine tablets for point-of-use treatment of drinking water.
MeSH term(s)	Adult ; Case-Control Studies ; Cholera/epidemiology ; Disease Outbreaks ; Drinking Water ; Female ; Humans ; India/epidemiology ; Male
Chemical Substances	Drinking Water
Language	English
Publishing date	2021-03-22
Publishing country	India
Document type	Journal Article
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
DOI	10.4103/ijph.IJPH_1118_20
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Article ; Online: Inhibitory potential of iRGD peptide-conjugated garcinol-loaded biodegradable nanoparticles in rat colorectal carcinoma.

Paul, Brahamacharry / Gaonkar, Raghuvir H / Dutta, Debasmita / Dasi, Rajesh / Mukherjee, Biswajit / Ganguly, Shantanu / Das, Sujoy K

Biomaterials advances

2022 Volume 134, Page(s) 112714

Abstract: Targeted drug delivery has become attention in chemotherapy during the last decade. The principle of chemotherapy seeks maximum effect to the desired site and the minimum impact to other undesired sites of action. The nanoparticulated drug delivery ... ...

Abstract	Targeted drug delivery has become attention in chemotherapy during the last decade. The principle of chemotherapy seeks maximum effect to the desired site and the minimum impact to other undesired sites of action. The nanoparticulated drug delivery system progressed a lot in this aspect in the last twenty years. Plant-derived natural products and their semisynthetic analogues boosted chemotherapy through their excellent mechanistic approach to killing cancer cells. Keeping in mind the available molecular targets in colorectal carcinoma (CRC), in this article, we proposed a peptide conjugated novel polymeric nanoparticle to deliver garcinol against colorectal carcinoma. Integrin binding peptide iRGD, sequence c(CRGDKGPDC), has been selected as a targeting moiety, as most CRC overexpress integrins. We encapsulated garcinol in biodegradable polymeric nanoparticle (PLGA)-conjugated with iRGD peptide on the particles' surface, and analyzed its (iRGD-GAR-NP's) in vitro and in vivo antineoplastic potential against CRC in a comparative way with gracinol (GAR) and garcinol-loaded PLGA nanoparticles (GAR-NP). In vitro cellular studies on human CRC cell lines, HCT116 and HT-29, revealed the superior cytotoxic potential of iRGD-GAR-NP over GAR and GAR-NP. The IC
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Humans ; Nanoparticles ; Oligopeptides ; Polylactic Acid-Polyglycolic Acid Copolymer/therapeutic use ; Polymers/therapeutic use ; Rats ; Terpenes ; Tissue Distribution
Chemical Substances	Antineoplastic Agents ; N-end cysteine peptide tumor-homing peptide ; Oligopeptides ; Polymers ; Terpenes ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; garcinol (TR1VR1V71B)
Language	English
Publishing date	2022-02-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.msec.2022.112714
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Article: Limited Invasive Protocol: Optimizing Diagnostic Modalities in Corticotropin Mediated Cushing Syndrome.

Gupta, Rahul / Walia, Rama / Ahuja, Chirag / Dutta, Aditya / Bhadada, Sanjay K / Bhansali, Anil / Chhabra, Rajesh / Singh, Apinderpreet / Dhandapani, Sivashanmugam

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2022 Volume 28, Issue 8, Page(s) 767–773

Abstract: Background: To limit the role of bilateral inferior petrosal sinus sampling (BIPSS) in distinguishing between Cushing disease (CD) and ectopic Cushing syndrome (ECS), recent reports have proposed a noninvasive approach based on a combination of ... ...

Abstract	Background: To limit the role of bilateral inferior petrosal sinus sampling (BIPSS) in distinguishing between Cushing disease (CD) and ectopic Cushing syndrome (ECS), recent reports have proposed a noninvasive approach based on a combination of biochemical testing and radiological imaging as an alternative to the conventional invasive strategy (CIS). However, this strategy requires further validation. The current study aimed to evaluate 2 limited invasive protocols (LIP-1 and LIP-2) in limiting the role of BIPSS while maintaining a diagnostic accuracy similar to that of CIS. Methods: This was a single-center study conducted on individuals with corticotropin-dependent Cushing syndrome. The LIPs were based on performing high-dose dexamethasone suppression (>50% cut-off in first [LIP-1] and >80% in second [LIP-2]) and magnetic resonance imaging of the sella in all individuals and selective use of computed tomography of the chest and abdomen before BIPSS. These LIPs were evaluated for limiting the use of BIPSS, their accuracy, and cost in comparison to CIS. Results: Of the 206 individuals, 114 (97 of CD and 21 of ECS) were eligible for the current study. Using LIP-1, LIP-2, and CIS, BIPSS could have been avoided in 62.3%, 35.9%, and 25.4% of individuals, respectively. The positive predictive value for CD using LIP-1 and LIP-2 was 98.9% and 100%, respectively. The cost per patient evaluated using LIP-1, LIP-2, and CIS was $602.21, $966.81, and $1107.78, respectively. Conclusion: LIPs represent an equally accurate, less invasive, and more cost-effective alternative to the CIS for distinguishing between CD and ECS.
MeSH term(s)	Adrenocorticotropic Hormone ; Cushing Syndrome/diagnosis ; Diagnosis, Differential ; Humans ; Magnetic Resonance Imaging ; Petrosal Sinus Sampling/methods ; Pituitary ACTH Hypersecretion/diagnostic imaging
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.1016/j.eprac.2022.04.013
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Zs.A 5034: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Prospective Evaluation of Response to Treatment, Survival Functions, Recurrence Pattern and Toxicity Profile in Indian Patients with Oligo-Brain Metastasis Treated with Only SRS.

Dutta, Debnarayan / Reddy, Sruti K / Kamath, Ram K / Sreenija, Yarlagadda / Nair, Haridas / Sashidharan, Ajay / Remesan Nair, R Anoop / Pushpuja, K U / Kannan, Rajesh / Edappattu, Annex / Haridas, Nikhil K / Jose, Wesley M / Keechilat, Pavithran

Neurology India

2023 Volume 71, Issue 1, Page(s) 62–71

Abstract: Background: Prospective analysis of oligo-brain metastasis in Indian patients treated with SRS-only treatment.: Methods: Between January 2017 and May 2022, 235 patients were screened and 138 histologically proven and radiologically confirmed. One to ... ...

Abstract	Background: Prospective analysis of oligo-brain metastasis in Indian patients treated with SRS-only treatment. Methods: Between January 2017 and May 2022, 235 patients were screened and 138 histologically proven and radiologically confirmed. One to five brain metastasis patients aged more than 18 years with good Karnofsky performance status (KPS >70) accrued in ethical and scientific committee-approved prospective observational study protocol for treatment with only radiosurgery (SRS) with robotic radiosurgery (CyberKnife, CK) [AIMS IRB: 2020-071; CTRI No: REF/2022/01/050237]. Immobilization was performed with a thermoplastic mask, contrast CT simulation was performed with 0.625 mm slices, fused with T1 contrast/T2 FLAIR MRI images for contouring. Planning target volume (PTV) margin of 2-3 mm and a dose of 20-30 Gy in 1-5 fractions. Response to treatment, new brain lesions free survival, overall survival, and toxicity profile after CK were evaluated. Results: in total,: 138 patients with 251 lesions were accrued (median age 59 years (interquartile range [IQR] 49-67 years; female 51%; headache in 34%, motor deficit in 7%, KPS >90 in 56%; lung primary in 44%, breast in 30%; oligo-recurrence in 45%; synchronous oligo-metastases in 33%; adenocarcinoma primary in 83%). One hundred seven patients (77%) received upfront Stereotactic radiotherapy (SRS), 15 (11%) received postoperative SRS, 12 (9%) received whole brain radiotherapy (WBRT) before SRS, and 3 (2%) received WBRT plus SRS boost. The majority had solitary (56%) brain metastasis, 28% had two to three lesions, and 16% had four to five brain lesions. Frontal (39%) was the most common site. Median PTV was 15.5 mL (IQR - 8.1-28.5 mL). Seventy-one (52%) patients were treated with single fractions, 14% with three, and 33% with five fractions. Fraction schedules were 20-2 4 Gy/1fr; 27 Gy/3fr, and 25 Gy/5 fractions (mean BED 74.6 Gy [SD ± 48.1; mean MU 16608], mean treatment time was 49 min (range 17-118 min]. Twelve Gy normal brain volume was 40.8 mL (3.2%) (range 19.3-73.7 mL). At a mean follow-up of 15 months (SD 11.9 months; max 56 months), the mean actuarial OS after SRS-only treatment was 23.7 months (95% confidence interval [CI] 20-28). Further 124 (90%) patients had >3 months, 108 (78%) had >6 months, 65 (47%) had >12 months, and 26 (19%) had >24 months follow-up. Intracranial disease and extracranial disease were controlled in 72 (52.2%) and 60 (43.5%), respectively. "In-field" recurrence, "out-of-field," and "both in and out-of-field" recurrences were in 11%, 42%, and 46%, respectively. At the last follow-up, 55 patients (40%) were alive, 75 (54%) died due to disease progression, and the status of 8 (6%) patients was not known. Among 75 patients who died, 46 (61%) had extracranial disease progression, 12 (16%) had only intracranial progression, and 8 (11%) had unrelated causes. Also, 12/117 (9%) had radiological confirmation of radiation necrosis. Prognostication based on western patients (primary tumor type, number of lesions extracranial disease) showed similar outcomes. Conclusions: SRS alone in brain metastasis is feasible in the Indian subcontinent with similar survival outcomes, recurrence patterns, and toxicity as published in the western literature. Patient selection, dose schedule, and planning need to be standardized to have similar outcomes. WBRT can be safely omitted in Indian patients with oligo-brain metastasis. Western prognostication nomogram is applicable in the Indian patient population.
MeSH term(s)	Aged ; Female ; Humans ; Middle Aged ; Asian People ; Brain/diagnostic imaging ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Disease Progression ; Radiation Injuries ; Male
Language	English
Publishing date	2023-03-02
Publishing country	India
Document type	Observational Study ; Journal Article
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.370470
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Article ; Online: Hedgehog Signaling: Implications in Liver Pathophysiology.

Dutta, Rajesh Kumar / Jun, JiHye / Du, Kuo / Diehl, Anna Mae

Seminars in liver disease

2023 Volume 43, Issue 4, Page(s) 418–428

Abstract: The purpose of this review is to summarize current knowledge about the role of the Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a morphogenic signaling pathway that is active in development. In most healthy tissues, pathway ... ...

Abstract	The purpose of this review is to summarize current knowledge about the role of the Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a morphogenic signaling pathway that is active in development. In most healthy tissues, pathway activity is restricted to stem and/or stromal cell compartments, where it enables stem cell self-renewal and tissue homeostasis. Aberrant over-activation of Hedgehog signaling occurs in many cancers, including hepatocellular and cholangio-carcinoma. The pathway is also activated transiently in stromal cells of injured tissues and orchestrates normal wound healing responses, including inflammation, vascular remodeling, and fibrogenesis. In liver, sustained Hedgehog signaling in stromal cells plays a major role in the pathogenesis of cirrhosis. Hedgehog signaling was thought to be silenced in healthy hepatocytes. However, recent studies show that targeted disruption of the pathway in hepatocytes dysregulates lipid, cholesterol, and bile acid metabolism, and promotes hepatic lipotoxicity, insulin resistance, and senescence. Hepatocytes that lack Hedgehog activity also produce a secretome that activates Hedgehog signaling in cholangiocytes and neighboring stromal cells to induce inflammatory and fibrogenic wound healing responses that drive progressive fibrosis. In conclusion, Hedgehog signaling must be precisely controlled in adult liver cells to maintain liver health.
MeSH term(s)	Adult ; Humans ; Hedgehog Proteins/metabolism ; Liver Diseases/metabolism ; Liver/pathology ; Signal Transduction/physiology ; Liver Cirrhosis/metabolism
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603177-8
ISSN	1098-8971 ; 0272-8087
ISSN (online)	1098-8971
ISSN	0272-8087
DOI	10.1055/a-2187-3382
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Article ; Online: Conventional vs Short Duration of Antibiotics in Patients With Moderate or Severe Cholangitis: Noninferiority Randomized Trial.

Srinu, Deshidi / Shah, Jimil / Jena, Anuraag / Jearth, Vaneet / Singh, Anupam K / Mandavdhare, Harshal S / Sharma, Vishal / Irrinki, Santosh / Sakaray, Yashwant Raj / Gupta, Rajesh / Gautam, Vikas / Rana, Surinder / Dutta, Usha

The American journal of gastroenterology

2023 Volume 119, Issue 1, Page(s) 176–182

Abstract: Introduction: Successful biliary drainage and antibiotics are the mainstays of therapy in management of patients with acute cholangitis. However, the duration of antibiotic therapy after successful biliary drainage has not been prospectively evaluated. ... ...

Abstract	Introduction: Successful biliary drainage and antibiotics are the mainstays of therapy in management of patients with acute cholangitis. However, the duration of antibiotic therapy after successful biliary drainage has not been prospectively evaluated. We conducted a single-center, randomized, noninferiority trial to compare short duration of antibiotic therapy with conventional duration of antibiotic therapy in patients with moderate or severe cholangitis. Methods: Consecutive patients were screened for the inclusion criteria and randomized into either conventional duration (CD) group (8 days) or short duration (SD) group (4 days) of antibiotic therapy. The primary outcome was clinical cure (absence of recurrence of cholangitis at day 30 and >50% reduction of bilirubin at day 15). Secondary outcomes were total days of antibiotic therapy and hospitalization within 30 days, antibiotic-related adverse events, and all-cause mortality at day 30. Results: The study included 120 patients (the mean age was 55.85 ± 13.52 years, and 50% were male patients). Of them, 51.7% patients had malignant etiology and 76.7% patients had moderate cholangitis. Clinical cure was seen in 79.66% (95% confidence interval, 67.58%-88.12%) patients in the CD group and 77.97% (95% confidence interval, 65.74%-86.78%) patients in the SD group ( P = 0.822). On multivariate analysis, malignant etiology and hypotension at presentation were associated with lower clinical cure. Total duration of antibiotics required postintervention was lower in the SD group (8.58 ± 1.92 and 4.75 ± 2.32 days; P < 0.001). Duration of hospitalization and mortality were similar in both the groups. Discussion: Short duration of antibiotics is noninferior to conventional duration in patients with moderate-to-severe cholangitis in terms of clinical cure, recurrence of cholangitis, and overall mortality.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Anti-Bacterial Agents ; Acute Disease ; Cholangitis/drug therapy ; Cholangitis/etiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000002499
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